From Bioblast
- high-resolution terminology - matching measurements at high-resolution
Complex II
Description
Complex II or succinate:quinone oxidoreductase (SQR) is the only membrane-bound enzyme in the TCA cycle and is part of the electron transfer pathway. The reversible oxidoreduction of succinate and fumarate is catalyzed in a soluble domain and coupled to the reversible oxidoreduction of quinol and quinone in the mitochondrial inner membrane. CII consists in most species of four subunits. The flavoprotein succinate dehydrogenase is the largest polypeptide of CII, located on the matrix face of the mt-inner membrane. Succinate:quinone oxidoreductases (SQRs, SDHABCD) favour oxidation of succinate and reduction of quinone in the canonical forward direction of the TCA cycle and electron transfer into the Q-junction. In contrast, quinol:fumarate reductases (QFRs, fumarate reductases, FRDABCD) tend to operate in the reverse direction reducing fumarate and oxidizing quinol.
Abbreviation: CII
Reference: Gnaiger 2020 BEC MitoPathways; Gnaiger E (2023) Complex II ambiguities ― FADH2 in the electron transfer system. MitoFit Preprints 2023.3. https://doi.org/10.26124/mitofit:2023-0003
List of publications: Complex II
| Year | Reference | Mammal and model | Tissue and cell | Stress | Diseases | |
|---|---|---|---|---|---|---|
| Balnis 2024 Sci Adv | 2024 | Balnis J, Tufts A, Jackson EL, Drake LA, Singer DV, Lacomis D, Lee CG, Elias JA, Doles JD, Maher LJ 3rd, Jen A, Coon JJ, Jourd'heuil D, Singer HA, Vincent CE, Jaitovich A (2024) Succinate dehydrogenase-complex II regulates skeletal muscle cellular respiration and contractility but not muscle mass in genetically induced pulmonary emphysema. Sci Adv [Epub ahead of print]. https://doi.org/10.1126/sciadv.ado8549 | Mouse | Skeletal muscle | Other | |
| Jiang 2024 Nat Metab | 2024 | Jiang S, Yuan T, Rosenberger FA, Mourier A, Dragano NRV, Kremer LS, Rubalcava-Gracia D, Hansen FM, Borg M, Mennuni M, Filograna R, Alsina D, Misic J, Koolmeister C, Papadea P, de Angelis MH, Ren L, Andersson O, Unger A, Bergbrede T, Di Lucrezia R, Wibom R, Zierath JR, Krook A, Giavalisco P, Mann M, Larsson NG (2024) Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity. Nat Metab [Epub ahead of print]. https://doi.org/10.1038/s42255-024-01038-3 | Mouse | Liver | Obesity Other | |
| Gnaiger 2024 J Biol Chem | 2024 | Gnaiger E (2024) Complex II ambiguities ― FADH2 in the electron transfer system. J Biol Chem 300:105470. https://doi.org/10.1016/j.jbc.2023.105470 | ||||
| Mathiyazakan 2023 Antimicrob Agents Chemother | 2023 | Mathiyazakan V, Wong CF, Harikishore A, Pethe K, Grüber G (2023) Cryo-electron microscopy structure of the Mycobacterium tuberculosis cytochrome bcc:aa3 supercomplex and a novel inhibitor targeting subunit cytochrome cI. Antimicrob Agents Chemother 67:e0153122. https://doi.org/10.1128/aac.01531-22 | ||||
| Som 2023 Am J Physiol Cell Physiol | 2023 | Som R, Fink BD, Yu L, Sivitz WI (2023) Oxaloacetate regulates complex II respiration in brown fat: dependence on UCP1 expression. Am J Physiol Cell Physiol 324:C1236-48. doi: 10.1152/ajpcell.00565.2022 | Mouse | Fat | Oxidative stress;RONS | Obesity |
| Chang 2023 Front Endocrinol (Lausanne) | 2023 | Chang JS (2023) Recent insights into the molecular mechanisms of simultaneous fatty acid oxidation and synthesis in brown adipocytes. Front Endocrinol (Lausanne) 14:1106544. https://doi.org/10.3389/fendo.2023.1106544 | ||||
| Liu 2023 Int J Biol Sci | 2023 | Liu Y, Sun Y, Guo Y, Shi X, Chen X, Feng W, Wu LL, Zhang J, Yu S, Wang Y, Shi Y (2023) An overview: the diversified role of mitochondria in cancer metabolism. Int J Biol Sci 19:897-915. https://doi.org/10.7150/ijbs.81609 | Cancer | |||
| Frangos 2023 J Biol Chem | 2023 | Frangos SM, DesOrmeaux GJ, Holloway GP (2023) Acidosis attenuates CPT-I supported bioenergetics as a potential mechanism limiting lipid oxidation. https://doi.org/10.1016/j.jbc.2023.105079 | Mouse | Skeletal muscle | ||
| Koizumi 2023 Front Cardiovasc Med | 2023 | Koizumi T, Watanabe M, Yokota T, Tsuda M, Handa H, Koya J, Nishino K, Tatsuta D, Natsui H, Kadosaka T, Koya T, Nakao M, Hagiwara H, Kamada R, Temma T, Tanaka S, Anzai T (2023) Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats. Front Cardiovasc Med 10: 1005408. | Rat | Heart | Cardiovascular Diabetes | |
| Sadri 2023 Function (Oxf) | 2023 | Sadri S, Zhang X, Audi SH, Cowley AW Jr, Dash RK (2023) Computational modeling of substrate-dependent mitochondrial respiration and bioenergetics in the heart and kidney cortex and outer medulla. Function (Oxf) 4:zqad038. https://doi.org/10.1093/function/zqad038 | Rat | Heart Kidney | ||
| Egan 2023 Physiol Rev | 2023 | Egan B, Sharples AP (2023) Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training. Physiol Rev 103:2057-170. https://doi.org/10.1152/physrev.00054.2021 | ||||
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| Martell 2023 Nat Commun | 2023 | Martell E, Kuzmychova H, Kaul E, Senthil H, Chowdhury SR, Morrison LC, Fresnoza A, Zagozewski J, Venugopal C, Anderson CM, Singh SK, Banerji V, Werbowetski-Ogilvie TE, Sharif T (2023) Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 medulloblastoma. https://doi.org/10.1038/s41467-023-38049-9 | Human | Nervous system | Cancer | |
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| Arnold 2023 J Biol Chem | 2023 | Arnold PK, Finley LWS (2023) Regulation and function of the mammalian tricarboxylic acid cycle. J Biol Chem 299:102838. https://doi.org/10.1016/j.jbc.2022.102838 | ||||
| Scandella 2023 Trends Endocrinol Metab | 2023 | Scandella V, Petrelli F, Moore DL, Braun SMG, Knobloch M (2023) Neural stem cell metabolism revisited: a critical role for mitochondria. Trends Endocrinol Metab 34:446-61. https://doi.org/10.1016/j.tem.2023.05.008 | ||||
| Shu 2023 Front Immunol | 2023 | Shu P, Liang H, Zhang J, Lin Y, Chen W, Zhang D (2023) Reactive oxygen species formation and its effect on CD4+ T cell-mediated inflammation. Front Immunol 14:1199233. doi: 10.3389/fimmu.2023.1199233 | ||||
| Iverson 2023 J Biol Chem | 2023 | Iverson TM, Singh PK, Cecchini G (2023) An evolving view of Complex II – non- canonical complexes, megacomplexes, respiration, signaling, and beyond. J Biol Chem 299:104761. https://doi.org/10.1016/j.jbc.2023.104761 | ||||
| Karavaeva 2023 Biochim Biophys Acta Bioenerg | 2023 | Karavaeva V, Sousa FL (2023) Modular structure of complex II: An evolutionary perspective. Biochim Biophys Acta Bioenerg 1864:148916. https://doi.org/10.1016/j.bbabio.2022.148916 | ||||
| Keidar 2023 Front Physiol | 2023 | Keidar N, Peretz NK, Yaniv Y (2023) Ca2+ pushes and pulls energetics to maintain ATP balance in atrial cells: computational insights. Front Physiol 14:1231259. https://doi.org/10.3389/fphys.2023.1231259 | ||||
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| Diaz 2023 Front Mol Biosci | 2023 | Diaz EC, Adams SH, Weber JL, Cotter M, Børsheim E (2023) Elevated LDL-C, high blood pressure, and low peak V˙O2 associate with platelet mitochondria function in children-The Arkansas Active Kids Study. Front Mol Biosci 10:1136975. https://doi.org/10.3389/fmolb.2023.1136975 | Human | Blood cells Platelet | Aging;senescence | |
| Cojocaru 2023 Antioxidants (Basel) | 2023 | Cojocaru KA, Luchian I, Goriuc A, Antoci LM, Ciobanu CG, Popescu R, Vlad CE, Blaj M, Foia LG (2023) Mitochondrial dysfunction, oxidative stress, and therapeutic strategies in diabetes, obesity, and cardiovascular disease. Antioxidants (Basel) 12:658. https://doi.org/10.3390/antiox12030658 | Oxidative stress;RONS | Cardiovascular Diabetes Obesity | ||
| Faria 2023 Pharmaceutics | 2023 | Faria R, Boisguérin P, Sousa Â, Costa D (2023) Delivery systems for mitochondrial gene therapy: a review. Pharmaceutics 15:572. https://doi.org/10.26124/mitofit:2023-0003.v610.3390/pharmaceutics15020572 | ||||
| Che 2023 Plant Cell Environ | 2023 | Che X, Zhang T, Li H, Li Y, Zhang L, Liu J (2023) Nighttime hypoxia effects on ATP availability for photosynthesis in seagrass. Plant Cell Environ 46:2841-50. https://doi.org/10.1111/pce.14654 | Hypoxia | |||
| Jezek 2023 Antioxid Redox Signal | 2023 | Ježek P, Jabůrek M, Holendová B, Engstová H, Dlasková A (2023) Mitochondrial cristae morphology reflecting metabolism, superoxide formation, redox homeostasis, and pathology. Antioxid Redox Signal 39:635–83. https://doi.org/10.1089/ars.2022.0173 | ||||
| Luptak 2023 Antioxidants (Basel) | 2023 | Ľupták M, Fišar Z, Hroudová J (2023) Different effects of SSRIs, Bupropion, and Trazodone on mitochondrial functions and monoamine oxidase isoform activity. Antioxidants (Basel) 12:1208. https://doi.org/10.3390/antiox12061208 | Pig | Nervous system | Neurodegenerative | |
| Fromenty 2023 J Hepatol | 2023 | Fromenty B, Roden M (2023) Mitochondrial alterations in fatty liver diseases. J Hepatol 78:415-29. https://doi.org/10.1016/j.jhep.2022.09.020 | ||||
| Goetzman 2023 Antioxidants (Basel) | 2023 | Goetzman E, Gong Z, Zhang B, Muzumdar R (2023) Complex II biology in aging, health, and disease. Antioxidants (Basel) 12:1477. https://doi.org/10.3390/antiox12071477 | Aging;senescence | |||
| Du Z 2023 Proc Natl Acad Sci U S A | 2023 | Du Z, Zhou X, Lai Y, Xu J, Zhang Y, Zhou S, Feng Z, Yu L, Tang Y, Wang W, Yu L, Tian C, Ran T, Chen H, Guddat LW, Liu F, Gao Y, Rao Z, Gong H (2023) Structure of the human respiratory complex II. Proc Natl Acad Sci U S A 120:e2216713120. https://doi.org/10.1073/pnas.2216713120 | Human | |||
| Onukwufor 2022 Antioxidants (Basel) | 2022 | Onukwufor JO, Dirksen RT, Wojtovich AP (2022) Iron dysregulation in mitochondrial dysfunction and Alzheimer's disease. Antioxidants (Basel) 11:692. https://doi.org/10.3390/antiox11040692 | ||||
| Tseng 2022 Cells | 2022 | Tseng W-W, Wei A-C (2022) Kinetic mathematical modeling of oxidative phosphorylation in cardiomyocyte mitochondria. Cells 11:4020. https://doi.org/10.3390/cells11244020 | ||||
| Betiu 2022 Int J Mol Sci | 2022 | Bețiu AM, Noveanu L, Hâncu IM, Lascu A, Petrescu L, Maack C, Elmér E, Muntean DM (2022) Mitochondrial effects of common cardiovascular medications: the good, the bad and the mixed. Int J Mol Sci 23:13653. https://doi.org/10.3390/ijms232113653 | ||||
| El-Gammal 2022 Pflugers Arch | 2022 | El-Gammal Z, Nasr MA, Elmehrath AO, Salah RA, Saad SM, El-Badri N (2022) Regulation of mitochondrial temperature in health and disease. Pflugers Arch 474:1043-51. https://doi.org/10.1007/s00424-022-02719-2 | ||||
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| Xing 2022 Atlantis Press | 2022 | Xing Yunxie (2022) Is genome instability a significant cause of aging? A review. Advances in Social Science, Education and Humanities Research 664, Atlantis Press. https://doi.org/10.2991/assehr.k.220504.260 | ||||
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| Fahlbusch 2022 Int J Mol Sci | 2022 | Fahlbusch P, Nikolic A, Hartwig S, Jacob S, Kettel U, Köllmer C, Al-Hasani H, Lehr S, Müller-Wieland D, Knebel B, Kotzka J (2022) Adaptation of oxidative phosphorylation machinery compensates for hepatic lipotoxicity in early stages of MAFLD. Int J Mol Sci 23:6873. https://doi.org/10.26124/10.3390/ijms23126873 | ||||
| Vorotnikov 2022 Biomedicines | 2022 | Vorotnikov AV, Khapchaev AY, Nickashin AV, Shirinsky VP (2022) In vitro modeling of diabetes impact on vascular endothelium: Are essentials engaged to tune metabolism? Biomedicines 10:3181. https://doi.org/10.3390/biomedicines10123181 | ||||
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| Joshi 2022 Biomolecules | 2022 | Joshi A, Ito T, Picard D, Neckers L (2022) The mitochondrial HSP90 paralog TRAP1: structural dynamics, interactome, role in metabolic regulation, and inhibitors. Biomolecules 12:880. https://doi.org/10.3390/biom12070880 | ||||
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| Yamauchi 2022 Sci Rep | 2022 | Yamauchi Y, Nakamura A, Yokota T, Takahashi K, Kawata S, Tsuchida K, Omori K, Nomoto H, Kameda H, Cho KY, Anzai T, Tanaka S, Terauchi Y, Miyoshi H, Atsumi T (2022) Luseogliflozin preserves the pancreatic beta-cell mass and function in db/db mice by improving mitochondrial function. Sci Rep 12: 9740. | Mouse | Islet cell;pancreas;thymus | Diabetes | |
| Aya 2022 Eur J Pharmacol | 2022 | Shiraki A, Oyama J, Shimizu T, Nakajima T, Yokota T, Node K (2022) Empagliflozin improves cardiac mitochondrial function and survival through energy regulation in a murine model of heart failure. Eur J Pharmacol 931: 175194. | Mouse | Heart | Cardiovascular | |
| Simon 2022 Function (Oxf) | 2022 | Simon L, Molina PE (2022) Cellular bioenergetics: experimental evidence for alcohol-induced adaptations. Function (Oxf) 3:zqac039. https://doi.org/10.1093/function/zqac039 | ||||
| Takada 2022 Proc Natl Acad Sci U S A | 2022 | Takada S, Maekawa S, Furihata T, Kakutani N, Setoyama D, Ueda K, Nambu H, Hagiwara H, Handa H, Fumoto Y, Hata S, Masunaga T, Fukushima A, Yokota T, Kang D, Kinugawa S, Sabe H (2022) Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure. Proc Natl Acad Sci U S A 119: e2203628119. | Mouse | Heart | Cardiovascular | |
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| Maklashina 2022 J Biol Chem | 2022 | Maklashina E, Iverson TM, Cecchini G (2022) How an assembly factor enhances covalent FAD attachment to the flavoprotein subunit of complex II. J Biol Chem 298:102472. https://doi.org/10.1016/j.jbc.2022.102472 | Human Eubacteria | |||
| Benit 2022 Biomedicines | 2022 | Bénit P, Goncalves J, El Khoury R, Rak M, Favier J, Gimenez-Roqueplo AP, Rustin P (2022) Succinate dehydrogenase, succinate, and superoxides: a genetic, epigenetic, metabolic, environmental explosive crossroad. Biomedicines 10:1788. https://doi.org/10.3390/biomedicines10081788 | ||||
| Atallah 2022 Biomedicines | 2022 | Atallah R, Olschewski A, Heinemann A (2022) Succinate at the crossroad of metabolism and angiogenesis: roles of SDH, HIF1α and SUCNR1. Biomedicines 10:3089. https://doi.org/10.3390/biomedicines10123089 | ||||
| Rai 2022 G3 (Bethesda) | 2022 | Rai M, Carter SM, Shefali SA, Mahmoudzadeh NH, Pepin R, Tennessen JM (2022) The Drosophila melanogaster enzyme glycerol-3-phosphate dehydrogenase 1 is required for oogenesis, embryonic development, and amino acid homeostasis. G3 (Bethesda) 12:jkac115. https://doi.org/10.1093/g3journal/jkac115 | Drosophila | |||
| Eyenga 2022 Cells | 2022 | Eyenga P, Rey B, Eyenga L, Sheu SS (2022) Regulation of oxidative phosphorylation of liver mitochondria in sepsis. Cells 11:1598. https://doi.org/10.3390/cells11101598 | ||||
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| Davis 2021 J Appl Physiol | 2021 | Davis MS, Barrett MR (2021) Effect of conditioning and physiology hyperthermia on canine skeletal muscle mitochondrial oxygen consumption. J Appl Physiol. 130:1317-1325 | Dog | Skeletal muscle | Temperature | |
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| Szczerbinski 2021 Cells | 2021 | Szczerbinski L, Taylor MA, Puchta U, Konopka P, Paszko A, Citko A, Szczerbinski K, Goscik J, Gorska M, Larsen S, Kretowski A (2021) The response of mitochondrial respiration and quantity in skeletal muscle and adipose tissue to exercise in humans with prediabetes. Cells 10:3013. | Human | Skeletal muscle Fat | Diabetes | |
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| Prasuhn 2021 Front Cell Dev Biol | 2021 | Prasuhn J, Davis RL, Kumar KR (2021) Targeting mitochondrial impairment in Parkinson's disease: challenges and opportunities. Front Cell Dev Biol 8:615461. https://doi.org/10.3389/fcell.2020.615461 | ||||
| Middleton 2021 Therap Adv Gastroenterol | 2021 | Middleton P, Vergis N (2021) Mitochondrial dysfunction and liver disease: role, relevance, and potential for therapeutic modulation. Therap Adv Gastroenterol 14:17562848211031394. https://doi.org/10.1177/17562848211031394 | ||||
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| Lindfors 2011 Proc Natl Acad Sci U S A | 2011 | Lindfors C, Nilsson IA, Garcia-Roves PM, Zuberi AR, Karimi M, Donahue LR, Roopenian DC, Mulder J, Uhlen M, Ekstroem TJ, Davisson MT, Hoekfelt TG, Schalling M, Johansen JE (2011) Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse. Proc Natl Acad Sci U S A 108:18108-13. | Mouse | Nervous system | Oxidative stress;RONS Mitochondrial disease | |
| De Oliveira 2011 Neuroscience | 2011 | de Oliveira J, Hort MA, Moreira EL, Glaser V, Ribeiro-do-Valle RM, Prediger RD, Farina M, Latini A, de Bem AF (2011) Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: Relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress. Neuroscience 197:99-106. | Mouse | Nervous system | Oxidative stress;RONS | Alzheimer's Neurodegenerative |
| Viader 2011 J Neurosci | 2011 | Viader A, Golden JP, Baloh RH, Schmidt RE, Hunter DA, Milbrandt J (2011) Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function. J Neurosci 31:10128-40. | Mouse | Nervous system | Neurodegenerative | |
| Begriche 2011 J Hepatol | 2011 | Begriche K, Massart J, Robin MA, Borgne-Sanchez A, Fromenty B (2011) Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver. J Hepatol 54:773-94. https://doi.org/10.1016/j.jhep.2010.11.006 | ||||
| Keane 2011 Parkinsons Dis | 2011 | Keane PC, Kurzawa M, Blain PG, Morris CM (2011) Mitochondrial dysfunction in Parkinson's disease. Parkinsons Dis 2011:716871. https://doi.org/10.4061/2011/716871 | ||||
| Van Bergen 2011 PLoS One | 2011 | Van Bergen NJ, Crowston JG, Kearns LS, Staffieri SE, Hewitt AW, Cohn AC, Mackey DA, Trounce IA (2011) Mitochondrial oxidative phosphorylation compensation may preserve vision in patients with OPA1-linked autosomal dominant optic atrophy. PLoS One 6:e21347. | Human | Nervous system Islet cell;pancreas;thymus | Mitochondrial disease | |
| Brown 2011 Am J Physiol Regul Integr Comp Physiol | 2011 | Brown JC, Chung DJ, Belgrave KR, Staples JF (2011) Mitochondrial metabolic suppression and reactive oxygen species production in liver and skeletal muscle of hibernating thirteen-lined ground squirrels. Am J Physiol Regul Integr Comp Physiol 302:15-28. | Other mammals | Skeletal muscle Liver | Oxidative stress;RONS | |
| Chowdhury 2010 Am J Physiol Endocrinol Metab | 2010 | Chowdhury SK, Sangle GV, Xie X, Stelmack GL, Halayko AJ, Shen GX (2010) Effects of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells. Am J Physiol Endocrinol Metab 298:E89-98. | Pig | Endothelial;epithelial;mesothelial cell | Oxidative stress;RONS Mitochondrial disease | |
| Korsten 2010 Biochim Biophys Acta | 2010 | Korsten A, de Coo IF, Spruijt L, de Wit LE, Smeets HJ, Sluiter W (2010) Patients with Leber hereditary optic neuropathy fail to compensate impaired oxidative phosphorylation. Biochim Biophys Acta 1797:197-203. | Human | Nervous system Blood cells Lymphocyte | Inherited Neurodegenerative | |
| Kim 2010 Korean Diabetes J | 2010 | Kim EH, Koh EH, Park JY, Lee KU (2010) Adenine nucleotide translocator as a regulator of mitochondrial function: implication in the pathogenesis of metabolic syndrome. Korean Diabetes J 34:146-53. https://doi.org/10.4093/kdj.2010.34.3.146 | ||||
| Schoenfeld 2010 Biochim Biophys Acta | 2010 | Schönfeld P, Wieckowski MR, Lebiedzinska M, Wojtczak L (2010) Mitochondrial fatty acid oxidation and oxidative stress: Lack of reverse electron transfer-associated production of reactive oxygen species. Biochim Biophys Acta 1797:929-38. | Rat | Heart | Oxidative stress;RONS | |
| Iftikar 2010 JEMBE | 2010 | Iftikar F, MacDonald JR, Hickey AJ (2010) Thermal limits of portunid crab heart mitochondria: Could more thermo-stable mitochondria advantage invasive species? JEMBE 395:232-9. | Crustaceans | Heart | ||
| Nilsson 2010 Thesis | 2010 | Nilsson I (2010) Hypothalmic regulation of food intake – focus on the anx/anx mouse. Thesis Karolinska Institute Stockholm, Department of Molecular Medicine and Sugery, 62 pp. | Mouse | Nervous system | Oxidative stress;RONS | |
| Armstrong 2010 J Comp Physiol B | 2010 | Armstrong C, Staples JF (2010) The role of succinate dehydrogenase and oxaloacetate in mitochondrial metabolism during mammalian hibernation and arousal. J Comp Physiol B 180:775-83. | Other mammals | Liver | ||
| Freyer 2010 Nucleic Acids Res | 2010 | Freyer C, Park CB, Ekstrand MI, Shi Y, Khvorostova J, Wibom R, Falkenberg M, Gustafsson CM, Larsson NG (2010) Maintenance of respiratory chain function in mouse hearts with severely impaired mtDNA transcription. Nucleic Acids Res 38:6577–88. | Mouse | Heart | Cardiovascular | |
| Lauritzen 2010 Mol Cell Biol | 2010 | Lauritzen KH, Moldestad O, Eide L, Carlsen H, Nesse G, Storm JF, Mansuy IM, Bergersen LH, Klungland A (2010) Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior. Mol Cell Biol 30:1357-67. | Mouse | Nervous system | Mitochondrial disease | |
| Guillet 2010 Neurogenetics | 2010 | Guillet V, Gueguen N, Verny C, Ferre M, Homedan C, Loiseau D, Procaccio V, Amati-Bonneau P, Bonneau D, Reynier P, Chevrollier A (2010) Adenine nucleotide translocase is involved in a mitochondrial coupling defect in MFN2-related Charcot-Marie-Tooth type 2A disease. Neurogenetics 11:127-33. | Human | Nervous system | Mitochondrial disease | |
| Kotarsky 2010 Mitochondrion | 2010 | Kotarsky H, Karikoski R, Mörgelin M, Marjavaara S, Bergman P, Zhang DL, Smet J, van Coster R, Fellman V (2010) Characterization of complex III deficiency and liver dysfunction in GRACILE syndrome caused by a BCS1L mutation. Mitochondrion 10:497-509. | Human | Fibroblast | Inherited | |
| Xie 2010 Acta Biochim Pol | 2010 | Xie X, Chowdhury SR, Sangle G, Shen GX (2010) Impact of diabetes-associated lipoproteins on oxygen consumption and mitochondrial enzymes in porcine aortic endothelial cells. Acta Biochim Pol 57:393-8. | Pig | Endothelial;epithelial;mesothelial cell | Diabetes | |
| Guillet 2010 neurogenetics | 2010 | Guillet V, Gueguen N, Verny C, Ferre M, Homedan C, Loiseau D, Procaccio V, Amati-Bonneau P, Bonneau D, Reynier P, Chevrollier A (2010) Adenine nucleotide translocase is involved in a mitochondrial coupling defect in MFN2-related Charcot-Marie-Tooth type 2A disease. Neurogenetics 11:127-33. | Human | Fibroblast | Other | |
| Jones 2010 Biochim Biophys Acta | 2010 | Jones TT, Brewer GJ (2010) Age-related deficiencies in Complex I endogenous substrate availability and reserve capacity of Complex IV in cortical neuron electron transport. Biochim Biophys Acta 1797:167-76. | Rat | Nervous system | Aging;senescence Neurodegenerative | |
| Casasnovas 2009 J Med Genet | 2010 | Casasnovas C, Banchs I, Cassereau J, Gueguen N, Chevrollier A, Martínez-Matos JA, Bonneau D, Volpini V (2010) Phenotypic spectrum of MFN2 mutations in the Spanish population. J Med Genet 47:249-56. | Human | Nervous system Fibroblast | Inherited Neurodegenerative | |
| Groeger 2010 Crit Care | 2010 | Groeger M, Wagner F, Baumgart K, Huber-Lang M, Knoeferl M, Georgieff M, Radermacher P, Szabo C, Calzia E (2010) Mitochondrial respiration and cytochrome c inhibition by sulfide in peritoneal macrophages in vitro: Effects of temperature and pH. Crit Care 14:P6. | Macrophage-derived | |||
| Casasnovas 2010 J Med Genet | 2010 | Casasnovas C, Banchs I, Cassereau J, Gueguen N, Chevrollier A, Martinez-Matos JA, Bonneau D, Volpini V (2010) Phenotypic spectrum of MFN2 mutations in the Spanish population. J Med Genet 47:249-56. | Human | Nervous system | Other | |
| Stankova 2010 Toxicol In Vitro | 2010 | Staňková P, Kučera O, Lotková H, Roušar T, Endlicher R, Cervinková Z (2010) The toxic effect of thioacetamide on rat liver in vitro. Toxicol In Vitro 24:2097-2103. | Liver | Oxidative stress;RONS | ||
| Anderson 2009 J Am Coll Cardiol | 2009 | Anderson EJ, Kypson AP, Rodriguez E, Anderson CA, Lehr EJ, Neufer PD (2009) Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart. J Am Coll Cardiol 54:1891-8. | Human | Heart | Oxidative stress;RONS Mitochondrial disease | Aging;senescence Diabetes |
| Keeney 2009 Exp Neurol | 2009 | Keeney PM, Dunham LD, Quigley CK, Morton SL, Bergquist KE, Bennett JP (2009) Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships. Exp Neurol 220:374-82. | Human | Blood cells Platelet | Mitochondrial disease | Parkinson's |
| Larsen 2009 Diabetologia | 2009 | Larsen S, Ara I, Rabøl R, Andersen JL, Boushel RC, Dela F, Helge JW (2009) Are substrate use during exercise and mitochondrial respiratory capacity decreased in arm and leg muscle in type 2 diabetes? Diabetologia 52:1400-8. | Human | Skeletal muscle | Diabetes | |
| Rhein 2009 Cell Mol Neurobiol | 2009 | Rhein V, Baysang G, Rao S, Meier F, Bonert A, Müller-Spahn F, Eckert A (2009) Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells. Cell Mol Neurobiol 29:1063-71. | Human | Nervous system Neuroblastoma | Alzheimer's Neurodegenerative | |
| Bredholt T 2009 Mol Cancer | 2009 | Bredholt T, Dimba EA, Hagland HR, Wergeland L, Skavland J, Fossan KO, Tronstad KJ, Johannessen AC, Vintermyr OK, Gjertsen BT (2009) Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. Mol Cancer 8:101. | Human | Blood cells | Cell death | Cancer |
| Anderson 2009 J Clin Invest | 2009 | Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin C-T, Price JW, Kang L, Rabinovitch PS, Szeto HH, Houmard JA, Cortright RN, Wasserman DH, Neufer PD (2009) Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest 119:573-81. | Human Mouse Rat | Skeletal muscle | Oxidative stress;RONS | Diabetes |
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