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Benit 2022 Biomedicines

From Bioblast
Publications in the MiPMap
Bรฉnit P, Goncalves J, El Khoury R, Rak M, Favier J, Gimenez-Roqueplo AP, Rustin P (2022) Succinate dehydrogenase, succinate, and superoxides: a genetic, epigenetic, metabolic, environmental explosive crossroad. Biomedicines 10:1788. https://doi.org/10.3390/biomedicines10081788

ยป PMID: 35892689 Open Access

Benit P, Goncalves J, El Khoury R, Rak M, Favier J, Gimenez-Roqueplo AP, Rustin P (2022) Biomedicines

Abstract: Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism. This allowed researchers to uncover the implication of SDH in both the mitochondrial respiratory chain and the Krebs cycle. Nowadays, this theme is experiencing a real revival following the discovery of the role of SDH and succinate in a subset of tumors and cancers in humans. The aim of this review is to enlighten the many questions yet unanswered, ranging from fundamental to clinically oriented aspects, up to the danger of the current use of SDH as a target for a subclass of pesticides.

โ€ข Bioblast editor: Gnaiger E

Figure 1
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Selected quotes

  • In animals, as in most living organisms, SDH has no cellular isoform, unlike most enzymes of the Krebs cycle, except citrate synthase and succinyl CoA ligase.
Comment: CII (SDH) is the only TCA-cycle enzyme bound to the mtIM. Where could a 'cellular isoform' be located?
  • The identification of supercomplexes that kinetically insulate ubiquinone pools entails redox exchanges through spatially distant pools of ubiquinone [81]. The level of reduction of a given quinone pool is furthermore dependent on the kinetic properties of the dehydrogenase connected to the pool. Such kinetic compartmentation presumably holds true for all dehydrogenases, e.g., SDH (CII), glycerol 3 phosphate dehydrogenase, dihydroorotate dehydrogenase, NADH dehydrogenase (CI), dehydrogenases implicated in fatty acid oxidation, etc. (Figure 3).


Labels: MiParea: Pharmacology;toxicology 



Enzyme: Complex II;succinate dehydrogenase 


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