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Area-Gomez 2019 J Clin Invest

From Bioblast
Publications in the MiPMap
Area-Gomez E, Guardia-Laguarta C, Schon EA, Przedborski S (2019) Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas. J Clin Invest 129:34-45.

» PMID: 30601141 Open Access

Area-Gomez E, Guardia-Laguarta C, Schon EA, Przedborski S (2019) J Clin Invest

Abstract: Mitochondrial respiratory deficiencies have been observed in numerous neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. For decades, these reductions in oxidative phosphorylation (OxPhos) have been presumed to trigger an overall bioenergetic crisis in the neuron, resulting in cell death. While the connection between respiratory defects and neuronal death has never been proven, this hypothesis has been supported by the detection of nonspecific mitochondrial DNA mutations in these disorders. These findings led to the notion that mitochondrial respiratory defects could be initiators of these common neurodegenerative disorders, instead of being consequences of a prior insult, a theory we believe to be misconstrued. Herein, we review the roots of this mitochondrial hypothesis and offer a new perspective wherein mitochondria are analyzed not only from the OxPhos point of view, but also as a complex organelle residing at the epicenter of many metabolic pathways.

Bioblast editor: Gnaiger E

Area-Gomez 2019 J Clin Invest CORRECTED.png

Correction: FADH2 and Complex II

Ambiguity alert.png
FADH2 is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2023).
Gnaiger E (2023) Complex II ambiguities ― FADH2 in the electron transfer system. J Biol Chem. - »Bioblast link«


Enzyme: Complex II;succinate dehydrogenase