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[[File:Case_western_reserve_university.png|150px|left|Case Western Reserve University]] ::::* '''The First Annual Charles L. Hoppel, M.D. Award for Outstanding Contributions in Mitochondrial Research

|title='''Cleveland, OH ''', 2019 Nov 09. The Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research. |abstract= The Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research

|title='''Cleveland, OH ''', 2018 Nov 09. The Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research. |abstract= The Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research

|title='''Cleveland, OH ''', 2022 Nov 14. The Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research. |info=[https://case.edu/medicine/events/charles-l-hoppel-md-endowment-mitochondrial-biology Website]

|title=Luft R, Ikkos D, Palmieri G, Ernster L, Afzelius B (1962) A case of severe hypermetabolism of nonthyroid origin with a defect in the mainten

...>''Q''</sub>. Abstract units ''u''_''Q'' (such as dm³=L, kg, J) are linked to measured quantities (such as volume, mass, energy): == Lower case ==

|institution=Case Western Reserve University School of Medicine |Contact=Hoppel Charles L

|authors=De Bari L, Vacca RA, Valenti D ...ar phase. Then we examined whether and how the mitochondrial metabolism of L-LAC and D-LAC occurs in human cancer cells, as compared to normal cells.

...]. The [[malate-anaplerotic pathway control state]] (M alone) is a special case related to [[malic enzyme]] (mtME). The [[glutamate-anaplerotic pathway con == N_''L'' ==

|title=Bețiu AM, Noveanu L, Hâncu IM, Lascu A, Petrescu L, Maack C, Elmér E, Muntean DM (2022) Mitochondrial effects of common cardi |authors=Betiu AM, Noveanu L, Hancu IM, Lascu A, Petrescu L, Maack C, Elmer Eskil, Muntean DM

...3) Boosting mitochondrial metabolism research in South America: building a case for a local ''Drosophila'' stock center. https://doi.org/10.26124/mitofit:2 ...df Boosting mitochondrial metabolism research in South America: building a case for a local ''Drosophila'' stock center.]<br/>

|firstname=Charles L Case Western Reserve University School of Medicine, US

| ''L''+S_''L'' | [[LEAK respiration]] (''L'') + [[S]] (S_''L'')

| ''L''+S_''L'' | [[LEAK respiration]] (''L'') + [[S]] (S_''L'')

|title=Anderson CJ, Bredvik K, Burstein SR, Davis C, Meadows SM, Dash J, Case L, Milner TA, Kawamata H, Zuberi A, Piersigilli A, Lutz C, Manfredi G (2019) ...ors=Anderson CJ, Bredvik K, Burstein SR, Davis C, Meadows SM, Dash J, Case L, Milner TA, Kawamata H, Zuberi A, Piersigilli A, Lutz C, Manfredi G

|title=Tipton PH, Aigner MJ, Finto D, Haislet JA, Pehl L, Sanford P, Williams M (2012) Consider the accuracy of height and weight me |authors=Tipton PH, Aigner MJ, Finto D, Haislet JA, Pehl L, Sanford P, Williams M

|title=Onsager L (1931) Reciprocal relations in irreversible processes. I. Phys Rev 37:405-2 ...rinciple of the least dissipation of energy" is generalized to include the case of anisotropic heat conduction. A further generalization is announced. (§5

...=Ma L, Fu Q, Xu B, Zhou H, Gao J, Shao X, Xiong J, Gu Q, Wen S, Li F, Shen L, Chen G, Fang H, Lyu J (2017) Breast cancer-associated mitochondrial DNA ha ...=Ma L, Fu Q, Xu B, Zhou H, Gao J, Shao X, Xiong J, Gu Q, Wen S, Li F, Shen L, Chen G*, Fang H, Lyu J

...cts revealed the dominance of potent anti-oxidants in ''L. nummularia'', ''L. punctate'' respectively [2]. Saponine and phenoloid fractions on mitochond ...lu. and succ. mediated ATP production was observed. Saponine fraction of ''L. punctate'' reduces complex I but elevates complex II. It does not influenc

...16) Dealing with the sulfur part of cysteine: four enzymatic steps degrade l-cysteine to pyruvate and thiosulfate in ''Arabidopsis'' mitochondria. Physi ...ate. After transamination to 3-mercaptopyruvate, the sulfhydryl group from l-cysteine is transferred to glutathione by sulfurtransferase 1 and oxidized

...ng concentrations of [[ADP]] and inorganic phosphate (which may not be the case in [[State 3]]), oxygen, and defined reduced CHNO-fuel substrates. ...reases with enzyme turnover during ''P'', the low enzyme turnover during ''L'' may counteract the effect of the higher ''pmF''. OXPHOS capacity is expre

...</sub> and system volume ''V'' are identical, but this applies only to the case of a ''pure'' sample. ''Concentration'' is related to samples s per total v

...proteolytic cleavage of the N-terminal histone H3 tail by cathepsins B and L upon induction of differentiation into neurons and glia. In contrast, CSTB-

...k compartment B, and (3) the internal barrier compartment with thickness ''l''. In a two-compartmental description, a system boundary is defined of zero ...ub>d</sub> = -''u''·''α''·Δ_d''F'' = -''u''·Δ_d''Π''/''l''

...y in the presence of oleate was reduced, with normalization to (or, in the case of T3, even below) control levels. Both hormones effectively reduced intrac |keywords=3,5,3′-triiodo-L-thyronine, 3,5-diiodo-L-thyronine, Acylcarnitines, Insulin resistance, Skeletal muscle, L6 rat myob

|authors=Lai Nicola, Kummitha Chinna, Hoppel Charles L ....01 different from Wmt group, # different from SSmt) and a similar ''P''/''L'' (Wmt 14±2; SSmt 14±3; IFmt 16±6). The electron transfer capacity upon

...nsitive assay for the diagnosis of injuries in the N-pathway, since in the case of GM impairment N-pathway capacity can be compensated partially by activat ...n]] is prevented in the presence of [[Oligomycin]] as a control with the ''L''(n) previously obtained.

|title=Blakely EL, Rennie KJ, Jones L, Elstner M, Chrzanowska-Lightowlers ZMA, White CB, Shield JPH, Pilz DT, Tur |authors=Blakely EL, Rennie KJ, Jones L, Elstner M, Chrzanowska-Lightowlers ZMA, White CB, Shield JPH, Pilz DT, Tur

...) much higher after ischemia in both metabolic states, particularly in the case of succinate oxidation compared to pyruvate+malate, (iv) the highest in Sta

...DAC) located within the mitochondrial outer membrane. Consequently, in the case of the CK system ADP produced by mitochondrial CK (MtCK) within the interme ...cellular energy metabolism. Alterations in their function can be found in case of several pathological conditions. Simple oxygraphic analysis can be perfo

|authors=Valenti D, de Bari L, Vacca RA ...r pathological conditions in which an energy deficit is present, as in the case of Down syndrome, EGCG (10-20 µM) exerts a cytoprotective effect acting as

== F_''L'' == ...Fatty acid oxidation with low or high concentration of [[Malate]]. In the case of permeabilized fibers (pfi), high concentration of [[Malate]] is required

This is a prospective, hypothesis testing project with a matched case-control, repeated-measures design. Two groups of subjects will be recruited ...; 2-School of Med, Case Western Reserve Univ; Cleveland, OH, USA. - cxh416@case.edu

...agne T, Mondy N (2017) Doping for sex: Bad for mitochondrial performances? Case of testosterone supplemented ''Hyla arborea'' during the courtship period. |authors=Desprat JL, Teulier L, Puijalon S, Dumet A, Romestaing C, Tattersall GJ, Lengagne T, Mondy N

[[Hoppel CL|Hoppel Charles L]], O2k-Network Lab: [[US OH Cleveland Hoppel CL]] [[Lemieux H|Lemieux Hélène]], O2k-Network Lab: [[CA Rimouski Blier PU]]

...nal hypoxia, hyperoxia, hypoxia, limiting O₂ pressure ''p''_l, normoxia, oxygen O₂, O₂ concentration ''c''<su |editor=Tindle-Solomon L

|title=Bartesaghi S, Wenzel J, Trujillo M, López M, Joseph J, Kalyanaraman B, Radi R (2010) Lipid peroxyl radicals medi ...inhibited by BTBE but not by its phenylalanine analogue, BPBE (''N-t''-BOC l-phenylalanine ''tert''-butyl ester), providing direct evidence for the reac

|title=Pajuelo DR, Ježek P, Olejár T, Alán L (2013) Some mitophagy markers in liver and skeletal muscle in Goto Kakizaki |authors=Pajuelo D, Jezek P, Olejar T, Alan L

...udies in fructose fed rats appear to support this view [2]. If this is the case, soleus muscle may be less likely to develop mitochondrial dysfunction than :::# Warren BE, Lou PH, Lucchinetti E, Zhang L, Clanachan AS, Affolter A, Hersberger M, Zaugg M, Lemieux H (2014), "Early

...ally induced in mt-preparations by addition of succinate&rotenone. In this case, only [[Complex III]] and [[Complex IV]] are involved in pumping protons fr == SRot_''L'' ==

...tio]] (if the name contains a fraction such as P/E or difference such as P-L, then no hyphen follows these symbols, to avoid confusion between the minus ...ate]], but: [[Electron-transfer-pathway state]], [[ET-pathway state]], [[E-L coupling efficiency]]

|title=Mebarek L, Denis M, Grégori G (2011) A new method to measure prokaryote respiration |authors=Mebarek L, Denis M, Gregori G

...011 gives information of the linear coupling control ([[LEAK respiration|''L'']]-[[Oxidative phosphorylation| ''P'']]) with NADH linked-substrates ([[GM ...me ''c'' test early in the protocol ensures comparability of all states in case of any effect of ''c''.

|title=Broskey NT, Greggio C, Boss A, Boutant M, Dwyer A, Schlueter L, Hans D, Gremion G, Kreis R, Boesch C, Canto AC, Amati F (2014) Skeletal mu |authors=Broskey NT, Greggio C, Boss A, Boutant M, Dwyer A, Schlueter L, Hans D, Gremion G, Kreis R, Boesch C, Canto AC, Amati F

:::* ''L'', ''P'', ''E'' ([[Uncoupler]]s, U: FCCP, CCCP, DNP) Coupling states: [[Image:L.jpg|link=LEAK respiration|LEAK]] [[Image:P.jpg|link=OXPHOS capacity|OXPHOS]

| [[LEAK]], ''L'' + S_''L'' (Eq 5) 3ceOmy = ''L''_vce + S_''L'',dce

...me ''c'' test early in the protocol ensures comparability of all states in case of any effect of ''c''. ...E-capacities. This is not a problem when NSP = NSE (Gnaiger 2009). In this case, it may be assumed that SP = SE (Votion et al 2012), such that NSP can be c

...me ''c'' test early in the protocol ensures comparability of all states in case of any effect of ''c''. ...mM) in horse skeletal muscle fibres (Votion et al 2012), which was not the case when P was titrated in steps of 1 mM.

...chrome c test early in the protocol ensures comparability of all states in case of any effect of c. ...E-capacities. This is not a problem when NSP = NSE (Gnaiger 2009). In this case, it may be assumed that SP = SE (Votion et al 2012), such that NSP can be c

...umeni S, Evangelakou Z, Tsakiri EN, Debattisti V, Papassideri IS, Scorrano L, Trougakos IP ...ting through a circuit of sensors that modulate proteolytic machineries in case of mitostasis disruption.

...y]]Prola A, Khadhraoui N, Vandestienne A, Blondelle J, Wintrebert M, Tiret L, <u>Pilot-Storck Fanny</u> (2022) ''Hacd1'' and ''Hacd2'' genes control mit ...Alexandre, Khadhraoui N, Vandestienne A, Blondelle J, Wintrebert M, Tiret L, Pilot-Storck Fanny

...otocols provide an assessment of the coupling control [[LEAK respiration|''L'']]-[[Oxidative phosphorylation| ''P'']] with NADH linked-substrates ([[GM] ...chrome c test early in the protocol ensures comparability of all states in case of any effect of c.

...</sub></sub> [kg·x^-1] or ''V''_{''U''_''X''} [L·x^-1] ...ub>B</sub></sub> [kg·x^-1] or ''V''_{''U''_B} [L·x^-1]

|abbr=''L'' ...ned and remain consistent within a given context, then the simple symbol ''L'' for respiratory rate can be used as a substitute for the more explicit ex

Das (l), using a modified Thunberg technique, reported that the enzyme was 50 per ...regulatory effects upon oxidative metabolism. Such does not seem to be the case, however, although the reasons are as yet obscure.

...f cytochrome ''c'' in the protocol ensures comparability of all states in case of any effect of cytochrome ''c'. ...oblem when NS_''P'' = NS_''E'' (Gnaiger 2009). In this case, it may be assumed that S_''P'' = S_''E'' (Votion et al

|authors=Meszaros A, Strifler G, Komlodi T, Nagy A, Cao C, Kaszaki J, Tretter L, Boros M In case of rat samples, low respiratory control rates and extremely high cytochrome

...n on recovery of mitochondrial respiration in peripheral artery disease: a case control study. https://doi.org/10.1186/s12967-021-02908-0J

...nia, failure to thrive, ptosis, and varying lactic acidemia (up to 12 mmol/L) beginning from the neonatal period. A low-degree dilated cardiomyopathy of

|info='''A: Coupling control ([[LEAK respiration|''L'']]-[[Oxidative phosphorylation| ''P'']]-[[ET capacity| ''E'']]) with NADH- ...specifically focus on assessing the coupling control ([[LEAK respiration|''L'']]-[[Oxidative phosphorylation| ''P'']]-[[ET capacity| ''E'']]) with NADH-

...al dysfunction is a cause or a consequence of insulin resistance.In eather case, whether this is a primary or an acquired defect it is present and needs to |editor=[[Plangger M]], [[Tindle-Solomon L]]

| cell-count concentration || [[Concentration]] || ''C''_ce || [x∙L­^-1] || Fig. 1.5; Eq. 1.9; ''C''_ce = ''N''<sub>ce</su ...; Fig. 3.2; mass per single cell ''M''_{''X''_ce}; upper case ''M'' and subscript ''X'' signal 'per count', subscript ce signals the enti

| [[PGM]](L) | LEAK state with type N substrates, N_''L'': Non-phosphorylating resting state with NADH-linked (type N) substr

...tion was similar to wild type cells under coupled conditions; although, in case of S68A, mutant uncoupling with FCCP did not lead to significant increase i ...ot secondary due to the lack of electron flow through CII (as might be the case in cells with nonfunctional CII). Instead, it is directly linked to the red

...Carmen (2020) Covid-19 in critically ill patients in the Seattle region - case series. N Engl J Med 2020;NEJMoa2004500 [published online ahead of print, 2 ..._query=Covid-19+in+Critically+Ill+Patients+in+the+Seattle+Region+%E2%80%94+Case+Series PMID: 32227758 Open Access]

|authors=Komlodi T, Horvath G, Adam V, Tretter L ...ochrome ''c'', bypassing the intermediate components of the ET-pathway. In case of Complex I inhibition it avoids NADH accumulation and thus inhibition of

::::# Weigh 324 mg of Gp and dissolve in 845 µL H2O. ::::* Titration volume ('''2-mL O2k-chamber'''): 20 µL using a 50 µL Hamilton syringe.

...use of an altered SIRT3 expression at the protein level, which was not the case in these experiments, or an altered SIRT3 activity due to a changed mitocho ...use of an altered SIRT3 expression at the protein level, which was not the case in these experiments, or an altered SIRT3 activity due to a changed mitocho

...e between 3.0-4.99 mmol l^-1, and 46 had LA with lactate 15 mmol l^-1. Females (73.6%) were 25 times more likely to be cases [AOR 25 ...antiretroviral therapy-induced lipodystrophy in HIV-1 infected patients: a case-control study. Curr HIV Res 7:244-53.

...lected in a nomenclature that is not easily applicable to the more general case of open systems [2]. At present, IUPAC recommendations [3] fall short of pr ...nd pressures, rendering the variability of phenomenological coefficients ''L'' non-linearly dependent on the force under simple experimental conditions

|title=[[Image:LemieuxH.jpg|left|90px|Hélène Lemieux]] Altered mitochondrial metabolism in the diabetic heart. ...esult in various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is characterized by metabolic disturbances such as imp

...]] measured in the absence of adenylates - [[LEAK state without adenylates|L(n)]]. Therefore, [[oligomycin]] can be used to verify whether this occurs a ...e in the presence of rotenone for S-pathway control state. In the specific case of S-pathway control state, rotenone should be added to avoid reverse elect

...f cytochrome ''c'' in the protocol ensures comparability of all states in case of any effect of cytochrome ''c''. ...-004 protocol provide a quick assessment of the linear coupling control (''L''-''P''-''E'') with NADH linked-substrates (PM) and the pathway control in

::::* Titration volume ('''2-mL O2k-chamber'''): 1 µL using a 10 µL Hamilton syringe. ::::# Take 100 µL of the 5 mM stock solution.

|authors=Morales-Garcia L, Cruz-Cruz I, Uribe-Alvarez C, Chiquete-Felix N, Uribe-Carvajal S ...drome may result from defects in different respiratory complexes. One such case is the disfunction of chaperonin SURF1, which catalyzes incorporation of su

...e defined as ''Rox''-corrected rates, in contrast to total rates ''R''´, ''L''´, ''P''´ and ''E''´. When expressing ''Rox'' as a fraction of ET capac ...ppropriate correction for [[instrumental background oxygen flux]]. In this case, ''Rox'' is 'mitochondrial non-ET pathway' rather than ‘non-mitochondrial

...se an accumulation of intermediates. The experiments show that this is the case if fumarate together with an excess of pyruvate is added. alpha-Ketoglutara ...7-8 g Na₂HPO₄, 2 H₂0 and 20 mL N HCI in 1 L.

...l, Chem Material Engineering, Univ Cagliari, Sardinia, Italy. – nicola.lai@case.edu ...g the integrated functional activity of human skeletal muscle mitochondria-case studies. Mitochondrion 4: 377-85.

|title=Du C, Duan Y, Wang XF, Lin Y, Na L, Wang X, Chen K, Wang X (2019) Attenuation of equine lentivirus alters mito ...larized anti-inflammatory macrophages by inhibition of glycolysis. In this case, a decrease in the mitochondrial membrane potential and impairment of the e

...atio (RCR) in C2C12, as observed with palmitate treatment. This is not the case for Huh7 cells, where RCR is unchanged after insulin treatment, while lower |editor=[[Plangger M]], [[Tindle-Solomon L]]

:::: In the case of delay, please call Oroboros Instruments Mobile: +43 677 64 79 29 17 or O ...nz train station. Please make sure to bring some cash in EURO with you, in case you need it.

::::* [[Hoppel CL|Charles L Hoppel]] (Case Western Reserve University School of Medicine, Cleveland, OH, US) ::::* [[Hsiao CP|Chao-Pin Hsiao]] (Case Western Reserve University School of Medicine, Cleveland, OH, US)

Charles L Hoppel Center for Mitochondrial Diseases, Departments of Pharmacology & Medicine, Case Western Reserve School of Medicine, Cleveland, OH, USA; Email: [email protected]

::::* '''''P''=''E''''': The specific case of equal OXPHOS- and ET capacity (''P/E''=1) yields the important informati ...and there is an apparent ''E-P'' excess capacity. For example, this is the case in healthy human skeletal muscle mitochondria (Pesta et al 2011) and even m

...coupling state, but a lower phosphorylation capacity, in which case the ''L/E'' ratio (LEAK/ET capacity) would provide information on the coupling stat

::::#Centre l’Oxygène, Recherche Développement (CORD), FARAH, Univ Liege, Belgium ...athy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study. Lancet Glob Health 5:e458-e66.

|abstract=[[Leigh syndrome]], a case of mitochondrial disease, is a subacute necrotising [[encephalomyopathy]] f ...S, Bénit P, Chretien D, de Lonlay P, Goldenberg A, Odent S, Hertz-Pannier L, Vincent-Delorme C, Cormier-Daire V, Rustin P, Rötig A, Munnich A (2003) T

|authors=Shevchuk I, Kaldma A, Chekulayev V, Klepinin A, Ounpuu L, Timohhina N, Tepp K, Heck K, Valvere V, Kaambre T ...) was found to be high for CRC and healthy colon tissue, as well as in the case of Caco-2 cell culture (where the respiratory chain is controlled also by C

|authors=Crisostomo L, Jarak I, Carvalho RA, Sousa M, Barros A, Alves MG, Oliveira PF ...n glycerol-depleted medium. However, lactate excretion is enhanced in this case, without any contribution from glucose nor cell death, since there was no c

...its efficacy was due to its positive inotropic effect. This may not be the case. Cardioprotection in both rat and rabbit is seen with concentrations of oua ...h.gov/pubmed/17306295 Pasdois P, Beauvoit B, Costa AD, Vinassa B, Tariosse L, Bonoron-Adèle S, Garlid KD, Dos Santos P (2007) Sarcoplasmic ATP-sensitiv

...aviour restored [42]. It was suggested, however, that the mobility in this case was provided by movement of protein-quinone complexes, rather than by free ...1</sub> complex) is able to reduce all of these same cytochrome ''bc''_l complexes. .. Further evidence for the mobility comes from an extensi

...z train station. Please make sure to bring some cash in EUROs with you, in case you need it. ...spiration|35px|ROUTINE]] [[Image:E.jpg|link=ET capacity|35px|ETS]] [[Image:L.jpg|link=LEAK respiration|35px|LEAK]] [[Image:ROX.jpg|link=Residual oxygen

...inhibition by rotenone and antimycin A (ROX state), and LEAK respiration ''L''. The glycoBHI was based on four key aspects of cellular proton efflux rat ::::# Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

...stion. To be answered, it is a CASE like any case with numbers. And in any case, extending the perspective helps to answer this particular question. ...e with a negative volume change of B in the system, Δ''V''_B < 0 L. The change in volume Δ''V''_B of B in the system can be positiv

...pel]], Director, Ctr Mitochondrial Diseases; Professor, Dept Pharmacology, Case Western Reserve Univ, Cleveland, Ohio, US ...m: '''[[Busada A |Ashley Busada]], [[Lin CT |Peter Chien-Te Lin]], [[Reese L |Lauren Reese]], [[Ryan TE |Terence E Ryan]], [[Smith C |Cheryl Smith]], [[

...ells or small animals, such as nematodes. It is suggested to use the upper case letter ''M'' as the symbol for the quantity mass per object. The term ''ele ...is the sum of (elementary ) lean body mass and fat mass, ''M'' = ''M''_L + ''M''_F, or the sum of the reference body mass of an indi

...ub>2</sub> production in the LEAK state at low O₂ flow, S_''L''. Respiration is stimulated by ADP (OXPHOS capacity, S<sub ::: - In the case of HEK293T cells, however, due to the high malate-linked anaplerotic capaci

...BFE, and [[body mass excess]], BME, are linearly related, which is not the case for the body mass index, BMI. ...y controlled samples with well-defined exclusion criteria. This is not the case for the self-selected sample used in the analyses of Meeuwsen et al (2010),

...Carmen (2020) Covid-19 in critically ill patients in the Seattle region - case series. N Engl J Med 2020;NEJMoa2004500 [published online ahead of print, 2 ...inform the Commission/Agency/Funding Body, which will examine on a case-by-case basis the possible application of the rules on force majeure. Moreover, be

::::* Woolliams J, Lloyd M, Spengler JD (2005) The case for sustainable laboratories: first steps at Harvard University. Internatio ::::* Krogstie J, Ståhlbröst A, Holst M, Jelle T, Kulseng L, Gudmundsdottir Á (2013) Using a living lab methodology for developing ene

...exercise induced by Functional Electrical Stimulation (FES) in the special case of Spinal Cord Injury patients affected by complete injury of the Conus Cau ...Musarò A, Sandri M, Vogelauer M, Trimmel L, Cvecka J, Hamar D, Kovarik J, Löfler S, Sarabon N, Protasi F, Adami N, Biral D, Zampieri S, Carraro U (201

...des a consistent expression of biochemical coupling efficiency, Δ''j_E-L'', ranging from 0.0 at zero coupling to 1.0 at the limit of a complet ...In the present example, [[LEAK respiration]] is the background state (''Y=L'') and ''P=E'' is the reference state (''Z'').

:::: In the case of delay, please call Oroboros Instruments Mobile: +43 677 64 79 29 17 or O ...z train station. Please make sure to bring some cash in EUROs with you, in case you need it.

...ion of CII and CIII, with a further decline proceeding gradually as in the case of inhibition of CII in the presence of succinate. Our results will permit 1. Desplanches D, Hoppeler H, Tüscher L, Mayet MH, Spielvogel H, Ferretti G, et al. (1996) Muscle tissue adaptation

:::: In the case of delay, please call Oroboros Instruments Mobile: +43 677 64 79 29 17 or O | '''[[NO Oslo Eide L]]''' - Oslo University Hospital, NO

::::* Titration volume: in 1µL steps using a 10 µL syringe (2 mL O2k-chamber). * ''c_added'': titrated, free concentration of safranin [M = mmol/L]

...Main Unit: L 45 cm, W 31 cm, H 25 cm; 13.45 kg without packing box or Peli Case.

...ed to allow directly interact with the headgroups of lipid bilayers in the case of a plant LEA protein. ...cidic: D or E) or blue (basic: H, K, or R). Hydrophobic residues (A, G, I, L, M, V, or W) are colored gray and hydrophilic residues (N, Q, S, T, or Y) a

...e to set new, hopefully long and fruitful collaborations.'' - [[Crisostomo L |Luís Crisóstomo, MSc, PhD Student]], Porto, PT. ...iency and ATP/O₂ ratios ('''[[Hoppel CL |Charles L Hoppel]]''', Case Western Reserve University School of Medicine, Ohio, US).

...Gonzalez-Freire M, Dunn CA, Singh AK, Macian F, Cuervo AM, Sen R, Ferrucci L (2019) Age-associated changes in human CD4+ T cells point to mitochondrial ...le:Bon 2022 J Clin Case Rep Stud CORRECTION.png|400px|link=Bon 2022 J Clin Case Rep Stud]]

...evious procedure, but an excess volume is available that may be helpful in case of having to remove any trapped gas bubble from the chamber. ...[L] (1 L = 1 dm³; 1 m³ = 1000 dm³ = 1000 L; 1 cm³ = 1 mL).

...INE respiration (''R''), optionally oligomycin-induced LEAK respiration (''L''), uncoupler-stimulated ET capacity (''E''), and inhibitor-induced residua

...rdins-Proulx P, White EP, Adamson JJ, Ram K, Poisot T, Gravel D (2013) The case for open preprints in biology. PLoS Biol 11:e1001563. doi: 10.1371/journal. ...nger rule: scientists should not publish the same manuscript twice [Altman L (1996) The Ingelfinger rule, embargoes, and journal peer review - part 1. T

:::: Small experimental chamber volumes of 20-50 µL generate problems rather than providing resolution with small amounts of ti ...or a respirometric assay. Approach (1) would lead you to search for a 100 µL volume respirometer, to maintain a classical 1 mg/mL protein concentration.

|''' Hélène Lemieux, Erich Gnaiger''' (Innsbruck, AT) |'''Dominique-Marie Votion''' (BE), Hélène Lemieux, Ange Mouithys-Mickalad, Didier Serteyn, Erich Gnaiger. Study o

...z train station. Please make sure to bring some cash in EUROs with you, in case you need it. | '''[[US MA Needham Kropp L]]''' - Stealth BioTherapeutics, US

...the NaR photocycle: NaR₅₁₉ ₊ hν → K₅₉₅ → (L₄₅₀ ↔ M₄₉₅) → O₅₈₅ → NaR<sub>519</sub ...delay of aging, a phenomenon known in amphibian (the axolotl / salamander case).

:::: [[File:Hoppel 2012x.jpg|80px|Hoppel Charles L]] :::: [[Hoppel Charles L]], O2k-Network Lab: [[US OH Cleveland Hoppel CL]]

...], [[Kramer Philip A |Philip A Kramer]], [[Gonzalez-Armenta Jenny L |Jenny L Gonzalez-Armenta]], [[Grings Mateus |Mateus Grings]], and the Oroboros team ::::* [[Zdrazilova Lucie |Lucie Zdrazilova]]: see Zdrazilova L, Hansikova H, Gnaiger E (2021) Comparable respiratory activity in attached

|[[Hoffman DL|Hoffman David L]] |[[Knaub L|Knaub Leslie]]

:::: In the case of delay, please call Oroboros Instruments Mobile: +43 677 64 79 29 17 or O ...z train station. Please make sure to bring some cash in EUROs with you, in case you need it.

...publication obtained from a particular project — not intentionally, but in case of unforseen discontinuation, rotation of staff, or any other impracticabil ...guidelines or consensus statements. - [[Axelrod Christopher L |Christopher L Axelrod]]

::::* Sainero-Alcolado L, Liaño-Pons J, Ruiz-Pérez MV, Arsenian-Henriksson M. Targeting mitochondr ...s, we can assume that BBB crossing is an issue that can be overcome in the case of etomoxir and that more trials examining the use of this drug to treat gl

...luding; historical measured regional vitamin D deficiency rates (<25 nmol/L), intakes, and plasma vitamin D levels; fortification and supplementation p ..., Lahore, H., McDonnell, S. L., Baggerly, C. A., French, C. B., Aliano, J. L., & Bhattoa, H. P. (2020). Vitamin D Supplementation Could Prevent and Trea

::::* [http://www.adera.fr/ Association pour le développement de l'enseignement et des recherches aupres des universities et des enterprises d | [[Zampieri L | Luca Zampieri]]

...e fluorescent product according to the supplier is called UltroxRed in the case of Amplex^® UltraRed which has a similar structure to resorufin) ...m light and moisture. The storage solution should then be divided into 20 µL aliquots and stored in the dark in a desiccator, protected from moisture at

...ting to get a better understanding of bioenergetics. ..'' - [[Chakrabarti L |Lisa Chakrabarti, University of Nottingham, UK]] === A1: Connecting mitochondrial physiology - global perspectives and case studies ===

# [[Gueguen 2005 J Physiol | Gueguen N, Lefaucheur L, Ecolan P, Fillaut M, Herpin P (2005) Ca2+-activated myosin-ATPases, creati ...the integrated functional activity of human skeletal muscle mitochondria – case studies. Mitochondrion 4:377-85.]] - Cytochrome ''c'' test.

...rdan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van H ...Lioger D, Diot A, Rousset P, Patureau Mirand P, Boirie Y, Morio B, Mosoni L (2005) Due to reverse electron transfer, mitochondrial H2O2 release increas

File:Hoppel 2012x.jpg|'''[[Hoppel CL| Hoppel Charles L]]''' (Case Western Reserve University, Cleveland, US)

::: ''Chairs:'' [[Laner V |Verena Laner]], [[Hoppel CL|Charles L Hoppel]] ::::* [[MitoPedia: DatLab |'''Gradl L, Capek O, Plattner C, Droescher S, Doerrier C, Gnaiger E''']] (ORO) '''Rele

* Cecatto C, Cardoso LHD, Ozola M, Korzh S, Zvejniece L, Gukalova B, Doerrier C, Dambrova M, Gnaiger E, Makrecka-Kuka M, Liepinsh E |'''"(…) L-Erg [L-Ergothioneine] treatment prevented and delayed cystine lithiasis in a cysti

[[File:CASE-items.png|right|250px]] ...b>) and adding sequentially item after item. In this case, you should read CASE backwards. The term 'item' derives from the Latin word ''item'' meaning 'al

::::* 1 µM stock solution: Dilute 100 µL of 100 µM TPP stock solution with 9.9 mL 100 mM KCl solution. ...t be strictly necessary. In this case the research will have to judge on a case basis. If the correction is obviously rather difficult, the danger of intr

:::# Gueguen N, Lefaucheur L, Ecolan P, Fillaut M, Herpin P (2005) Ca²⁺-activated myosin-ATPa ...the integrated functional activity of human skeletal muscle mitochondria – case studies. Mitochondrion 4:377-85. - [[Puchowicz 2004 Mitochondrion |»Biobla

...ssues and cells is faced with '''E'''volution, '''A'''ge, '''G'''ender, '''L'''ifestyle and '''E'''nvironment ('''EAGLE''') as essential background cond ...th and disease with regard to '''E'''volution, '''A'''ge, '''G'''ender, '''L'''ifestyle and '''E'''nvironment.</big>

:::# Burger G, Gray MW, Forget L, Lang BF (2013) Strikingly bacteria-like and gene-rich mitochondrial genome :::# Dai Q, Shah AA, Garde RV, Yonish BA, Zhang L, Medvitz NA, Miller SE, Hansen EL, Dunn CN, Price TM (2013) A truncated pro

...00004. - [[File:CASE-cell count.png|right|300px|thumb|Figure 1.4.]] [[File:CASE-cell count and elementary mass.png|right|300px|thumb|Figure 1.5.]] :::# Gueguen N, Lefaucheur L, Ecolan P, Fillaut M, Herpin P (2005) Ca²⁺-activated myosin-ATPa

| [[Chakrabarti L]] (UK) | [[Juhasz L]] (HU)

...High Altitude Training Center Kühtai, Kuehtai (Tyrol, Austria), 2020 m a.s.l. (42 min from Innsbruck). :::: [http://www.hotelastoria.at/index.php?id=13&L=1 www.hotelastoria.at]

..., whereas the RCR>9 in imt comes closer to ''in vivo'' values. The low ''P-L'' control efficiency in permeabilized fibers is an unresolved puzzle, and c ...A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pokorná E, Duška F (2020) High resolution respirometry to assess functio

* Szczerbinski L, Taylor MA, Puchta U, Konopka P, Paszko A, Citko A, Szczerbinski K, Goscik ...i T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron overload and ''Hfe<sup>-/-

File:IMG 3355.JPG|Left: The O2-Lab in the MiPArt Gallery (l to r): Erich Gnaiger, Katrin Stecher, Mario Fasching, Andrea Eigentler, Kat ...ciated with the production and marketing of the Oxygraph-2k (5 FTE in each case at WGT and Oroboros) will be assured for years as a result of the improved

...a, Pereira Rita, Pereira Susana P, Perez Valencia Juan Alberto, Perks Kara L, Pesta Dominik, Petit Patrice X, Pettersen Nitschke Ina Katrine, Pichaud Ni :::# Burger G, Gray MW, Forget L, Lang BF (2013) Strikingly bacteria-like and gene-rich mitochondrial genome

:::: '''1.7. Ref 53''' Beier UH, Angelin A, Akimova T, Wang L, Liu Y, Xiao H, Koike MA, Hancock SA, Bhatti TR, Han R, Jiao J, Veasey SC, :::: '''1.15. Ref 60''' de Beauchamp L, Himonas E, Helgason GV (2022) Mitochondrial metabolism as a potential ther

*Fišar Z, Jirák R, Zvěřová M, Setnička V, Habartová L, Hroudová J, Vaníčková Z, Raboch J (2019) Plasma amyloid beta levels an *Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing