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O2k-Publications: Cancer

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O2k-Publications: Cancer

O2k-Publications in the MiPMap

»O2k-Publications: Topics

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 YearReferenceOrganismTissue;cellRegulation;kinetics
Torcasio 2024 J Transl Med2024Torcasio R, Gallo Cantafio ME, Veneziano C, De Marco C, Ganino L, Valentino I, Occhiuzzi MA, Perrotta ID, Mancuso T, Conforti F, Rizzuti B, Martino EA, Gentile M, Neri A, Viglietto G, Grande F, Amodio N (2024) Targeting of mitochondrial fission through natural flavanones elicits anti-myeloma activity. J Transl Med 22:208. https://doi.org/10.1186/s12967-024-05013-0HumanBlood cells
Yang 2023 Redox Biol2023Yang X, Gu C, Cai J, Li F, He X, Luo L, Xiao W, Hu B, Hu J, Qian H, Ren S, Zhang L, Zhu X, Yang L, Yang J, Yang Z, Zheng Y, Huang X, Wang Z (2023) Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis. https://doi.org/10.1016/j.redox.2023.103002HumanLiver
Ren 2023 Cell Discov2023Ren X, Yan J, Zhao Q, Bao X, Han X, Zheng C, Zhou Y, Chen L, Wang B, Yang L, Lin X, Liu D, Lin Y, Li M, Fang H, Lu Z, Lyu J (2023) The Fe-S cluster assembly protein IscU2 increases α-ketoglutarate catabolism and DNA 5mC to promote tumor growth. https://doi.org/10.1038/s41421-023-00558-8HumanIslet cell;pancreas;thymus
Mendoza-Fuentes 2023 PeerJ2023Mendoza-Fuentes A, GonzĂĄlez-Burgos E, Aparicio Trejo OE, Delgado-Lamas G, RodrĂ­guez-ChĂĄvez JL, Pedraza-Chaverri J, GĂłmez-Serranillos MP, Araiza-Olivera D (2023) The cytotoxicity effect of 7-hydroxy-3,4-dihydrocadalene from Heterotheca inuloides and semisynthetic cadalenes derivates towards breast cancer cells: involvement of oxidative stress-mediated apoptosis. https://doi.org/10.7717/peerj.15586Human
Yang 2023 Cell Death Discov2023Yang H, Gao Y, Xu D, Xu K, Liang SQ, Yang Z, Scherz A, Hall SRR, Forster S, Berezowska S, Yao F, Ochsenbein AF, Marti TM, Kocher GJ, Schmid RA, Dorn P, Peng RW (2023) MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma. https://doi.org/10.1038/s41420-023-01307-2HumanLung;gill
Endothelial;epithelial;mesothelial cell
Martell 2023 Acta Neuropathol Commun2023Martell E, Kuzmychova H, Senthil H, Kaul E, Chokshi CR, Venugopal C, Anderson CM, Singh SK, Sharif T (2023) Compensatory cross-talk between autophagy and glycolysis regulates senescence and stemness in heterogeneous glioblastoma tumor subpopulations. https://doi.org/10.1186/s40478-023-01604-yHumanNervous systemAerobic glycolysis
Martell 2023 Nat Commun2023Martell E, Kuzmychova H, Kaul E, Senthil H, Chowdhury SR, Morrison LC, Fresnoza A, Zagozewski J, Venugopal C, Anderson CM, Singh SK, Banerji V, Werbowetski-Ogilvie TE, Sharif T (2023) Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 medulloblastoma. https://doi.org/10.1038/s41467-023-38049-9HumanNervous system
Mioc 2023 Molecules2023Mioc M, Mioc A, Racoviceanu R, Ghiulai R, Prodea A, Milan A, Barbu Tudoran L, Oprean C, Ivan V, Șoica C (2023) The antimelanoma biological assessment of triterpenic acid functionalized gold nanoparticles. https://doi.org/10.3390/molecules28010421HumanEndothelial;epithelial;mesothelial cell
Boykov 2023 Sci Rep2023Boykov IN, Montgomery MM, Hagen JT, Aruleba RT, McLaughlin KL, Coalson HS, Nelson MA, Pereyra AS, Ellis JM, Zeczycki TN, Vohra NA, Tan SF, Cabot MC, Fisher-Wellman KH (2023) Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer types. https://doi.org/10.1038/s41598-023-43963-5MouseHeart
Endothelial;epithelial;mesothelial cell
Peixoto 2023 J Physiol Biochem2023Peixoto ÁS, Moreno MF, Castro É, Perandini LA, Belchior T, Oliveira TE, Vieira TS, Gilio GR, Tomazelli CA, Leonardi BF, Ortiz-Silva M, Silva Junior LP, Moretti EH, Steiner AA, Festuccia WT (2023) Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning. https://doi.org/10.1007/s13105-023-00970-4MouseLiver
Fat
Cruz-Gregorio 2023 Phytother Res2023Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Medina-Campos ON, Sciutto E, Fragoso G, Pedraza-Chaverri J (2023) α-Mangostin induces oxidative damage, mitochondrial dysfunction, and apoptosis in a triple-negative breast cancer model. https://doi.org/10.1002/ptr.7812MouseEndothelial;epithelial;mesothelial cell
Liu 2023 Pharmacol Res2023Liu S, Yue S, Guo Y, Han JY, Wang H (2023) Sorafenib induces cardiotoxicity through RBM20-mediated alternative splicing of sarcomeric and mitochondrial genes. https://doi.org/10.1016/j.phrs.2023.107017RatHeart
Fisher-Wellman 2023 Cancers (Basel)2023Fisher-Wellman KH, Kassai M, Hagen JT, Neufer PD, Kester M, Loughran TP Jr, Chalfant CE, Feith DJ, Tan SF, Fox TE, Ung J, Fabrias G, Abad JL, Sharma A, Golla U, Claxton DF, Shaw JJP, Bhowmick D, Cabot MC (2023) Simultaneous inhibition of ceramide hydrolysis and glycosylation synergizes to corrupt mitochondrial respiration and signal caspase driven cell death in drug-resistant acute myeloid leukemia. https://doi.org/10.3390/cancers15061883HumanBlood cells
Clemente 2023 Commun Biol2023Clemente N, Baroni S, Fiorilla S, Tasso F, Reano S, Borsotti C, Ruggiero MR, Alchera E, Corrazzari M, Walker G, Follenzi A, Crich SG, Carini R (2023) Boosting intracellular sodium selectively kills hepatocarcinoma cells and induces hepatocellular carcinoma tumor shrinkage in mice. https://doi.org/10.1038/s42003-023-04946-4HumanLiver
Mahmoud 2023 Pharmacol Res2023Mahmoud AM, Kostrzewa M, Marolda V, Cerasuolo M, Maccarinelli F, Coltrini D, Rezzola S, Giacomini A, Mollica MP, Motta A, Paris D, Zorzano A, Marzo VD, Ronca R, Ligresti A (2023) Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer. https://doi.org/10.1016/j.phrs.2023.106683MouseEndothelial;epithelial;mesothelial cellATP production
Wang 2023 Cancer Cell Int2023Wang Y, Wang J, Chen L, Chen Z, Wang T, Xiong S, Zhou T, Wu G, He L, Cao J, Liu M, Li H, Gu H (2023) PRRG4 regulates mitochondrial function and promotes migratory behaviors of breast cancer cells through the Src-STAT3-POLG axis. https://doi.org/10.1186/s12935-023-03178-0HumanEndothelial;epithelial;mesothelial cell
Antona 2023 Cell Death Discov2023Antona A, Leo G, Favero F, Varalda M, Venetucci J, Faletti S, Todaro M, Mazzucco E, Soligo E, Saglietti C, Stassi G, Manfredi M, Pelicci G, CorĂ  D, Valente G, Capello D (2023) Targeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility, and differentiation. https://doi.org/10.1038/s41420-023-01502-1HumanEndothelial;epithelial;mesothelial cell
Karavyraki 2022 MitoFit2022Karavyraki M, Gnaiger E, Porter RK (2022) A comparison of bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. https://doi.org/10.26124/mitofit:2022-0022 — 2022-11-11 published in Bioenerg Commun 2022.11.HumanAerobic glycolysis
Antona 2022 Cancers (Basel)2022Antona A, Varalda M, Roy K, Favero F, Mazzucco E, ZuccalĂ  M, Leo G, Soggia G, Bettio V, Tosi M, Gaggianesi M, Riva B, Reano S, Genazzani A, Manfredi M, Stassi G, CorĂ  D, D'Alfonso S, Capello D (2022) Dissecting the mechanism of action of spiperone-a candidate for drug repurposing for colorectal cancer. https://doi.org/10.3390/cancers14030776HumanEndothelial;epithelial;mesothelial cell
Zhang 2022 Int J Mol Sci2022Zhang A, Gupte AA, Chatterjee S, Li S, Ayala AG, Miles BJ, Hamilton DJ (2022) Enhanced succinate oxidation with mitochondrial complex II reactive oxygen species generation in human prostate cancer. https://doi.org/10.3390/ijms232012168HumanGenital
Deng 2022 Cell Mol Life Sci2022Deng H, Gao Y, Trappetti V, Hertig D, Karatkevich D, Losmanova T, Urzi C, Ge H, Geest GA, Bruggmann R, Djonov V, Nuoffer JM, Vermathen P, Zamboni N, Riether C, Ochsenbein A, Peng RW, Kocher GJ, Schmid RA, Dorn P, Marti TM (2022) Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage. https://doi.org/10.1007/s00018-022-04453-5HumanEndothelial;epithelial;mesothelial cell
Karavyraki 2022 BEC2022Karavyraki M, Gnaiger E, Porter RK (2022) Bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. Bioenerg Commun 2022.11. https://doi.org/10.26124/bec:2022-0011HumanAerobic glycolysis
Wang 2022 Transl Cancer Res2022Wang B, Liu B, Luo Q, Sun D, Li H, Zhang J, Jin X, Cheng X, Niu J, Yuan Q, Chen Y (2022) PANK1 associates with cancer metabolism and immune infiltration in clear cell renal cell carcinoma: a retrospective prognostic study based on the TCGA database. https://doi.org/10.21037/tcr-22-1488HumanKidney
Endothelial;epithelial;mesothelial cell
Delfinis 2022 JCI Insight2022Delfinis LJ, Bellissimo CA, Gandhi S, DiBenedetto SN, Garibotti MC, Thuhan AK, Tsitkanou S, Rosa-Caldwell ME, Rahman FA, Cheng AJ, Wiggs MP, Schlattner U, Quadrilatero J, Greene NP, Perry CG (2022) Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress. https://doi.org/10.1172/jci.insight.155147MouseSkeletal musclePCr;Cr
Torres-Quesada 2022 Cancers (Basel)2022Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Physiological cell culture media tune mitochondrial bioenergetics and drug sensitivity in cancer cell models. https://doi.org/10.3390/cancers14163917HumanOther cell linesCoupling efficiency;uncoupling
Cruz-Gregorio 2022 Antioxidants (Basel)2022Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Medina-Campos ON, Sciutto E, Fragoso G, Pedraza-Chaverri J (2022) GK-1 Induces oxidative stress, mitochondrial dysfunction, decreased membrane potential, and impaired autophagy flux in a mouse model of breast cancer. https://doi.org/10.3390/antiox12010056MouseEndothelial;epithelial;mesothelial cell
Kluckova 2022 Hemasphere2022Kluckova K, Clear AJ, D'Avola A, Rassenti LZ, Kipps TJ, Gribben JG, Riches JC (2022) B-cell receptor signaling induced metabolic alterations in chronic lymphocytic leukemia can be partially bypassed by TP53 abnormalities. https://doi.org/10.1097/hs9.0000000000000722Blood cells
Fialova 2022 Biomed Pharmacother2022Fialova JL, Hönigova K, Raudenska M, Miksatkova L, Zobalova R, Navratil J, Ơmigovå J, Moturu TR, Vicar T, Balvan J, Vesela K, Abramenko N, Kejik Z, Kaplanek R, Gumulec J, Rosel D, Martasek P, Bråbek J, Jakubek M, Neuzil J, Masarik M (2022) Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration. https://doi.org/10.1016/j.biopha.2022.113582HumanEndothelial;epithelial;mesothelial cell
Torres-Quesada 2022 MitoFit2022Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Human Plasma-Like Media fine-tune mitochondrial function and alter drug sensitivity in cancer cell lines. https://doi.org/10.26124/mitofit:2022-0008 — 2022-08-13 published in https://doi.org/10.3390/cancers14163917HumanOther cell linesCoupling efficiency;uncoupling
Erdem 2022 Nat Commun2022Erdem A, Marin S, Pereira-Martins DA, Geugien M, Cunningham A, Pruis MG, WeinhÀuser I, Gerding A, Bakker BM, Wierenga ATJ, Rego EM, Huls G, Cascante M, Schuringa JJ (2022) Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability. https://doi.org/10.1038/s41467-022-29639-0HumanOther cell lines
Siow 2022 J Cell Sci2022Siow WX, Kabiri Y, Tang R, Chao YK, Plesch E, Eberhagen C, Flenkenthaler F, Fröhlich T, Bracher F, Grimm C, Biel M, Zischka H, Vollmar AM, Bartel K (2022) Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells. https://doi.org/10.1242/jcs.259455MouseLiverIon;substrate transport
Nadeu 2022 Nat Med2022Nadeu F, Royo R, Massoni-Badosa R, Playa-Albinyana H, Garcia-Torre B, Duran-Ferrer M, Dawson KJ, Kulis M, Diaz-Navarro A, Villamor N, Melero JL, Chapaprieta V, Dueso-Barroso A, Delgado J, Moia R, Ruiz-Gil S, Marchese D, GirĂł A, Verdaguer-Dot N, Romo M, Clot G, Rozman M, Frigola G, Rivas-Delgado A, Baumann T, Alcoceba M, GonzĂĄlez M, Climent F, Abrisqueta P, CastellvĂ­ J, Bosch F, Aymerich M, Enjuanes A, Ruiz-GaspĂ  S, LĂłpez-Guillermo A, Jares P, BeĂ  S, Capella-Gutierrez S, GelpĂ­ JL, LĂłpez-Bigas N, Torrents D, Campbell PJ, Gut I, Rossi D, Gaidano G, Puente XS, Garcia-Roves PM, Colomer D, Heyn H, Maura F, MartĂ­n-Subero JI, Campo E (2022) Detection of early seeding of Richter transformation in chronic lymphocytic leukemia. https://doi.org/10.1038/s41591-022-01927-8HumanLymphocyte
Blood cells
Lelcu 2021 Children (Basel)2021Lelcu T, Bßnă AM, Dănilă MD, Popoiu CM, Aburel OM, Arghirescu ST, Borza C, Muntean DM (2021) Assessment of platelet mitochondrial respiration in a pediatric population: A pilot study in healthy children and children with acute lymphoblastic leukemia. https://doi.org/10.3390/children8121196HumanPlatelet
Bastos Sant'Anna Silva 2021 Cancers (Basel)2021Bastos Sant'Anna Silva AC, Perez Valencia JA, Sciacovelli M, Lalou C, Sarlak S, Tronci L, Nikitopoulou E, Meszaros AT, Frezza C, Rossignol R, Gnaiger E, Klocker H (2021) Succinate anaplerosis has an onco-driving potential in prostate cancer cells. https://doi.org/10.3390/cancers13071727HumanGenitalSubstrate
Wigner 2021 Sci Rep2021Wigner P, Zielinski K, Labieniec-Watala M, Marczak A, Szwed M (2021) Doxorubicin-transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells. Sci Rep 11:4544.HumanOther cell lines
Palacka 2021 Int J Mol Sci2021Palacka P, GvozdjĂĄkovĂĄ A, RausovĂĄ Z, KucharskĂĄ J, SlopovskĂœ J, ObertovĂĄ J, Furka D, Furka S, Singh KK, SumbalovĂĄ Z (2021) Platelet mitochondrial bioenergetics reprogramming in patients with urothelial carcinoma. https://doi.org/10.3390/ijms23010388HumanPlatelet
Zunica 2021 Cancer Metab2021Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP (2021) Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15. Cancer Metab 9:36.Human
Mouse
Endothelial;epithelial;mesothelial cell
Sighel 2021 Cell Rep2021Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, Soldano A, Adami V, Ambrosini C, Broso F, Rosatti EF, Longhi S, Buccarelli M, D'Alessandris QG, Giannetti S, Pacioni S, Ricci-Vitiani L, Rorbach J, Pallini R, Roulland S, Amunts A, Mancini I, Modelska A, Quattrone A (2021) Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Rep 35:109024.HumanNervous system
Stem cells
Klepinina 2021 PLoS One2021Klepinina L, Klepinin A, Truu L, Chekulayev V, Vija H, Kuus K, Teino I, Pook M, Maimets T, Kaambre T (2021) Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS One 16:e0245348.HumanEndothelial;epithelial;mesothelial cell
Brito 2021 BMC Cancer2021Brito A, Merle C, Lagarde P, Faustin B, Devin A, Lartigue L, Chibon F (2021) Cell fusion enhances energy metabolism of mesenchymal tumor hybrid cells to sustain their proliferation and invasion. BMC Cancer 21:863.HumanFibroblast
Meng 2021 FEBS Open Bio2021Meng L, Chen D, Meng G, Lu L, Han C (2021) Dysregulation of the Sirt5/IDH2 axis contributes to sunitinib resistance in human renal cancer cells. FEBS Open Bio 11:921-31.HumanKidney
Kripnerova 2021 J Clin Med2021KripnerovĂĄ M, Parmar HS, Ć ĂĄna J, KopkovĂĄ A, RadovĂĄ L, Sopper S, Biernacki K, Jedlička J, KohoutovĂĄ M, KuncovĂĄ J, Peychl J, Rudolf E, Červinka M, Houdek Z, Dvoƙák P, HoufkovĂĄ K, PeĆĄta M, TĆŻma Z, DolejĆĄovĂĄ M, TichĂĄnek F, BabuĆĄka V, Leba M, SlabĂœ O, Hatina J (2021) Complex interplay of genes underlies invasiveness in fibrosarcoma progression model. J Clin Med 10:2297.MouseFibroblast
Chowdhury 2021 Cancers (Basel)2021Chowdhury SR, Peltier C, Hou S, Singh A, Johnston JB, Gibson SB, Marshall A, Banerji V (2021) Ex vivo mitochondrial respiration parallels biochemical response to ibrutinib in CLL cells. Cancers (Basel) 13:E354.HumanLymphocyte
Amoedo 2021 J Clin Invest2021Amoedo ND, Sarlak S, Obre E, Esteves P, Bégueret H, Kieffer Y, Rousseau B, Dupis A, Izotte J, Bellance N, Dard L, Redonnet-Vernhet I, Punzi G, Rodrigues MF, Dumon E, Mafhouf W, Guyonnet-Dupérat V, Gales L, Palama T, Bellvert F, Dugot-Senan N, Claverol S, Baste JM, Lacombe D, Rezvani HR, Pierri CL, Mechta-Grigoriou F, Thumerel M, Rossignol R (2021) Targeting the mitochondrial trifunctional protein restrains tumor growth in oxidative lung carcinomas. J Clin Invest 131:e133081.HumanLung;gill
Zhang 2021 Pharmaceutics2021Zhang H, Zhang A, Gupte AA, Hamilton DJ (2021) Plumbagin elicits cell-specific cytotoxic effects and metabolic responses in melanoma cells. Pharmaceutics 13:706.HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Schmidt 2021 Cancer Metab2021Schmidt CA, McLaughlin KL, Boykov IN, Mojalagbe R, Ranganathan A, Buddo KA, Lin CT, Fisher-Wellman KH, Neufer PD (2021) Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells. Cancer Metab 9:3.HumanLiver
Coppin 2020 Cell Death Dis2020Coppin L, Jannin A, Ait Yahya E, Thuillier C, Villenet C, Tardivel M, Bongiovanni A, Gaston C, de Beco S, Barois N, van Seuningen I, Durand E, Bonnefond A, Vienne JC, Vamecq J, Figeac M, Vincent A, Delacour D, Porchet N, Pigny P (2020) Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface. Cell Death Dis 11:360.HumanIslet cell;pancreas;thymus
Endothelial;epithelial;mesothelial cell
Makrecka-Kuka 2020 Sci Rep2020Makrecka-Kuka M, Dimitrijevs P, Domracheva I, Jaudzems K, Dambrova M, Arsenyan P (2020) Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production. https://doi.org/10.1038/s41598-020-78620-8.MouseEndothelial;epithelial;mesothelial cell
Hayes 2020 Nutrients2020Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan CJ, Tuorto F, Nolan DP, Kelly VP (2020) Queuine micronutrient deficiency promotes Warburg metabolism and reversal of the mitochondrial ATP synthase in HeLa cells. Nutrients 12:E871.HumanHeLa
Pola 2020 Invest New Drugs2020Pola M, Kolarova H, Ruzicka J, Zholobenko A, Modriansky M, Mosinger J, Bajgar R (2020) Effects of zinc porphyrin and zinc phthalocyanine derivatives in photodynamic anticancer therapy under different partial pressures of oxygen in vitro. Invest New Drugs 39:89-97.HumanHeLa
Mayoral-Varo 2020 PLoS One2020Mayoral-Varo V, Calcabrini A, SĂĄnchez-BailĂłn MP, MartĂ­nez-Costa ÓH, GonzĂĄlez-PĂĄramos C, Ciordia S, Hardisson D, AragĂłn JJ, FernĂĄndez-Moreno MÁ, MartĂ­n-PĂ©rez J (2020) c-Src functionality controls self-renewal and glucose metabolism in MCF7 breast cancer stem cells . PLoS One 15:e0235850.HumanEndothelial;epithelial;mesothelial cell
D'Onofrio 2020 Sci Rep2020D'Onofrio N, Cacciola NA, Martino E, Borrelli F, Fiorino F, Lombardi A, Neglia G, Balestrieri ML, Campanile G (2020) ROS-mediated apoptotic cell death of human colon cancer LoVo cells by milk ÎŽ-valerobetaine. Sci Rep 10:8978.HumanEndothelial;epithelial;mesothelial cellCyt c
Robledo-Cadena 2020 Pharmaceuticals (Basel)2020Robledo-Cadena DX, Gallardo-PĂ©rez JC, DĂĄvila-Borja V, Pacheco-VelĂĄzquez SC, Belmont-DĂ­az JA, Ralph SJ, Blanco-Carpintero BA, Moreno-SĂĄnchez R, RodrĂ­guez-EnrĂ­quez S (2020) Non-steroidal anti-inflammatory drugs increase cisplatin, paclitaxel, and doxorubicin efficacy against human cervix cancer cells. Pharmaceuticals (Basel) 13:463.HumanEndothelial;epithelial;mesothelial cell
HeLa
Fibroblast
Rebane-Klemm 2020 Cancers (Basel)2020Rebane-Klemm E, Truu L, Reinsalu L, Puurand M, Shevchuk I, Chekulayev V, Timohhina N, Tepp K, Bogovskaja J, Afanasjev V, Suurmaa K, Valvere V, Kaambre T (2020) Mitochondrial respiration in KRAS and BRAF mutated colorectal tumors and polyps. Cancers (Basel) 12:E815.HumanEndothelial;epithelial;mesothelial cell
Vulczak 2020 Cells2020Vulczak A, Souza AO, Ferrari GD, Azzolini AECS, Pereira-da-Silva G, Alberici LC (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:E628.MouseEndothelial;epithelial;mesothelial cell
Bianchi 2020 IUBMB Life2020Bianchi SE, Pegues MA, Dias CK, Mascia F, Doneda E, Pittol V, Rao A, Klamt F, Bassani VL (2020) Achyrocline satureioides compounds, achyrobichalcone and 3-O-methylquercetin, induce mitochondrial dysfunction and apoptosis in human breast cancer cell lines. IUBMB Life 72:2133-45.HumanEndothelial;epithelial;mesothelial cell
Li 2020 Cells2020Li M, Wang L, Wang Y, Zhang S, Zhou G, Lieshout R, Ma B, Liu J, Qu C, Verstegen MMA, Sprengers D, Kwekkeboom J, van der Laan LJW, Cao W, Peppelenbosch MP, Pan Q (2020) Mitochondrial fusion via OPA1 and MFN1 supports liver tumor cell metabolism and growth. Cells 9:E121.HumanLiver
Sharma 2020 Integr Cancer Ther2020Sharma P, Singh S (2020) Combinatorial effect of DCA and let-7a on triple-negative MDA-MB-231 cells: A metabolic approach of treatment. Integr Cancer Ther 19:1534735420911437.HumanEndothelial;epithelial;mesothelial cell
Parri 2020 Curr Opin Biotechnol2020Parri M, Ippolito L, Cirri P, Ramazzotti M, Chiarugi P (2020) Metabolic cell communication within tumour microenvironment: models, methods and perspectives. Curr Opin Biotechnol 63:210-19.
Schoepf 2020 Nat Commun2020Schöpf Bernd, Weissensteiner Hansi, SchĂ€fer Georg, Fazzini Federica, Charoentong Pornpimol, Naschberger Andreas, Rupp Bernhard, Fendt Liane, Bukur Valesca, Giese Irina, Sorn Patrick, Sant’Anna-Silva Ana Carolina, Iglesias-Gonzalez Javier, Sahin Ugur, Kronenberg Florian, Gnaiger Erich, Klocker Helmut (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. https://doi.org/10.1038/s41467-020-15237-5HumanGenital
Other cell lines
Coupling efficiency;uncoupling
Flux control
Inhibitor
Visavadiya 2020 Mol Cell Biochem2020Visavadiya NP, Pena GS, Khamoui AV (2020) Mitochondrial dynamics and quality control are altered in a hepatic cell culture model of cancer cachexia. Mol Cell Biochem 476:23-34.MouseLiver
Mann 2020 Sci Rep2020Mann J, Yang N, Montpetit R, Kirschenman R, Lemieux H, Goping IS (2020) BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis. https://doi.org/10.1038/s41598-019-57282-1HumanOther cell lines
Silva Ferraz 2020 Biochem Pharmacol2020Silva Ferraz L, Torres da Costa R, Alves da Costa C, Augusto JoĂŁo Ribeiro C, Costa Arruda D, Stuchi Maria-Engler S, Rodrigues T (2020) Targeting mitochondria in melanoma: interplay between MAPK signaling pathway and mitochondrial dynamics . Biochem Pharmacol 178:114104.HumanEndothelial;epithelial;mesothelial cell
Jian 2020 Cell Metab2020Jian C, Fu J, Cheng X, Shen LJ, Ji YX, Wang X, Pan S, Tian H, Tian S, Liao R, Song K, Wang HP, Zhang X, Wang Y, Huang Z, She ZG, Zhang XJ, Zhu L, Li H (2020) Low-dose sorafenib acts as a mitochondrial uncoupler and ameliorates nonalcoholic steatohepatitis. Cell Metab 31:892-908. https://doi.org/10.1016/j.cmet.2020.04.011MouseLiver
Contreras Mostazo 2020 Cancers (Basel)2020Mostazo MGC, Kurrle N, Casado M, Fuhrmann D, Alshamleh I, HĂ€upl B, MartĂ­n-Sanz P, BrĂŒne B, Serve H, Schwalbe H, SchnĂŒtgen F, Marin S, Cascante M (2020) Metabolic plasticity is an essential requirement of acquired tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Cancers (Basel) 12:E3443.HumanBlood cells
Khamoui 2020 Physiol Genomics2020Khamoui AV, Tokmina-Roszyk D, Rossiter HB, Fields GB, Visavadiya NP (2020) Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia. Physiol Genomics 52:203-16.MouseLiver
Macasoi 2020 Oncol Rep2020Macașoi I, Pavel IZ, Moacă AE, Avram S, David LV, Coricovac D, Mioc A, Spandidos DA, Tsatsakis A, Șoica C, Dumitrașcu V, Dehelean C (2020) Mechanistic investigations of antitumor activity of a Rhodamine B‑oleanolic acid derivative bioconjugate. Oncol Rep 44:1169-83.HumanEndothelial;epithelial;mesothelial cell
De Souza 2020 Heliyon2020De Souza CEA, Andrade Pires AR, Cardoso CR, Carlos RM, Cadena SMSC, Acco A (2020) Antineoplastic activity of a novel ruthenium complex against human hepatocellular carcinoma (HepG2) and human cervical adenocarcinoma (HeLa) cells. Heliyon 6:e03862.HumanLiver
HeLa
Kunz 2020 J Biol Chem2020Kunz HE, Dorschner JM, Berent TE, Meyer T, Wang X, Jatoi A, Kumar R, Lanza IR (2020) Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. J Biol Chem 295:17441-59.MouseSkeletal muscle
Roy Chowdhury 2020 Cancers (Basel)2020Roy Chowdhury S, Bouchard EDJ, Saleh R, Nugent Z, Peltier C, Mejia E, Hou S, McFall C, Squires M, Hewitt D, Davidson L, Shen GX, Johnston JB, Doucette C, Hatch GM, Fernyhough P, Marshall A, Gibson SB, Dawe DE, Banerji V (2020) Mitochondrial respiration correlates with prognostic markers in chronic lymphocytic leukemia and is normalized by ibrutinib treatment. Cancers (Basel) 12:E650.HumanLymphocyte
Blood cells
Messner 2020 Thesis2020Messner M (2020) Sorafenib resistance of hepatocellular carcinoma. PhD Thesis 130.HumanLiver
Lara-Marqueza 2020 J Funct Foods2020Lara-Mårquez M, Båez-Magaña M, Raymundo-Ramos C, Spagnuolo PA, Macías-Rodríguez L, Salgado-Garciglia R, Ochoa-Zarzosa A, López-Meza JE (2020) Lipid-rich extract from Mexican avocado (Persea americana var. drymifolia) induces apoptosis and modulates the inflammatory response in Caco-2 human colon cancer cells. J Funct Foods 64:103658.HumanEndothelial;epithelial;mesothelial cell
Cruz 2020 Cancers (Basel)2020Cruz B, Oliveira A, Viana LR, Lopes-Aguiar L, Canevarolo R, Colombera MC, Valentim RR, Garcia-FĂłssa F, de Sousa LM, Castelucci BG, Consonni SR, Martins-de-Souza D, de Jesus MB, Russell ST, Gomes-Mardondes MCC (2020) Leucine-tich diet modulates the metabolomic and proteomic profile of skeletal muscle during cancer cachexia. Cancers (Basel) 12:E1880.MouseSkeletal muscle
Mann 2019 Oncogene2019Mann J, Githaka JM, Buckland TW, Yang N, Montpetit R, Patel N, Li L, Baksh S, Godbout R, Lemieux H, Goping IS (2019) Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism. Oncogene 38:3325-39.HumanEndothelial;epithelial;mesothelial cell
Aubin 2019 Thesis2019Aubin M (2019) Glucocorticoids and acute lymphoid leukemia: a proteomic approach. Doctoral Dissertation 99.HumanLymphocyte
Viana 2019 Sci Rep2019Viana LR, Tobar N, Busanello ENB, Marques AC, de Oliveira AG, Lima TI, Machado G, Castelucci BG, Ramos CD, Brunetto SQ, Silveira LR, Vercesi AE, Consonni SR, Gomes-Marcondes MCC (2019) Leucine-rich diet induces a shift in tumour metabolism from glycolytic towards oxidative phosphorylation, reducing glucose consumption and metastasis in Walker-256 tumour-bearing rats. Sci Rep 9:15529.RatEndothelial;epithelial;mesothelial cell
Altinok 2019 J Cell Physiol2019Altinok O, Poggio JL, Stein DE, Bowne WB, Shieh AC, Snyder NW, Orynbayeva Z (2019) Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria. J Cell Physiol 235:2569-81.HumanOther cell lines
Reda 2019 Sci Rep2019Reda A, Refaat A, Abd-Rabou AA, Mahmoud AM, Adel M, Sabet S, Ali SS (2019) Role of mitochondria in rescuing glycolytically inhibited subpopulation of triple negative but not hormone-responsive breast cancer cells. Sci Rep 9:13748.HumanEndothelial;epithelial;mesothelial cell
Gao 2019 Cancer Cell Int2019Gao Y, Dorn P, Liu S, Deng H, Hall SRR, Peng RW, Schmid RA, Marti TM (2019) Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment. Cancer Cell Int 19:317.HumanLung;gill
Endothelial;epithelial;mesothelial cell
Wang 2019 Free Radic Biol Med2019Wang SQ, Yang XY, Cui SX, Gao ZH, Qu XJ (2019) Heterozygous knockout insulin-like growth factor-1 receptor (IGF-1R) regulates mitochondrial functions and prevents colitis and colorectal cancer. Free Radic Biol Med 134:87-98.MouseHeart
Liver
Endothelial;epithelial;mesothelial cell
Kulkarni 2019 Haematologica2019Kulkarni PP, Tiwari A, Singh N, Gautam D, Sonkar VK, Agarwal V, Dash D (2019) Aerobic glycolysis fuels platelet activation: small-molecule modulators of platelet metabolism as anti-thrombotic agents. Haematologica 104:806-18.HumanBlood cells
Platelet
Lemieux 2019 bioRxiv2019Lemieux H, Subarsky P, Doblander C, Wurm M, Troppmair J, Gnaiger E (2019) Mitochondrial respiratory function as an early biomarker of apoptosis induced by growth factor removal. bioRxiv doi: https://doi.org/10.1101/151480 .MouseBlood cellsCoupling efficiency;uncoupling
Cyt c
Flux control
Inhibitor
Q-junction effect
Threshold;excess capacity
Uncoupler
Sundstroem 2019 Acta Neuropathol Commun2019SundstrĂžm T, Prestegarden L, Azuaje F, Aasen SN, RĂžsland GV, Varughese JK, Bahador M, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Ingham ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Beschorner R, Bjerkvig R, Thorsen F (2019) Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Commun 7:55.HumanEndothelial;epithelial;mesothelial cell
Aguilar 2019 Cell Rep2019Aguilar E, Esteves P, Sancerni T, Lenoir V, Aparicio T, Bouillaud F, Dentin R, Prip-Buus C, Ricquier D, Pecqueur C, Guilmeau S, Alves-Guerra MC (2019) UCP2 deficiency increases colon tumorigenesis by promoting lipid synthesis and depleting NADPH for antioxidant defenses. Cell Rep 28:2306-16.MouseEndothelial;epithelial;mesothelial cell
Bousseau 2019 FASEB J2019Bousseau S, Marchand M, Soleti R, Vergori L, Hilairet G, Recoquillon S, Le Mao M, Gueguen N, Khiati S, Clarion L, Bakalara N, Martinez MC, Germain S, Lenaers G, Andriantsitohaina R (2019) Phostine 3.1a as a pharmacological compound with antiangiogenic properties against diseases with excess vascularization. FASEB J 33:5864-75.HumanEndothelial;epithelial;mesothelial cell
Esteves 2019 Oncogene2019Esteves P, Dard L, Brillac A, Hubert C, Sarlak S, Rousseau B, Dumon E, Izotte J, Bonneu M, Lacombe D, Dupuy JW, Amoedo N, Rossignol R (2019) Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F. Oncogene 39:617-36.HumanEndothelial;epithelial;mesothelial cell
Ruzickova 2019 Thesis2019Ruzickova A (2019) Horizontal transfer of mitochondria and its role in carcinogenesis. Master's Thesis 85.Mouse
Majiene 2019 Nutrients2019Majiene D, Kuseliauskyte J, Stimbirys A, Jekabsone A (2019) Comparison of the effect of native 1,4-naphthoquinones plumbagin, menadione, and lawsone on viability, redox status, and mitochondrial functions of C6 glioblastoma cells. Nutrients 11:E1294.RatNervous system
Moscheni 2019 Cancers (Basel)2019Moscheni C, Malucelli E, Castiglioni S, Procopio A, De Palma C, Sorrentino A, Sartori P, Locatelli L, Pereiro E, Maier JA, Iotti S (2019) 3D quantitative and ultrastructural analysis of mitochondria in a model of doxorubicin sensitive and resistant human colon carcinoma cells. Cancers (Basel) 11:E1254.HumanEndothelial;epithelial;mesothelial cell
Halle 2019 Am J Physiol Regul Integr Comp Physiol2019Halle JL, Pena GS, Paez HG, Castro AJ, Rossiter HB, Visavadiya NP, Whitehurst MA, Khamoui AV (2019) Tissue-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia. Am J Physiol Regul Integr Comp Physiol 317:R68-R82.MouseSkeletal muscle
Liver
Fat
Gaiser 2019 Adv Ther (Weinh)2019Gaiser A, Hafner S, Schmiech M, BĂŒchele B, SchĂ€fer P, Arnim CA, Calzia, E, Feuring‐Buske M, Buske C, Vick B, Jeremias I, Syrovets T, Simmet T (2019) Gold nanoparticles with selective antileukemic activity in vitro and in vivo target mitochondrial respiration. Adv Ther (Weinh) doi:10.1002/adtp.201800149.HumanBlood cells
De Moura Escobar 2019 Toxicol In Vitro2019de Moura Escobar SJ, Simone M, de Oliveira Ribeiro CA, Martinez GR, Winnischofer SMB, Witting PK, Rocha MEM (2019) Cytotoxic effects of 4'-hydroxychalcone on human neuroblastoma cells (SH-SY5Y). Toxicol In Vitro 61:104640.HumanNeuroblastoma
Malagrino 2019 Oxid Med Cell Longev2019MalagrinĂČ F, Zuhra K, Mascolo L, Mastronicola D, Vicente JB, Forte E, GiuffrĂš A (2019) Hydrogen sulfide oxidation: adaptive changes in mitochondria of SW480 colorectal cancer cells upon exposure to hypoxia. Oxid Med Cell Longev 2019:8102936.HumanEndothelial;epithelial;mesothelial cellInhibitor
Grauso 2019 Sci Rep2019Grauso M, Lan A, Andriamihaja M, Bouillaud F, Blachier F (2019) Hyperosmolar environment and intestinal epithelial cells: impact on mitochondrial oxygen consumption, proliferation, and barrier function in vitro. Sci Rep 9:11360.HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Ramkumar 2019 Mitochondrion2019Ramkumar B, Dharaskar SP, Mounika G, Paithankar K, Sreedhar AS (2019) Mitochondrial chaperone, TRAP1 as a potential pharmacological target to combat cancer metabolism. Mitochondrion 50:42-50.HumanLung;gill
HEK
Neuroblastoma
Bajzikova 2019 Cell Metab2019Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman Werner JH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab 29:399-416.MouseEndothelial;epithelial;mesothelial cell
Genital
Other cell lines
Sukovas 2019 J Bioenerg Biomembr2019Sukovas A, Silkuniene G, Trumbeckaite S, Jasukaitiene A, Degutyte-Fomins L, Mildaziene V, Gulbinas A, Baniene R, Dambrauskas Z, Paskauskas S (2019) Hyperthermia potentiates cisplatin cytotoxicity and negative effects on mitochondrial functions in OVCAR-3 cells. J Bioenerg Biomembr 51:301-10.HumanGenitalTemperature
Rodriguez-Enriquez 2019 Toxicol Appl Pharmacol2019Rodríguez-Enríquez S, Pacheco-Velåzquez SC, Marín-Hernåndez Á, Gallardo-Pérez JC, Robledo-Cadena DX, Hernåndez-Reséndiz I, García-García JD, Belmont-Díaz J, López-Marure R, Hernåndez-Esquivel L, Sånchez-Thomas R, Moreno-Sånchez R (2019) Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress. Toxicol Appl Pharmacol 370:65-77.RatHeart
Liver
Turnbull 2019 Am J Physiol Cell Physiol2019Turnbull PC, Hughes MC, Perry CGR (2019) The fatty acid derivative palmitoylcarnitine abrogates colorectal cancer cell survival by depleting glutathione. Am J Physiol Cell Physiol 317:C1278-88.HumanEndothelial;epithelial;mesothelial cellFatty acid
Djeungoue-Petga 2019 Cell Death Dis2019Djeungoue-Petga MA, Lurette O, Jean S, Hamel-CÎté G, Martín-Jiménez R, Bou M, Cannich A, Roy P, Hebert-Chatelain E (2019) Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells. Cell Death Dis 10:940.HumanEndothelial;epithelial;mesothelial cell
Alvarez 2019 Chem Biol Interact2019Álvarez Santos MR, Duarte YB, GĂŒiza FM, Romero BohĂłrquez AR, Mendez-Sanchez SC (2019) Effects of new tetrahydroquinoline-isoxazole hybrides on bioenergetics of hepatocarcinoma Hep-G2 cells and rat liver mitochondria. Chem Biol Interact 302:164-71.HumanLiver
Bottoni 2019 Adv Exp Med Biol2019Bottoni P, Scatena R (2019) Mitochondrial metabolism in cancer. A tangled topic. Which role for proteomics? Adv Exp Med Biol 1158:1-16.
Neyroud 2019 J Muscle Res Cell Motil2019Neyroud D, Nosacka RL, Judge AR, Hepple RT (2019) Colon 26 adenocarcinoma (C26)-induced cancer cachexia impairs skeletal muscle mitochondrial function and content. J Muscle Res Cell Motil 40:59-65.MouseSkeletal muscle
Cruz-Gregorio 2019 Biomolecules2019Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Coronado-Martinez I, Pedraza-Chaverri J, Lizano M (2019) E6 oncoproteins from high-risk human papillomavirus induce mitochondrial metabolism in a head and neck squamous cell carcinoma model. Biomolecules 9:E351.HumanEndothelial;epithelial;mesothelial cell
Teh 2019 Mol Cancer Ther2019Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M (2019) Respiratory capacity and reserve predict cell sensitivity to mitochondria inhibitors: mechanism-based markers to identify metformin-responsive cancers. Mol Cancer Ther 18:693-705.Human
Mouse
Other cell lines
Scatena 2019 Curr Med Chem2019Scatena R, Bottoni P (2019) The tangled mitochondrial metabolism in cancer: An innovative pharmacological approach. Curr Med Chem 27:2106-17.
Arena 2018 Mol Cell2018Arena G, Cissé MY, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold JJ, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Casas F, Marine JC, Etienne-Manneville S, Bernex F, LombÚs A, Cameron CE, Dubouchaud H, Ricchetti M, Linares LK, Le Cam L (2018) Mitochondrial MDM2 regulates respiratory complex I activity independently of p53. Mol Cell 69:594-609.HumanLung;gill
Other cell lines
Jose 2018 Redox Biol2018Jose C, Hebert-Chatelain E, Dias Amoedo N, Roche E, Obre E, Lacombe D, Rezvani HR, Pourquier P, Nouette-Gaulain K, Rossignol R (2018) Redox mechanism of levobupivacaine cytostatic effect on human prostate cancer cells. Redox Biol 18:33-42.HumanGenital
Paech 2018a Toxicology2018Paech F, Mingard C, GrĂŒnig D, Abegg VF, Bouitbir J, KrĂ€henbĂŒhl S (2018) Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells. Toxicology 395:34-44.Human
Mouse
Liver
Other cell lines
Hernandez-Resendiz 2018 J Cell Physiol2018Hernåndez-Reséndiz I, Gallardo-Pérez JC, López-Macay A, Robledo-Cadena DX, García-Villa E, Gariglio P, Saavedra E, Moreno-Sånchez R, Rodríguez-Enríquez S (2018) Mutant p53R248Q downregulates oxidative phosphorylation and upregulates glycolysis under normoxia and hypoxia in human cervix cancer cells. J Cell Physiol 234:5524-36.HumanHeLa
Wu 2018 Adv Sci2018Wu S, Zhang A, Li S, Chatterjee S, Qi R, Segura-Ibarra V, Ferrari M, Gupte A, Blanco E, Hamilton DJ (2018) Polymer functionalization of isolated mitochondria for cellular transplantation and metabolic phenotype alteration. Adv Sci 1700530.MouseLiver
Tillmans 2018 Thesis2018Tillmans F (2018) Effect of normobaric hypoxia on leukemic vell lines in vitro. Dissertation p92.HumanOther cell lines
Lymphocyte
Touat 2018 J Clin Invest2018Touat M, Sourisseau T, Dorvault N, Chabanon RM, Garrido M, Morel D, Krastev DB, Bigot L, Adam J, Frankum JR, Durand S, Pontoizeau C, SouquĂšre S, Kuo MS, Sauvaigo S, Mardakheh F, Sarasin A, Olaussen KA, Friboulet L, Bouillaud F, Pierron G, Ashworth A, LombĂšs A, Lord CJ, Soria JC, Postel-Vinay S (2018) DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade. J Clin Invest 128:1671-87.HumanLung;gill
Other cell lines
Ounpuu 2018 Biochem Cell Biol2018Ounpuu L, Truu L, Shevchuk I, Chekulayev V, Klepinin A, Koit A, Tepp K, Puurand M, Rebane-Klemm E, KÀÀmbre T (2018) Comparative analysis of the bioenergetics of human adenocarcinoma Caco-2 cell line and postoperative tissue samples from colorectal cancer patients. Biochem Cell Biol [Epub ahead of print].HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Kriel 2018 Sci Rep2018Kriel J, Mueller-Nedebock K, Maarman G, Mbizana S, Ojuka E, Klumperman B, Loos B (2018) Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics. Sci Rep 8:10348.HumanNervous system
Other cell lines
Zhou 2018 Free Radic Biol Med2018Zhou L, Yi Y, Yuan Q, Zhang J, Li Y, Wang P, Xu M, Xie S (2018) VAOS, a novel vanadyl complexes of alginate saccharides, inducing apoptosis via activation of AKT-dependent ROS production in NSCLC. Free Radic Biol Med 129:177-85.HumanLung;gill
Pacheco-Velazquez 2018 Mol Pharm2018Pacheco-Velåzquez SC, Robledo-Cadena DX, Hernåndez-Reséndiz I, Gallardo-Pérez JC, Moreno-Sånchez R, Rodríguez-Enríquez S (2018) Energy metabolism drugs block triple negative breast metastatic cancer cell phenotype. Mol Pharm 15:2151-64.HumanGenital
Other cell lines
Fuhrmann 2018 Cell Mol Life Sci2018Fuhrmann DC, Wittig I, Dröse S, Schmid T, Dehne N, BrĂŒne B (2018) Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia. Cell Mol Life Sci 75:3051-67.Human
Ramil 2018 Thesis2018Ramil LR, Gulbinas A, Cesna V (2018) “HIPEC” hyperthermic intraperitoneal chemotherapy. Evaluation of intraperitoneal free cancer cells. Master's Thesis.HumanEndothelial;epithelial;mesothelial cell
Fox 2018 Thesis2018Fox JC (2018) FROST450, a novel microtubule targeting agent: resistance and cross-resistance in an ovarian cancer cell line. Bachelor's Thesis 27.HumanGenital
Goswami 2018 Biophys J2018Goswami I, Perry JB, Allen ME, Brown DA, von Spakovsky MR, Verbridge SS (2018) Influence of pulsed electric fields and mitochondria-cytoskeleton interactions on cell respiration. Biophys J 114:2951-64.MouseOther cell lines
Cronin 2018 Nature2018Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Latremoliere A, Wirnsberger G, Lametschwandtner G, Busslinger M, Zicha S, Latini A, Robson SC, Waisman A, Andrews N, Costigan M, Channon KM, Weiss G, Kozlov AV, Tebbe M, Johnsson K, Woolf CJ, Penninger JM (2018) The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature 563:564-68.MouseLymphocyte
Lim 2018 Sci Rep2018Lim SC, Tajika M, Shimura M, Carey KT, Stroud DA, Murayama K, Ohtake A, McKenzie M (2018) Loss of the mitochondrial fatty acid ÎČ-oxidation protein medium-chain acyl-Coenzyme A dehydrogenase disrupts oxidative phosphorylation protein complex stability and function. Sci Rep 8:153.HumanOther cell lines
Ziegler 2018 Cell2018Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, MĂŒller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, MĂŒller S, MĂŒller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR (2018) Mitophagy in intestinal epithelial cells triggers adaptive immunity during tumorigenesis. Cell 174:88-101.MouseEndothelial;epithelial;mesothelial cell
Zdralevic 2018 J Biol Chem2018Ćœdralević M, Brand A, Di Ianni L, Dettmer K, Reinders J, Singer K, Peter K, Schnell A, Bruss C, Decking SM, Koehl G, Felipe-Abrio B, Durivault J, Bayer P, Evangelista M, O'Brien T, Oefner PJ, Renner K, PouyssĂ©gur J, Kreutz M (2018) Double genetic disruption of lactate dehydrogenase A and B is required to ablate the 'Warburg effect' restricting tumor growth to oxidative metabolism. J Biol Chem 293:15947-61.HumanEndothelial;epithelial;mesothelial cell
Trumbeckaite 2018 J Bioenerg Biomembr2018Trumbeckaite S, Cesna V, Jasukaitiene A, Baniene R, Gulbinas A (2018) Different mitochondrial response to cisplatin and hyperthermia treatment in human AGS, Caco-2 and T3M4 cancer cell lines. J Bioenerg Biomembr 50:329-38.HumanOther cell lines
Weber 2018 Int J Mol Sci2018Weber A, Klocker H, Oberacher H, Gnaiger E, Neuwirt H, Sampson N, Eder IE (2018) Succinate accumulation is associated with a shift of mitochondrial respiratory control and HIF-1α upregulation in PTEN negative prostate cancer cells. Int J Mol Sci 19:2129.HumanGenital
Zhou 2018 Cell Death Dis2018Zhou C, Sun H, Zheng C, Gao J, Fu Q, Hu N, Shao X, Zhou Y, Xiong J, Nie K, Zhou H, Shen L, Fang H, Lyu J (2018) Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth. Cell Death Dis 9:161.HumanIslet cell;pancreas;thymus
Other cell lines
Temelie 2018 Oxid Med Cell Longev2018Temelie M, Savu DI, Moisoi N (2018) Intracellular and intercellular signalling mechanisms following DNA damage are modulated by PINK1. Oxid Med Cell Longev 1391387.Human
Mouse
Nervous system
Other cell lines
Fibroblast
Machado-Neto 2018 Cell Death Dis2018Machado-Neto JA, Fenerich BA, Scopim-Ribeiro R, Eide CA, Coelho-Silva JL, Dechandt CRP, Fernandes JC, Rodrigues Alves APN, Scheucher PS, SimÔes BP, Alberici LC, de Figueiredo Pontes LL, Tognon CE, Druker BJ, Rego EM, Traina F (2018) Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms. Cell Death Dis 9:311.Human
Mouse
Other cell lines
Fuhr 2018 EBioMedicine2018Fuhr L, El-Athman R, Scrima R, Cela O, Carbone A, Knoop H, Li Y, Hoffmann K, Laukkanen MO, Corcione F, Steuer R, Meyer TF, Mazzoccoli G, Capitanio N, RelĂłgio A (2018) The circadian clock regulates metabolic phenotype rewiring via HKDC1 and modulates tumor progression and drug response in colorectal cancer. EBioMedicine 33:105-121.HumanOther cell lines
Kuehn 2018 Biochem Pharmacol2018KĂŒhn B, Brat C, Fettel J, Hellmuth N, Maucher IV, Bulut U, Hock KJ, Grimmer J, Manolikakes G, RĂŒhl M, KĂŒhn A, Zacharowski K, Matrone C, Urbschat A, Roos J, Steinhilber D, Maier TJ (2018) Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells. Biochem Pharmacol 155:48-60.HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Fatty acid
Ruas 2018 Sci Rep2018Ruas JS, Siqueira-Santos ES, Rodrigues-Silva E, Castilho RF (2018) High glycolytic activity of tumor cells leads to underestimation of electron transport system capacity when mitochondrial ATP synthase is inhibited. https://doi.org/10.1038/s41598-018-35679-8HumanNervous system
Other cell lines
ADP
ATP
Uncoupler
Lica 2018 Stem Cells Dev2018Lica JJ, Grabe GJ, Heldt M, Misiak M, Bloch P, Serocki M, Switalska M, Wietrzyk J, Baginski M, Hellmann A, Borowski E, Skladanowski A (2018) Cell density-dependent cytological stage profile and its application for a screen of cytostatic agents active towards Leukemic Stem Cells. Stem Cells Dev 27:488-513.Human
Mouse
Heart
Blood cells
Other cell lines
Baaten 2018 Haematologica2018Baaten CCFMJ, Moenen FCJI, Henskens YMC, Swieringa F, Wetzels RJH, van Oerle R, Heijnen HFG, Ten Cate H, Holloway GP, Beckers EAM, Heemskerk JWM, van der Meijden PEJ (2018) Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy. Haematologica 103:1557-67.HumanBlood cells
Platelet
Sant'Anna-Silva 2018 Front Oncol2018Sant'Anna-Silva ACB, Santos GC, Campos SPC, Oliveira Gomes AM, PĂ©rez-Valencia JA, Rumjanek FD (2018) Metabolic profile of oral squamous carcinoma cell lines relies on a higher demand of lipid metabolism in metastatic cells. Front Oncol 8:13.HumanOther cell lines
Fibroblast
Inhibitor
De Sales 2018 Molecules2018de Sales NFF, Silva da Costa L, Carneiro TIA, Minuzzo DA, Oliveira FL, Cabral LMC, Torres AG, El-Bacha T (2018) Anthocyanin-rich grape pomace extract (Vitis vinifera L.) from wine industry affects mitochondrial bioenergetics and glucose metabolism in human hepatocarcinoma HepG2 cells. Molecules 23.HumanLiver
Other cell lines
Song 2018 J Cell Physiol2018Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z (2018) Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor ÎșB and STAT3 in vitro and in vivo. J Cell Physiol 234:777-88.HumanIslet cell;pancreas;thymus
Koit 2018 US Patent2018Koit A, Kaambre T (2018) Method for selecting patients responsive for cancer treatments. US Patent US20180017547A1.Human
Favero 2017 Thesis2017Favero BC (2017) Efeitos da leucina sobre a via da mTOR e da miostatina em cultura celular de miotĂșbulos. Dissertation p55.MouseSkeletal muscle
Dolezal 2017 J Biol Chem2017Dolezal JM, Wang H, Kulkarni S, Jackson L, Lu J, Ranganathan S, Goetzman ES, Bharathi SS, Beezhold K, Byersdorfer CA, Prochownik EV (2017) Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma. J Biol Chem 292:10068-86.MouseLiver
Phillips 2017 Cancer Res2017Phillips CM, Zatarain JR, Nicholls ME, Porter C, Widen SG, Thanki K, Johnson P, Jawad MU, Moyer MP, Randall JW, Hellmich JL, Maskey M, Qiu S, Wood TG, Druzhyna N, Szczesny B, MĂłdis K1, Szabo C, Chao C, Hellmich MR. (2017) Upregulation of Cystathionine-ÎČ-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis.. Cancer Res. 77(21):5741-5754.HumanEndothelial;epithelial;mesothelial cell
Crouch 2017 PLOS ONE2017Crouch ML, Knowels G, Stuppard R, Ericson NG, Bielas JH, Marcinek DJ, Syrjala KL (2017) Cyclophosphamide leads to persistent deficits in physical performance and in vivo mitochondria function in a mouse model of chemotherapy late effects. PLOS ONE 12:e0181086.MouseSkeletal muscle
Rohde 2017 Cell Death Differ2017Rohde K, Kleinesudeik L, Roesler S, Löwe O, Heidler J, Schröder K, Wittig I, Dröse S, Fulda S (2017) A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis. Cell Death Differ 24:83-97.MouseFibroblast
Cunha de Padua 2017 Carbohydr Polym2017Cunha de Padua MM, Suter Correia Cadena SM, de Oliveira Petkowicz CL, Martinez GR, Rodrigues Noleto G (2017) Toxicity of native and oxovanadium (IV/V) galactomannan complexes on HepG2 cells is related to impairment of mitochondrial functions. Carbohydr Polym 173:665-75.HumanLiver
Rouet 2017 US Patent2017Rouet P, Smih F (2017) ApoO for use in method for treating cancer and various pathophysiological situations. US Patent US20170035842 A1.Human
Mouse
Heart
Liver
Cockova 2017 Thesis2017Čočková Z (2017) Modulation of RNA demethylase FTO function in SH-SY5Y cells: the effect on insulin signaling and mitochondrial respiration. Diploma Thesis p70.HumanNervous systemInhibitor
Blecha 2017 Free Radic Biol Med2017Blecha J, Novais SM, Rohlenova K, Novotna E, Lettlova S, Schmitt S, Zischka H, Neuzil J, Rohlena J (2017) Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death. Free Radic Biol Med 112:253-66.Endothelial;epithelial;mesothelial cell
Cunha-de 2017 Thesis2017Cunha-de Padua MM (2017) Mecanismos citotĂłxicos da galactomanana de sementes de Schizolobium amazonicum e seus complexos com oxovanĂĄdio em cĂ©lulas de hepatocarcinoma humano (HepG2) e efeito do silenciamento da enzima glucose-6-fosfato isomerase (GPI) na sobrevivĂȘncia de cĂ©lulas de adenocarcinoma de cĂłlon humano (LS174T). Doctoral Thesis p160.HumanLiver
Other cell lines
Huang 2017 Sci Rep2017Huang L, Zhang K, Guo Y, Huang F, Yang K, Chen L, Huang K, Zhang F, Long Q, Yang Q (2017) Honokiol protects against doxorubicin cardiotoxicity via improving mitochondrial function in mouse hearts. Sci Rep 7:11989.MouseHeart
Sidlauskas 2017 Neurosci Lett2017Sidlauskas K, Sidlauskiene R, Li N, Liobikas J (2017) 5-Hydroxy-1,4-naphthalenedione exerts anticancer effects on glioma cells through interaction with the mitochondrial electron transport chain. Neurosci Lett 639:207-14.RatNervous system
Other cell lines
Inhibitor
Asiri 2017 Thesis2017Asiri A (2017) Effects of asiatic acid on neurite outgrowth in Neuro-2a cells. Master's Thesis p42.MouseNervous system
Comelli 2017 J Bioenerg Biomembr2017Comelli M, Pretis I, Buso A, Mavelli I (2017) Mitochondrial energy metabolism and signalling in human glioblastoma cell lines with different PTEN gene status. J Bioenerg Biomembr 50:33-52.HumanNervous system
Koit 2017 Oxid Med Cell Longev2017Koit A, Shevchuk I, Ounpuu L, Klepinin A, Chekulayev V, Timohhina N, Tepp K, Puurand M,Truu L, Heck K, Valvere V, Guzun R, Kaambre T (2017) Mitochondrial respiration in human colorectal and breast cancer clinical material is regulated differently. Oxid Med Cell Longev 2017:1372640.HumanEndothelial;epithelial;mesothelial cellADP
Geoghegan 2017 Oncol Lett2017Geoghegan F, Chadderton N, Farrar GJ, Zisterer DM1, Porter RK (2017) Direct effects of phenformin on metabolism/bioenergetics and viability of SH-SY5Y neuroblastoma cells. Oncol Lett 14:6298-306.HumanNervous system
Cunha 2017 Int J Biol Macromol2017Cunha de Padua MM, Suter Correia Cadena SM, de Oliveira Petkowicz CL, Martinez GR, Rodrigues Noleto G (2017) Galactomannan from Schizolobium amazonicum seed and its sulfated derivatives impair metabolism in HepG2 cells. Int J Biol Macromol 101:64-473.HumanLiver
Zhou 2017 Oxid Med Cell Longev2017Zhou H, Nie K, Qiu R, Xiong J, Shao X, Wang B, Shen L, Lyu J, Fang H (2017) Generation and bioenergetic profiles of cybrids with east Asian mtDNA haplogroups. Oxid Med Cell Longev 2017:1062314.Human
Alves 2017 Free Radic Biol Med2017Alves de Souza CE, Alves de Souza HM, Stipp MC, Corso CR, Galindo CM, Cardoso CR, Dittrich RL, de Souza Ramos EA, Klassen G, Carlos RM, Correia Cadena SMS, Acco A (2017) Ruthenium complex exerts antineoplastic effects that are mediated by oxidative stress without inducing toxicity in Walker-256 tumor-bearing rats. Free Radic Biol Med 110:228-39.Rat
Balcaitis 2017 Thesis2017Balcaitis D (2017) The investigation of derivates of the 1,4-naphthoquinone effects to mitochondrial oxygen consumption in glioblastoma cells. Diploma Thesis p43.RatNervous system
Other cell lines
Xhani 2017 Thesis2017Xhani M (2017) Cellular redox homeostasis and environmental toxicity. Dissertation p110.HumanLiver
Other cell lines
Greenall 2017 Oncogenesis2017Greenall SA, Lim YC, Mitchell CB, Ensbey KS, Stringer BW, Wilding AL, O'Neill GM, McDonald KL, Gough DJ, Day BW, Johns TG (2017) Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma. Oncogenesis 6:e336.HumanNervous system
Ren 2017 Front Pharmacol2017Ren YJ, Wang XH, Ji C, Guan YD, Lu XJ, Liu XR, Zhang HH, Guo LC, Xu QH, Zhu WD, Ming ZJ, Yang JM, Cheng Y, Zhang Y (2017) Silencing of NAC1 expression induces cancer cells oxidative stress in hypoxia and potentiates the therapeutic activity of elesclomol. Front Pharmacol 8:804.HumanHeLa
Other cell lines
Lopez 2017 Sci Rep2017Lopez Sanchez MIG, Waugh HS, Tsatsanis A, Wong BX, Crowston JG, Duce JA, Trounce IA (2017) Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta. Sci Rep 7:9835.Human
Yang 2017 Cell Death Dis2017Yang N, Weinfeld M, Lemieux H, Montpetit B, Goping IS (2017) Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis. Cell Death Dis 8:e2587.Saccharomyces cerevisiae
Human
Lymphocyte
Canevarolo 2017 Thesis2017Canevarolo RR (2017) ResistĂȘncia ao metotrexato estĂĄ diretamente associada Ă  concentração de glutationa em linhagens de leucemia linfoide aguda. Dissertation p159.HumanMacrophage-derived
Ma 2017 Int J Cancer2017Ma L, Fu Q, Xu B, Zhou H, Gao J, Shao X, Xiong J, Gu Q, Wen S, Li F, Shen L, Chen G, Fang H, Lyu J (2017) Breast cancer-associated mitochondrial DNA haplogroup promotes neoplastic growth via ROS-mediated AKT activation. Int J Cancer 142:1786-96.Human
Rodrigues-Silva 2017 J Neurooncol2017Rodrigues-Silva E, Siqueira-Santos ES, Ruas JS, Ignarro RS, Figueira TR, Rogério F, Castilho RF (2017) Evaluation of mitochondrial respiratory function in highly glycolytic glioma cells reveals low ADP phosphorylation in relation to oxidative capacity. 10.1007/s11060-017-2482-0RatNervous systemInhibitor
Valis 2017 Oncotarget2017ValiĆĄ K, GrobĂĄrovĂĄ V, HernychovĂĄ L, BugåƈovĂĄ M4, Kavan D, Kalous M, ČernĂœ J, StodĆŻlkovĂĄ E, Kuzma M, Flieger M, ČernĂœ J, NovĂĄk P (2017) Reprogramming of leukemic cell metabolism through the naphthoquinonic compound Quambalarine B. Oncotarget 8:103137-53.RatLiver
Welker 2017 Thesis2017Welker L (2017) Metabolic and morphologic shifts in Neuro2a cells cultured in galactose medium. Master's Thesis p26.Mouse
Jackson 2017 Cancer Res2017Jackson LE, Kulkarni S, Wang H, Lu J, Dolezal JM, Bharathi SS, Ranganathan S, Patel MS, Deshpande R, Alencastro F, Wendell SG, Goetzman ES, Duncan AW, Prochownik EV (2017) Genetic dissociation of glycolysis and the TCA cycle affects neither normal nor neoplastic proliferation. Cancer Res 77:5795-807.MouseLiver
Saintas 2017 PLOS ONE2017Saintas E, Abrahams L, Ahmad GT, Ajakaiye AM, AlHumaidi AS, Ashmore-Harris C, Clark I, Dura UK, Fixmer CN, Ike-Morris C, Mato Prado M, Mccullough D, Mishra S, Schöler KM, Timur H, Williamson MD, Alatsatianos M, Bahsoun B, Blackburn E, Hogwood CE, Lithgow PE, Rowe M, Yiangou L, Rothweiler F, Cinatl J Jr, Zehner R, Baines AJ, Garrett MD, Gourlay CW, Griffin DK, Gullick WJ, Hargreaves E, Howard MJ, Lloyd DR, Rossman JS, Smales CM, Tsaousis AD, von der Haar T, Wass MN, Michaelis M (2017) Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS. PLOS ONE 12:e0172140.HumanNervous system
Other cell lines
Jang 2017 Biol Open2017Jang DH, Seeger SC, Grady ME, Shofer FC, Eckmann DM (2017) Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes. Biol Open 6:1831-9.HumanEndothelial;epithelial;mesothelial cell
Fibroblast
Ounpuu 2017 Biochim Biophys Acta2017Ounpuu L, Klepinin A, Pook M, Teino I, Peet N, Paju K, Tepp K, Chekulayev V, Shevchuk I, Koks S, Maimets T, Kaambre T (2017) 2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells. Biochim Biophys Acta 1861:2146-54.HumanStem cells
Lim 2016 FASEB J2016Lim SC, HroudovĂĄ J, Van Bergen NJ, Lopez Sanchez MI, Trounce IA, McKenzie M (2016) Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly. FASEB J 30:2236-48.HumanOther cell lines
Cerwenka 2016 Mol Cell Oncol2016Cerwenka A, Kopitz J, Schirmacher P, Roth W, Gdynia G (2016) HMGB1: The metabolic weapon in the arsenal of NK cells. Mol Cell Oncol 3:e1175538.HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Peruzzo 2016 Cell Cycle2016Peruzzo P, Comelli M, Di Giorgio E, Franforte E, Mavelli I, Brancolini C (2016) Transformation by different oncogenes relies on specific metabolic adaptations. Cell Cycle 15:2656-68.MouseFibroblast
Jardim-Messeder 2016 Anticancer Res2016Jardim-Messeder D, Moreira-Pacheco F (2016) 3-Bromopyruvic acid inhibits tricarboxylic acid cycle and glutaminolysis in HepG2 cells. Anticancer Res 36:2233-41.MouseLiver
Kidney
Holandino 2016 Bioelectrochemistry2016Holandino C, Teixeira CA, de Oliveira FA, Barbosa GM, Siqueira CM, Messeder DJ, de Aguiar FS, da Veiga VF, Girard-Dias W, Miranda K, Galina A, Capella MA, Morales MM (2016) Direct electric current treatment modifies mitochondrial function and lipid body content in the A549 cancer cell line. Bioelectrochemistry 111:83-92.HumanLung;gill
Other cell lines
Casinelli 2016 Cell Death Discov2016Casinelli G, LaRosa J, Sharma M, Cherok E, Banerjee S, Branca M, Edmunds L, Wang Y, Sims-Lucas S, Churley L, Kelly S, Sun M, Stolz D, Graves JA (2016) N-Myc overexpression increases cisplatin resistance in neuroblastoma via deregulation of mitochondrial dynamics. Cell Death Discov 2:16082.HumanNervous system
Other cell lines
Schoepf 2016 FEBS J2016Schöpf B, SchÀfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. https://doi.org/10.1111/febs.13733HumanEndothelial;epithelial;mesothelial cell
Genital
Other cell lines
Fibroblast
Wang 2016 J Biol Chem2016Wang H, Lu J, Edmunds LR, Kulkarni S, Dolezal J, Tao J, Ranganathan S, Jackson L, Fromherz M, Stolz DB, Uppala R, Bharathi S, Monga SP, Goetzman ES, Prochownik EV (2016) Coordinated activities of multiple Myc-dependent and Myc-independent biosynthetic pathways in Hepatoblastoma. J Biol Chem 291:26241-51.MouseLiver
Brandt 2016 Chem Biol Interact2016Brandt AP, Gozzi GJ, Pires Ado R, Martinez GR, Dos Santos Canuto AV, Echevarria A, Di Pietro A, Cadena SM (2016) Impairment of oxidative phosphorylation increases the toxicity of SYD-1 on hepatocarcinoma cells (HepG2). Chem Biol Interact 256:154-60.HumanLiver
Other cell lines
Birkenmeier 2016 Int J Cancer2016Birkenmeier Katrin, Droese Stefan, Wittig Ilka, Winkelmann Ria, Kaefer Viktoria, Doering Claudia, Hartmann Sylvia, Wenz Tina, Reichert Andreas S, Brandt Ulrich, Hansmann Martin‐Leo (2016) Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation. Int J Cancer 138:2231-46.HumanOther cell lines
HeLa
Macrophage-derived
Rohlenova 2016 Antioxid Redox Signal2016Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2high breast cancer. Antioxid Redox Signal 26:84-103.Human
Mouse
Liver
Genital
Other cell lines
Ruas 2016 PLOS ONE2016Ruas JS, Siqueira-Santos ES, Amigo I, Rodrigues-Silva E, Kowaltowski AJ, Castilho RF (2016) Underestimation of the maximal capacity of the mitochondrial electron transport system in oligomycin-treated cells. PLOS ONE 11:e0150967.Human
Rat
Nervous system
Genital
Other cell lines
Inhibitor
Substrate
Liu 2016 Apoptosis2016Liu X, Gao RW, Li M, Si CF, He YP, Wang M, Yang Y, Zheng QY, Wang CY (2016) The ROS derived mitochondrial respiration not from NADPH oxidase plays key role in Celastrol against angiotensin II-mediated HepG2 cell proliferation. Apoptosis 21:1315-26.HumanLiver
Other cell lines
Villani 2016 Mol Metab2016Villani LA, Smith BK, Marcinko K, Ford RJ, Broadfield LA, Green AE, Houde VP, Muti P, Tsakiridis T, Steinberg GR (2016) The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration. Mol Metab 5:1048-56.HumanGenitalInhibitor
Zhunussova 2016 PLOS ONE2016Zhunussova A, Vitol EA, Polyak B, Tuleukhanov S, Brooks AD, Sensenig R, Friedman G, Orynbayeva Z (2016) Mitochondria-mediated anticancer effects of non-thermal atmospheric plasma. PLOS ONE 11:e0156818.HumanGenital
Other cell lines
Bueno 2016 Thesis2016Bueno e Silva MM (2016) AlteraçÔes mitocondriais e reprogramação metabólica em células de glioblastoma após tratamento com temozolomida. Dissertation p71.HumanNervous system
Other cell lines
Inhibitor
Gdynia 2016 Nat Commun2016Gdynia G, Sauer SW, Kopitz J, Fuchs D, Duglova K, Ruppert T, Miller M, Pahl J, Cerwenka A, Enders M, MairbĂ€url H, KamiƄski MM, Penzel R, Zhang C, Fuller JC, Wade RC, Benner A, Chang-Claude J, Brenner H, Hoffmeister M, Zentgraf H, Schirmacher P, Roth W (2016) The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. Nat Commun 7:10764.HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Bastian 2016 Cancer Lett2016Bastian A, Matsuzaki S, Humphries KM, Pharaoh GA, Doshi A, Zaware N, Gangjee A, Ihnat MA (2016) AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization. Cancer Lett pii: S0304-3835(16)30745-5.MouseInhibitor
Breitenbach 2016 Biomolecules2016Breitenbach M, Eckl P (Ed.) (2016) Oxidative stress in health and disease. Biomolecules p512.
Gilliam 2016 Am J Physiol Endocrinol Metab2016Gilliam LA, Lark DS, Reese LR, Torres MJ, Ryan TE, Lin CT, Cathey BL, Neufer PD (2016) Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction. Am J Physiol Endocrinol Metab 311:E293-301.MouseSkeletal muscle
Coelho 2016 Oncol Rep2016Coelho RG, Cazarin JM, Cavalcanti de Albuquerque JP, de Andrade BM, Carvalho DP (2016) Differential glycolytic profile and Warburg effect in papillary thyroid carcinoma cell lines. Oncol Rep 36:3673-81.HumanOther cell linesAerobic glycolysis
Kalinina 2016 J Biophotonics2016Kalinina S, Breymayer J, SchĂ€fer P, Calzia E, Shcheslavskiy V, Becker W, RĂŒck A (2016) Correlative NAD(P)H-FLIM and oxygen sensing-PLIM for metabolic mapping. J Biophotonics 9:800-11.HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Brecht 2016 Toxicol In Vitro2016Brecht K, Riebel V, Couttet P, Paech F, Wolf A, Chibout SD, Pognan F, KrĂ€henbĂŒhl S, Uteng M (2016) Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin. Toxicol In Vitro 40:55-65.HumanIslet cell;pancreas;thymus
Nissinen 2016 Sci Rep2016Nissinen TA, Degerman J, RÀsÀnen M, Poikonen AR, Koskinen S, Mervaala E, Pasternack A, Ritvos O, KivelÀ R, Hulmi JJ (2016) Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes. Sci Rep 6:32695.MouseSkeletal muscle
Leucci 2016 Nature2016Leucci E, Vendramin R, Spinazzi M, Laurette P, Fiers M, Wouters J, Radaelli E, Eyckerman S, Leonelli C, Vanderheyden K, Rogiers A, Hermans E, Baatsen P, Aerts S, Amant F, Van Aelst S, van den Oord J, de Strooper B, Davidson I, Lafontaine DL, Gevaert K, Vandesompele J, Mestdagh P, Marine JC (2016) Melanoma addiction to the long non-coding RNA SAMMSON. Nature 531:518-22.HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Schoenenberger 2016 Cancer Res2016Schönenberger D, Harlander S, Rajski M, Jacobs RA, Lundby AK, Adlesic M, Hejhal T, Wild PJ, Lundby C, Frew IJ (2016) Formation of renal cysts and tumors in Vhl/Trp53-deficient mice requires HIF1α and HIF2α. Cancer Res 76:2025-36.MouseNervous systemATP production
Raesaenen 2016 Proc Natl Acad Sci U S A2016RÀsÀnen M, Degerman J, Nissinen TA, Miinalainen I, KerkelÀ R, Siltanen A, Backman JT, Mervaala E, Hulmi JJ, KivelÀ R, Alitalo K (2016) VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection. Proc Natl Acad Sci U S A 113:13144-49.MouseHeart
Morad 2016 J Lipid Res2016Morad SA, Ryan TE, Neufer PD, Zeczycki TN, Davis TS, MacDougall MR, Fox TE, Tan SF, Feith DJ, Loughran TP Jr, Kester M, Claxton DF, Barth BM, Deering TG, Cabot MC (2016) Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia. J Lipid Res 57:1231-42.HumanBlood cells
Other cell lines
Klepinin 2016 J Bioenerg Biomembr2016Klepinin A, Ounpuu L, Guzun R, Chekulayev V, Timohhina N, Tepp K, Shevchuk I, Schlattner U, Kaambre T (2016) Simple oxygraphic analysis for the presence of adenylate kinase 1 and 2 in normal and tumor cells. J Bioenerg Biomembr 48:531-48.Human
Rat
Mouse
Heart
Nervous system
Endothelial;epithelial;mesothelial cell
Genital
ATP
AMP
Pasdar 2015 PLoS One2015Pasdar EA, Smits M, Stapelberg M, Bajzikova M, Stantic M, Goodwin J, Yan B, Stursa J, Kovarova J, Sachaphibulkij K, Bezawork-Geleta A, Sobol M, Filimonenko A, Tomasetti M, Zobalova R, Hozak P, Dong LF, Neuzil J (2015) Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents. PLoS One 10:e0119549.Human
Mouse
Endothelial;epithelial;mesothelial cell
Other cell lines
Rodrigues 2015 J Cell Biochem2015Rodrigues MF, Carvalho É, Pezzuto P, Rumjanek FD, AmoĂȘdo ND (2015) Reciprocal modulation of histone deacetylase inhibitors sodium butyrate and trichostatin a on the energy metabolism of breast cancer cells. Int J Biochem Cell Biol 116:797-808.HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Schoeckel 2015 Cancer Metab2015Schöckel L, Glasauer A, Basit F, Bitschar K, Truong H, Erdmann G, Algire C, HÀgebarth A, Willems PH, Kopitz C, Koopman WJ, Héroult M (2015) Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth. Cancer Metab 3:11.Human
Mouse
Endothelial;epithelial;mesothelial cell
Other cell lines
Teh 2015 Oncogene2015Teh JT, Zhu WL, Ilkayeva OR, Li Y, Gooding J, Casey PJ, Summers SA, Newgard CB, Wang M (2015) Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism. Oncogene 34:3296-304.HumanOther cell lines
Chekulayev 2015 Biochem Biophys Rep2015Chekulayev V, Mado K, Shevchuk I, Koit A, Kaldma A, Klepinin A, Timohhina N, Tepp K, Kandashvili M, Ounpuu L, Heck K, Truu L, Planken A, Valvere V, Kaambre T (2015) Metabolic remodeling in human colorectal cancer and surrounding tissues: alterations in regulation of mitochondrial respiration and metabolic fluxes. Biochem Biophys Rep 4:111-25.HumanEndothelial;epithelial;mesothelial cellADP
Yan 2015 BMC Cancer2015Yan B, Stantic M, Zobalova R, Bezawork-Geleta A, Stapelberg M, Stursa J, Prokopova K, Dong L, Neuzil J (2015) Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner. BMC Cancer 15:401.Human
Mouse
Genital
Other cell lines
Tomsik 2015 J Organomet Chem2015TomsĂ­k P, Muthna D, Rezacova M, Micuda S, Cmielova J, Hroch M, Endlicher R, Cervinkova Z, Rudolf E, Hann S, StĂ­bal D, Therrien B, SĂŒss-Fink G (2015) [(p-MeC6H4Pri)2Ru2(SC6H4-p-But)3]Cl (diruthenium-1), a dinuclear arene ruthenium compound with very high anticancer activity: An in vitro and in vivo study. J Organomet Chem 782:42-51.RatLiver
Victorino 2015 Tumour Biol2015Victorino VJ, Barroso WA, Assunção AK, Cury V, Jeremias IC, Petroni R, Chausse B, Ariga SK, Herrera AC, Panis C, Lima TM, Souza HP (2015) PGC-1ÎČ regulates HER2-overexpressing breast cancer cells proliferation by metabolic and redox pathways. Tumour Biol 37:6035-44.HumanGenital
Other cell lines
Tan 2015 Cell Metab2015Tan AS, Baty JW, Dong L, Bezawork-Geleta A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B, Pesdar EA, Sobol M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K, Sachaphibulkij K, Rohlena J, Hozak P, Truksa J, Eccles D, Haupt LM, Griffiths LR, Neuzil J, Berridge MV (2015) Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metab 21:81-94.Human
Mouse
Endothelial;epithelial;mesothelial cell
Genital
Other cell lines
Garama 2015 Mol Cell Biol2015Garama DJ, Harris TJ, White CL, Rossello FJ, Abdul-Hay M, Gough DJ, Levy DE (2015) A synthetic lethal interaction between glutathione synthesis and mitochondrial reactive oxygen species provides a tumor-specific vulnerability dependent on STAT3. Mol Cell Biol 35:3646-56.MouseEndothelial;epithelial;mesothelial cell
Fibroblast
Singh 2015 Free Radic Biol Med2015Singh P, Sharma R, McElhanon K, Allen CD, Megyesi JK, BeneĆĄ H, Singh SP (2015) Sulforaphane protects the heart from doxorubicin-induced toxicity. Free Radic Biol Med 86:90-101.MouseHeart
Other cell lines
Lim 2015 Am J Cancer Res2015Lim SC, Carey KT, McKenzie M (2015) Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I). Am J Cancer Res 5:689-701.HumanKidney
Other cell lines
HEK
HeLa
Fibroblast
Gouspillou 2015 Sci Rep2015Gouspillou G, Scheede-Bergdahl C, Spendiff S, Vuda M, Meehan B, Mlynarski H, Archer-Lahlou E, Sgarioto N, Purves-Smith FM, Konokhova Y, Rak J, Chevalier S, Taivassalo T, Hepple RT, Jagoe RT (2015) Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle. Sci Rep 5:8717.Mouse
Rodrigues 2016 Biochem J2015Rodrigues MF, Obre E, Melo FH, Santos-Jr GC, Galina A, Jasiulionis MG, Rossignol R, Rumjanek FD, Amoedo ND (2016) Enhanced OXPHOS, glutaminolysis and beta-oxidation constitute the metastatic phenotype of melanoma cells. https://doi.org/10.1042/BJ20150645MouseEndothelial;epithelial;mesothelial cell
Other cell lines
ATP production
Ruiz-Perez 2015 J Biol Chem2015Ruiz-Pérez MV, Medina MÁ, Urdiales JL, KeinÀnen TA, Sånchez-Jiménez F (2015) Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells. J Biol Chem 290:6106-19.HumanNervous system
Other cell lines
Neuroblastoma
Ofer 2015 Mol Endocrinol2015Ofer P, Heidegger I, Eder IE, Schöpf B, Neuwirt H, Geley S, Klocker H, Massoner P (2015) Both IGF1R and INSR knockdown exert anti-tumorigenic effects in prostate cancer in vitro and in vivo. Mol Endocrinol 29:1694-707.HumanGenital
Other cell lines
Zhunussova 2015 Am J Cancer Res2015Zhunussova A, Sen B, Friedman L, Tuleukhanov S, Brooks AD, Sensenig R, Orynbayeva Z (2015) Tumor microenvironment promotes dicarboxylic acid carrier-mediated transport of succinate to fuel prostate cancer mitochondria. Am J Cancer Res 5:1665-79.Human
Rat
Endothelial;epithelial;mesothelial cell
Genital
Other cell lines
pH
Substrate
Park 2015 Proc Natl Acad Sci USA2015Park JH, Kang HJ, Lee YK, Kang H, Kim J, Chung JH, Chang JS, McPherron AC, Lee SB (2015) Inactivation of EWS reduces PGC-1α protein stability and mitochondrial homeostasis. Proc Natl Acad Sci USA 112:6074-9.MouseFat
Tesori 2015 Sci Rep2015Tesori V, Piscaglia AC, Samengo D, Barba M, Bernardini C, Scatena R, Pontoglio A, Castellini L, Spelbrink JN, Maulucci G, Puglisi MA, Pani G, Gasbarrini A (2015) The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing. Sci Rep 5:9149.RatLiver
Other cell lines
Stem cells
Truksa 2015 Antioxid Redox Signal2015Truksa J, Dong L, Rohlena J, Stursa J, Vondrusova M, Goodwin J, Nguyen M, Kluckova K, Rychtarcikova Z, Lettlova S, Spacilova J, Stapelberg M, Zoratti M, Neuzil J (2015) Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesis. Antioxid Redox Signal 22:883-900.Human
Mouse
Genital
Other cell lines
Peyta 2015 Biochim Biophys Acta2015Peyta L, Jarnouen K, Pinault M, Coulouarn C, Guimaraes C, Goupille C, de Barros JP, Chevalier S, Dumas JF, Maillot F, Hatch GM, Loyer P, Servais S (2015) Regulation of hepatic cardiolipin metabolism by TNFα: Implication in cancer cachexia. Biochim Biophys Acta 1851:1490-500.RatLiver
Other cell lines
Dueregger 2015 PLoS One2015Dueregger A, Schöpf B, Eder T, Höfer J, Gnaiger E, Aufinger A, Kenner L, Perktold B, Ramoner R, Klocker H, Eder IE (2015) Differential utilization of dietary fatty acids in benign and malignant cells of the prostate. PLoS One 10(8):e0135704.HumanGenital
Other cell lines
Smolkova 2015 Int J Biochem Cell Biol2015SmolkovĂĄ K, Dvoƙák A, Zelenka J, VĂ­tek L, JeĆŸek P (2015) Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells. Int J Biochem Cell Biol 65:125-33.HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Kluckova 2015 Methods Mol Biol2015Kluckova K, Dong L, Bajzikova M, Rohlena J, Neuzil J (2015) Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents. Methods Mol Biol 1265:181-94.MouseEndothelial;epithelial;mesothelial cell
Genital
Other cell lines
Plecita-Hlavata 2015 J Bioenerg Biomembr2015PlecitĂĄ-HlavatĂĄ L, JeĆŸek J, JeĆŸek P (2015) Aglycemia keeps mitochondrial oxidative phosphorylation under hypoxic conditions in HepG2 cells. J Bioenerg Biomembr 47(6):467-76.HumanLiver
Sundstroem 2015 PhD Thesis2015SundstrĂžm T (2015) Experimental modeling and novel therapeutic strategies in melanoma brain metastasis. PhD Thesis 1-146.MouseNervous system
Kaldma 2014 Int J Biochem Cell Biol2014Kaldma A, Klepinin A, Chekulayev V, Mado K, Shevchuk I, Timohhina N, Tepp K, Kandashvili M, Varikmaa M, Koit A, Planken M, Heck K, Truu L, Planken A, Valvere V, Rebane E, Kaambre T (2014) An in situ study of bioenergetic properties of human colorectal cancer: The regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome. Int J Biochem Cell Biol 55C:171-86.HumanGenitalADP
Inhibitor
PCr;Cr
Galina 2014 Int J Biochem Cell Biol2014Galina A (2014) Mitochondria: 3-Bromopyruvate vs. mitochondria? A small molecule that attacks tumors by targeting their bioenergetic diversity. Insect Biochem Mol Biol S1357-2725.
Chini 2014 Clin Cancer Res2014Chini CC, Gonzalez Guerrico A, Nin V, Camacho-Pereira J, Escande C, Barbosa M, Chini EN (2014) Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors. Clin Cancer Res 20:120-30.HumanIslet cell;pancreas;thymus
Other cell lines
Hunter 2014 PhD Thesis2014Hunter FW (2014) Old target; new paradigm: Determinants of sensitivity to hypoxia-directed anticancer prodrugs. PhD Thesis:1-353.Other mammalsCHO
Amoedo 2014 Int J Biochem Cell Biol2014Amoedo ND, Rodrigues MF, Rumjanek FD (2014) Mitochondria: are mitochondria accessory to metastasis? Int J Biochem Cell Biol 51: 53-7.
Petruzzelli 2014 Cell Metab2014Petruzzelli M, Schweiger M, Schreiber R, Campos-Olivas R, Tsoli M, Allen J, Swarbrick M, Rose-John S, Rincon M, Robertson G, Zechner R, Wagner EF (2014) A switch from white to brown fat increases energy expenditure in cancer-associated cachexia. Cell Metab 20:433-47.MouseFat
Rossato 2014 PLoS One2014Rossato FA, Zecchin KG, La Guardia PG, Ortega RM, Alberici LC, Costa RA, Catharino RR, Graner E, Castilho RF, Vercesi AE (2014) Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic Melan-A cells associated with inhibition of mitochondrial respiration. PLoS One 9:e101060.MouseEndothelial;epithelial;mesothelial cell
Other cell lines
Stokich 2014 Cryobiology2014Stokich B, Osgood Q, Grimm D, Moorthy S, Chakraborty N, Menze MA (2014) Cryopreservation of hepatocyte (HepG2) cell monolayers: Impact of trehalose. Cryobiology 69:281-90.HumanLiver
Dickinson 2013 Thesis University of Warwick - Great Britain2013Dickinson A (2013) The role of mitochondrial DNA in tumorigenesis. Thesis University of Warwick - Great Britain 292pp.HumanOther cell lines
Mathieu 2013 J Med Chem2013Mathieu V, Van Den Berge E, Ceusters Justine D, Konopka T, Cops A, BruyĂšre C, Pirker C, Berger W, Trieu-Van T, Serteyn D, Kiss R, Robiette R (2013) New 5-Aryl-1H-imidazoles display in vitro antitumor activity against apoptosis-resistant cancer models, including melanomas, through mitochondrial targeting. J Med Chem 56:6626-37.HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Gottfried 2013 PLoS One2013Gottfried E, Lang SA, Renner K, Bosserhoff A, Gronwald W, Rehli M, Einhell S, Gedig I, Singer K, Seilbeck A, Mackensen A, Grauer O, Hau P, Dettmer K, Andreesen R, Oefner PJ, Kreutz M (2013) New aspects of an old drug - Diclofenac targets MYC and glucose metabolism in tumor cells. PLoS One 8:e66987.Human
Mouse
Endothelial;epithelial;mesothelial cell
Blood cells
Other cell lines
Lymphocyte
Kaambre 2013 Front Physiol2013Kaambre T, Chekulayev V, Shevchuk I, Tepp K, Timohhina N, Varikmaa M, Bagur R, Klepinin A, Anmann T, Koit A, Kaldma A, Guzun R, Valvere V, Saks V (2013) Metabolic control analysis of respiration in human cancer tissue. Front Physiol 4:151.HumanEndothelial;epithelial;mesothelial cellADP
Flux control
Inhibitor
PCr;Cr
Bhattacharyya 2013 PLoS One2013Bhattacharyya S, Saha S, Giri K, Lanza IR, Nair KS, Jennings NB, Rodriguez-Aguayo C, Lopez-Berestein G, Basal E, Weaver AL, Visscher DW, Cliby W, Sood AK, Bhattacharya R, Mukherjee P (2013) Cystathionine Beta-Synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance. PLoS One 8:e79167.HumanGenital
Other cell lines
Vielhaber 2013 Acta Neuropathol2013Vielhaber S, Debska-Vielhaber G, Peeva V, Schoeler S, Kudin AP, Minin I, Schreiber S, Dengler R, Kollewe K, Zuschratter W, Kornblum C, Zsurka G, Kunz WS (2013) Mitofusin 2 mutations affect mitochondrial function by mitochondrial DNA depletion. Acta Neuropathol 125:245-56.HumanSkeletal muscleInhibitor
Threshold;excess capacity
Teixeira 2013 Thesis Universidade Federal do Rio de Janeiro - Brazil2013Teixeira CAA (2013) Mechanisms of antitumoral effects of direct electric current: an in vitro study in lung adenocarcinoma. Thesis Universidade Federal do Rio de Janeiro - Brazil 345pp.HumanLung;gill
Other cell lines
Felser 2013 Toxicol Sci2013Felser A, Blum K, Lindinger PW, Bouitbir J, Kraehenbuehl S (2013) Mechanisms of hepatocellular toxicity associated with dronedarone - a comparison to amiodarone. Toxicol Sci 131:480-90.Human
Rat
LiverInhibitor
mt-Membrane potential
Fatty acid
Gilliam 2013 Free Radic Biol Med2013Gilliam LA, Fisher-Wellman KH, Lin CT, Maples JM, Cathey BL, Neufer PD (2013) The anticancer agent doxorubicin disrupts mitochondrial energy metabolism and redox balance in skeletal muscle. Free Radic Biol Med 65:988-96.RatSkeletal muscle
Dickinson 2013 Cell Death Differ2013Dickinson A, Yeung KY, Donoghue J, Baker MJ, Kelly RDW, McKenzie M, Johns TG, St. John JC (2013) The regulation of mitochondrial DNA copy number in glioblastoma cells. Cell Death Differ 20:1644–53.HumanNervous system
Other cell lines
Santidrian 2013 J Clin Invest2013Santidrian AF, Matsuno-Yagi A, Ritland M, Seo BB, Leboeuf SE, Gay LJ, Yagi T, Felding-Habermann B (2013) Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest 123:1068-81.HumanGenital
Chiusa 2012 J Mol Cell Cardiol2012Chiusa M, Hool SL, Truetsch P, Djafarzadeh S, Jakob SM, Seifriz F, Scherer SJ, Suter TM, Zuppinger C, Zbinden S (2012) Cancer therapy modulates VEGF signaling and viability in adult rat cardiac microvascular endothelial cells and cardiomyocytes. J Mol Cell Cardiol 52:1164-75.RatHeart
Hebert-Chatelain 2012 Biochim Biophys Acta2012Hebert-Chatelain E, Jose C, Gutierrez Cortes N, Dupuy JW, Rocher C, Dachary-Prigent J, Letellier T (2012) Preservation of NADH ubiquinone-oxidoreductase activity by Src kinase-mediated phosphorylation of NDUFB10. Biochim Biophys Acta 1817:718-725.HumanATP
ATP production
Piccoli 2012 Free Radic Biol Med2012Piccoli C, D'Aprile A, Scrima R, Ambrosi L, Zefferino R, Capitanio N (2012) Subcytotoxic mercury chloride inhibits gap junction intercellular communication by a redox- and phosphorylation-mediated mechanism. Free Radic Biol Med 52: 916-927.HumanNervous system
Lee 2012 Invest Ophthalmol Vis Sci2012Lee S, Sheck L, Crowston JG, Van Bergen NJ, O'Neill EC, O'Hare F, Kong YX, Chrysostomou V, Vincent AL, Trounce IA (2012) Impaired complex-I-linked respiration and ATP synthesis in primary open-angle glaucoma patient lymphoblasts. Invest Ophthalmol Vis Sci 53:2431-7.HumanBlood cells
Lymphocyte
ATP
Substrate
Rodrigues-Ferreira 2012 J Bioenerg Biomembr2012Rodrigues-Ferreira C, Pereira da Silva AP, Galina A (2012) Effect of the antitumoral alkylating agent 3-bromopyruvate on mitochondrial respiration: role of mitochondrially bound hexokinase. J Bioenerg Biomembr 44:39-49.Human
Mouse
Nervous system
Liver
Other cell lines
Halsne 2012 DNA Repair (Amst)2012Halsne R, Esbensen Y, Wang W, Scheffler K, Suganthan R, Bjoeraas M, Eide L (2012) Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis. DNA Repair (Amst) 11:278-85.MouseNervous system
Domenis 2012 Int J Mol Sci2012Domenis R, Bisetto E, Rossi D, Comelli M, Mavelli I (2012) Glucose-modulated mitochondria adaptation in tumor cells: a focus on ATP synthase and inhibitor factor 1. Int J Mol Sci 13:1933-50.HumanLiver
Hirsch 2012 PloS One2012Hirsch A, Hahn D, KempnĂĄ P, Hofer G, Mullis PE, Nuoffer JM, FlĂŒck CE (2012) Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells. PLoS One 7:e30956.Human
Pig
Other cell linesSubstrate
Kaambre 2012 J Bioenerg Biomembr2012Kaambre T, Chekulayev V, Shevchuk I, Karu-Varikmaa M, Timohhina N, Tepp K, Bogovskaja J, KĂŒtner R, Valvere V, Saks V (2012) Metabolic control analysis of cellular respiration in situ in intraoperational samples of human breast cancer. J Bioenerg Biomembr 44:539-58.Human
Rat
Heart
Endothelial;epithelial;mesothelial cell
ADP
Flux control
Inhibitor
PCr;Cr
Jose 2012 Thesis2012Jose C (2012) RÎle des mitochondries dans la tumorigénÚse: implications pour le traitement du cancer. PhD Thesis 272.HumanOther cell lines
HeLa
Jardim-Messeder 2012 Int J Biochem Cell Biol2012Jardim-Messeder D, Camacho-Pereira J, Galina A (2012) 3-Bromopyruvate inhibits calcium uptake by sarcoplasmic reticulum vesicles but not SERCA ATP hydrolysis activity. Int J Biochem Cell Biol 44:801-7.RabbitSkeletal muscleADP
Inhibitor
Kluza 2011 PLoS One2011Kluza J, Jendoubi M, Ballot C, Dammak A, Jonneaux A, Idziorek T, Joha S, Dauphin V, Malet-Martino M, Balayssac S, Maboudou P, Briand G, Formstecher P, Quesnel B, Marchetti P (2011) Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells. PLoS One 6:e21924Human
Mouse
Blood cellsSubstrate
Oliva 2011 PloS One2011Oliva CR, Moellering DR, Gillespie GY, Griguer CE (2011) Acquisition of chemoresistance in gliomas is associated with increased mitochondrial coupling and decreased ROS production. PloS One 6:e24665.HumanNervous system
Eberhart 2011 Biochim Biophys Acta2011Eberhart K, Rainer J, Bindreither D, Ritter I, Gnaiger E, Kofler R, Oefner PJ, Renner K (2011) Glucocorticoid-induced alterations in mitochondrial membrane properties and respiration in childhood acute lymphoblastic leukemia. Biochim Biophys Acta 1807:719-25.HumanBlood cells
Kristiansen 2011 J Biol Chem2011Kristiansen G, Hu J, Wichmann D, Stiehl DP, Rose M, Gerhardt J, Bohnert A, ten Haaf A, Moch H, Raleigh J, Varia MA, Subarsky P, Scandurra FM, Gnaiger E, Gleixner E, Bicker A, Gassmann M, Hankeln T, Dahl E, Gorr TA (2011) Endogenous myoglobin in breast cancer is hypoxia-inducible by alternate transcription and functions to impair mitochondrial activity: a role in tumor suppression? https://doi.org/10.1074/jbc.M111.227553HumanGenital
Other cell lines
Aerobic glycolysis
Oxygen kinetics
Substrate
Wang 2011 Mol Oncol2011Wang X, Moraes CT (2011) Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels. Mol Oncol 5: 399-409.
Domenis 2011 J Bioenerg Biomembr2011Domenis R, Comelli M, Bisetto E, Mavelli I (2011) Mitochondrial bioenergetic profile and responses to metabolic inhibition in human hepatocarcinoma cell lines with distinct differentiation characteristics. J Bioenerg Biomembr 43: 493-505.HumanLiver
Amoedo 2011 PLoS One2011Amoedo ND, Rodrigues MF, Pezzuto P, Galina A, da Costa RM, de Almeida FC, El-Bacha T, Rumjanek FD (2011) Energy metabolism in h460 lung cancer cells: effects of histone deacetylase inhibitors. PLoS One 6:e22264.HumanLung;gillAerobic glycolysis
ADP
Verschoor 2010 PLoS One2010Verschoor ML, Wilson LA, Verschoor CP, Singh G (2010) Ets-1 regulates energy metabolism in cancer cells. PLoS One 5: e13565.Human
Fang 2010 Cell2010Fang M, Shen Z, Huang S, Zhao L, Chen S, Mak TW, Wang X (2010) The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell 143:711-24.Aerobic glycolysis
Mirebeau-Prunier 2010 FEBS J2010Mirebeau-Prunier D, Le Pennec S, Jacques C, Gueguen N, Poirier J, Malthiery Y, Savagner F (2010) Estrogen-related receptor alpha and PGC-1-related coactivator constitute a novel complex mediating the biogenesis of functional mitochondria. FEBS J 277:713-25.Human
Namgaladze 2010 Atherosclerosis2010Namgaladze D, Preiss S, Dröse S, Brandt U, BrĂŒne B (2010) Phospholipase A2-modified low density lipoprotein induces mitochondrial uncoupling and lowers reactive oxygen species in phagocytes. Atherosclerosis 208:142-7.HumanBlood cells
Smolkova 2010 J Bioenerg Biomembr2010SmolkovĂĄ K, Bellance N, Scandurra F, GĂ©not E, Gnaiger E, PlecitĂĄ-HlavatĂĄ L, JeĆŸek P, Rossignol R (2010) Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia. https://doi.org/10.1007/s10863-009-9267-xHumanFibroblastOxygen kinetics
Yang 2010 Cancer Biol Ther2010Yang D, Wang MT, Tang Yong, Chen Y, Jiang H, Jones TT, Rao K, Brewer GJ, Singh KK, Nie D (2010) Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L). Canc Biol Ther 9:122-33.MouseFibroblastAerobic glycolysis
ADP
Inhibitor
Substrate
Bellance 2009 Int J Biochem Cell Biol2009Bellance N, Benard G, Furt F, Begueret H, SmolkovĂĄ K, Passerieux E, Delage JP, Baste JM, Moreau P, Rossignol R (2009) Bioenergetics of lung tumors: Alteration of mitochondrial biogenesis and respiratory capacity. Int J Biochem Cell Biol 41:2566-77.HumanFibroblastADP
Substrate
Garedew 2009 Respir Physiol Neurobiol2009Garedew A, KĂ€mmerer U, Singer D (2009) Respiratory response of malignant and placental cells to changes in oxygen concentration. Respir Physiol Neurobiol 165:154-60.HumanBlood cells
Bredholt T 2009 Mol Cancer2009Bredholt T, Dimba EA, Hagland HR, Wergeland L, Skavland J, Fossan KO, Tronstad KJ, Johannessen AC, Vintermyr OK, Gjertsen BT (2009) Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. Mol Cancer 8:101.HumanBlood cellsADP
Inhibitor
Samper 2009 Free Radic Biol Med2009Samper E, Morgado L, Estrada JC, Bernad A, Hubbard A, Cadenas S, Melov S (2009) Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas. Free Radic Biol Med 46:387-96.Aerobic glycolysis
Eberhart 2009 Leukemia2009Eberhart K, Renner K, Ritter I, Kastenberger M, Singer K, Hellerbrand C, Kreutz M, Kofler R, Oefner PJ (2009) Low doses of 2-deoxy-glucose sensitize acute lymphoblastic leukemia cells to glucocorticoid-induced apoptosis. Leukemia 23:2167-70.HumanBlood cells
Lymphocyte
Haendeler 2009 Arterioscler Thromb Vasc Biol2009Haendeler J, Dröse S, BĂŒchner N, Jakob S, Altschmied J, Goy C, Spyridopoulos I, Zeiher AM, Brandt U, Dimmeler S (2009) Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler Thromb Vasc Biol 29:929-35.Human
Mouse
Heart
Endothelial;epithelial;mesothelial cell
Fibroblast
Substrate
Pereira 2009 Biochem J2009Pereira da Silva AP, El-Bacha T, Kyaw N, dos Santos RS, Da Silva WS, Almeida FC, Da Poian AT, Galina A (2009) Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate. Biochem J 417:717-26.HumanLiver
Mufazalov 2009 Mol Biol (Mosk)2009Mufazalov IA, Pen'kov DN, Cherniak BV, Pletiushkina OIu, Vysokikh MIu, Kirpichnikov MP, Dolgikh DA, Kruglov AA, Kuprash DV, Skulachev VP, Nedospasov SA (2009) Preparation and characterization of mouse embryonic fibroblasts with K72W mutation in somatic cytochrome c gene. Mol Biol (Mosk) 43:648-56.MouseFibroblastCyt c
Hervouet 2008 Carcinogenesis2008Hervouet E, CĂ­zkovĂĄ A, Demont J, VojtĂ­skovĂĄ A, Pecina P, Franssen-van Hal NL, Keijer J, Simonnet H, IvĂĄnek R, Kmoch S, Godinot C, Houstek J (2008) HIF and reactive oxygen species regulate oxidative phosphorylation in cancer. Carcinogenesis 29:1528-37.
Soller 2007 Mol Pharmacol2007Soller M, Dröse S, Brandt U, BrĂŒne B, von Knethen A (2007) Mechanism of Thiazolidinedione-dependent cell death in Jurkat T cells. Mol Pharmacol 71:1535-44.Heart
Other cell lines
Inhibitor
mt-Membrane potential
Kuhnt 2007 Neurochem Res2007Kuhnt T, Pelz T, Qu X, Haensgen G, Dunst J, Gellerich FN (2007) Mitochondrial OXPHOS functions in R1H rhabdomyosarcoma and skeletal muscles of the rat. Neurochem Res 32:973–80.RatSkeletal muscleSubstrate
Hervouet 2006 Biochem Biophys Res Commun2006Hervouet E, Pecina P, Demont J, VojtĂ­ĆĄkovĂĄ A, Simonnet H, HouĆĄtek J, Godinot C (2006) Inhibition of cytochrome c oxidase subunit 4 precursor processing by the hypoxia mimic cobalt chloride. Biochem Biophys Res Commun 344:1086-93.Human
Saccharomyces cerevisiae
Fungi
Inhibitor
Labajova 2006 Anal Biochem2006Labajova A, Vojtiskova A, Krivakova P, Kofranek J, Drahota Z, Houstek J (2006) Evaluation of mitochondrial membrane potential using a computerized device with a tetraphenylphosphonium-selective electrode. Anal Biochem 353:37-42.RatLivermt-Membrane potential
Pye 2006 Nucleic Acids Research2006Pye D, Kyriakouli DS, Taylor GA, Johnson R, Elstner M, Meunier B, Chrzanowska-Lightowlers ZMA, Taylor RW, Turnbull DM, Lightowlers RN (2006) Production of transmitochondrial cybrids containing naturally occurring pathogenic mtDNA variants. Nucleic Acids Research 34:e95Human
Hervouet 2005 Carcinogenesis2005Hervouet E, Demont J, Pecina P, VojtĂ­skovĂĄ A, Houstek J, Simonnet H, Godinot C (2005) A new role for the von Hippel-Lindau tumor suppressor protein: Stimulation of mitochondrial oxidative phosphorylation complex biogenesis. Carcinogenesis 26:531-9.
Chowdhury 2005 Biochem Biophys Res Comm2005Chowdhury SK, Gemin A, Singh G (2005) High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines. Biochem Biophys Res Comm 333:1139-45.HumanGenitalSubstrate
Renner 2003 Biochim Biophys Acta2003Renner K, Amberger A, Konwalinka G, Gnaiger E (2003) Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells. Biochim Biophys Acta 1642:115-23.HumanBlood cellsCoupling efficiency;uncoupling
Cyt c
Pasdois 2003 J Bioenerg Biomembr2003Pasdois P, Deveaud C, Voisin P, Bouchaud V, Rigoulet M, Beauvoit B (2003) Contribution of the phosphorylable complex I in the growth phase-dependent respiration of C6 glioma cells in vitro. J Bioenerg Biomembr 35:439-50.RatNeuroblastoma
Opalka 2002 Biochem Pharmacol2002Opalka JR, Gellerich FN, Kling L, MĂŒller-Beckmann B, Zierz S (2002) Effect of the new matrix metalloproteinase inhibitor RO-28-2653 on mitochondrial function. Biochem Pharmacol 63:725-32.RatHeart
Renner 2002 Mol Biol Rep2002Renner K, Kofler R, Gnaiger E (2002) Mitochondrial function in glucocorticoid triggered T-ALL cells with transgenic Bcl-2 expression. Mol Biol Rep 29:97-101.HumanBlood cells
Perrin 2002 Biochimie2002Perrin A, Roudier E , Duborjal H, Bachelet C, Riva-Lavieille C, Leverve X, Massarelli R (2002) Pyruvate reverses metabolic effects produced by hypoxia in glioma and hepatoma cell cultures. Biochimie 84:1003-11.Human
Rat
Nervous system
Liver
Savagner 2001 J Clin Endocrinol Metabol2001Savagner F, Franc B, Guyetant S, Rodien P, Reynier P, Malthiery Y (2001) Defective mitochondrial ATP synthesis in oxyphilic thyroid tumors. J Clin Endocrinol Metabol 86:4920-25.HumanCoupling efficiency;uncoupling
Knoblechner 1994 BTK-2941994
BTK1994
Knoblechner A, Steinlechner R, Schirmer M, Gellerich FN, Margreiter R, Konwalinka G, Gnaiger E (1994) The effect of 2-chlorodeoxy-adenosine on endogenous respiration of a human lymphoma cell line (U-937). In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:294-6.
HumanBlood cells
O2k-Publications in the MiPMap

O2k-Publications: Cancer - Abstracts

Sort in ascending/descending order by a click on one of the small symbols in squares below.
 YearReferenceOrganismTissue;cellRegulation;kinetics
Strich 2023 MiPschool Obergurgl2023
MiPsociety
Bioenergetic profiling of kinase inhibitors reveals drug off-targer effects in colon cancer cell models
Porter 2022 Abstract Bioblast20226.3. «10+5»
Porter Richard K
Karavyraki M, Gnaiger E, Porter Richard K (2022) A comparison of bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001
»MitoFit Preprint« »Watch the presentation«
HumanAerobic glycolysis
Van der Ende 2019 MiPschool Coimbra2019
Miranda van der Ende
Mitochondrial respiration in muscle tissue of colon cancer patients.
HumanSkeletal muscle
Lelcu 2019 MiP20192019
Theia Lelcu
Assessment of platelet respiration in blood malignancies: a pilot study in children and adults.
HumanPlatelet
Timohhina 2019 MiP20192019
Natalja Timohhina
Metabolic effects of mitochondria-targeted antioxidant peptides in colorectal cancer cells.
HumanEndothelial;epithelial;mesothelial cell
Bastos Sant'Anna Silva 2019 Life Sciences Meeting 2019 Innsbruck AT2019Cellular succinate transport and mitochondrial respiratory function in prostate cancer.HumanGenitalIon;substrate transport
Garipi 2018 MiPschool Tromso E22018Phenotyping mitochondrial metabolism in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS productionHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Escames 2018 MiP20182018
Germaine Escames
Suppression of AKT/mTOR pathway and activation of mitophagy by melatonin via mitocondrial regulation in head and neck cancer. Escames_Presentation
Human
Mouse
Other cell lines
Bastos Sant'Anna Silva 2018 Life Sciences Meeting 2018 Innsbruck AT2018Effect of cell-permeable succinate and malonate prodrugs on mitochondrial respiration in prostate cancer cells.Kidney
Other cell lines
HEK
Calcium
Substrate
Evinova 2018 MiP20182018
MiPsociety
High-resolution respirometry of neuroblastoma SH-SY 5Y cell line.
HumanOther cell lines
Neuroblastoma
Threshold;excess capacity
Chang 2018 Life Sciences Meeting 2018 Innsbruck AT2018pH dependence of mitochondrial respiration and H2O2 production in oral cancer cells – a pilot study.HumanHEK
Kidney
Rodriguez-Hernandez 2018 Free Radic Biol Med2018Rodriguez-HernĂĄndez A, StaƈkovĂĄ P, GonzĂĄlez R, De la Rosa AJ, Álamo-Martinez JM, Marin-GĂłmez LM, Sobotka O, Kučera O, Padillo FJ, ČervinkovĂĄ Z, MuntanĂ© J (2018) The alteration of mitochondrial function is associated with the induction of endoplasmic reticulum stress autophagy and apoptosis by Sorafenib in liver cancer cells. Free Radic Biol Med.Liver
Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT2018Cellular succinate transport and mitochondrial respiratory function in prostate cancer.HumanHEK
Genital
Substrate
Ion;substrate transport
Schoepf 2018 33rd Annual EAU Congress Copenhagen2018Shift of mitochondrial oxidative phosphorylation is associated with mtDNA mutational load in primary prostate cancer tissue.HumanGenital
Roy Chowdhury 2018 J Thorac Oncol2018Roy Chowdhury S, Saleh R, Girard C, Peltier C, Desautels D, Dawe D, Banerji V, Banerji S (2018) Targeting mitochondrial metabolism as a selective therapeutic approach in small cell lung cancer (SCLC). J Thorac Oncol.HumanLung;gill
Malagrino 2018 Free Radic Biol Med2018MalagrinĂČ F, Zuhra K, Mastronicola D, Mascolo L, Vicente JB, Forte E, GiuffrĂš A (2018) H2S metabolism in colon cancer cells: Effect of hypoxia. Free Radic Biol Med.
Ounpuu 2018 MiP20182018
Lyudmila Ounpuu
Metabolic plasticity of cancer stem-like cells.
HumanStem cells
Bastos Sant'Anna Silva 2018 MiPschool Tromso C42018
Ana Bastos Sant'Anna
Role of succinate in prostate cancer cells: uptake and mitochondrial respiratory function.
HumanGenital
Pereira da Silva Grilo da Silva 2018 MiP20182018
Filomena Pereira da Silva Grilo da Silva
The unspecific effect of etomoxir on mitochondrial respiration.
Human
Mouse
Nervous system
Liver
Other cell lines
Inhibitor
Substrate
Uncoupler
Ounpuu 2017 MiP20172017
Ljudmila Ounpuu
The role of dietary fibers in the energy metabolism of human colon cancer cells.
Human
Truu 2017 Abstract IOC1222017Bioenergetics of colorectal cancer.Endothelial;epithelial;mesothelial cell
Gnaiger 2017 Abstract MitoEAGLE Barcelona2017
COST Action MitoEAGLE
Quality first: a paradigm shift in mt-respiratory control towards global connection.
Human
Mouse
Heart
Genital
Truu 2017 MiP20172017
Laura Truu
Bioenergetic comparison of human colorectal and breast cancer clinical patients.
Human
Phillips 2017 Cancer Research2017Abstract 3548: Hypoxia-induced Cystathionine-ÎČ-synthase (CBS) expression: impact on colonic epithelial cells metabolism, proliferation and migration.Endothelial;epithelial;mesothelial cell
Bufe 2017 TRACT PhD project abstract2017Metabolic profiles in normal, dysplastic and cancerous oral cells.HumanOther cell lines
Karavyraki 2017 MiPschool Obergurgl2017
KaravyrakiMarilena.jpg
Mitochondrial function and morphology linked to metabolic differences in normal, dysplastic and cancerous oral cells.
Human
Gnaiger 2017 Abstract EUROMIT2017 Cologne2017
EUROMIT2017
Again not a Warburg effect - mitochondrial function in primary prostate cancer.
HumanEndothelial;epithelial;mesothelial cell
Genital
Fibroblast
Labieniec-Watala 2017 MiP20172017
Magda Labieniec-Watala
Lack of the effect of low metformin concentrations on the response of breast cancer cell mitochondria to radiotherapy under conditions of the in vitro experimental hyperglycemia. Labieniec-Watala_Presentation
HumanGenital
Skolik 2017 Abstract IOC1222017What can we learn from different sugars as substrates for cancer cells?HumanLiver
Klepinin 2017 MiP20172017
MiPsociety
Novel method to study the role of the adenylate kinase network in health and disease.
Human
Rat
Heart
Stem cells
Karavyraki 2017 Abstract IOC1222017Mitochondrial function and morphology linked to metabolic differences in normal, dysplastic and cancerous oral cells.HumanEndothelial;epithelial;mesothelial cell
Scatena 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Mitochondria and cancer stem cells in hepatocarcinoma. An illustrative example of a tangled methodological approach.
Liver
Weber 2016 Abstract Mito Xmas Meeting Innsbruck2016Loss of PTEN in prostate cancer cells leads to a switch to succinate-mediated mitochondrial respiration associated with increased expression of NaDC3 and HIF-1alpha.Human
Mouse
GenitalSubstrate
Schoepf 2016 Abstract Mito Xmas Meeting Innsbruck2016Mitochondrial function in primary prostate cancer.HumanFlux control
Zatarain 2016 Abstract Cancer Research2016Abstract 4276: Cystathionine-ÎČ-synthase overexpression increases cell proliferation, migration, bioenergetics and tumorigenesis in a non-tumorigenic colorectal cancer (CRC) cell line.Human
Mouse
Endothelial;epithelial;mesothelial cell
Schoepf 2016 Abstract Androgens 20162016Mitochondrial function and mitochondrial heteroplasmy levels differ between benign and malignant prostate tissue.Genital
Kaambre 2015 Abstract MiP20152015Quantitative characterization of respiratory parameters of human colorectal and breast cancer clinical material.HumanEndothelial;epithelial;mesothelial cell
Shevchuk 2015 Abstract MiP20152015Analysis of energy fluxes in colorectal cancer saponin skinned tissues and Caco-2 cells.HumanEndothelial;epithelial;mesothelial cell
Coelho 2015 Abstract Thyroid Cancer2015AMPK overactivation in BCPAP tumor cells induces cell death through increased reactive oxygen species (ROS).
Amoedo 2015 Abstract MiP20152015The energy requirement of metastatic cells.Mouse
Rat
Other cell lines
Amoedo 2014 Abstract MiP20142014The metabolic panorama during tumor progression towards malignancy.Other cell linesAerobic glycolysis
ATP production
Fatty acid
Bristot 2014 Abstract MiP20142014High-resolution respirometry and bioenergetics evaluation in fibroblasts derived from patients with TP53 germline mutations.HumanFibroblast
El-Bacha 2014 Abstract MiP20142014Cytotoxicity of grape pomace extract (Vitis vinifera L.) from Brazilian wine industry in human hepatocarcinoma HepG2 cells.HumanLiverAerobic glycolysis
ATP production
Rodrigues 2014 Abstract MiP20142014Bioenergetics’ traits of tongue cancer metastatic cells.MouseLymphocyte
Kandashvili 2014 Abstract MiP20142014Regulation of energy metabolism in human colorectal cancer cells in situ.HumanEndothelial;epithelial;mesothelial cellADP
Schoepf 2014 Abstract MiP20142014OXPHOS analysis in small prostate biopsies.HumanGenital
Kluckova 2014 Abstract MiP20142014Proximal ubiquinone binding site in mitochondrial respiratory Complex II is a target for vitamin E analog MitoVES, an experimental anti-cancer agent. Mitochondr Physiol Network 19.13.Other cell lines
Maedo 2014 Abstract IOC 2014-04 Schroecken2014Maedo K, Kaldma A, Planken A, Klepinin A, Chekulayev V, Varikmaa M, Tepp K, Chevchuk I, Kaambre T (2014) Regulation of mitochondrial respiration in human colorectal cancer cells in situ: the possible role of beta-tubulins. Mitochondr Physiol Network 19.02.HumanEndothelial;epithelial;mesothelial cellADP
Rodrigues 2013 Abstract MiP20132013Rodrigues MF, Amoedo ND, Rumjanek FD (2013) Studies of bioenergetics alterations in breast cancer lines induced by histone desacetylase inhibitors. Mitochondr Physiol Network 18.08.GenitalAerobic glycolysis
Zelenka 2013 Abstract MiP20132013Zelenka J, Smolkova K, Dvorak A, Vitek L, Jezek P (2013) Reverse carboxylation glutaminolysis in breast cancer cells. Mitochondr Physiol Network 18.08.HumanOther cell lines
HeLa
Zelenka J 2013 Abstract MiP20132013Zelenka J, Alan L, Jezek P(2013) Response of cancer cells to mitochondrial DNA damage. Mitochondr Physiol Network 18.08.Other cell linesAerobic glycolysis
ATP
Coupling efficiency;uncoupling
Ion;substrate transport
Bajzikova 2013 Abstract IOC792013Bajzikova M (2013) Mitochondrially targeted vitamin E succinate and its effects on mitochondrial oxidative phosphorylation system. Mitochondr Physiol Network 18.07.HumanOther cell lines
Galina 2013 Abstract MiP20132013Galina A, Messeder DJM, Camacho-Pereira J, Pereira da Silva AP, Rodrigues-Ferreira C (2013) Effects of antitumor alkylating agent 3-bromopyruvate on energy transducing pathways in hepatoma HepG2, liver mitochondria and SERCA: Is there any role for mitochondrial hexokinase activity? Mitochondr Physiol Network 18.08.RatSkeletal muscle
Nervous system
Liver
Other cell lines
Calcium
Flux control
mt-Membrane potential
Redox state
Threshold;excess capacity
Amoedo 2013 Abstract MiP20132013AmoĂȘdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08.MouseEndothelial;epithelial;mesothelial cell
Other cell lines
Aerobic glycolysis
Skulachev 2013 Abstract MiP20132013Skulachev VP (2013) SkQ1, the first mitochondria-targeted medicine available in drugstores. Mitochondr Physiol Network 18.08.Human
Mouse
Horse
Dog
Rabbit
Fishes
Other invertebrates
Fungi
Plants
Heart
Skeletal muscle
Nervous system
Kidney
Islet cell;pancreas;thymus
Other cell lines
HeLa
Fibroblast
Stem cells
mt-Membrane potential
Threshold;excess capacity
Uncoupler
Beach 2013 Abstract MiP20132013Beach A, Richard VR, Leonov A, Burstein MT, Feldman R, Gentile C, Titorenko VI (2013) Lithocholic acid delays aging in yeast and exhibits an anti-tumor effect in human cells by altering mitochondrial composition, structure and function. Mitochondr Physiol Network 18.08.Human
Saccharomyces cerevisiae
Other cell lines
Neuroblastoma
mt-Membrane potential
Amoedo 2012 Abstract Bioblast2012Amoedo ND, Rodrigues MF, Pereira SAS, Melo FH, Jasiulionis MG, Galina A, Rumjanek FD (2012) Mitochondrial function and bioenergetics during malignant transformation and metastasis. Mitochondr Physiol Network 17.12.MouseOther cell linesAerobic glycolysis
Substrate
Tronstad 2012 Abstract Bioblast2012Nikolaisen J, Nilsson LIH, Hagland HR, Koopman WJ, Tronstad KJ (2012) Mitochondrial morphology and biogenesis in cellular stress. Mitochondr Physiol Network 17.12.Human
Rat
Liver
Endothelial;epithelial;mesothelial cell
Blood cells
Acuna-Castroviejo 2012 Abstract Bioblast2012Acuna-Castroviejo D (2012) Melatonin and the quality of life: the melatonin-mitochondrion connection. Mitochondr Physiol Network 17.12.Mouse
Rat
Heart
Skeletal muscle
Nervous system
Liver
ATP production
Ion;substrate transport
mt-Membrane potential
Redox state
Silva MiP 20112011Silva da Costa L, Pereira da Silva AP, Da Poian AT, El-Bacha T (2011) Mitochondrial bioenergetic alterations in mouse neuroblastoma cells infected with Sindbis Virus: Implications to viral replication and neuronal death. MiP2011.NeuroblastomaATP production
Inhibitor
Substrate
El-Bacha MiP20102010Amoedo ND, Rodrigues MF, Pezutto P, Lourenco MVC, Madeiro da Costa RF, Oliveira MF, Galina A, Rumjanek FD, El-Bacha T (2010) Metabolic reprogramming of lung cancer cell induced by sodium butyrate: studies on mitochondrial physiology and bioenergetics.Other cell lines
Amoedo 2010 Abstract MiP20102010AmoĂȘdo ND, Rodrigues MF, Pezutto P, Lourenço MVC, Madeiro da Costa RF, Oliveira MF, Galina A, Rumjanek FD, El-Bacha T (2010) Metabolic reprogramming of lung cancer cell induced by sodium butyrate: Studies on mitochondrial physiology and bioenergetics. Mitochondr Physiol Network 15.06.HumanEndothelial;epithelial;mesothelial cell
Fibroblast
Aerobic glycolysis
ADP
Substrate
Amino acid

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