Parri 2020 Curr Opin Biotechnol
| Parri M, Ippolito L, Cirri P, Ramazzotti M, Chiarugi P (2020) Metabolic cell communication within tumour microenvironment: models, methods and perspectives. Curr Opin Biotechnol 63:210-19. |
Parri M, Ippolito L, Cirri P, Ramazzotti M, Chiarugi P (2020) Curr Opin Biotechnol
Abstract: Environmental cues are essential in defining tumour malignancy, by promoting tumour initiation, progression and metastatic spreading. Stromal cells may metabolically cooperate or compete with cancer cells, playing a mandatory role in defining cancer metabolic plasticity, potentially dictating the final tumour outcome. Assessing shared nutrients between different tumoural or stromal compartments is essential to understand the impact of environmental nutrients on the metabolic plasticity of tumours. Here, we review analytical and computational approaches for studying the tumour metabolic microenvironment, the destiny of nutrients shared among tumour and stromal populations, as well as the molecular modules of these metabolic relationships.
Copyright © 2020. Published by Elsevier Ltd.
• Bioblast editor: Plangger M
Labels: MiParea: Respiration, Exercise physiology;nutrition;life style
Pathology: Cancer
HRR: Oxygraph-2k
2020-10
