Glycerophosphate pathway control state

From Bioblast


high-resolution terminology - matching measurements at high-resolution


Glycerophosphate pathway control state

Description

Gp-pathway

The glycerophosphate pathway control state (Gp) is an ET-pathway level 3 control state, supported by the fuel substrate glycerophosphate and electron transfer through glycerophosphate dehydrogenase Complex into the Q-junction. The glycerolphosphate shuttle represents an important pathway, particularly in liver and blood cells, of making cytoplasmic NADH available for mitochondrial oxidative phosphorylation. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophos-phate dehydrogenase. On the outer face of the inner mitochondrial membrane, mitochondrial glycerophosphate dehydrogenase oxidises glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein donates its reducing equivalents to the electron transfer-pathway at the level of CoQ.

Abbreviation: Gp

Reference: Electron-transfer-pathway state, Gnaiger 2020 BEC MitoPathways

Communicated by Gnaiger E 2016-01-25, edited 2016-11-19.

Gp(L)

Gp(P)

Gp(E)

Details

Glycerophosphate oxidation is 10-fold higher in rabbit gracilis mitochondria (fast-twitch white muscle; 99% type IIb) compared to soleus (slow-twitch red muscle; 98% type I). Activity is comparatively low in human vastus lateralis. Glycerophosphate is an important substrate for respiration in brown adipose tissue mitochondria.


Questions.jpg


Click to expand or collaps
Publications: Gp-pathway control state - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>


Questions.jpg


Click to expand or collaps
»Abstracts: Gp-pathway control state


MitoPedia concepts: Respiratory state, SUIT state, Recommended 


MitoPedia topics: EAGLE 

Cookies help us deliver our services. By using our services, you agree to our use of cookies.