Glycerophosphate pathway control state

From Bioblast


high-resolution terminology - matching measurements at high-resolution


Glycerophosphate pathway control state

Description

Gp-pathway

The glycerophosphate pathway control state (Gp) is an ET-pathway level 3 control state, supported by the fuel substrate glycerophosphate and electron transfer through glycerophosphate dehydrogenase Complex into the Q-junction. The glycerolphosphate shuttle represents an important pathway, particularly in liver and blood cells, of making cytoplasmic NADH available for mitochondrial oxidative phosphorylation. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophos-phate dehydrogenase. On the outer face of the inner mitochondrial membrane, mitochondrial glycerophosphate dehydrogenase oxidises glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein donates its reducing equivalents to the electron transfer-pathway at the level of CoQ.

Abbreviation: Gp

Reference: Electron-transfer-pathway state, Gnaiger 2020 BEC MitoPathways

Communicated by Gnaiger E 2016-01-25, edited 2016-11-19.

Gp(L)

Gp(P)

Gp(E)

Details

Glycerophosphate oxidation is 10-fold higher in rabbit gracilis mitochondria (fast-twitch white muscle; 99% type IIb) compared to soleus (slow-twitch red muscle; 98% type I). Activity is comparatively low in human vastus lateralis. Glycerophosphate is an important substrate for respiration in brown adipose tissue mitochondria.


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 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Cardoso 2025 Biochim Biophys Acta Mol Basis Dis2025Cardoso LHD, Cecatto C, Ozola M, Korzh S, Zvejniece L, Gukalova B, Doerrier C, Dambrova M, Makrecka-Kuka M, Gnaiger E, Liepinsh E (2025) Fatty acid β-oxidation in brain mitochondria: Insights from high-resolution respirometry in mouse, rat and Drosophila brain, ischemia and aging models. Biochim Biophys Acta Mol Basis Dis 1871:167544. https://doi.org/10.1016/j.bbadis.2024.167544ET
OXPHOS
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HomogenateMouse
Rat
Drosophila
Heart
Nervous system
Kidney
MiPNet21.14 Reference sample HRR2024-12-06
O2k-Protocols
Development of a reference sample for high-resolution respirometry.
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HumanHEK
Allerton 2024 Sci Rep2024Allerton TD, Stampley JE, Li Z, Yu X, Quiariate H, Doiron JE, White G, Wigger Z, Gartia MR, Lefer DJ, Soto P, Irving BA (2024) Nitric oxide donors rescue metabolic and mitochondrial dysfunction in obese Alzheimer's model. Sci Rep 14:26118. https://doi.org/10.1038/s41598-024-75870-8ET
OXPHOS
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Gp
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Permeabilized tissueMouseNervous system
Al-Sabri 2024 Sci Rep2024Al-Sabri MH, Ammar N, Korzh S, Alsehli AM, Hosseini K, Fredriksson R, Mwinyi J, Williams MJ, Boukhatmi H, Schiöth HB (2024) Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes. https://doi.org/10.1038/s41598-024-53446-wLEAK
OXPHOS
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Permeabilized tissueDrosophilaSkeletal muscle
Hunter-Manseau 2024 Insect Sci2024Hunter-Manseau F, Cormier SB, Strang R, Pichaud N (2024) Fasting as a precursor to high-fat diet enhances mitochondrial resilience in Drosophila melanogaster. Insect Sci [Epub ahead of print]. https://doi.org/10.1111/1744-7917.13355LEAK
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Permeabilized tissueDrosophila
Mahapatra 2024 J Gerontol A Biol Sci Med Sci2024Mahapatra G, Gao Z, Bateman JR 3rd, Lockhart SN, Bergstrom J, Piloso JE, Craft S, Molina AJA (2024) Peripheral blood cells from older adults exhibit sex-associated differences in mitochondrial function. J Gerontol A Biol Sci Med Sci [Epub ahead of print]. https://doi.org/10.1093/gerona/glae098ROUTINE
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HumanBlood cells
Jiang 2024 Nat Metab2024Jiang S, Yuan T, Rosenberger FA, Mourier A, Dragano NRV, Kremer LS, Rubalcava-Gracia D, Hansen FM, Borg M, Mennuni M, Filograna R, Alsina D, Misic J, Koolmeister C, Papadea P, de Angelis MH, Ren L, Andersson O, Unger A, Bergbrede T, Di Lucrezia R, Wibom R, Zierath JR, Krook A, Giavalisco P, Mann M, Larsson NG (2024) Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity. Nat Metab [Epub ahead of print]. https://doi.org/10.1038/s42255-024-01038-3LEAK
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Isolated mitochondriaMouseLiver
Leo 2024 MitoFit2024Leo E, Rychtarova L, Garcia-Souza LF, Åsander Frostner E, Elmér E, Gnaiger E (2024) High-resolution respirometry in a small-volume chamber. MitoFit Preprints 2024.4.v2. https://doi.org/10.26124/mitofit:2024-0004.v2 - Accepted on 2024-10-27 as Manuscript JoVE67442R2 for publication in JoVEET
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Human
Mouse
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Blood cells
HUVEC
Platelet
Brunner 2024 Life Sci Alliance2024Brunner S, Höring M, Liebisch G, Schweizer S, Scheiber J, Giansanti P, Hidrobo M, Hermeling S, Oeckl J, Prudente de Mello N, Perocchi F, Seeliger C, Strohmeyer A, Klingenspor M, Plagge J, Küster B, Burkhardt R, Janssen KP, Ecker J (2024) Mitochondrial lipidomes are tissue specific - low cholesterol contents relate to UCP1 activity. Life Sci Alliance 7:e202402828. https://doi.org/10.26508/lsa.202402828ET
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Isolated mitochondriaMouseFat
Cardoso 2024 MitoFit FAO2024Cardoso LHD, Cecatto C, Ozola M, Korzh S, Zvejniece L, Gukalova B, Doerrier C, Dambrova M, Makrecka-Kuka M, Gnaiger E, Liepinsh E (2024) Fatty acid β-oxidation in brain mitochondria: Insights from high-resolution respirometry in mouse, rat and Drosophila brain, ischemia and aging models. MitoFit Preprints 2023.10. https://doi.org/10.26124/mitofit:2023-0010.v2 Published 2024-10-17 BBA Mol Basis Dis (2025)OXPHOS
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HomogenateMouse
Rat
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Heart
Nervous system
Kidney
Batterson 2023 Physiol Rep2023Batterson PM, McGowan EM, Borowik AK, Kinter MT, Miller BF, Newsom SA, Robinson MM (2023) High-fat diet increases electron transfer flavoprotein synthesis and lipid respiration in skeletal muscle during exercise training in female mice. https://doi.org/10.14814/phy2.15840LEAK
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Isolated mitochondriaMouseSkeletal muscle
Menail 2023 FASEB J2023Menail HA, Cormier SB, Léger A, Robichaud S, Hebert-Chatelain E, Lamarre SG, Pichaud N (2023) Age-related flexibility of energetic metabolism in the honey bee Apis mellifera. https://doi.org/10.1096/fj.202300654rLEAK
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Permeabilized tissueHexapods
Rodriguez 2023 BEC2023Rodríguez E, Bettinazzi S, Inwongwan S, Camus MF, Lane N (2023) Harmonizing protocols to measure Drosophila respiratory function in mitochondrial preparations. Bioenerg Commun 2023.3. https://doi.org/10.26124/bec:2023-0003LEAK
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Homogenate
Drosophila
Adant 2022 Mol Metab2022Adant I, Bird M, Decru B, Windmolders P, Wallays M, de Witte P, Rymen D, Witters P, Vermeersch P, Cassiman D, Ghesquière B (2022) Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction. https://doi.org/10.1016/j.molmet.2022.101537LEAK
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Permeabilized cellsHumanFibroblast
Nath 2022 Cell Rep2022Nath AS, Parsons BD, Makdissi S, Chilvers RL, Mu Y, Weaver CM, Euodia I, Fitze KA, Long J, Scur M, Mackenzie DP, Makrigiannis AP, Pichaud N, Boudreau LH, Simmonds AJ, Webber CA, Derfalvi B, Hammon Y, Rachubinski RA, Di Cara F (2022) Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses . Cell Rep 38:110433.LEAK
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Intact cells
Alencar 2022 MitoFit2022Alencar MB, Ramos EV, Silber AM, Zíková A, Oliveira MF (2022) The extraordinary energy metabolism of the bloodstream Trypanosoma brucei forms: a critical review and a hypothesis. https://doi.org/10.26124/mitofit:2022-0009.v22022-12-05 published in Bioenerg Commun 2022.17.GpProtists
Pallag 2022 Int J Mol Sci2022Pallag G, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation supports mitochondrial ATP production when Complex I is inhibited. Int J Mol Sci 23:5111. https://doi.org/10.3390/ijms23095111LEAK
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Isolated mitochondriaMouseLiver
Kidney
Heimler 2022 BEC2022Heimler SR, Phang HJ, Bergstrom J, Mahapatra G, Dozier S, Gnaiger E, Molina AJA (2022) Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older adult women. Bioenerg Commun 2022.2. https://doi.org/10.26124/bec:2022-0002OXPHOS
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Permeabilized cellsHumanBlood cells
Arbon 2022 Antimicrob Agents Chemother2022Arbon D, Ženíšková K, Šubrtová K, Mach J, Štursa J, Machado M, Zahedifard F, Leštinová T, Hierro-Yap C, Neuzil J, Volf P, Ganter M, Zoltner M, Zíková A, Werner L, Sutak R (2022) Repurposing of MitoTam: Novel anti-cancer drug candidate exhibits potent activity against major protozoan and fungal pathogens. https://doi.org/10.1128/aac.00727-22GpIntact cellsProtists
O'Hanlon 2022 Neurobiol Dis2022O'Hanlon ME, Tweedy C, Scialo F, Bass R, Sanz A, Smulders-Srinivasan TK (2022) Mitochondrial electron transport chain defects modify Parkinson's disease phenotypes in a Drosophila model. https://doi.org/10.1016/j.nbd.2022.105803LEAK
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HomogenateDrosophila
Fuertes-Agudo 2022 Antioxidants (Basel)2022Fuertes-Agudo M, Luque-Tévar M, Cucarella C, Brea R, Boscá L, Quintana-Cabrera R, Martín-Sanz P, Casado M (2022) COX-2 expression in hepatocytes improves mitochondrial function after hepatic ischemia-reperfusion injury.OXPHOS
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Isolated mitochondriaMouseLiver
Chojnacka 2022 Mol Biol Cell2022Chojnacka KJ, Elancheliyan P, Mussulini BHM, Mohanraj K, Callegari S, Gosk A, Banach T, Góral T, Szczepanowska K, Rehling P, Serwa RA, Chacinska A (2022) Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel complex III-specific assembly factor in mitochondria. https://doi.org/10.1091/mbc.e21-03-0143LEAK
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HumanHEK
Alencar 2022 BEC2022Alencar MB, Ramos EV, Silber AM, Zíková A, Oliveira MF (2022) The extraordinary energy metabolism of the bloodstream Trypanosoma brucei forms: a critical review and hypothesis. Bioenerg Commun 2022.17. https://doi.org/10.26124/bec:2022-0017GpProtists
Fernandez-Vizarra 2022 Cell Metab2022Fernández-Vizarra E, López-Calcerrada S, Sierra-Magro A, Pérez-Pérez R, Formosa LE, Hock DH, Illescas M, Peñas A, Brischigliaro M, Ding S, Fearnley IM, Tzoulis C, Pitceathly RDS, Arenas J, Martín MA, Stroud DA, Zeviani M, Ryan MT, Ugalde C (2022) Two independent respiratory chains adapt OXPHOS performance to glycolytic switch. https://doi.org/10.1016/j.cmet.2022.09.005LEAK
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Intact cells
HumanHEK
Horvath 2022 Antioxidants (Basel)2022Horváth G, Sváb G, Komlódi T, Ravasz D, Kacsó G, Doczi J, Chinopoulos C, Ambrus A, Tretter L (2022) Reverse and forward electron flow-induced H2O2 formation is decreased in α-ketoglutarate dehydrogenase (α-KGDH) subunit (E2 or E3) heterozygote knock out animals. https://doi.org/10.3390/antiox11081487S
Gp
Isolated mitochondriaMouseNervous system
Rai 2022 G3 (Bethesda)2022Rai M, Carter SM, Shefali SA, Mahmoudzadeh NH, Pepin R, Tennessen JM (2022) The Drosophila melanogaster enzyme glycerol-3-phosphate dehydrogenase 1 is required for oogenesis, embryonic development, and amino acid homeostasis. G3 (Bethesda) 12:jkac115. https://doi.org/10.1093/g3journal/jkac115GpDrosophila
Schmidt 2021 Cancer Metab2021Schmidt CA, McLaughlin KL, Boykov IN, Mojalagbe R, Ranganathan A, Buddo KA, Lin CT, Fisher-Wellman KH, Neufer PD (2021) Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells. Cancer Metab 9:3.LEAK
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Isolated mitochondriaHumanLiver
Rodriguez 2021 Front Genet2021Rodríguez E, Grover Thomas F, Camus MF, Lane N (2021) Mitonuclear interactions produce diverging responses to mild stress in Drosophila Larvae. Front Genet 12:734255. https://doi.org/10.3389/fgene.2021.734255ET
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Permeabilized tissueDrosophilaOther cell lines
Hierro-Yap 2021 J Biol Chem2021Hierro-Yap C, Šubrtová K, Gahura O, Panicucci B, Dewar C, Chinopoulos C, Schnaufer A, Zíková A (2021) Bioenergetic consequences of FoF1-ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei. J Biol Chem 296:100357.Gp
CIV
Permeabilized cells
Intact cells
Protists
Wall 2021 Dis Model Mech2021Wall JM, Basu A, Zunica ERM, Dubuisson OS, Pergola K, Broussard JP, Kirwan JP, Axelrod CL, Johnson AE (2021) CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases. Dis Model Mech 14:dmm048603.LEAK
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Permeabilized tissueDrosophilaSkeletal muscle
Antico 2021 Sci Adv2021Antico O, Ordureau A, Stevens M, Singh F, Nirujogi RS, Gierlinski M, Barini E, Rickwood ML, Prescott A, Toth R, Ganley IG, Harper JW, Muqit MMK (2021) Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1. Sci Adv 7:eabj0722.LEAK
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Intact cellsMouseNervous system
Fischer 2021 Antioxidants2021Fischer C, Volani C, Komlódi T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron overload and Hfe-/- related hemochromatosis alter hepatic mitochondrial function. Antioxidants 10:1818. https://doi.org/10.3390/antiox10111818LEAK
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MouseLiver
Palacka 2021 Int J Mol Sci2021Palacka P, Gvozdjáková A, Rausová Z, Kucharská J, Slopovský J, Obertová J, Furka D, Furka S, Singh KK, Sumbalová Z (2021) Platelet mitochondrial bioenergetics reprogramming in patients with urothelial carcinoma. https://doi.org/10.3390/ijms23010388LEAK
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HumanPlatelet
Peruzzotti-Jametti 2021 PLoS Biol2021Peruzzotti-Jametti L, Bernstock JD, Willis CM, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Krzak G, Kittel A, Beninca C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Peacock B, Muller KH, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2021) Neural stem cells traffic functional mitochondria via extracellular vesicles. PLoS Biol 19:3001166.LEAK
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Permeabilized cellsMouseNervous system
Stem cells
MiPNet21.17 BloodCellsIsolation2020-10-22
O2k-Protocols
O2k-Protocols: Isolation of blood cells for HRR.
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HumanBlood cells
Platelet
Zussman 2020 J Autoimmun2020Zussman R, Xu LY, Damani T, Groom KM, Chen Q, Seers B, Viall CA, Chamley LW, Hickey A (2020) Antiphospholipid antibodies can specifically target placental mitochondria and induce ROS production. J Autoimmun 111:102437.LEAK
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Permeabilized tissueHumanGenital
Hayes 2020 Nutrients2020Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan CJ, Tuorto F, Nolan DP, Kelly VP (2020) Queuine micronutrient deficiency promotes Warburg metabolism and reversal of the mitochondrial ATP synthase in HeLa cells. Nutrients 12:E871.LEAK
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HumanHeLa
Stepanova 2020 Methods Cell Biol2020Stepanova A, Galkin A (2020) Measurement of mitochondrial H2O2 production under varying O2 tensions. https://doi.org/10.1016/bs.mcb.2019.12.008LEAK
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Isolated mitochondriaMouseNervous system
MitoEAGLE blood cells 12020Åsander Frostner Eleonor*, Aburel Oana M*, Avram Vlad F*, Calabria Elisa, Castelo Rueda Maria Paulina*, Chamkha Imen*, Čižmárová Beata, Danila Maria-Daniela*, Doerrier Carolina*, Eckert Gunter P*, Ehinger Johannes K, Elmer Eskil*, Garcia-Souza Luiz F*, Gnaiger Erich*, Hoppel Florian*, Karabatsiakis Alexander*, Keppner Gloria, Kidere Dita*, Krako Jakovljević Nina, Labieniec-Watala Magdalena*, Lelcu Theia*, Micankova Petra, Michalak Slawomir*, Molina Anthony JA*, Pavlovic Kasja, Pichler Irene*, Piel Sarah, Rousar Tomas, Rybacka-Mossakowska Joanna, Schartner Melanie, Siewiera Karolina*, Silaidos Carmina*, Sjövall Fredrik*, Sobotka Ondrej*, Sumbalova Zuzana*, Swiniuch Daria, Vernerova Andrea*, Volani Chiara*, Vujacic-Mirski Ksenija*, Watala Cezary* (2020) Interlaboratory guide to mitochondrial respiratory studies with peripheral blood mononuclear cells and platelets. - Updated: 2020-03-06 - *ConfirmedLEAK
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Peruzzotti-Jametti 2020 bioRxiv2020Peruzzotti-Jametti L, Bernstock JD, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Kittel A, Benincá C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2020) Neural stem cells traffic functional mitochondria via extracellular vesicles to correct mitochondrial dysfunction in target cells. bioRxiv doi: https://doi.org/10.1101/2020.01.29.923441 .LEAKN
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Permeabilized cellsMouseStem cells
Szibor 2020 J Biol Chem2020Szibor Marten, Gizatullina Zemfira, Gainutdinov Timur, Endres Thomas, Debska-Vielhaber Grazyna, Kunz Matthias, Karavasili Niki, Hallmann Kerstin, Schreiber Frank, Bamberger Alexandra, Schwarzer Michael, Doenst Torsten, Heinze Hans-Jochen, Leßmann Volkmar, Vielhaber Stefan, Kunz Wolfram S, Gellerich Frank Norbert (2020) Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply. J Biol Chem 295:4383-97.LEAK
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MouseNervous system
Frambach 2020 Biochim Biophys Acta Mol Basis Dis2020Frambach SJCM, van de Wal MAE, van den Broek PHH, Smeitink JAM, Russel FGM, de Haas R, Schirris TJJ (2020) Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165727.LEAK
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Permeabilized tissueMouseSkeletal muscle
Pajuelo-Reguera 2020 Cells2020Pajuelo Reguera David, Čunátová Kristýna, Vrbacký Marek, Pecinová Alena, Houštěk Josef, Mráček Tomáš, Pecina Petr (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:E443.OXPHOS
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Oxidase;biochemical oxidation
HumanHEK
Stankova 2020 Int J Mol Sci2020Staňková P, Kučera O, Peterová E, Lotková H, Maseko TE, Nožičková K, Červinková Z (2020) Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease. Int J Mol Sci 21:E1101.LEAK
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HomogenateMouseLiver
De-Souza 2020 J Biol Chem2020De-Souza EA, Pimentel FSA, De-Queiroz ALFV, Camara H, Felix-Formiga ML, Machado CM, Pinto S, Galina A, Mori MA, Montero-Lomelí M, Masuda CA (2020) The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. J Biol Chem 295:3773-82.LEAK
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Isolated mitochondria
Intact cells
Caenorhabditis elegans
Saccharomyces cerevisiae
Friederich-Persson 2020 Am J Physiol Renal Physiol2020Friederich-Persson M, Persson P (2020) Mitochondrial angiotensin II receptors regulate oxygen consumption in kidney mitochondria from healthy and type 1 diabetic rats. Am J Physiol Renal Physiol 318:F683-88.LEAK
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Isolated mitochondriaRatKidney
Rodriguez 2020 J Gerontol A Biol Sci Med Sci2020Rodríguez E, Hakkou M, Hagen TM, Lemieux H, Blier PU (2020) Divergences in the control of mitochondrial respiration are associated with lifespan variation in marine bivalves. J Gerontol A Biol Sci Med Sci 76:796-804.LEAK
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Isolated mitochondriaMolluscs
BEC 2020.1 doi10.26124bec2020-0001.v12020Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1LEAK
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Isolated mitochondria
Gnaiger 2020 BEC MitoPathways2020Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002LEAK
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Human
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Fibroblast
Contreras Mostazo 2020 Cancers (Basel)2020Mostazo MGC, Kurrle N, Casado M, Fuhrmann D, Alshamleh I, Häupl B, Martín-Sanz P, Brüne B, Serve H, Schwalbe H, Schnütgen F, Marin S, Cascante M (2020) Metabolic plasticity is an essential requirement of acquired tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Cancers (Basel) 12:E3443.LEAK
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HumanBlood cells
McLaughlin 2020b Sci Rep2020McLaughlin KL, Hagen JT, Coalson HS, Nelson MAM, Kew KA, Wooten AR, Fisher-Wellman KH (2020) Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs. Sci Rep 10:17599.LEAK
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Isolated mitochondriaMouseHeart
Liver
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Fat
Simard 2020b Metabolites2020Simard CJ, Touaibia M, Allain EP, Hebert-Chatelain E, Pichaud N (2020) Role of the mitochondrial pyruvate carrier in the occurrence of metabolic inflexibility in Drosophila melanogaster exposed to dietary sucrose. Metabolites 10:E411.LEAK
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ROX
Permeabilized tissueDrosophila
Simard 2020 Metabolites2020Simard C, Lebel A, Allain EP, Touaibia M, Hebert-Chatelain E, Pichaud N (2020) Metabolic characterization and consequences of mitochondrial pyruvate carrier deficiency in Drosophila melanogaster. Metabolites 109:E363.LEAK
OXPHOS
ET
N
S
Gp
NS
ROX
Permeabilized tissueDrosophila
Pajuelo 2020 Cells2020Pajuelo Reguera D, Čunátová K, Vrbacký M, Pecinová A, Houštěk J, Mráček T, Pecina P (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:443.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cellsHumanHEK
Lin 2020 Preprints2020Lin M, Fu T, Hsu C, Huang S, Lin Y, Wang J (2020) Cycling exercise training enhances mitochondrial bioenergetics of platelets in patients with peripheral arterial disease: a randomized controlled trial. Preprints 2020070567.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Dawid 2020 Biochim Biophys Acta Bioenerg2020Dawid C, Weber D, Musiol E, Janas V, Baur S, Lang R, Fromme T (2020) Comparative assessment of purified saponins as permeabilization agents during respirometry. Biochim Biophys Acta Bioenerg 1861:148251.LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
NS
ROX
Permeabilized cells
Isolated mitochondria
Intact cells
Human
Mouse
Nervous system
HEK
Politis-Barber 2020 Am J Physiol Endocrinol Metab2020Politis-Barber V, Brunetta HS, Paglialunga S, Petrick HL, Holloway GP (2020) Long-term high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration. Am J Physiol Endocrinol Metab 319:E376-87.LEAK
OXPHOS
F
N
Gp
NS
Permeabilized cellsMouseFat
Dolezelova 2020 PLoS Biol2020Doleželová E, Kunzová M, Dejung M, Levin M, Panicucci B, Regnault C, Janzen CJ, Barrett MP, Butter F, Zíková A (2020) Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei. PLoS Biol 18:e3000741.LEAK
ROUTINE
S
Gp
CIV
Permeabilized cells
Intact cells
Protists
Coppin 2020 Cell Death Dis2020Coppin L, Jannin A, Ait Yahya E, Thuillier C, Villenet C, Tardivel M, Bongiovanni A, Gaston C, de Beco S, Barois N, van Seuningen I, Durand E, Bonnefond A, Vienne JC, Vamecq J, Figeac M, Vincent A, Delacour D, Porchet N, Pigny P (2020) Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface. Cell Death Dis 11:360.LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanIslet cell;pancreas;thymus
Endothelial;epithelial;mesothelial cell
Cormier 2019 Sci Rep2019Cormier RPJ, Champigny CM, Simard CJ, St-Coeur PD, Pichaud N (2019) Dynamic mitochondrial responses to a high-fat diet in Drosophila melanogaster. Sci Rep 9:4531.LEAK
OXPHOS
ET
N
Gp
NS
ROX
CIV
Permeabilized tissueDrosophilaSkeletal muscle
Gaviraghi 2019 Anal Biochem2019Gaviraghi A, Oliveira MF (2019) A method for assessing mitochondrial physiology using mechanically permeabilized flight muscle of Aedes aegypti mosquitoes. Anal Biochem 576:33-41.LEAK
OXPHOS
ET
N
Gp
CIV
ROX
Permeabilized tissueHexapodsSkeletal muscle
De-Souza-Ferreira 2019 J Neurochem2019de-Souza-Ferreira E, Rios-Neto IM, Martins EL, Galina A (2019) Mitochondria-coupled glucose phosphorylation develops after birth to modulate H2O2 release and calcium handling in rat brain. J Neurochem 149:624-40.LEAK
OXPHOS
ET
N
Gp
CIV
NS
Isolated mitochondriaRatNervous system
Pichaud 2019 Front Genet2019Pichaud N, Bérubé R, Côté G, Belzile C, Dufresne F, Morrow G, Tanguay RM, Rand DM, Blier PU (2019) Age dependent dysfunction of mitochondrial and ROS metabolism induced by mitonuclear mismatch. Front Genet 10:130.LEAK
OXPHOS
ET
N
Gp
CIV
ROX
Permeabilized tissueDrosophilaSkeletal muscle
Bettinazzi 2019 Cryobiology2019Bettinazzi S, Gendron AD, Breton S (2019) The effect of cryopreservation on mitochondrial function in freshwater mussel tissue samples (Bivalvia: Unionida). Cryobiology 88:106-109.LEAK
OXPHOS
ET
N
Gp
CIV
NS
ROX
S
Other combinations
Permeabilized tissueMolluscsLung;gill
Robinson 2019 Am J Physiol Cell Physiol2019Robinson MM, Sather BK, Burney ER, Ehrlicher SE, Stierwalt HD, Franco MC, Newsom SA (2019) Robust intrinsic differences in mitochondrial respiration and H2O2 emission between L6 and C2C12 cells. Am J Physiol Cell Physiol 317:C339-C347.LEAK
OXPHOS
ET
F
N
S
Gp
NS
Other combinations
ROX
Permeabilized cellsMouse
Rat
Skeletal muscle
Silva Ramos 2019 PLoS Genet2019Silva Ramos E, Motori E, Brüser C, Kühl I, Yeroslaviz A, Ruzzenente B, Kauppila JHK, Busch JD, Hultenby K, Habermann BH, Jakobs S, Larsson NG, Mourier A (2019) Mitochondrial fusion is required for regulation of mitochondrial DNA replication. PLoS Genet 15:e1008085.LEAK
OXPHOS
ET
N
S
Gp
Permeabilized cells
Isolated mitochondria
MouseHeart
Fibroblast
Bahhir 2019 PLoS Genet2019Bahhir D, Yalgin C, Ots L, Jaervinen S, George J, Naudi A, Krama T, Krams I, Tamm M, Andjelkovic A, Dufour E, Gonzalez de Cozar JM, Gerards M, Parhiala M, Pamplona R, Jacobs HT, Joers P (2019) Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms. PLoS Genet 15:e1008410.LEAK
OXPHOS
N
Gp
CIV
ROX
HomogenateDrosophila
Gonzalez-Armenta 2019 J Nutr2019Gonzalez-Armenta JL, Gao Z, Appt SE, Vitolins MZ, Michalson KT, Register TC, Shively CA, Molina AJA (2019) Skeletal muscle mitochondrial respiration is elevated in female cynomolgus macaques fed a western compared with a mediterranean diet. J Nutr 149:1493-502.LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Permeabilized tissueOther mammalsSkeletal muscle
Hsu 2019 J Clin Med2019Hsu CC, Tsai HH, Fu TC, Wang JS (2019) Exercise training enhances platelet mitochondrial bioenergetics in stroke patients: a randomized controlled trial. J Clin Med 8:E2186.LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Permeabilized cellsHumanPlatelet
Blood cells
Tiebe 2019 Sci Rep2019Tiebe M, Lutz M, Senyilmaz Tiebe D, Teleman AA (2019) Crebl2 regulates cell metabolism in muscle and liver cells. Sci Rep 9:19869.LEAK
OXPHOS
ROUTINE
F
N
Gp
ROX
Permeabilized cells
Intact cells
MouseSkeletal muscle
Liver
Electron-transfer-pathway state2019Gnaiger E (2019) ET-pathway states. Mitochondr Physiol Network 2019-06-11 (last edit since 2016-11-08).LEAK
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
SMP
Bettinazzi 2019 Proc Biol Sci2019Bettinazzi S, Rodríguez E, Milani L, Blier PU, Breton S (2019) Metabolic remodelling associated with mtDNA: insights into the adaptive value of doubly uniparental inheritance of mitochondria. Proc Biol Sci 286:20182708.LEAK
OXPHOS
ET
N
Gp
CIV
NS
ROX
Permeabilized cellsMolluscsLung;gill
Genital
Fisher-Wellman 2019 Cell Rep2019Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM (2019) Respiratory phenomics across multiple models of protein hyperacylation in cardiac mitochondria reveals a marginal impact on bioenergetics. Cell Rep 26:1557-72.LEAK
OXPHOS
ET
F
N
S
Gp
Isolated mitochondriaMouseHeart
Skeletal muscle
Hedges 2019 Comp Biochem Physiol A Mol Integr Physiol2019Hedges CP, Wilkinson RT, Devaux JBL, Hickey AJR (2019) Hymenoptera flight muscle mitochondrial function: Increasing metabolic power increases oxidative stress. Comp Biochem Physiol A Mol Integr Physiol 230:115-21.OXPHOS
ET
LEAK
N
S
Gp
CIV
NS
ROX
Permeabilized tissueOther invertebratesSkeletal muscle
Douros 2019 JCI Insight2019Douros JD, Niu J, Sdao SM, Gregg T, Fisher-Wellman KH, Bharadwaj MS, Molina A, Arumugam R, Martin MD, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell JE, D'Alessio D (2019) Sleeve gastrectomy rapidly enhances islet function independently of body weight. JCI Insight 4:126688.LEAK
OXPHOS
ET
N
Gp
NS
Permeabilized tissueMouseIslet cell;pancreas;thymus
MiPNet21.06 SUIT RP2018-06-25
O2k-Protocols
SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.
LEAK
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Jang 2018 Intensive Care Med Exp2018Jang DH, MD, Khatri UG, Shortal BP, Kelly M, Lambert DS, Hardy K, Eckmann DM (2018) Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive Care Med Exp 6:4.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cellsHumanBlood cells
Allard 2018 J Clin Endocrinol Metab2018Allard NAE, Schirris TJJ, Verheggen RJ, Russel FGM, Rodenburg RJ, Smeitink JAM, Thompson PD, Hopman MTE, Timmers S (2018) Statins affect skeletal muscle performance: evidence for disturbances in energy metabolism. J Clin Endocrinol Metab 103:75-84.OXPHOSF
N
S
Gp
CIV
NS
Permeabilized tissueHumanSkeletal muscle
Simard 2018 J Vis Exp2018Simard CJ, Pelletier G, Boudreau LH, Hebert-Chatelain E, Pichaud N (2018) Measurement of mitochondrial oxygen consumption in permeabilized fibers of Drosophila using minimal amounts of tissue. J Vis Exp 134.LEAK
OXPHOS
N
Gp
CIV
NS
ROX
Permeabilized tissueDrosophila
Lal 2018 Springer2018Lal MA (2018) Respiration. In: Bhatla SC, Lal MA (eds) Plant physiology, development and metabolism. Springer, Singapore:253-314. https://doi.org/10.1007/978-981-13-2023-1_7S
Gp
Jang 2018 J Med Toxicol2018Jang DH, Khatri UG, Mudan A, Love JS, Owiredu S, Eckmann DM (2018) Translational application of measuring mitochondrial functions in blood cells obtained from patients with acute poisoning. J Med Toxicol 14:144-51.LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Oemer 2018 Proc Nat Acad Sci U S A2018Oemer G, Lackner L, Muigg K, Krumschnabel G, Watschinger K, Sailer S, Lindner H, Gnaiger E, Wortmann SB, Werner ER, Zschocke J, Keller MA (2018) The molecular structural diversity of mitochondrial cardiolipins. Proc Nat Acad Sci U S A 115:4158-63. https://doi.org/10.1073/pnas.1719407115LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanHeLa
Doerrier 2018 Methods Mol Biol2018Doerrier C, Garcia-Souza LF, Krumschnabel G, Wohlfarter Y, Mészáros AT, Gnaiger E (2018) High-Resolution FluoRespirometry and OXPHOS protocols for human cells, permeabilized fibers from small biopsies of muscle, and isolated mitochondria. Methods Mol Biol 1782:31-70. https://doi.org/10.1007/978-1-4939-7831-1_3LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Intact cells
Human
Mouse
Rat
Saccharomyces cerevisiae
Heart
Skeletal muscle
Endothelial;epithelial;mesothelial cell
Blood cells
HEK
Platelet
Perks 2018 Cell Rep2018Perks KL, Rossetti G, Kuznetsova I, Hughes LA, Ermer JA, Ferreira N, Busch JD, Rudler DL, Spahr H, Schöndorf T, Shearwood AJ, Viola HM, Siira SJ, Hool LC, Milenkovic D, Larsson NG, Rackham O, Filipovska A (2018) PTCD1 is required for 16S rRNA maturation complex stability and mitochondrial ribosome assembly. Cell Rep 23:127-42.LEAK
OXPHOS
ET
N
Gp
S
Isolated mitochondriaMouseHeart
Monaco 2018b Diabetologia2018Monaco CMF, Hughes MC, Ramos SV, Varah NE, Lamberz C, Rahman FA, McGlory C, Tarnopolsky MA, Krause MP, Laham R, Hawke TJ, Perry CGR (2018) Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes. Diabetologia 61:1411-23.OXPHOSN
S
Gp
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Boutoual 2018 Scientific Reports2018Boutoual, R., Meseguer, S., Villarroya, M., Martin-Hernandez, E., Errami, M., Martin, M. A., Casado, M., and Armengod, M. E. (2018) Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARgamma-UCP2-AMPK axis. Scientific reports 8, 1163LEAK
ROUTINE
OXPHOS
ET
F
S
Gp
Permeabilized cells
Intact cells
HumanOther cell lines
Fibroblast
Clarke 2018 Methods Mol Biol2018Clarke KJ, Porter RK (2018) The importance of calcium ions for determining mitochondrial glycerol-3-phosphate dehydrogenase activity when measuring uncoupling protein 1 (UCP1) function in mitochondria isolated from brown adipose tissue. Methods Mol Biol 1782:325-36.LEAKS
Gp
Isolated mitochondriaRatFat
Burney 2018 Thesis2018Burney E (2018) Characterization of mitochondrial metabolism in L6 rat myoblasts. Bachelor's Thesis p50.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
NS
Other combinations
ROX
Permeabilized cells
Intact cells
RatOther cell lines
Komlodi 2018 J Bioenerg Biomembr2018Komlódi T, Geibl FF, Sassani M, Ambrus A, Tretter L (2018) Membrane potential and delta pH dependency of reverse electron transport-associated hydrogen peroxide production in brain and heart mitochondria. J Bioenerg Biomembr 50:355-365LEAKS
Gp
Isolated mitochondriaGuinea pigHeart
Nervous system
Mahapatra 2018 Clin Sci (Lond)2018Mahapatra G, Smith SC, Hughes TM, Wagner B, Maldjian JA, Freedman BI, Molina AJA (2018) Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes. Clin Sci (Lond) 132:2509-18. https://doi.org/10.1042/CS20180690LEAK
OXPHOS
ET
F
N
S
Gp
NS
Other combinations
ROX
Permeabilized cellsHumanNervous system
Blood cells
Champigny 2018 Mar Drugs2018Champigny CM, Cormier RPJ, Simard CJ, St-Coeur PD, Fortin S, Pichaud N (2018) Omega-3 monoacylglyceride effects on longevity, mitochondrial metabolism and oxidative stress: insights from Drosophila melanogaster. Mar Drugs 16:E453.LEAK
OXPHOS
ET
N
S
NS
ROX
Gp
Permeabilized tissueDrosophila
Lobo-Jarne 2018 Cell Rep2018Lobo-Jarne T, Nývltová E, Pérez-Pérez R, Timón-Gómez A, Molinié T, Choi A, Mourier A, Fontanesi F, Ugalde C, Barrientos A (2018) Human COX7A2L regulates complex III biogenesis and promotes supercomplex organization remodeling without affecting mitochondrial bioenergetics. Cell Rep 25:1786-99.LEAK
OXPHOS
ET
N
S
NS
ROX
Gp
Permeabilized cellsHumanHEK
Other cell lines
Thompson 2018 EMBO Mol Med2018Thompson K, Mai N, Oláhová M, Scialó F, Formosa LE, Stroud DA, Garrett M, Lax NZ, Robertson FM, Jou C, Nascimento A, Ortez C, Jimenez-Mallebrera C, Hardy SA, He L, Brown GK, Marttinen P, McFarland R, Sanz A, Battersby BJ, Bonnen PE, Ryan MT, Chrzanowska-Lightowlers ZM, Lightowlers RN, Taylor RW (2018) OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect. EMBO Mol Med 10:e9060.LEAK
OXPHOS
N
CIV
ROX
Gp
Other combinations
HomogenateDrosophila
Efimova 2018 Thesis2018Efimova I (2018) Structural composition and functional properties of mitochondrial FoF1 ATP synthase on models of specific subunits deficiencies. PhD Thesis 94.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cellsHumanHEK
Stepanova 2018 J Neurochem2018Stepanova A, Konrad C, Manfredi G, Springett R, Ten V, Galkin A (2018) The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A. J Neurochem 148:731-45.LEAK
OXPHOS
N
S
Gp
NS
ROX
Isolated mitochondriaMouseNervous system
Chretien 2017 bioRxiv2017Chretien D, Benit P, Ha HH, Keipert S, El-Khoury R, Chang YT, Jastroch M, Jacobs H, Rustin P, Rak M (2017) Mitochondria are physiologically maintained at close to 50 C. bioRxiv doi: https://doi.org/10.1101/133223 .OXPHOSGpPermeabilized cellsHEK
Categories of SUIT protocols2017Gnaiger E (2017) Categories of SUIT protocols and ETS pathway control states. MiPNet 2017-03-12; original 2016-03-20; edited 2016-08-21.F
N
S
Gp
CIV
NS
Other combinations
ROX
Jeong 2017 Exp Mol Med2017Jeong JH, Cheol Kang Y, Piao Y, Kang S, Pak YK (2017) miR-24-mediated knockdown of H2AX damages mitochondria and the insulin signaling pathway. Exp Mol Med 49:e313.OXPHOSN
S
Gp
CIV
ROX
Permeabilized cellsHumanLiver
Pecinova 2017 Oxid Med Cell Longev2017Pecinova A, Drahota Z, Kovalcikova J, Kovarova N, Pecina P, Alan L, Zima M, Houstek J, Mracek T (2017) Pleiotropic effects of biguanides on mitochondrial reactive oxygen species production. Oxid Med Cell Longev 7038603.LEAK
OXPHOS
ET
N
S
Gp
NS
Isolated mitochondriaRatFat
Rana 2017 Nat Commun2017Rana A, Oliveira MP, Khamoui AV, Aparicio R, Rera M, Rossiter HB, Walker DW (2017) Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster. https://doi.org/10.1038/s41467-017-00525-4OXPHOSN
Gp
NS
Drosophila
Kake-Guena 2017 J Therm Biol2017Kake-Guena SA, Touisse K, Warren BE, Scott KY, Blier PU, Lemieux H (2017) Temperature-related differences in mitochondrial function among clones of the cladoceran Daphnia pulex. J Therm Biol 69:23-31.LEAK
OXPHOS
S
Gp
CIV
NS
ROX
Permeabilized tissueCrustaceans
Schreiber 2017 Cell Metab2017Schreiber R, Diwoky C, Schoiswohl G, Feiler U, Wongsiriroj N, Abdellatif M, Kolb D, Hoeks J, Kershaw EE, Sedej S, Schrauwen P, Haemmerle G, Zechner R (2017) Cold-induced thermogenesis depends on ATGL-mediated lipolysis in cardiac muscle, but not brown adipose tissue. Cell Metab 26:753-63.LEAKN
Gp
HomogenateMouseFat
Cavalcanti-de-Albuquerque 2017 Mol Neurobiol2017Cavalcanti-de-Albuquerque JP, de Souza Ferreira E, de Carvalho DP, Galina A (2017) Mitochondria-bound hexokinase (mt-HK) activity differ in cortical and hypothalamic synaptosomes: differential role of mt-HK in H2O2 depuration. Mol Neurobiol 55:5889-5900.LEAK
OXPHOS
N
S
Gp
ROX
Intact cellsRatNervous system
Permer 2017 Bachelor Thesis2017Permer M (2017) Respirometrische Charakterisierung kryopräservierter HEK 239T Zellen. Bachelor Thesis 1-56.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanOther cell lines
HEK
Comelli 2017 J Bioenerg Biomembr2017Comelli M, Pretis I, Buso A, Mavelli I (2017) Mitochondrial energy metabolism and signalling in human glioblastoma cell lines with different PTEN gene status. J Bioenerg Biomembr 50:33-52.LEAK
ROUTINE
OXPHOS
ET
N
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanNervous system
Masson 2017 Sci Rep2017Masson SWC, Hedges CP, Devaux JBL, James CS, Hickey AJR (2017) Mitochondrial glycerol 3-phosphate facilitates bumblebee pre-flight thermogenesis. Sci Rep 7:13107.OXPHOS
ET
N
Gp
NS
Permeabilized tissueHexapodsSkeletal muscle
MiPNet21.07 MitoFit DatLab PT2016-07-20
O2k-Protocols
MitoFit DatLab proficiency test.
LEAK
OXPHOS
ET
F
N
S
Gp
CIV
Other combinations
ROX
Permeabilized cellsHuman
Teulier 2016 Proc Biol Sci2016Teulier L, Weber JM, Crevier J, Darveau CA (2016) Proline as a fuel for insect flight: enhancing carbohydrate oxidation in hymenopterans. Proc Biol Sci 283: 20160333.OXPHOSF
N
S
Gp
NS
Other combinations
ROX
Permeabilized tissueHexapodsSkeletal muscle
Wolff 2016 J Evol Biol2016Wolff JN, Pichaud N, Camus MF, Côté G, Blier PU, Dowling DK (2016) Evolutionary implications of mitochondrial genetic variation: mitochondrial genetic effects on OXPHOS respiration and mitochondrial quantity change with age and sex in fruit flies. J Evol Biol 29:736-47.LEAK
OXPHOS
ET
N
Gp
CIV
Other combinations
ROX
Permeabilized tissueDrosophilaSkeletal muscle
Hartmannova 2016 Hum Mol Genet2016Hartmannová H, Piherová L, Tauchmannová K, Kidd K, Acott PD, Crocker JF, Oussedik Y, Mallet M, Hodaňová K, Stránecký V, Přistoupilová A, Barešová V, Jedličková I, Živná M, Sovová J, Hůlková H, Robins V, Vrbacký M, Pecina P, Kaplanová V, Houštěk J, Mráček T, Thibeault Y, Bleyer AJ, Kmoch S (2016) Acadian variant of Fanconi syndrome is caused by mitochondrial respiratory chain complex I deficiency due to a non-coding mutation in complex I assembly factor NDUFAF6. Hum Mol Genet 25:4062-79.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cellsHumanFibroblast
Newell 2016 Physiol Entomol2016Newell C, Kane CL, Kane DC (2016) Mitochondrial substrate specificity in beetle flight muscle: assessing respiratory oxygen flux in small samples from Dermestes maculatus and Tenebrio molitor. Physiol Entomol p7.OXPHOSF
N
Gp
Other combinations
Permeabilized tissueHexapodsSkeletal muscle
Scialo 2016 Cell Metab2016Scialò F, Sriram A, Fernández-Ayala D, Gubina N, Lõhmus M, Nelson G, Logan A, Cooper HM, Navas P, Enríquez JA, Murphy MP, Sanz A (2016) Mitochondrial ROS produced via reverse electron transport extend animal lifespan. Cell Metab 23:725-34.LEAK
OXPHOS
N
Gp
CIV
Other combinations
ROX
HomogenateDrosophila
Silva Ramos 2016 Biochim Biophys Acta2016Silva Ramos E, Larsson NG, Mourier A (2016) Bioenergetic roles of mitochondrial fusion. Biochim Biophys Acta 1857:1277-83.LEAK
OXPHOS
ET
S
Gp
Permeabilized cellsMouseFibroblast
Lark 2016 Am J Physiol Cell Physiol2016Lark DS, Torres MJ, Lin CT, Ryan TE, Anderson EJ, Neufer PD (2016) Direct real-time quantification of mitochondrial oxidative phosphorylation efficiency in permeabilized skeletal muscle myofibers. Am J Physiol Cell Physiol 311:C239-45.LEAK
OXPHOS
ET
N
Gp
NS
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
Chakraborty 2016 Pancreatology2016Chakraborty M, Hickey AJ, Petrov MS, Macdonald JR, Thompson N, Newby L, Sim D, Windsor JA, Phillips AR (2016) Mitochondrial dysfunction in peripheral blood mononuclear cells in early experimental and clinical acute pancreatitis. Pancreatology 16:739-47.LEAK
OXPHOS
ROUTINE
ET
N
Gp
CIV
NS
ROX
S
Permeabilized cellsHuman
Rat
Blood cells
Scialo 2016 PLOS ONE2016Scialo F, Sriram A, Stefanatos R, Sanz A (2016) Practical recommendations for the use of the GeneSwitch Gal4 system to knock-Down genes in Drosophila melanogaster. PLOS ONE 11:e0161817.LEAK
OXPHOS
N
CIV
Other combinations
ROX
Gp
HomogenateDrosophila
Rovenko 2015 Comp Biochem Physiol A Mol Integr Physiol2015Rovenko BM, Kubrak OI, Gospodaryov DV, Yurkevych IS, Sanz A, Lushchak OV, Lushchak VI (2015) Restriction of glucose and fructose causes mild oxidative stress independently of mitochondrial activity and reactive oxygen species in Drosophila melanogaster. Comp Biochem Physiol A Mol Integr Physiol 187:27-39.OXPHOSN
Gp
CIV
Other combinations
ROX
HomogenateDrosophila
Syrjanen 2015 Front Zool2015Syrjanen L, Valanne S, Kuuslahti M, Tuomela T, Sriram A, Sanz A, Jacobs HT, Ramet M, Parkkila S. (2015) β carbonic anhydrase is required for female fertility in Drosophila melanogaster. Front Zool 12:19.OXPHOSN
Gp
CIV
Other combinations
HomogenateDrosophila
Schirris 2015 Cell Metab2015Schirris TJ, Renkema GH, Ritschel T, Voermans NC, Bilos A, van Engelen BG, Brandt U, Koopman WJ, Beyrath JD, Rodenburg RJ, Willems PH, Smeitink JA, Russel FG (2015) Statin-induced myopathy is associated with mitochondrial complex III inhibition. Cell Metab 22:399-407.ROUTINE
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cellsHuman
Mouse
Skeletal muscle
Other cell lines
Ramos-Filho 2015 PLoS One2015Ramos-Filho D, Chicaybam G, de-Souza-Ferreira E, Guerra Martinez C, Kurtenbach E, Casimiro-Lopes G, Galina A (2015) High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles. PLoS One 10:e0131766.LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Permeabilized tissueRatSkeletal muscle
Soares 2015 PLoS One2015Soares JB, Gaviraghi A, Oliveira MF (2015) Mitochondrial physiology in the major arbovirus vector Aedes aegypti: substrate preferences and sexual differences define respiratory capacity and superoxide production. PLoS One 10:e0120600.LEAK
OXPHOS
ET
N
S
Gp
NS
Other combinations
ROX
Permeabilized tissue
Isolated mitochondria
HexapodsSkeletal muscle
Patil 2015 J Nutr Biochem2015Patil YN, Dille KN, Burk DH, Cortez CC, Gettys TW (2015) Cellular and molecular remodeling of inguinal adipose tissue mitochondria by dietary methionine restriction. J Nutr Biochem 26:1235-47.LEAK
OXPHOS
ET
F
N
S
Gp
ROX
Isolated mitochondriaMouseSkeletal muscle
Liver
Fat
Jiroutkova 2015 Crit Care2015Jiroutková K, Krajčová A, Ziak J, Fric M, Waldauf P, Džupa V, Gojda J, Němcova-Fürstová V, Kovář J, Elkalaf M, Trnka J, Duška F (2015) Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness. Crit Care 19:448.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
Other combinations
ROX
HomogenateHumanSkeletal muscle
Mourier 2015 J Cell Biol2015Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG (2015) Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. J Cell Biol 208:429-42.LEAK
OXPHOS
ET
N
S
Gp
Other combinations
Permeabilized cells
Isolated mitochondria
MouseHeart
Fibroblast
Baggio 2014 Nucleic Acids Res2014Baggio F, Bratic A, Mourier A, Kauppila TE, Tain LS, Kukat C, Habermann B, Partridge L, Larsson NG5 (2014) Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation. Nucleic Acids Res 42:13920-38.LEAK
OXPHOS
ET
N
S
Gp
CIV
Other combinations
Permeabilized tissueDrosophila
Hexapods
Pecina 2014 Biochim Biophys Acta Clinical2014Pecina P, Houstkova H, Mracek T, Pecinova A, Nuskova H.Tesarova M, Hansikova H, Janota J, Zemanc J, Houstek J (2014) Noninvasive diagnostics of mitochondrial disorders in isolated lymphocytes with high resolution respirometry. Biochim Biophys Acta Clinical 2:62–71. https://doi.org/10.1016/j.bbacli.2014.09.003LEAK
OXPHOS
N
Gp
CIV
Other combinations
ROX
Permeabilized cellsHumanBlood cells
Lymphocyte
Tretter 2014 Free Radic Biol Med2014Tretter L, Horvath G, Hölgyesi A, Essek F, Adam-Vizi V (2014) Enhanced hydrogen peroxide generation accompanies the beneficial bioenergetic effects of methylene blue in isolated brain mitochondria. Free Radic Biol Med 77:317-30.LEAK
OXPHOS
N
S
Gp
Isolated mitochondriaGuinea pigNervous system
Ludzki 2014 Thesis2014Ludzki AC (2014) Palmitoyl-CoA inhibition of mitochondrial ADP sensitivity is attenuated by exercise training in human skeletal muscle. Master's Thesis 1-86.LEAK
OXPHOS
F
N
S
Gp
NS
Permeabilized tissueHuman
Mouse
Skeletal muscle
Petruzzelli 2014 Cell Metab2014Petruzzelli M, Schweiger M, Schreiber R, Campos-Olivas R, Tsoli M, Allen J, Swarbrick M, Rose-John S, Rincon M, Robertson G, Zechner R, Wagner EF (2014) A switch from white to brown fat increases energy expenditure in cancer-associated cachexia. Cell Metab 20:433-47.GpMouseFat
Divakaruni 2014 Curr Protoc Toxicol2014Divakaruni AS, Rogers GW, Murphy AN (2014) Measuring mitochondrial function in permeabilized cells using the Seahorse XF Analyzer or a clark-type oxygen electrode. Curr Protoc Toxicol 60:25.2.1-25.2.16.LEAK
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Permeabilized cellsMouseSkeletal muscle
Other cell lines
Gnaiger 2014 MitoPathways2014
O2k-Protocols
Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. Oroboros MiPNet Publications, Innsbruck:80 pp. — see 5th edition: Gnaiger 2020 BEC MitoPathways.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Intact cells
Human
Mouse
Heart
Skeletal muscle
Fibroblast
Cavalcanti-de-Albuquerque 2014 J Appl Physiol2014Cavalcanti-de-Albuquerque JP, Salvador IC, Martins EL, Jardim-Messeder D, Werneck-de-Castro JP, Galina A, Carvalho DP (2014) Role of estrogen on skeletal muscle mitochondrial function in ovariectomized rats: a time course study in different fiber types. J Appl Physiol 116:779-89.LEAK
OXPHOS
F
N
Gp
NS
ROX
Permeabilized tissueRatSkeletal muscle
Enriquez 2014 Mol Syndromol2014Enriquez JA, Lenaz G (2014) Coenzyme Q and the respiratory chain: coenzyme Q pool and mitochondrial supercomplexes. Mol Syndromol 5:119-40.N
S
CIV
Gp
Isolated mitochondria
Kupsch 2014 J Neural Transm2014Kupsch A, Schmidt W, Gizatullina Z, Debska-Vielhaber G, Voges J, Striggow F, Panther P, Schwegler H, Heinze HJ, Vielhaber S, Gellerich FN (2014) 6-Hydroxydopamine impairs mitochondrial function in the rat model of Parkinson's disease: respirometric, histological, and behavioral analyses. J Neural Transm 121:1245-57.LEAK
OXPHOS
N
S
Gp
Permeabilized tissueRatNervous system
Chakraborty 2014 J Cardiovasc Dis2014Chakraborty M, Phillips ARJ, Macdonald J, Windsor JA, Hickey AJR (2014) Mitochondrial respiration in mononuclear cells and heart fibers in spontaneously hypertensive rats. J Cardiovasc Dis ISSN:2330-459.LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
RatHeart
Blood cells
Clarke 2013 Int J Biochem Cell Biol2013Clarke KJ, Porter RK (2013) Uncoupling protein 1 dependent reactive oxygen species production by thymus mitochondria. Int J Biochem Cell Biol 45:81-9.LEAK
ET
N
S
Gp
Isolated mitochondriaRatIslet cell;pancreas;thymus
Wredenberg 2013 PLoS Genet2013Wredenberg A, Lagouge M, Bratic A, Metodiev MD, Spåhr H, Mourier A, Freyer C, Ruzzenente B, Tain L, Grönke S, Baggio F, Kukat C, Kremmer E, Wibom R, Polosa PL, Habermann B, Partridge L, Park CB, Larsson NG (2013) MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals. PLoS Genet 9:e1003178.LEAK
OXPHOS
ET
N
S
Gp
NS
Permeabilized tissueDrosophila
Tretter 2012 Free Radic Biol Med2012Tretter Laszlo, Adam-Vizi Vera (2012) High Ca2+ load promotes hydrogen peroxide generation via activation of α-glycerophosphate dehydrogenase in brain mitochondria. Free Radic Biol Med 53:2119-30.GpIsolated mitochondriaGuinea pigNervous system
Guillet 2011 FASEB J2011Guillet V, Gueguen N, Cartoni R, Chevrollier A, Desquiret V, Angebault C, Amati-Bonneau P, Procaccio V, Bonneau D, Martinou JC, Reynier P (2011) Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation. FASEB J 25:1618-27.LEAK
OXPHOS
ET
N
S
Gp
CIV
ROX
Isolated mitochondriaMouseNervous system
Bratic 2011 PLoS Genet2011Bratic A, Wredenberg A, Grönke S, Stewart JB, Mourier A, Ruzzenente B, Kukat C, Wibom R, Habermann B, Partridge L, Larsson NG (2011) The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster. PLoS Genet 7:e1002324.LEAK
OXPHOS
ET
N
S
Gp
NS
Other combinations
Permeabilized tissueDrosophila
Pichaud 2010 J Exp Biol2010Pichaud N, Chatelain EH, Ballard JWO, Tanguay R, Morrow G, Blier PU (2010)Thermal sensitivity of mitochondrial metabolism in two distinct mitotypes of Drosophila simulans: Evaluation of mitochondrial plasticity. J Exp Biol 213:1665-75.OXPHOS
ET
N
Gp
Isolated mitochondriaDrosophilaSkeletal muscle
Tahara 2009 Free Radic Biol Med2009Tahara EB, Navarete FD, Kowaltowski AJ (2009) Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation. Free Radic Biol Med 46:1283-97.LEAK
ET
OXPHOS
F
N
NS
ROX
S
Gp
Isolated mitochondriaRatHeart
Skeletal muscle
Nervous system
Liver
Kidney
Giulivi 2008 Biochem J2008Giulivi C, Ross-Inta C, Horton AA, Luckhart S (2008) Metabolic pathways in Anopheles stephensi mitochondria. Biochem J 415:309-16.LEAK
OXPHOS
F
N
S
Gp
CIV
Other combinations
ROX
Isolated mitochondriaHuman
Rat
Birds
Hexapods
Skeletal muscle
Gnaiger 2007 MitoPathways2007
O2k-Protocols
Gnaiger E ed (2007) Mitochondrial pathways and respiratory control. 1st ed. Oroboros MiPNet Publications, Innsbruck:96 pp. ISBN 978-3-9502399-0-4. — see 5th edition: Gnaiger 2020 BEC MitoPathways.
F
N
S
Gp
NS
Vrbacky 2007 Biochim Biophys Acta2007Vrbacky M, Drahota Z, Mracek T, Vojtískova A, Jesina P, Stopka P, Houstek J (2007) Respiratory chain components involved in the glycerophosphate dehydrogenase-dependent ROS production by brown adipose tissue mitochondria. Biochim Biophys Acta 1767:989-97.S
Gp
Isolated mitochondriaOther mammalsFat
Ponsot 2005 J Cell Physiol2005Ponsot E, Zoll J, N'guessan B, Ribera F, Lampert E, Richard R, Veksler V, Ventura-Clapier R, Mettauer B (2005) Mitochondrial tissue specificity of substrates utilization in rat cardiac and skeletal muscles. J Cell Physiol 203:479-86.OXPHOSF
N
Gp
Permeabilized tissueRatHeart
Skeletal muscle
Rauchova 2005 Biochem Biophys Res Comm2005Rauchova H, Vrbacky M, Bergamini C, Fato R, Lenaz G, Houstek J, Drahota Z (2005) Inhibition of glycerophosphate-dependent H2O2 generation in brown fat mitochondria by idebenone. Biochem Biophys Res Comm 339:362-6.S
Gp
Other combinations
Chowdhury 2005 Biochem Biophys Res Comm2005Chowdhury SK, Gemin A, Singh G (2005) High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines. Biochem Biophys Res Comm 333:1139-45.LEAK
OXPHOS
ET
GpPermeabilized cellsHumanGenital
Rauchova 2003 Acta Biochim Pol2003Rauchová H, Drahota Z, Rauch P, Fato R, Lenaz G (2003) Coenzyme Q releases the inhibitory effect of free fatty acids on mitochondrial glycerophosphate dehydrogenase. Acta Biochim Pol 50:405-13.N
S
Gp
Other combinations
Isolated mitochondriaOther mammalsFat
Rasmussen 2001 Am J Physiol Endocrinol Metab2001Rasmussen UF, Rasmussen HN, Krustrup P, Quistorff B, Saltin B, Bangsbo J (2001) Aerobic metabolism of human quadriceps muscle: in vivo data parallel measurements on isolated mitochondria. Am J Physiol Endocrinol Metab 280:E301-7.LEAK
OXPHOS
ET
F
N
S
Gp
NS
Isolated mitochondriaHumanSkeletal muscle
Villani 1997 Proc Natl Acad Sci U S A1997Villani G, Attardi G (1997) In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells. Proc Natl Acad Sci U S A 94:1166-71.ROUTINE
ET
OXPHOS
N
S
Gp
ROX
Intact cells
Permeabilized cells
HumanFibroblast
Moyes 1989 J Exp Biol1989Moyes CD, Buck LT, Hochachka PW, Suarez RK (1989) Oxidative properties of carp red and white muscle. J Exp Biol 143:321-31.OXPHOSF
N
Gp
Isolated mitochondriaSkeletal muscle
Klingenberg 1970 Eur J Biochem1970Klingenberg M (1970) Localization of the glycerol-phosphate dehydrogenase in the outer phase of the mitochondrial inner membrane. Eur J Biochem 13:247-52.ETGpIsolated mitochondria


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»Abstracts: Gp-pathway control state
Publications in the MiPMap

Abstracts: Gp-pathway control state

Sort in ascending/descending order by a click on one of the small symbols in squares below.
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Timon-Gomez 2023 EUROMIT2023 Bologna2023
Timon-Gomez Alba
Timon-Gomez A, Cardoso L, Baglivo E, Doerrier C, Gnaiger E (2023) Mitochondrial injury in warm ischemia studied by high-resolution respirometry. EUROMIT2023 International Conference on Mitochondrial Pathology.
OXPHOS
ET
F
N
S
Gp
Homogenate
Isolated mitochondria
Intact cells
Human
Mouse
Heart
Nervous system
HEK
Cecatto 2023 BPS2023 San Diego2023
Sabine Schmitt
Cecatto C, Schmitt Sabine, Cardoso L, Videja M, Dambrova M, Makrecka-Kuka M, Liepinsh E, Gnaiger E (2023) Contribution of fatty acid oxidation to respiratory control in brain mitochondria. 67th Annual Meeting of the Biophysical Society.
OXPHOSF
N
Gp
NS
Permeabilized tissue
Homogenate
MouseHeart
Nervous system
Kidney
Irving 2022 Abstract Bioblast20227.4. «5 min»
Irving Brian
Irving Brian A, Stampley J, Quiriarte H, Wigger Z, Stephens J, Soto P, Allerton TA (2022) Impact of nitric oxide promotors on mitochondrial bioenergetics in a murine model of Alzheimer's disease. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »Watch the presentation«
LEAK
OXPHOS
ET
N
Gp
NS
ROX
Permeabilized tissue
Homogenate
MouseNervous system
Molina 2022 Abstract Bioblast20223.2. «10+5»
Molina Anthony JA
Heimler SR, Phang HJ, Bergstrom J, Mahapatra G, Dozier S, Gnaiger E, Molina Anthony JA (2022) Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older women. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001
»Bioenergetics Communications« »Watch the presentation«
OXPHOS
ET
F
N
S
Gp
ROX
Permeabilized cellsHumanBlood cells
Sumbalova 2019a MiP20192019
Zuzana Sumbalova
Platelet mitochondrial function, coenzyme Q10, and oxidative stress in patients with chronic kidney diseases.
LEAK
OXPHOS
F
N
S
Gp
CIV
NS
ROX
Intact cellsHumanPlatelet
Sumbalova 2019b MiP20192019
Zuzana Sumbalova
The decline of mitochondrial respiration in isolated platelets after short-term storage.
LEAK
OXPHOS
F
N
S
Gp
CIV
NS
ROX
Intact cellsHumanPlatelet
Garcia 2019 MiPschool Coimbra2019
Geovana Garcia
Functional interactions between the Drosophila melanogaster mitochondrial glycerol-3-phosphate dehydrogenase and a xenotopically expressed alternative oxidase.
LEAK
OXPHOS
N
Gp
Drosophila
Komlodi 2018 AussieMit2018Komlodi T, Hunger M, Moore AL, Gnaiger E (2018) Electron transfer at the Q-junction: new perspectives from combined measurement of mitochondrial O2 flux, H2O2 flux, and coenzyme Q redox state. AussieMit 2018 Melbourne AU.LEAK
OXPHOS
S
Gp
Isolated mitochondriaMouseNervous system
Chang 2018 Life Sciences Meeting 2018 Innsbruck AT2018pH dependence of mitochondrial respiration and H2O2 production in oral cancer cells – a pilot study.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cellsHumanHEK
Kidney
Doerrier 2018 ESCI20182018
Carolina Anneliese Doerrier
High-resolution respirometry, two techniques combined in one to explore mitochondrial function in health and disease
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
ROX
CIV
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Skeletal muscle
Nervous system
Blood cells
HEK
Komlodi 2018 EBEC20182018Electron supply to the Q-junction: assessment of mitochondrial respiration, H2O2 flux and the redox state of the Q-pool.LEAK
OXPHOS
S
Gp
Isolated mitochondriaMouseNervous system
Doerrier 2018 EBEC20182018
Carolina Anneliese Doerrier
Respiratory mapping of mitochondrial pathways for establishing a database of mitochondrial physiology.
LEAK
ROUTINE
OXPHOS
ET
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N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
Blood cells
HEK
Platelet
Gnaiger 2018 MiP20182018
Erich Gnaiger
Mitochondrial respiratory control by fuel substrates and specific inhibitors of respiratory enzymes: Building blocks of mitochondrial physiology Part 2.
OXPHOSN
F
S
Gp
DQ
CIV
NS
Other combinations
Gnaiger 2018 MiPschool Tromso A12018
Erich Gnaiger
Mitochondrial states and rates: 1. Electron transfer pathways and respiratory control. 2. Coupling control.
LEAK
ET
OXPHOS
F
N
S
Gp
DQ
CIV
NS
Other combinations
Gainutdinov 2017 MITOEAGLE Obergurgl2017
COST Action MitoEAGLE
Different ways of reactive oxygen species (ROS) formation by brain mitochondria.
N
S
Gp
Isolated mitochondriaMouse
Rat
Nervous system
Wu 2017 FASEB J2017Effects of eccentric and concentric cycling exercise regimens on hypoxia-mediated mitochondrial bioenergetics of platelets in sedentary males.F
N
S
Gp
HumanBlood cells
Platelet
Doerrier 2017 MiPschool C22017
DoerrierC.JPG
Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
HEK
Gnaiger 2017 MiPschool A42017
Gnaiger Erich.jpg
Respiratory pathway control in mitochondrial core energy metabolism: from bioenergetics to mitochondrial physiology.
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Ukropec 2017 MITOEAGLE Obergurgl2017
COST Action MitoEAGLE
Could functional state of muscle mitochondria reflect exercise-induced changes in insulin sensitivity, glucose tolerance and cognitive performance in individuals with mild cognitive impairment?
LEAK
OXPHOS
ET
F
N
S
Gp
NS
Permeabilized cellsSkeletal muscle
Komlodi 2017 MiPschool Obergurgl2017
Timea Komlodi
Electron pressure exerted by convergent succinate- and glycerophosphate-pathways to the Q-junction regulate reversed electron transfer to Complex I and H2O2 production.
LEAK
OXPHOS
N
S
Gp
Other combinations
ROX
Isolated mitochondriaMouseNervous system
Collins 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
The effects of a Mediterranean versus Western diet on nonhuman primate skeletal muscle bioenergetics.
OXPHOSF
N
S
Gp
CIV
NS
ROX
Intact cells
Doerrier 2017 Abstract MitoEAGLE Barcelona2017
COST Action MitoEAGLE
SUIT reference protocol for comparative mitochondrial physiology.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
HEK
Sobotka 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
The effect of 24 weeks of high-fat and high-cholesterol diet on rat liver mitochondria. Sobotka_Presentation
OXPHOS
ET
F
N
S
Gp
ROX
Isolated mitochondriaRatLiver
Sumbalova 2016b Abstract MitoFit Science Camp 20162016Human blood cells: isolation and HRR.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Lymphocyte
Platelet
Lamberti 2016 Abstract MitoFit Science Camp 20162016Development of a reference sample for HRR.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
HumanKidney
HEK
Doerrier 2016 Abstract MitoFit Science Camp 20162016Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Blood cells
HEK
Platelet
Sobotka 2016 Abstract IOC1162016Sobotka O, Kucera Otto, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11LEAK
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Isolated mitochondriaRatLiver
Doerrier 2016b Abstract Mito Xmas Meeting Innsbruck2016Searching for specific targets of ischemic damage of cardiac mitochondria using O2k-Fluorometry.LEAK
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Isolated mitochondriaMouseHeart
Pecina 2014 Abstract MiP20142014Manifestation of mitochondrial disorders of nuclear origin in lymphocytes.OXPHOSN
S
Gp
CIV
Permeabilized cellsHumanBlood cells
Lymphocyte
Darveau 2013 Abstract MiP20132013Darveau CA, Teulier L, Crevier J, Weber JM (2013) Diversity and evolution of mitochondrial metabolism: Proline as a metabolic reward for pollinators. Mitochondr Physiol Network 18.08.OXPHOSN
S
Gp
NS
Other combinations
Permeabilized tissueHexapodsSkeletal muscle
Pecina 2013 Abstract MiP20132013Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
Gp
NS
Other combinations
ROX
Permeabilized cells
Homogenate
HumanBlood cells
Lymphocyte
Cavalcanti de Albuquerque 2013 Abstract MiP20132013Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Intact organism
Permeabilized tissue
RatSkeletal muscle
Shabalina 2013 Abstract MiP20132013Shabalina IG, Petrovic N, Kalinovich AV, Cannon B, Nedergaard J (2013) Comparative study of brown and white adipose tissue mitochondria in mice upon cold acclimation. Mitochondr Physiol Network 18.08.OXPHOS
ET
GpIsolated mitochondriaFat
Pichaud 2013 Abstract MiP20132013Pichaud N, Blier PU(2013) Importance of mitochondrial haplotypes in the expression of metabolic phenotypes under different conditions. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized tissueDrosophila
Hexapods
Skeletal muscle
Oliveira MF 2013 Abstract MiP20132013Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Intact organism
Intact organ
Permeabilized cells
Permeabilized tissue
Homogenate
Intact cells
Human
Drosophila
Hexapods
Other invertebrates
Skeletal muscle
Neuroblastoma


MitoPedia concepts: Respiratory state, SUIT state, Recommended 


MitoPedia topics: EAGLE 

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