Mahapatra 2018 Clin Sci (Lond)
| Mahapatra G, Smith SC, Hughes TM, Wagner B, Maldjian JA, Freedman BI, Molina AJA (2018) Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes. Clin Sci (Lond) 132:2509-18. https://doi.org/10.1042/CS20180690 |
Mahapatra G, Smith SC, Hughes TM, Wagner B, Maldjian JA, Freedman BI, Molina AJA (2018) Clin Sci (Lond)
Abstract: Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology.
• Bioblast editor: Gnaiger E • O2k-Network Lab: US CA San Diego Molina AJA
Cited by
- Gnaiger E (2021) Bioenergetic cluster analysis – mitochondrial respiratory control in human fibroblasts. MitoFit Preprints 2021.8. https://doi.org/10.26124/mitofit:2021-0008
Labels: MiParea: Respiration, Gender, mt-Medicine, Patients
Pathology: Aging;senescence, Diabetes
Organism: Human Tissue;cell: Nervous system, Blood cells Preparation: Permeabilized cells
Coupling state: LEAK, OXPHOS, ET
Pathway: F, N, S, Gp, NS, Other combinations, ROX
HRR: Oxygraph-2k
BMI, MitoFit 2021 BCA
