Search results

• Biochemical coupling efficiency
  ...'' = ''E''). The biochemical coupling efficiency is independent of kinetic control by the phosphorylation system. == Keywords ==
  901 bytes (110 words) - 01:27, 31 December 2020
• L/R coupling-control ratio
  ...ng-control ratio combines the effects of coupling (''L/E''), physiological control of energy demand, and limitation by the OXPHOS capacity. == Keywords ==
  833 bytes (104 words) - 01:32, 31 December 2020
• L/P coupling-control ratio
  ...rol ratio''' or LEAK/OXPHOS coupling-control ratio combines the effects of coupling (''L/E'') and limitation by the phosphorylation system (''P/E''); ''L/P'' = == Keywords ==
  963 bytes (120 words) - 18:26, 1 January 2021
• Uncoupling-control ratio
  ...6 Am J Physiol Cell Physiol|Steinlechner et al 1996]]). Compare [[ROUTINE-control ratio]] (''R/E'') [[Gnaiger 2008 POS|(Gnaiger 2008)]]. == Biochemical coupling efficiency: from 0 to <1 ==
  845 bytes (90 words) - 11:40, 11 November 2020
• Net P/E control ratio
  ...or [[LEAK respiration]]) as a fraction of [[ET capacity]]. The net ''P/E'' control ratio remains constant, if [[dyscoupling]] is fully compensated by an incre == Keywords ==
  657 bytes (86 words) - 01:31, 31 December 2020
• Net R/E control ratio
  ...or [[LEAK respiration]]) as a fraction of [[ET capacity]]. The net ''R/E'' control ratio remains constant, if [[dyscoupling]] is fully compensated by an incre == Keywords ==
  706 bytes (88 words) - 01:13, 31 December 2020
• R-L control efficiency
  |description=[[File:J(R-L).jpg|50 px|R-L ROUTINE-coupling efficiency]] ...The background state is the [[LEAK respiration|LEAK]] state, and the flux control variable is stimulation to ROUTINE respiration by physiologically controlle
  1 KB (179 words) - 20:19, 1 January 2021
• Coupling-control ratio
  ...'P/E'']], and two ''CCR'' for living cells, [[L/E |''L/E'']] and [[ROUTINE-control ratio |''R/E'']]. |info=[[Flux control ratio]], [[Gnaiger 2020 BEC MitoPathways]]
  2 KB (223 words) - 18:57, 7 February 2021
• Coupling-control state
  ...r]]s (e.g. [[CCCP]]). [[Coupling-control protocol]]s induce these coupling-control states sequentially at a constant [[electron-transfer-pathway state]]. '''Coupling-control states:''' [[Image:P.jpg|link=OXPHOS capacity|OXPHOS capacity]] [[Image:R.j
  2 KB (293 words) - 18:58, 7 February 2021
• R/E control ratio
  ...E respiration]] ''R'' and (noncoupled) [[ET capacity]] ''E''. The ''R/E'' control ratio is an expression of how close ROUTINE respiration operates to ET capa == Boundaries of the ''R/E'' control ratio ==
  2 KB (256 words) - 01:19, 31 December 2020
• L/E coupling-control ratio
  ...f oxygen consumption in ''L'' and ''E'' sequentially. The ''L/E'' coupling-control ratio is an index of [[uncoupling]] or [[dyscoupling]] at constant ET-capac == Keywords ==
  2 KB (237 words) - 21:12, 19 March 2022
• E-R control efficiency
  |description=[[Image:j(E-R).jpg|50 px|E-R control efficiency]] The '''''E-R'' control efficiency''', ''j_E-R'' = (''E-R'')/''E'' = 1-''R/E'', is an exp |info=[[Flux control efficiency]]
  1 KB (193 words) - 16:32, 13 December 2023
• E-P control efficiency
  ...ontrol over OXPHOS capacity. ''j_E-P'' increases with increasing control of the phosphorylation system over OXPHOS capacity. ''j_E-P'' = 1 |info=[[Flux control efficiency]], [[Gnaiger 2020 BEC MitoPathways]]
  2 KB (288 words) - 18:29, 1 January 2021
• E-P excess capacity
  ...erts a limiting effect on OXPHOS capacity. In addition, ''E-P'' depends on coupling efficiency, since ''P'' aproaches ''E'' at increasing uncoupling. == Keywords ==
  774 bytes (96 words) - 01:33, 31 December 2020
• Metabolic control variable
  |description=A '''metabolic control variable''' ''X'' causes the transition between a [[background state]] Y (b |info=[[Flux control efficiency]]
  858 bytes (123 words) - 18:19, 10 November 2020
• E-R reserve capacity
  == Keywords == {{Template:Keywords: Coupling control}}
  582 bytes (68 words) - 01:35, 31 December 2020
• E-L coupling efficiency
  ...ency |''P-L'' control efficiency]] if ''P=E'' as evaluated in a [[coupling-control protocol]]. |info=[[Flux control efficiency]]
  4 KB (522 words) - 23:34, 14 June 2022
• Coupling-control protocol
  ...e consisting of three coupling control states. The term '''phosphorylation control protocol''', PCP, has been introduced synonymous for CCP. ...sted to replace the term 'phosphorylation control protocol' by '''coupling-control protocol, CCP'''.
  6 KB (874 words) - 10:49, 30 October 2023
• E-L net ET capacity
  == Keywords == {{Template:Keywords: Coupling control}}
  781 bytes (111 words) - 01:32, 31 December 2020
• Flux control efficiency
  ...ontrol efficiencies''' express the control of respiration by a [[metabolic control variable]], ''X'', as a fractional change of flux from ''Y_X'' to ...to [[elasticity|elasticities]] of [[metabolic control analysis]], the flux control efficiency of ''X'' upon background ''Y_X'' is expressed as the c
  8 KB (1,272 words) - 18:27, 1 January 2021
• P/E control ratio
  ...''E-P'' control efficiency]], ''j_E-P'' = 1-''P/E''. The ''P/E'' control ratio increases with increasing capacity of the phosphorylation system up t ...ng]] of [[OXPHOS]], but mainly results from a diversity in the [[ET-excess control efficiency E-P]] in different species, tissues and cell lines.
  4 KB (623 words) - 01:14, 31 December 2020
• Mark specifications - DatLab
  | Coupling control protocol (ceCCP) in intact cells. | Coupling control protocol (ceCCP) in intact cells using TIP2k for automatic uncoupler titrat
  2 KB (232 words) - 11:55, 25 March 2022
• Cell ergometry
  ...ol efficiency]] ''j_P-L'' and [[E-L coupling efficiency |''E-L'' coupling efficiency]] ''j_E-L''. These normalized flux ratios are the basi == Keywords ==
  3 KB (459 words) - 01:26, 31 December 2020
• MitoEAGLE preprint 2017-09-21
  ...e=MitoEAGLE preprint 2018-02-18(21) The protonmotive force and respiratory control. |keywords=Mitochondrial respiratory control, coupling control, mitochondrial preparations, protonmotive force, chemiosmotic theory, oxida
  3 KB (369 words) - 12:48, 23 May 2020
• Flux control ratio
  ...trol ratios''' ''FCR''s are ratios of oxygen flux in different respiratory control states, normalized for maximum flux in a common reference state, to obtain ...SUIT protocol]]) provide an internal normalization, expressing respiratory control independent of mitochondrial content and thus independent of a marker for m
  3 KB (427 words) - 10:40, 24 October 2023
• Respiratory acceptor control ratio
  ...sons, ''RCR'' should be replaced by the [[E-L coupling efficiency |''E-L'' coupling efficiency]], 1-''L/E'' [4]. :::# Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. BEC 2020.2. - [[Gnaiger 2020 B
  3 KB (391 words) - 13:31, 29 May 2022
• Gnaiger 2011 Abstract SMRM-Hyderabad
  ...Boushel RC (2011) Conserved mitochondrial coupling and adaptive substrate control in Inuit and Caucasians: Acclimatization to active life styles in the Arcti |keywords=Haplotypes
  933 bytes (120 words) - 18:20, 10 January 2022
• Cardoso 2021 MitoFit MgG
  ...on was not inhibited in any of the coupling control states, hence coupling control efficiencies were not affected by MgG. |keywords=ATP, ATP production, high-resolution respirometry, Magnesium Green, mitocho
  3 KB (409 words) - 08:41, 8 January 2023
• P-L net OXPHOS capacity
  == Keywords == {{Template:Keywords: Coupling control}}
  1 KB (190 words) - 01:27, 31 December 2020
• Cardoso 2022 ESCI Bari
  ...T, Gnaiger E (2022) Bioenergetic fingerprinting with coupling and pathway control of coenzyme Q redox state and respiration in permeabilized HEK 293T cells. ...ing is challenged with targeting specific segments of pathway and coupling control of oxidative phosphorylation (OXPHOS) [1].
  4 KB (520 words) - 14:41, 30 May 2022
• Leung 1975 J Biol Chem
  ...Leung KH, Hinkle PC (1975) Reconstitution of ion transport and respiratory control in vesicles formed from reduced coenzyme Q-cytochrome c reductase and phosp ...ansient stimulation of electron transfer. The results indicate that energy coupling can be observed with isolated reduced coenzyme Q-cytochrome c reductase if
  2 KB (289 words) - 16:51, 24 February 2015
• R-L net ROUTINE capacity
  == Keywords == {{Template:Keywords: Coupling control}}
  1 KB (201 words) - 01:33, 31 December 2020
• Cardoso 2021 BEC MgG
  ...on was not inhibited in any of the coupling control states, hence coupling control efficiencies were not affected by MgG. |keywords=ATP, ATP production, high-resolution respirometry, Magnesium Green, mitocho
  4 KB (486 words) - 16:39, 21 January 2024
• Tueller 2017 Biochem Biophys Res Commun
  ...ancock CR (2017) Effects of curcumin and ursolic acid on the mitochondrial coupling efficiency and hydrogen peroxide emission of intact skeletal myoblasts. Bio ...lood glucose control. Our findings also show that changes to mitochondrial coupling efficiency after curcumin pretreatment may go undetected unless cells are a
  2 KB (320 words) - 07:50, 21 February 2020
• Sumbalova 2011 Abstract Mitochondrial Medicine
  |title=Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane poten ...Media:MiPNet14.05.jpg|Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane pote
  4 KB (526 words) - 18:19, 10 January 2022
• Komlodi 2021 MitoFit Q
  ...LHD, Doerrier C, Moore AL, Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. https:/ ...ww.mitofit.org/images/9/91/Komlodi_2021_MitoFit_Q.pdf Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria]
  5 KB (767 words) - 08:41, 8 January 2023
• Halle 2019 Am J Physiol Regul Integr Comp Physiol
  ...-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia. Am J Physiol Regul Integr Comp Physiol ...findings suggest that mitochondrial function is subject to tissue-specific control during cancer cachexia, whereby remodeling in WAT and liver arise early and
  3 KB (377 words) - 12:22, 9 July 2019
• P-L control efficiency
  ...''P/L''. Under these conditions, the respiratory control ratio and ''P-L'' control efficiency are related by a hyperbolic function, ''j_P-L'' = 1-RC » [[#Cell ergometry: OXPHOS-control and ET-coupling efficiency |'''MiPNet article''']]
  9 KB (1,431 words) - 20:35, 19 March 2022
• Tam 2016 Eur J Appl Physiol
  ...ased (''P'' = 0.031), leading to a significant increase in the respiratory control ratio (''P'' = 0.016). |keywords=Exercise training, Aerobic metabolism, Chronic hypoxia, Women, VO2max, Ener
  4 KB (611 words) - 20:14, 1 January 2021
• Huetter 2004 Biochem J
  ...production. Despite substantial differences in the [[respiratory acceptor control ratio]], ranging from 4 to 11 in the different experimental groups, a fixed |keywords=Aging, Coupling state, Mitochondria, Oxidative stress, Primary human fibroblast, Respiratio
  5 KB (690 words) - 15:45, 4 June 2022
• OXPHOS capacity
  ...PHOS capacity is expressed as the [[OXPHOS-control ratio]] (''P/E'' [[flux control ratio]]). (''2'') OXPHOS capacity is expressed per tissue or cell mass, int == Keywords ==
  6 KB (808 words) - 01:02, 31 December 2020
• Uncoupler titrations
  === Coupling-control protocol === ...ler titrations after inhibition of respiration by oligomycin in [[coupling-control protocol]]s with living cells yield the sequence of [[ROUTINE respiration]]
  4 KB (489 words) - 05:56, 19 July 2022
• Jacobs 2012 FASEB J
  ...m alterations in mitochondrial content. LEAK control coupling, respiratory control ratio, and oligomycin-induced LEAK respiration, all measures of mitochondri |keywords=High altitude (HA), Exercise capacity
  2 KB (307 words) - 12:05, 28 March 2018
• High-resolution respirometry
  ...ail to evaluate even minor alterations in respiratory coupling and pathway control patterns. ...⁺⁾. The [[PB-Module]] extends HRR to PhotoBiology with accurate control of the light intensity and measurement of photosynthesis. The O2k and the N
  4 KB (482 words) - 09:09, 2 April 2024
• Van den Berg 2010 Metabolism
  ...) High levels of whole-body energy expenditure are associated with a lower coupling of skeletal muscle mitochondria in C57Bl/6 mice. Metabolism 59:1612-8. ...coenzyme A as substrate. These results indicate that reduced mitochondrial coupling is associated with positive residual energy expenditure and high rates of t
  3 KB (353 words) - 16:24, 13 November 2017
• Sumbalova 2011 Abstract Bordeaux
  ...iethuechter A, Fasching M, Gnaiger E (2011) Coupling control and substrate control of mitochondrial membrane potential and respiration in the mouse brain, and |keywords=High-resolution respirometry, OXPHOS, mitochondrial membrane potential, ROS
  6 KB (803 words) - 18:16, 10 January 2022
• ROUTINE respiration
  ...is controlled by cellular energy demand, energy turnover and the degree of coupling to phosphorylation (intrinsic [[uncoupling]] and pathological [[dyscoupling ::::* DL-Protocol for coupling control with living cells and cell viability module (ce-pce): [[SUIT-003 O2 ce-pce
  6 KB (875 words) - 10:38, 17 November 2021
• Ragan 1975 J Biol Chem
  |title=Ragan CI, Hinkle PC (1975) Ion transport and respiratory control in vesicles formed from reduced nicotinamide adenine dinucleotide coenzyme ...y valinomycin plus nigericin and K+ ions. The results indicate that energy coupling can be observed with isolated NADH-coenzyme Q reductase if the enzyme compl
  2 KB (235 words) - 10:11, 26 February 2015
• Hals 2015 PLoS One
  ...in complex II-linked respiration. Coupling control ratios showed increased coupling efficiency for both complex I- and II-linked substrates in hypoxia-exposed ...oxygenation period increases substrate-stimulated respiratory capacity and coupling efficiency. Such effects are accompanied by up-regulation of mitochondrial
  3 KB (396 words) - 14:30, 13 November 2017
• Scheiber 2018 J Cardiovasc Transl Res
  ...loading is related to decreased mitochondrial ROS production and increased coupling efficiency in myocardium of human failing hearts, suggesting a novel pathom |keywords=Heart failure, Heart transplantation, High-resolution respirometry, Left ve
  2 KB (300 words) - 13:30, 7 March 2020
• Neyroud 2019 J Muscle Res Cell Motil
  ...s reductions in: maximal mitochondrial respiration capacity, mitochondrial coupling and mitochondrial content. |keywords=Mitochondrial content, Mitochondrial coupling, Mitochondrial homeostasis, Mitochondrial respiration, Muscle wasting, Oxid
  2 KB (246 words) - 12:12, 9 July 2019
• Komlodi 2021 BEC Q
  ...LHD, Doerrier C, Moore AL, Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. Bioener ...s determined by cyclic voltammetry. The voltammogram also provides quality control of the Q-sensor and reveals chemical interferences.
  6 KB (810 words) - 16:37, 21 January 2024
• MitoPedia: SUIT
  ...uence of titrations, e.g. NS(GM), NS(PM), FNSGp(PGM). The coupling/patwhay control diagram in the Figure shows a protocol of SUIT category FNS(PM). :* '''Coupling-control protocols''' (CCP) are a special case of SUIT protocols primarily applied t
  9 KB (1,166 words) - 19:56, 11 February 2023
• Porter 2016 J Burn Care Res
  ...cantly lower in burn victims for 1-year postinjury. Mitochondrial coupling control is diminished for up to 2 years postinjury in burn victims, resulting in gr |keywords=skeletal muscle, ucnoupling, burns, trauma
  3 KB (351 words) - 22:21, 1 August 2018
• Parker 2020 Thesis
  ...ower leak respiration and leak-related coupling control ratio than healthy control subjects. There was no significant change in measures of PBMC respiration f |keywords=Mitochondria, Respiratory, Type 2 diabetes, Dysfunction, Peripheral blood m
  3 KB (349 words) - 19:42, 30 July 2020
• Porter 2015 Burns
  ...l 10d post burn, where both respiratory capacity (''P''<0.05) and coupling control (''P''<0.05) were significantly lower than sham. These data highlight a dif |keywords=Apoptosis, Burn, Hypermetabolism, Mitochondria, Skeletal muscle
  3 KB (368 words) - 15:44, 13 November 2017
• Wohlwend 2013 Thesis
  ...ulations indicated an enzyme defect in β-oxidation, and that mitochondrial coupling efficiency of electron transfer during β-oxidation particularly in fat oxidation (coupling efficiency and relative flux) were found.
  4 KB (524 words) - 16:32, 13 November 2017
• Sumbalova 2011 Abstract Kagoshima
  ...P, Fasching M, Gnaiger E (2011) Mitochondrial membrane potential, coupling control, H₂O₂ production, and the upper limit of mitochondria
  3 KB (457 words) - 18:18, 10 January 2022
• Ciccone 2024 J Exp Biol
  ...one C, Kante F, Folkow LP, Hazlerigg DG, West AC, Wood SH (2024) Circadian coupling of mitochondria in a deep-diving mammal. J Exp Biol 227:jeb24699. https://d ...sts and found a circadian variation in mitochondrial activity, with higher coupling efficiency of complex I coinciding with the trough of arntl expression. The
  2 KB (297 words) - 16:11, 23 April 2024
• Braun 2001 Biochim Biophys Acta
  ...d (direct) channeling of that fraction of ADP to mitochondria. Compared to control, the direct ADP transfer was increased in MDX ventricles. In conclusion, ou |keywords=Mitochondria, Adenosine 5′-triphosphatase, Muscle, Respiration, Regulatio
  3 KB (387 words) - 10:54, 23 January 2019
• Colleoni 2012 Placenta
  ...delivery suite, with enhanced coupling, as indicated by higher respiratory control ratios, than in fresh placental samples transported to the laboratory on ic |keywords=Placenta
  1 KB (196 words) - 12:11, 27 March 2018
• Krumschnabel 1994 Physiol Zool
  |title=Krumschnabel G, Schwarzbaum PJ, Wieser W (1994) Coupling of energy supply and energy demand in isolated goldfish hepatocytes. Physio ...the concentration of ATP in the hepatocytes dropped within 30 min from the control steady state to a new, lower, steady state that was maintained for at least
  2 KB (286 words) - 12:09, 23 January 2019
• Oroboros Laboratory
  ...P) in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions; == Keywords ==
  4 KB (528 words) - 16:58, 15 February 2024
• Cardoso 2023 MiP2023
  ...] Electron transfer from beta-oxidation and TCA cycle and impact of OXPHOS coupling on NADH and coenzyme Q redox states. ...sh from different fuel substrates of the ETS or electron pull modulated by coupling and corresponding energy demand. Special emphasis on the interaction betwee
  4 KB (495 words) - 16:44, 12 July 2023
• Loughland 2022 J Exp Biol
  ...substrate oxidation rates, leak respiration rates or coupling (respiratory control ratios). Increased rates of ROS production did not lead to damage of protei ...lase, Mitochondria, Oxidative damage, Reactive oxygen species, Respiratory control ratio, Temperature
  3 KB (364 words) - 10:39, 5 December 2022
• Ackerly 2023 Comp Biochem Physiol A Mol Integr Physiol
  ...gnificantly higher OXPHOS Control Efficiency, OXPHOS Capacity and Coupling Control Ratios (i.e., LEAK/OXPHOS). There was no significant change to citrate synt |keywords=Fish, Heart, Low oxygen, Oxidative phosphorylation, Red muscle
  3 KB (348 words) - 16:47, 24 May 2023
• Pilot-Storck 2022 Abstract Bioblast
  ...M, Tiret L, <u>Pilot-Storck Fanny</u> (2022) ''Hacd1'' and ''Hacd2'' genes control mitochondrial energetic efficiency through the modulation of mitochondrial |abstract=Mitochondrial energy efficiency involves optimal coupling between oxidative processes and ADP phosphorylation, which implies an advan
  5 KB (701 words) - 08:32, 28 July 2022
• Chatfield 2019 JACC Basic Transl Sci
  ...art failure, RCR, Respiratory control ratio, SC CCF, Supercomplex coupling control factor, Heart failure, High-resolution respirometry, Mitochondrial-targeted
  2 KB (267 words) - 04:37, 12 February 2020
• Jacobs 2013 Exp Physiol
  ...ratory chain function remained unaltered, as both coupling and respiratory control did not change in response to hypoxic exposure. High altitude acclimatizati |keywords=High altitude acclimatization
  3 KB (404 words) - 13:09, 27 December 2021
• Krumschnabel 1996 Am J Physiol
  ...rumschnabel G, Biasi C, Schwarzbaum PJ, Wieser W (1996) Membrane-metabolic coupling and ion homeostasis in anoxia-tolerant and anoxia-intolerant hepatocytes. A ...ecies did chemical anoxia induce a change in pump density. Other potential control mechanisms are briefly discussed.
  2 KB (336 words) - 12:05, 23 January 2019
• Varikmaa 2013 Thesis
  ...drial outer membrane (mtOM) for ADP, is crucial for the efficiency of this coupling. To validate if tubulin participates in this regulation, reconstitution exp |keywords=Bioenergetics, Muscle cells, Energy metabolism, Tubulin, Dissertations
  5 KB (658 words) - 08:23, 20 October 2017
• Coenzyme Q
  ...LHD, Doerrier C, Moore AL, Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. Bioener ...LHD, Doerrier C, Moore AL, Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. Bioener
  5 KB (721 words) - 07:53, 7 March 2024
• MiPMap
  ...ity from mouse to man, and evaluation of altered mitochondrial respiratory control patterns in health and disease'' ([[Gnaiger 2009 Int J Biochem Cell Biol|Gn ...the backbone of the MiPMap project. The MiPMap labels can be considered as keywords which can be attached to various sources of information (publications). Wit
  7 KB (696 words) - 11:14, 20 October 2017
• Noncoupled respiration
  |abstract=Coupling of [[OXPHOS]] represents a complex concept. '''Uncoupler''' titrations prov ...link«]]</ref>,<ref>Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https:
  12 KB (1,557 words) - 20:27, 19 March 2022
• Liu 2016 EMBO Mol Med
  ...iu L, Fu T, Kong Y, Zhou Q, Vega RB, Zhu MS, Kelly DP, Gao X, Gan Z (2016) Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1 ...contractile proteins of oxidative-type fibers. However, the mechanism for coupling of mitochondrial function to the muscle contractile machinery during fiber
  2 KB (345 words) - 01:05, 1 March 2020
• Krumschnabel 2013 Abstract MiP2013
  ...ansfer to phosphorylation of ADP. To secure full accessibility of any flux control variables (substrates, ADP, etc.) to the mt organelle, mitochondria are eit ...ibility of complete mt-yield and preservation of mitochondrial respiratory control compared to permeabilized fibers.
  6 KB (817 words) - 18:28, 10 January 2022
• Baglivo 2022a ESCI Bari
  ...livo Eleonora]]Baglivo E, Cardoso LHD, Cecatto C, Gnaiger E (2022) Quality control of mitochondrial respiration medium in high-resolution respirometry with li ...ochondrial respiratory research. A frequently neglected problem is quality control of chemicals and incubation media. Mitochondrial respiration medium MiR05 i
  3 KB (465 words) - 15:24, 30 May 2022
• ET capacity
  ...tial]] is almost fully collapsed and provides a reference state for [[flux control ratio]]s. == Consequences for evaluation of coupling ==
  11 KB (1,488 words) - 20:30, 19 March 2022
• Warren 2017 Metabolism
  ...supported by PMS and the respiratory control ratio (index of mitochondrial coupling) for both PMS and PCM were lower following the clamp (P<0.05). IRS1 mRNA de ...induced H₂O₂ production and a concurrent decrease in coupling of mitochondrial respiration with ATP production in a cohort of healthy pre
  3 KB (365 words) - 12:27, 2 March 2018
• Pham 2014 Am J Physiol
  ...on in OXPHOS efficiency. However, with anoxic transition, STZ-diabetic and control heart tissues showed similar ATP hydrolysis capacities through reversal of |keywords=Diabetic cardiomypathy, Anoxia, Efficiency, Mitochondria, Oxidative phospho
  3 KB (431 words) - 15:40, 17 January 2023
• De-Souza-Ferreira 2019 J Neurochem
  ...tioning mitochondria-bound hexokinase as a hub for intracellular signaling control. This article is protected by copyright. All rights reserved. |keywords=Mitochondria, Brain, Calcium, Development, Hexokinase, Redox balance
  3 KB (401 words) - 12:17, 9 July 2019
• Renner 2003 Biochim Biophys Acta
  ...maintained in all treatments, as deduced from high respiratory uncoupling control ratios. Bcl-2 over-expression did not prevent apoptosis after gemcitabine-t |keywords=Apoptosis, Dexamethasone, Gemcitabine, Mitochondrial respiratory control, Cell cycle
  3 KB (319 words) - 14:04, 27 December 2021
• Schoenfeld 2004 Biochem J
  ...embrane H+ conductance and disturbs the protein-linked functions in energy coupling. This is most probably essential for the short-term toxicity of phytanic ac |keywords=ADP/ATP carrier, Branched-chain fatty acid, Mitochondria, Neurodegeneration
  3 KB (381 words) - 11:04, 27 March 2018
• Jorgensen 2009 Am J Physiol Endocrinol Metab
  ...''_O2max and an ~50 % increase (''P'' < 0.05) of the respiratory coupling ratio (RCR) combined with lower levels of UCP3 and PGC-1αmRNA levels (''P' ..., High-fat diet, Nutrient restriction, Maternal diet, Respiratory coupling control ratio
  3 KB (368 words) - 20:26, 12 November 2019
• Gnaiger 2013 Abstract MiP2013
  ...Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Biochemical coupling efficiency in permeabilized fibers from arm and leg muscle in Inuit versus ...e in fatty acid oxidation approaching the level of the Inuit, yet coupling control of oxidative phosphorylation was conserved. Our findings reveal that couple
  10 KB (1,454 words) - 18:29, 10 January 2022
• De Carvalho 2017 Toxicol Research
  ...acity and OXPHOS coupling efficiency, and induced changes in the substrate control ratio. Altogether, our results suggested that ''E. uniflora'' impairs the m |keywords=Mitochondrial dysfunction, Oxidative phosphorylation, Essential oil, Bioene
  2 KB (322 words) - 13:39, 26 June 2019
• Galambo 2022 Curr Res Physiol
  ...n. In addition, we found that the acceptor control ratio, representing the coupling between oxidation and phosphorylation, was significantly upregulated by CL. |keywords=Biological therapies, Mitochondria, Oxidative phosphorylation, Vascular bio
  2 KB (269 words) - 17:07, 3 January 2023
• Bastos Sant'Anna Silva 2018 Life Sciences Meeting 2018 Innsbruck AT
  ...e (SDH) or Complex II. SDH is located at the inner mitochondrial membrane, coupling the oxidation of succinate to fumarate in the tricarboxylic acid cycle (TCA ...e; noncancerous), LNCaP (prostate; cancer), and HEK293T (embryonic kidney; control).
  3 KB (396 words) - 19:04, 10 January 2022
• Bohanon 2017 Shock
  ...evere burn trauma on liver mitochondrial respiratory capacity and coupling control as well as the signaling events underlying these alterations. ...he respiratory control ratio for ADP (p = 0.04) and the mitochondrial flux control ratio (p = 0.03) were elevated in the liver of burned animals. Complex
  3 KB (366 words) - 16:45, 27 March 2018
• Stadlmann 2006 Cell Biochem Biophys
  ..., Pollheimer J, Moser PL, Zeimet AG, Offner FA, Gnaiger E (2006) Preserved coupling of oxidative phosphorylation but decreased mitochondrial respiratory capaci ...a significant decline of respiratory capacity (''p'' < 0.05). Respiratory control ratios (i.e., uncoupled respiration at optimum carbonyl cyanide p-trifluoro
  12 KB (1,918 words) - 13:59, 27 December 2021
• Electron transfer pathway
  ...ransfer chain, ETC) is a misnomer. Understanding mitochondrial respiratory control has suffered greatly from this inappropriate terminology, although textbook ...her flavoproteins, providing multiple entries into the Q-junction with two coupling sites downstream (Gnaiger 2014).
  5 KB (646 words) - 01:06, 31 December 2020
• Coenzyme Q2
  == Keywords == {{Template:Keywords: Q}}
  3 KB (441 words) - 22:11, 9 April 2022
• Rhein 2010 PloS One
  ...NA. Improvement of the OXPHOS efficiency was stronger in APP cells than in control cells. In APP cells, the GBE-induced amelioration of oxygen consumption mos |keywords=Ginkgo biloba extract, Alzheimer's disease,
  3 KB (447 words) - 16:14, 9 November 2016
• Evinova 2020 J Membr Biol
  ...SH-SY5Y cells, with basic information of respiration in different coupling control states including ROUTINE, LEAK, and maximal electron transport (ET) capacit |keywords=Bioenergetics, Intact cells, Mitochondria, Respiration, SH-SY5Y
  2 KB (277 words) - 15:41, 7 May 2020
• Guerrero 2005 Am J Physiol Regul Integr Comp Physiol
  ...rel JC, Hacini R, Chavanon O, Imbeaud S, Saks V, Pison C (2005) Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enha ...itochondrial respiration by creatine linked to a more efficient functional coupling adenine nucleotide translocase-mitochondrial creatine kinase, resulting in
  3 KB (413 words) - 15:20, 26 March 2018
• Lemieux 2011 Int J Biochem Cell Biol
  ...msroth S, Antretter H, Höfer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. ...identical in the four cardiac chambers of chronic heart failure patients. Coupling was preserved in heart disease and chronic heart failure, in contrast to th
  4 KB (626 words) - 22:52, 17 April 2024
• Lopez 2020 Function (Oxf)
  ...s predicts that increased levels of inorganic phosphate in TAC compared to control animals kinetically impair the myosin ATPase crossbridge cycle in decompens |keywords=Heart failure, Cardiac energetics, Mechano-energtic coupling, Trans aortic constriction, Ejection fraction, Computational modeling, Card
  3 KB (407 words) - 20:48, 6 November 2020
• O´Gorman 1996 Biochim Biophys Acta
  ...inclusions shown by electron microscopy, indicate that Mib-CK function and coupling to oxidative phosphorylation (OXPHOS), is impaired in these abnormal mitoch |keywords=Guanidino propionic acid; Creatine; Mitochondrial inclusion body; Creatine
  3 KB (364 words) - 14:08, 27 March 2015
• Manko 2013 Cell Biochem Funct
  ...onsumption of permeabilized acinar cells. These results suggest a stronger coupling between respiration and oxidative phosphorylation in sucrose-based solution |keywords=Pancreatic acinar cells; Mitochondria; Oxygen consumption; Respiratory stat
  2 KB (272 words) - 09:23, 8 November 2016
• Schlagowski 2014 J Appl Physiol
  ...everal skeletal muscle adaptations, highlighting the role of mitochondrial coupling as a critical factor for maximal exercise capacities. These results emphasi |keywords=2,4-dinitrophenol, Mitochondrial uncoupling, Exhaustive exercise Maximal ru
  3 KB (372 words) - 20:27, 7 March 2020

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