L/P coupling-control ratio

Description

The L/P coupling-control ratio or LEAK/OXPHOS coupling-control ratio combines the effects of coupling (L/E) and limitation by the phosphorylation system (P/E); L/P = (L/E) / (P/E) = 1/RCR.

Abbreviation: L/P

Reference: Gnaiger 2009 Int J Biochem Cell Biol, Gnaiger 2020 BEC MitoPathways, BEC 2020.1

Keywords

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The Blue Book 2020
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OXPHOS-, ROUTINE-, ET-, and LEAK states; respiratory capacities (P, R, E, L) corrected for residual oxygen consumption Rox.
4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation P» (ADP to ATP) without competing with P».
(P-L)/P is the OXPHOS P-L control efficiency. The biochemical coupling efficiency is independent of kinetic control by the phosphorylation system when expressed as the E-L coupling efficiency, (E-L)/E. (E-P)/E is the kinetic E-P control efficiency.

Bioblast links: Coupling control - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>

1. Mitochondrial and cellular respiratory rates in coupling-control states

» Baseline state

Respiratory rate	Defining relations
OXPHOS capacity	P = P´-Rox	mt-preparations
ROUTINE respiration	R = R´-Rox	living cells
ET capacity	E = E´-Rox	» Level flow
		» Noncoupled respiration - Uncoupler
LEAK respiration	L = L´-Rox	» Static head
		» LEAK state with ATP
		» LEAK state with oligomycin
		» LEAK state without adenylates
Residual oxygen consumption Rox	L = L´-Rox

Chance and Williams nomenclature: respiratory states

» State 1 —» State 2 —» State 3 —» State 4 —» State 5

2. Flux control ratios related to coupling in mt-preparations and living cells

» Flux control ratio

» Coupling-control ratio

» Coupling-control protocol

FCR	Definition
L/P coupling-control ratio	L/P	» Respiratory acceptor control ratio, RCR = P/L
L/R coupling-control ratio	L/R
L/E coupling-control ratio	L/E	» Uncoupling-control ratio, UCR = E/L (ambiguous)
P/E control ratio	P/E
R/E control ratio	R/E	» Uncoupling-control ratio, UCR = E/L
net P/E control ratio	(P-L)/E
net R/E control ratio	(R-L)/E

3. Net, excess, and reserve capacities of respiration

Respiratory net rate	Definition	Icon
P-L net OXPHOS capacity	P-L
R-L net ROUTINE capacity	R-L
E-L net ET capacity	E-L
E-P excess capacity	E-P
E-R reserve capacity	E-R

4. Flux control efficiencies related to coupling-control ratios

» Flux control efficiency j_Z-Y

» Background state

» Reference state

» Metabolic control variable

Coupling-control efficiency		Definition		Canonical term
P-L control efficiency	j_P-L	= (P-L)/P	= 1-L/P	P-L OXPHOS-flux control efficiency
R-L control efficiency	j_R-L	= (R-L)/R	= 1-L/R	R-L ROUTINE-flux control efficiency
E-L coupling efficiency	j_E-L	= (E-L)/E	= 1-L/E	E-L ET-coupling efficiency » Biochemical coupling efficiency
E-P control efficiency	j_E-P	= (E-P)/E	= 1-P/E	E-P ET-excess flux control efficiency
E-R control efficiency	j_E-R	= (E-R)/E	= 1-R/E	E-R ET-reserve flux control efficiency

5. General

» Basal respiration

» Cell ergometry

» Dyscoupled respiration

» Dyscoupling

» Electron leak

» Electron-transfer-pathway state

» Hyphenation

» Oxidative phosphorylation

» Oxygen flow

» Oxygen flux

» Permeabilized cells

» Phosphorylation system

» Proton leak

» Proton slip

» Respiratory state

» Uncoupling

List of publications: LEAK and OXPHOS

	Year	Reference	Mammal and model	Tissue and cell	Stress	Diseases
Serna 2022 BEC	BEC 2022.7	Serna JDC, Ramos VM, Cabral-Costa JV, Vilas-Boas EA, Amaral AG, Ohya G, da Silva CCC, Kowaltowski AJ (2022) Measuring mitochondrial Ca²⁺ efflux in isolated mitochondria and permeabilized cells. https://doi.org/10.26124/bec:2022-0007	Human Mouse	Liver Other cell lines	Permeability transition
Komlodi 2021 BEC Q	BEC 2021.3	Komlódi T, Cardoso LHD, Doerrier C, Moore AL, Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. https://doi.org/10.26124/bec:2021-0003	Mouse	Heart Nervous system
Cardoso 2021 BEC MgG	BEC 2021.1	Cardoso LHD, Doerrier C, Gnaiger E (2021) Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration. https://doi.org/10.26124/bec:2021-0001	Mouse	Heart
Gnaiger 2020 BEC MitoPathways	BEC 2020.2	Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5^th ed. https://doi.org/10.26124/bec:2020-0002	Human Mouse	Heart Skeletal muscle Fibroblast
BEC 2020.1 doi10.26124bec2020-0001.v1	BEC 2020.1	Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. https://doi.org/10.26124/bec:2020-0001.v1
Serna 2022 MitoFit	2022-05-24	Serna JDC, Ramos VM, Cabral-Costa JV, Vilas-Boas EA, Amaral AG, Ohya G, da Silva CCC, Kowaltowski AJ (2022) Measuring mitochondrial Ca²⁺ efflux in isolated mitochondria and permeabilized cells. https://doi.org/10.26124/mitofit:2022-0021 2022-07-28 Published in »Bioenergetics Communications 2022.7«	Human Mouse	Liver Other cell lines	Permeability transition
Komlodi 2022 MitoFit	2022-04-12	Komlódi T, Tretter L (2022) The protonmotive force – not merely membrane potential. https://doi.org/10.26124/mitofit:2022-0012
Pallag 2022 MitoFit Proline	2022-03-07	Pallag G, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation leading to high electron flow through reduction of ubiquinone supports ATP production by F₁F_O-ATPase in mitochondria with inhibited Complex I. https://doi.org/10.26124/mitofit:2022-0001.v3 - 2022-05-04 published in https://doi.org/10.3390/ijms23095111	Mouse	Heart Kidney Liver Nervous system
Ahn 2022 Aging Cell	2022	Ahn B, Ranjit R, Kneis P, Xu H, Piekarz KM, Freeman WM, Kinter M, Richardson A, Ran Q, Brooks SV, Van Remmen H (2022) Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia. Aging Cell 21:e13569.	Mouse	Skeletal muscle	Oxidative stress;RONS	Aging;senescence
Molinie 2022 Biochim Biophys Acta Bioenerg	2022	Molinié T, Cougouilles E, David C, Cahoreau E, Portais JC, Mourier A (2022) MDH2 produced OAA is a metabolic switch rewiring the fuelling of respiratory chain and TCA cycle. Biochim Biophys Acta Bioenerg 1863:148532.	Mouse	Heart Liver
Yamauchi 2022 Sci Rep	2022	Yamauchi Y, Nakamura A, Yokota T, Takahashi K, Kawata S, Tsuchida K, Omori K, Nomoto H, Kameda H, Cho KY, Anzai T, Tanaka S, Terauchi Y, Miyoshi H, Atsumi T (2022) Luseogliflozin preserves the pancreatic beta-cell mass and function in db/db mice by improving mitochondrial function. Sci Rep 12: 9740.	Mouse	Islet cell;pancreas;thymus		Diabetes
Nath 2022 Cell Rep	2022	Nath AS, Parsons BD, Makdissi S, Chilvers RL, Mu Y, Weaver CM, Euodia I, Fitze KA, Long J, Scur M, Mackenzie DP, Makrigiannis AP, Pichaud N, Boudreau LH, Simmonds AJ, Webber CA, Derfalvi B, Hammon Y, Rachubinski RA, Di Cara F (2022) Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses . Cell Rep 38:110433.
Guo 2022 Sci Adv	2022	Guo Q, Xu Z, Zhou D, Fu T, Wang W, Sun W, Xiao L, Liu L, Ding C, Yin Y, Zhou Z, Sun Z, Zhu Y, Zhou W, Jia Y, Xue J, Chen Y, Chen XW, Piao HL, Lu B, Gan Z (2022) Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4. https://doi.org/10.1126/sciadv.abo0340	Mouse	Skeletal muscle Fat		Obesity
Schober 2022 Hum Mol Genet	2022	Schober FA, Tang JX, Sergeant K, Moedas MF, Zierz CM, Moore D, Smith C, Lewis D, Guha N, Hopton S, Falkous G, Lam A, Pyle A, Poulton J, Gorman GS, Taylor RW, Freyer C, Wredenberg A (2022) Pathogenic SLC25A26 variants impair SAH transport activity causing mitochondrial disease. Hum Mol Genet [Epub ahead of print].	Mouse Drosophila	Fibroblast	Mitochondrial disease	Myopathy
Fischer 2022 Metabolites	2022	Fischer C, Valente de Souza L, Komlódi T, Garcia-Souza LF, Volani C, Tymoszuk P, Demetz E, Seifert M, Auer K, Hilbe R, Brigo N, Petzer V, Asshoff M, Gnaiger E, Weiss G (2022) Mitochondrial respiration in response to iron deficiency anemia. Comparison of peripheral blood mononuclear cells and liver. https://doi.org/10.3390/metabo12030270	Rat	Liver Blood cells		Other
Rios-Morales 2022 Biochim Biophys Acta Mol Basis Dis	2022	Rios-Morales M, Vieira-Lara MA, Homan E, Langelaar-Makkinje M, Gerding A, Li Z, Huijkman N, Rensen PCN, Wolters JC, Reijngoud DJ, Bakker BM (2022) Butyrate oxidation attenuates the butyrate-induced improvement of insulin sensitivity in myotubes. https://doi.org/10.1016/j.bbadis.2022.166476	Mouse	Skeletal muscle		Diabetes
De Goede 2022 FASEB J	2022	de Goede P, Wüst RCI, Schomakers BV, Denis S, Vaz FM, Pras-Raves ML, van Weeghel M, Yi CX, Kalsbeek A, Houtkooper RH (2022) Time-restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle. FASEB J 36:e22133.	Rat	Skeletal muscle		Diabetes
Tepp 2022 Biochem Biophys Rep	2022	Tepp K, Aid-Vanakova J, Puurand M, Timohhina N, Reinsalu L, Tein K, Plaas M, Shevchuk I, Terasmaa A, Kaambre T (2022) Wolframin deficiency is accompanied with metabolic inflexibility in rat striated muscles. Biochem Biophys Rep 30:101250.	Rat	Skeletal muscle
Thapa 2022 Physiol Rep	2022	Thapa D, Bugga P, Mushala BAS, Manning JR, Stoner MW, McMahon B, Zeng X, Cantrell PS, Yates N, Xie B, Edmunds LR, Jurczak MJ, Scott I (2022) GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation. https://doi.org/10.14814/phy2.15415	Mouse	Heart		Cardiovascular Obesity
Goudie 2022 Sci Rep	2022	Goudie L, Mancini NL, Shutt TE, Holloway GP, Mu C, Wang A, McKay DM, Shearer J (2022) Impact of experimental colitis on mitochondrial bioenergetics in intestinal epithelial cells. https://doi.org/10.1038/s41598-022-11123-w	Mouse	Endothelial;epithelial;mesothelial cell
Pallag 2022 Int J Mol Sci	2022	Pallag G, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation supports mitochondrial ATP production when Complex I is inhibited. https://doi.org/10.3390/ijms23095111	Mouse	Liver Kidney	Hypoxia
Lai 2022 PLoS One	2022	Lai RE, Holman ME, Chen Q, Rivers J, Lesnefsky EJ, Gorgey AS (2022) Assessment of mitochondrial respiratory capacity using minimally invasive and noninvasive techniques in persons with spinal cord injury. PLoS One 17:e0265141.		Skeletal muscle
Adant 2022 Mol Metab	2022	Adant I, Bird M, Decru B, Windmolders P, Wallays M, de Witte P, Rymen D, Witters P, Vermeersch P, Cassiman D, Ghesquière B (2022) Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction. https://doi.org/10.1016/j.molmet.2022.101537	Human	Fibroblast	Mitochondrial disease
Chinas 2022 Metabolites	2022	Chiñas Merlin A, Gonzalez K, Mockler S, Perez Y, Jia UA, Chicco AJ, Ullevig SL, Chung E (2022) Switching to a standard chow diet at weaning improves the effects of maternal and postnatal high-fat and high-sucrose diet on cardiometabolic health in adult male mouse offspring. https://doi.org/10.3390/metabo12060563	Mouse	Heart		Cardiovascular
Gnaiger 2021 MitoFit BCA	2021-09-21	Gnaiger E (2021) Bioenergetic cluster analysis – mitochondrial respiratory control in human fibroblasts. https://doi.org/10.26124/mitofit:2021-0008	Human	Fibroblast		Aging;senescence
Kumar 2021 JCI Insight	2021	Kumar A, Welch N, Mishra S, Bellar A, Silva RN, Li L, Singh SS, Sharkoff M, Kerr A, Chelluboyina AK, Sekar J, Attaway AH, Hoppel C, Willard B, Davuluri G, Dasarathy S (2021) Metabolic reprogramming during hyperammonemia targets mitochondrial function and postmitotic senescence. JCI Insight 6:e154089.	Mouse Rat	Skeletal muscle
Mazzoli 2021 Antioxidants (Basel)	2021	Mazzoli A, Spagnuolo MS, Nazzaro M, Gatto C, Iossa S, Cigliano L (2021) Fructose removal from the diet reverses inflammation, mitochondrial dysfunction, and oxidative stress in hippocampus. Antioxidants (Basel) 10:487.	Rat	Nervous system
Hoppel 2021 Cells	2021	Hoppel F, Garcia-Souza LF, Kantner-Rumplmair W, Burtscher M, Gnaiger E, Pesta D, Calabria E (2021) Human platelet mitochondrial function reflects systemic mitochondrial alterations: a protocol for application in field studies. https://doi.org/10.3390/cells10082088	Human	Platelet
Zweck 2021 Diabetes Care	2021	Zweck E, Scheiber D, Jelenik T, Bönner F, Horn P, Pesta D, Schultheiss HP, Boeken U, Akhyari P, Lichtenberg A, Kelm M, Roden M, Westenfeld R, Szendroedi J (2021) Exposure to type 2 diabetes provokes mitochondrial impairment in apparently healthy human hearts. Diabetes Care 44:e82-e84.	Human	Heart		Diabetes
Cai 2021 Free Radic Biol Med	2021	Cai H, Bian X, Chen L, Zhang N, Li L, Tang W, Liu X, Li Z (2021) Selective intra-arterial brain cooling induces cerebral protection against ischemia/reperfusion injury through SENP1-Sirt3 signaling. Free Radic Biol Med 171:272-83.	Mouse	Nervous system	Oxidative stress;RONS Ischemia-reperfusion
Branco Haas 2021 Thesis	2021	Branco Haas C (2021) Insulin signaling and microglia in the young and aged brain. PhD Thesis 135.
Furihata 2021 Commun Biol	2021	Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S (2021) Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure. Commun Biol 4:138.	Mouse	Heart		Aging;senescence Cardiovascular
Flensted-Jensen 2021 Free Radic Biol Med	2021	Flensted-Jensen M, Gram M, Dela F, Helge JW, Larsen S (2021) Six weeks of high intensity cycle training reduces H₂O₂ emission and increases antioxidant protein levels in obese adults with risk factors for type 2 diabetes. Free Radic Biol Med 173:1-6.	Human	Skeletal muscle		Obesity
Antico 2021 Sci Adv	2021	Antico O, Ordureau A, Stevens M, Singh F, Nirujogi RS, Gierlinski M, Barini E, Rickwood ML, Prescott A, Toth R, Ganley IG, Harper JW, Muqit MMK (2021) Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1. Sci Adv 7:eabj0722.	Mouse	Nervous system
Pereyra 2021 J Lipid Res	2021	Pereyra AS, Harris KL, Soepriatna AH, Waterbury QA, Bharathi SS, Zhang Y, Fisher-Wellman KH, Goergen CJ, Goetzman ES, Ellis JM (2021) Octanoate is differentially metabolized in liver and muscle and fails to rescue cardiomyopathy in CPT2 deficiency. J Lipid Res 62:100069.	Mouse	Heart Skeletal muscle Liver
Watt 2021 Nat Commun	2021	Watt KI, Henstridge DC, Ziemann M, Sim CB, Montgomery MK, Samocha-Bonet D, Parker BL, Dodd GT, Bond ST, Salmi TM, Lee RS, Thomson RE, Hagg A, Davey JR, Qian H, Koopman R, El-Osta A, Greenfield JR, Watt MJ, Febbraio MA, Drew BG, Cox AG, Porrello ER, Harvey KF, Gregorevic P (2021) Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease. Nat Commun 12:2887.	Mouse	Skeletal muscle		Obesity
Terwilliger 2021 Vasc Med	2021	Terwilliger ZS, Ryan TE, Goldberg EJ, Schmidt CA, Yamaguchi DJ, Karnekar R, Brophy P, Green TD, Zeczycki TN, Mac Gabhann F, Annex BH, McClung JM (2021) Racial differences in the limb skeletal muscle transcriptional programs of patients with critical limb ischemia. Vasc Med 26:247-58.	Human	Skeletal muscle		Cardiovascular
Colin 2021 J Cell Mol Med	2021	Colin M, Dechene L, Ceusters J, Niesten A, Demazy C, Lagneaux L, Zouaoui Boudjeltia K, Franck T, Van Antwerpen P, Renard P, Mathieu V, Serteyn D (2021) Priming of mesenchymal stem cells with a hydrosoluble form of curcumin allows keeping their mesenchymal properties for cell-based therapy development. J Cell Mol Med 25:4877-81.	Horse	Stem cells
Dubinin 2021 Free Radic Biol Med	2021	Dubinin MV, Semenova AA, Ilzorkina AI, Penkov NV, Nedopekina DA, Sharapov VA, Khoroshavina EI, Davletshin EV, Belosludtseva NV, Spivak AY, Belosludtsev KN (2021) Mitochondria-targeted prooxidant effects of betulinic acid conjugated with delocalized lipophilic cation F16. Free Radic Biol Med 168:55-69.	Rat	Liver
Cardinale 2021 J Appl Physiol (1985)	2021	Cardinale DA, Gejl KD, Petersen KG, Nielsen J, Ørtenblad N, Larsen FJ (2021) Short-term intensified training temporarily impairs mitochondrial respiratory capacity in elite endurance athletes. J Appl Physiol (1985) 131:388-400.	Human	Skeletal muscle
Schroeder 2021 Cell Rep	2021	Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Mueller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Uecal M, Schaefer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Toelle RC, Sotonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Racz B, Kiechl S, Eisenberg T, Madeo F (2021) Dietary spermidine improves cognitive function. Cell Rep 35:108985.	Mouse Drosophila	Nervous system		Aging;senescence
De Moura Alvorcem 2021 J Neurochem	2021	de Moura Alvorcem, L, Britto R, Cecatto C, Roginski AC, Rohden F, Scholl JN, Guma FCR, Figueiro F, Amaral AU, Zanatta G, Seminotti B, Wajner M, Leipnitz G. (2021) Ethylmalonic acid impairs bioenergetics by disturbing succinate and glutamate oxidation and induces mitochondrial permeability transition pore opening in rat cerebellum.. J Neurochem 158(2): 262–81.	Rat	Nervous system	Permeability transition Oxidative stress;RONS	Inherited
Hoppel 2021 Front Physiol	2021	Hoppel F, Calabria E, Pesta DH, Kantner-Rumplmair W, Gnaiger E, Burtscher M (2021) Effects of ultramarathon running on mitochondrial function of platelets and oxidative stress parameters: a pilot study. https://doi.org/10.3389/fphys.2021.632664	Human	Platelet	Oxidative stress;RONS
Peruzzotti-Jametti 2021 PLoS Biol	2021	Peruzzotti-Jametti L, Bernstock JD, Willis CM, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Krzak G, Kittel A, Beninca C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Peacock B, Muller KH, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2021) Neural stem cells traffic functional mitochondria via extracellular vesicles. PLoS Biol 19:3001166.	Mouse	Nervous system Stem cells		Neurodegenerative
Theall 2021 Physiol Rep	2021	Theall B, Stampley J, Cho E, Granger J, Johannsen NM, Irving BA, Spielmann G (2021) Impact of acute exercise on peripheral blood mononuclear cells nutrient sensing and mitochondrial oxidative capacity in healthy young adults. Physiol Rep 9:e15147.	Human	Blood cells
Dunn 2021 Arterioscler Thromb Vasc Biol	2021	Dunn LL, Kong SMY, Tumanov S, Chen W, Cantley J, Ayer A, Maghzal GJ, Midwinter RG, Chan KH, Ng MKC, Stocker R (2021) Hmox1 (heme oxygenase-1) protects against ischemia-mediated injury via stabilization of HIF-1α (hypoxia-inducible factor-1α). Arterioscler Thromb Vasc Biol 41:317-30.	Mouse	Skeletal muscle	Hypoxia
Dos Santos Escaliante 2021 Int J Biol Macromol	2021	Dos Santos Escaliante LA, Busato B, de Oliveira Petkowicz CL, Suter Correia Cadena SM, Rodrigues Noleto G (2021) Cytotoxic effect of xyloglucan and oxovanadium (IV/V) xyloglucan complex in HepG2 cells. Int J Biol Macromol 185:40-48.	Human	Liver
Marrocco 2021 J Immunol	2021	Marrocco A, Frawley K, Pearce LL, Peterson J, O'Brien JP, Mullett SJ, Wendell SG, St Croix CM, Mischler SE, Ortiz LA (2021) Metabolic adaptation of macrophages as mechanism of defense against crystalline silica. J Immunol 207:1627-40.	Mouse	Macrophage-derived		Other
Meng 2021 FEBS Open Bio	2021	Meng L, Chen D, Meng G, Lu L, Han C (2021) Dysregulation of the Sirt5/IDH2 axis contributes to sunitinib resistance in human renal cancer cells. FEBS Open Bio 11:921-31.	Human	Kidney	Oxidative stress;RONS	Cancer
Hansen 2021 Physiol Rep	2021	Hansen C, Olsen K, Pilegaard H, Bangsbo J, Gliemann L, Hellsten Y (2021) High metabolic substrate load induces mitochondrial dysfunction in rat skeletal muscle microvascular endothelial cells. Physiol Rep 9:e14855.	Rat	Skeletal muscle Endothelial;epithelial;mesothelial cell
Rodrigues 2021 Sci Rep	2021	Rodrigues AQ, Picolo VL, Goulart JT, Silva IMG, Ribeiro RB, Aguiar BA, Ferreira YB, Oliveira DM, Lucci CM, de Bem AF, Paulini F (2021) Metabolic activity in cryopreserved and grafted ovarian tissue using high-resolution respirometry. Sci Rep 11:21517.	Mouse	Genital	Cryopreservation
Matsumoto 2021 Circ Heart Fail	2021	Matsumoto J, Takada S, Furihata T, Nambu H, Kakutani N, Maekawa S, Mizushima W, Nakano I, Fukushima A, Yokota T, Tanaka S, Handa H, Sabe H, Kinugawa S (2021) Brain-derived neurotrophic factor improves impaired fatty acid oxidation via the activation of adenosine monophosphate-activated protein kinase-ɑ - proliferator-activated receptor-r coactivator-1ɑ signaling in skeletal muscle of mice with heart failure. Circ Heart Fail 14: e005890.	Mouse	Skeletal muscle		Cardiovascular
Liu 2021 Front Physiol	2021	Liu H, Tenzing N, van Patot MT, Qile M, Ge RL, Wuren T (2021) Enhanced placental mitochondrial respiration in Tibetan women at high altitude. Front Physiol 12:697022. doi: 10.3389/fphys.2021.697022	Human	Genital	Hypoxia
Mendham 2021 Diabetologia	2021	Mendham AE, Goedecke JH, Zeng Y, Larsen S, George C, Hauksson J, Fortuin-de Smidt MC, Chibalin AV, Olsson T, Chorell E (2021) Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity. Diabetologia 64:1642-59.	Human	Skeletal muscle		Obesity
King 2021 J Biol Chem	2021	King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, López-Domènech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP (2021) Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics. J Biol Chem 297:101196.	Mouse	Skeletal muscle
Morgan 2021 Resuscitation	2021	Morgan RW, Sutton RM, Himebauch AS, Roberts AL, Landis WP, Lin Y, Starr J, Ranganathan A, Delso N, Mavroudis CD, Volk L, Slovis J, Marquez AM, Nadkarni VM, Hefti M, Berg RA, Kilbaugh TJ (2021) A randomized and blinded trial of inhaled nitric oxide in a piglet model of pediatric cardiopulmonary resuscitation. Resuscitation 162:274-83 .	Pig	Nervous system		Cardiovascular
Gomez-Valades 2021 Cell Metab	2021	Gómez-Valadés AG, Pozo M, Varela L, Boudjadja MB, Ramírez S, Chivite I, Eyre E, Haddad-Tóvolli R, Obri A, Milà-Guasch M, Altirriba J, Schneeberger M, Imbernón M, Garcia-Rendueles AR, Gama-Perez P, Rojo-Ruiz J, Rácz B, Alonso MT, Gomis R, Zorzano A, D'Agostino G, Alvarez CV, Nogueiras R, Garcia-Roves PM, Horvath TL, Claret M (2021) Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca²⁺ homeostasis with adipose tissue lipolysis . Cell Metab 33:1820-35.e9.	Mouse	Nervous system
Salin 2021 Mar Environ Res	2021	Salin K, Mathieu-Resuge M, Graziano N, Dubillot E, Le Grand F, Soudant P, Vagner M (2021) The relationship between membrane fatty acid content and mitochondrial efficiency differs within- and between- omega-3 dietary treatments. Mar Environ Res 163:105205.	Fishes	Skeletal muscle
Babylon 2021 Antioxidants (Basel)	2021	Babylon L, Grewal R, Stahr PL, Eckert RW, Keck CM, Eckert GP (2021) Hesperetin nanocrystals improve mitochondrial function in a cell model of early Alzheimer disease. Antioxidants (Basel) 10:1003.	Human	Neuroblastoma		Alzheimer's
Dall 2021 J Biol Chem	2021	Dall M, Hassing AS, Niu L, Nielsen TS, Ingerslev LR, Sulek K, Trammell SAJ, Gillum MP, Barrès R, Larsen S, Poulsen SS, Mann M, Ørskov C, Treebak JT (2021) Hepatocyte-specific perturbation of NAD⁺ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes. J Biol Chem 297:101388.	Mouse	Liver		Other
Vidimce 2021 Front Pharmacol	2021	Vidimce J, Pillay J, Shrestha N, Dong LF, Neuzil J, Wagner KH, Holland OJ, Bulmer AC (2021) Mitochondrial function, fatty acid metabolism, and body composition in the hyperbilirubinemic gunn rat. Front Pharmacol 12:586715.	Rat	Skeletal muscle Liver
MacCannell 2021 Int J Obes (Lond)	2021	MacCannell ADV, Futers TS, Whitehead A, Moran A, Witte KK, Roberts LD (2021) Sexual dimorphism in adipose tissue mitochondrial function and metabolic flexibility in obesity. Int J Obes (Lond) 45:1773-81.	Mouse	Fat		Obesity
Deline 2021 Biochim Biophys Acta Bioenerg	2021	Deline ML, Grashei M, van Heijster FHA, Schilling F, Straub J, Fromme T (2021) Adenylate kinase derived ATP shapes respiration and calcium storage of isolated mitochondria. Biochim Biophys Acta Bioenerg 1862:148409.	Mouse	Liver
Friederich 2021 Mol Genet Metab	2021	Friederich MW, Geddes GC, Wortmann SB, Punnoose A, Wartchow E, Knight KM, Prokisch H, Creadon-Swindell G, Mayr JA, Van Hove JLK (2021) Pathogenic variants in MRPL44 cause infantile cardiomyopathy due to a mitochondrial translation defect. Mol Genet Metab 133:362-71.	Human	Fibroblast	Mitochondrial disease	Cardiovascular Myopathy
Gvozdjakova 2021 PLoS One	2021	Gvozdjáková A, Sumbalová Z, Kucharská J, Szamosová M, Čápová L, Rausová Z, Vančová O, Mojto V, Langsjoen P, Palacka P (2021) Platelet mitochondrial respiration and coenzyme Q₁₀ could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases. PLoS ONE 16:e0256135.	Human	Platelet		Other
Fink 2021 Pharmacol Res Perspect	2021	Fink BD, Yu L, Coppey L, Obrosov A, Shevalye H, Kerns RJ, Yorek MA, Sivitz WI (2021) Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats. Pharmacol Res Perspect 9:e00701.	Rat	Liver		Diabetes Obesity
Nedel 2021 Intensive Care Med Exp	2021	Nedel WL, Kopczynski A, Rodolphi MS, Strogulski NR, De Bastiani M, Montes THM, Abruzzi J Jr, Galina A, Horvath TL, Portela LV (2021) Mortality of septic shock patients is associated with impaired mitochondrial oxidative coupling efficiency in lymphocytes: a prospective cohort study. Intensive Care Med Exp 9:39.	Human	Lymphocyte		Sepsis
Tonnesen 2021 Mol Cell Biochem	2021	Tonnesen PT, Hjortbak MV, Lassen TR, Seefeldt JM, Bøtker HE, Jespersen NR (2021) Myocardial salvage by succinate dehydrogenase inhibition in ischemia-reperfusion injury depends on diabetes stage in rats. Mol Cell Biochem 476:2675-84.	Rat	Heart	Ischemia-reperfusion	Diabetes
Su 2021 Chin J Physiol	2021	Su Y, Wang Y, Xu P, Sun Y, Ping Z, Huang H, Cao X (2021) Study on the time-effectiveness of exercise preconditioning on heart protection in exhausted rats. Chin J Physiol 64:97-105.	Rat	Heart
Zanou 2021 Nat Commun	2021	Zanou N, Dridi H, Reiken S, Imamura de Lima T, Donnelly C, De Marchi U, Ferrini M, Vidal J, Sittenfeld L, Feige JN, Garcia-Roves PM, Lopez-Mejia IC, Marks AR, Auwerx J, Kayser B, Place N (2021) Acute RyR1 Ca²⁺ leak enhances NADH-linked mitochondrial respiratory capacity. Nat Commun 12:7219.	Mouse	Skeletal muscle
Bouche 2021 PLoS One	2021	Bouche L, Kamel R, Tamareille S, Garcia G, Villedieu C, Pillot B, Gueguen N, Chehaitly A, Chao de la Barca JM, Beaumont J, Baetz D, Ovize M, Sesaki H, Henrion D, Reynier P, Lenaers G, Prunier F, Mirebeau-Prunier D (2021) DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries. PLoS One 16:0248554.	Mouse	Heart	Ischemia-reperfusion	Cardiovascular
Seefeldt 2021 Sci Rep	2021	Seefeldt JM, Lassen TR, Vognstoft Hjortbak M, Jespersen NR, Kvist F, Hansen J, Boetker HE (2021) Cardioprotective effects of empagliflozin after ischemia and reperfusion in rats. Sci Rep 11:9544.	Rat	Heart	Ischemia-reperfusion	Cardiovascular
Valera-Alberni 2021 Cell Rep	2021	Valera-Alberni M, Joffraud M, Miro-Blanch J, Capellades J, Junza A, Dayon L, Núñez Galindo A, Sanchez-Garcia JL, Valsesia A, Cercillieux A, Söllner F, Ladurner AG, Yanes O, Cantó C (2021) Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation. Cell Rep 36:109565.	Mouse	Liver Fat
Schmidt 2021 Cancer Metab	2021	Schmidt CA, McLaughlin KL, Boykov IN, Mojalagbe R, Ranganathan A, Buddo KA, Lin CT, Fisher-Wellman KH, Neufer PD (2021) Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells. Cancer Metab 9:3.	Human	Liver		Cancer
Jimenez-Uribe 2021 Free Radic Biol Med	2021	Jimenez-Uribe AP, Bellido B, Aparicio-Trejo OE, Tapia E, Sanchez-Lozada LG, Hernandez-Santos JA, Fernandez-Valverde F, Hernandez-Cruz EY, Orozco-Ibarra M, Pedraza-Chaverri J (2021) Temporal characterization of mitochondrial impairment in the unilateral ureteral obstruction model in rats. Free Radic Biol Med 172:358-71.	Rat	Kidney		Other
Liu 2021 FASEB J	2021	Liu Z, Chaillou T, Santos Alves E, Mader T, Jude B, Ferreira DMS, Hynynen H, Cheng AJ, Jonsson WO, Pironti G, Andersson DC, Kenne E, Ruas JL, Tavi P, Lanner JT (2021) Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force. FASEB J 35:e22010.	Mouse	Skeletal muscle	Hypoxia
Nambu 2021 Cardiovasc Res	2021	Nambu H, Takada S, Maekawa S, Matsumoto J, Kakutani N, Furihata T, Shirakawa R, Katayama T, Nakajima T, Yamanashi K, Obata Y, Nakano I, Tsuda M, Saito A, Fukushima A, Yokota T, Nio-Kobayashi J, Yasui H, Higashikawa K, Kuge Y, Anzai T, Sabe H, Kinugawa S (2021) Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance. Cardiovasc Res 117:805-19.	Mouse	Skeletal muscle		Cardiovascular
Flockhart 2021 Cell Metab	2021	Flockhart M, Nilsson LC, Tais S, Ekblom B, Apro W, Larsen FJ (2021) Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers. Cell Metab 33:957-70.	Human	Skeletal muscle
Whitehead 2021 Nat Commun	2021	Whitehead A, Krause FN, Moran A, MacCannell ADV, Scragg JL, McNally BD, Boateng E, Murfitt SA, Virtue S, Wright J, Garnham J, Davies GR, Dodgson J, Schneider JE, Murray AJ, Church C, Vidal-Puig A, Witte KK, Griffin JL, Roberts LD (2021) Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis. Nat Commun 12:1905.	Human	Skeletal muscle
Cannon 2021 Respir Physiol Neurobiol	2021	Cannon DT, Nogueira L, Gutierrez-Gonzalez AK, Gilmore NK, Bigby TD, Breen EC (2021) Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension. Respir Physiol Neurobiol 295:103783.	Mouse	Skeletal muscle		Cardiovascular
Gratl 2021 J Transl Med	2021	Gratl A, Pesta D, Gruber L, Speichinger F, Raude B, Omran S, Greiner A, Frese JP (2021) The effect of revascularization on recovery of mitochondrial respiration in peripheral artery disease: a case control study. https://doi.org/10.1186/s12967-021-02908-0J	Human	Skeletal muscle	Ischemia-reperfusion
Santana-Roman 2021 Insects	2021	Santana-Román ME, Maycotte P, Uribe-Carvajal S, Uribe-Alvarez C, Alvarado-Medina N, Khan M, Siddiqui A, Pando-Robles V (2021) Monitoring mitochondrial function in Aedes albopictus C6/36 cell line during dengue virus infection. Insects 12:934.				Infectious
Braga 2021 Sci Rep	2021	Braga RR, Crisol BM, Brícola RS, Sant'ana MR, Nakandakari SCBR, Costa SO, Prada PO, da Silva ASR, Moura LP, Pauli JR, Cintra DE, Ropelle ER (2021) Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPR^mt in the hypothalamus of mice. Sci Rep 11:3813.	Mouse	Nervous system
Ljubojevic-Holzer 2021 Cardiovasc Res	2021	Ljubojevic-Holzer S, Kraler S, Djalinac N, Abdellatif M, Voglhuber J, Schipke J, Schmidt M, Kling KM, Franke GT, Herbst V, Zirlik A, von Lewinski D, Scherr D, Rainer PP, Kohlhaas M, Nickel A, Muehlfeld C, Maack C, Sedej S (2021) Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca²⁺ cycling. Cardiovasc Res [Epub ahead of Print].	Mouse	Heart		Cardiovascular
Xiao 2021 PLoS Genet	2021	Xiao L, Liu J, Sun Z, Yin Y, Mao Y, Xu D, Liu L, Xu Z, Guo Q, Ding C, Sun W, Yang L, Zhou Z, Zhou D, Fu T, Zhou W, Zhu Y, Chen XW, Li JZ, Chen S, Xie X, Gan Z (2021) AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1. PLoS Genet 17:e1009488.	Mouse	Skeletal muscle
Pamenter 2021 Biol Lett	2021	Pamenter ME, Gomez CR, Richards JG, Milsom WK (2021) Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles. Biol Lett 12:20150797.	Reptiles	Nervous system	Hypoxia
Lefranc 2021 Int J Mol Sci	2021	Lefranc C, Friederich-Persson M, Foufelle F, Nguyen Dinh Cat A, Jaisser F (2021) Adipocyte-mineralocorticoid receptor alters mitochondrial quality control leading to mitochondrial dysfunction and senescence of visceral adipose tissue. Int J Mol Sci 22:2881.	Mouse	Fat		Obesity
Oemer 2021 J Lipid Res	2021	Oemer G, Edenhofer ML, Wohlfarter Y, Lackner K, Leman G, Koch J, Cardoso LHD, Lindner HH, Gnaiger E, Dubrac S, Zschocke J, Keller MA (2021) Fatty acyl availability modulates cardiolipin composition and alters mitochondrial function in HeLa cells. https://doi.org/10.1016/j.jlr.2021.100111	Human	HeLa
Davis 2021 Comparative Exercise Physiology	2021	Davis Michael, Barrett Montana, Popken Andrea (2021) Effect of hyperthermia and acidosis on equine skeletal muscle mitochondrial oxygen consumption. Comparative Exercise Physiology 17:171-179.	Horse	Skeletal muscle	Temperature
Krako 2021 Int J Mol Sci	2021	Krako Jakovljevic N, Pavlovic K, Jotic A, Lalic K, Stoiljkovic M, Lukic L, Milicic T, Macesic M, Stanarcic Gajovic J, Lalic NM (2021) Targeting mitochondria in diabetes. Int J Mol Sci 22:6642.	Human	Skeletal muscle Liver Blood cells		Diabetes
McKenna 2021 Redox Biol	2021	McKenna HT, O'Brien KA, Fernandez BO, Minnion M, Tod A, McNally BD, West JA, Griffin JL, Grocott MP, Mythen MG, Feelisch M, Murray AJ, Martin DS (2021) Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness. Redox Biol 41:101907.	Human	Skeletal muscle		Other
Yardeni 2021 Proc Natl Acad Sci U S A	2021	Yardeni T, Cristancho AG, McCoy AJ, Schaefer PM, McManus MJ, Marsh ED, Wallace DC (2021) An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes. Proc Natl Acad Sci U S A 118:e2021429118.	Mouse	Nervous system		Autism
Basse 2021 Mol Metab	2021	Basse AL, Agerholm M, Farup J, Dalbram E, Nielsen J, Oertenblad N, Altıntas A, Ehrlich AM, Krag T, Bruzzone S, Dall M, de Guia RM, Jensen JB, Moeller AB, Karlsen A, Kjaer M, Barres R, Vissing J, Larsen S, Jessen N, Treebak JT (2021) Nampt controls skeletal muscle development by maintaining Ca²⁺ homeostasis and mitochondrial integrity. Mol Metab 53:101271.	Mouse	Skeletal muscle
Gupta 2021 Sci Rep	2021	Gupta MK, Sahu A, Sun Y, Mohan ML, Kumar A, Zalavadia A, Wang X, Martelli EE, Stenson K, Witherow CP, Drazba J, Dasarathy S, Naga Prasad SV (2021) Cardiac expression of microRNA-7 is associated with adverse cardiac remodeling. Sci Rep 11:22018.	Mouse	Heart
Giordano 2021 Gene Ther	2021	Giordano L, Aneja MK, Sommer N, Alebrahimdehkordi N, Seraji A, Weissmann N, Rudolph C, Plank C, Jacobs HT, Szibor M (2021) Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active. Gene Ther [Epub ahead of print].	Mouse	Fibroblast
Tungtur 2021 Sci Rep	2021	Tungtur SK, Wilkins HM, Rogers RS, Badawi Y, Sage JM, Agbas A, Jawdat O, Barohn RJ, Swerdlow RH, Nishimune H (2021) Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord. Sci Rep 11:11051.	Mouse	Nervous system		Neurodegenerative
Bischof 2021 Sci Transl Med	2021	Bischof C, Mirtschink P, Yuan T, Wu M, Zhu C, Kaur J, Pham MD, Gonzalez-Gonoggia S, Hammer M, Rogg EM, Sharma R, Bottermann K, Gercken B, Hagag E, Berthonneche C, Sossalla S, Stehr SN, Maxeiner J, Duda MA, Latreille M, Zamboni N, Martelli F, Pedrazzini T, Dimmeler S, Krishnan J (2021) Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease. Sci Transl Med 13:eabi7964.				Cardiovascular
Kruse 2021 Life (Basel)	2021	Kruse CJ, Stern D, Mouithys-Mickalad A, Niesten A, Art T, Lemieux H, Votion DM (2021) In vitro assays for the assessment of impaired mitochondrial bioenergetics in equine atypical myopathy. Life (Basel) 11:719.	Horse	Skeletal muscle		Myopathy
Giovarelli 2021 Pharmacol Res	2021	Giovarelli M, Zecchini S, Catarinella G, Moscheni C, Sartori P, Barbieri C, Roux-Biejat P, Napoli A, Vantaggiato C, Cervia D, Perrotta C, Clementi E, Latella L, De Palma C (2021) Givinostat as metabolic enhancer reverting mitochondrial biogenesis deficit in Duchenne Muscular Dystrophy. Pharmacol Res 170:105751.	Mouse	Skeletal muscle		Other
Bastos Sant'Anna Silva 2021 Cancers (Basel)	2021	Bastos Sant'Anna Silva AC, Perez Valencia JA, Sciacovelli M, Lalou C, Sarlak S, Tronci L, Nikitopoulou E, Meszaros AT, Frezza C, Rossignol R, Gnaiger E, Klocker H (2021) Succinate anaplerosis has an onco-driving potential in prostate cancer cells. https://doi.org/10.3390/cancers13071727	Human	Genital		Cancer
Burska 2021 Biochim Biophys Acta Mol Basis Dis	2021	Burska D, Stiburek L, Krizova J, Vanisova M, Martinek V, Sladkova J, Zamecnik J, Honzik T, Zeman J, Hansikova H, Tesarova M (2021) Homozygous missense mutation in UQCRC2 associated with severe encephalomyopathy, mitochondrial complex III assembly defect and activation of mitochondrial protein quality control. Biochim Biophys Acta Mol Basis Dis 1867:166147.	Human	Fibroblast		Myopathy
Liepinsh 2021 Free Radic Biol Med	2021	Liepinsh E, Kuka J, Vilks K, Svalbe B, Stelfa G, Vilskersts R, Sevostjanovs E, Goldins NR, Groma V, Grinberga S, Plaas M, Makrecka-Kuka M, Dambrova M (2021) Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage. Free Radic Biol Med 177:370-80.	Mouse	Heart	Ischemia-reperfusion
Taylor 2021 Int J Mol Sci	2021	Taylor OJ, Thatcher MO, Carr ST, Gibbs JL, Trumbull AM, Harrison ME, Winden DR, Pearson MJ, Tippetts TS, Holland WL, Reynolds PR, Bikman BT (2021) High-mobility group box 1 disrupts metabolic function with cigarette smoke exposure in a ceramide-dependent manner. Int J Mol Sci 18:1099.	Mouse	Skeletal muscle
Villanueva 2021 Transplant Direct	2021	Villanueva JE, Chew HC, Gao L, Doyle A, Scheuer SE, Hicks M, Jabbour A, Dhital KK, Macdonald PS (2021) The effect of increasing donor age on myocardial ischemic tolerance in a rodent model of donation after circulatory death. Transplant Direct 7:699.	Rat	Heart	Ischemia-reperfusion
Drake 2021 Proc Natl Acad Sci U S A	2021	Drake JC, Wilson RJ, Laker RC, Guan Y, Spaulding HR, Nichenko AS, Shen W, Shang H, Dorn MV, Huang K, Zhang M, Bandara AB, Brisendine MH, Kashatus JA, Sharma PR, Young A, Gautam J, Cao R, Wallrabe H, Chang PA, Wong M, Desjardins EM, Hawley SA, Christ GJ, Kashatus DF, Miller CL, Wolf MJ, Periasamy A, Steinberg GR, Hardie DG, Yan Z (2021) Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy. Proc Natl Acad Sci U S A 118:e2025932118.	Mouse	Skeletal muscle
Pesta 2021 Front Endocrinol (Lausanne)	2021	Pesta D, Jelenik T, Zaharia OP, Bobrov P, Görgens S, Bódis K, Karusheva Y, Krako Jakovljevic N, Lalic NM, Markgraf DF, Burkart V, Müssig K, Knebel B, Kotzka J, Eckel J, Strassburger K, Szendroedi J, Roden M (2021) NDUFB6 polymorphism is associated with physical activity-mediated metabolic changes in type 2 diabetes. https://doi.org/10.3389/fendo.2021.693683	Mouse	Skeletal muscle		Diabetes
Lei 2021 Ecotoxicol Environ Saf	2021	Lei C, Liao J, Li Q, Shi J, Zhang H, Guo J, Han Q, Hu L, Li Y, Pan J, Tang Z (2021) Copper induces mitochondria-mediated apoptosis via AMPK-mTOR pathway in hypothalamus of pigs. Ecotoxicol Environ Saf 220:112395.	Pig	Nervous system
Leduc-Gaudet 2021 bioRxiv	2021	Leduc-Gaudet JP, Miguez K, Marina Cefis M, Moamer A, Chaffer TJ, Faitg J, Reynaud O, Broering FE, Shams A, Mayaki D, Huck L, Sandri M, Gouspillou G, Hussain SNA (2021) Role of autophagy in sepsis-induced skeletal muscle dysfunction, whole-body metabolism, and survival. bioRxiv doi: https://doi.org/10.1101/2021.08.05.455081.	Mouse	Skeletal muscle		Sepsis
Wigner 2021 Sci Rep	2021	Wigner P, Zielinski K, Labieniec-Watala M, Marczak A, Szwed M (2021) Doxorubicin-transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells. Sci Rep 11:4544.	Human	Other cell lines		Cancer
Dorigatti 2021 Geroscience	2021	Dorigatti JD, Thyne KM, Ginsburg BC, Salmon AB (2021) Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice. Geroscience 43:1497-511.	Mouse	Skeletal muscle		Aging;senescence
Fischer 2021 Antioxidants	2021	Fischer C, Volani C, Komlódi T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron overload and Hfe^-/- related hemochromatosis alter hepatic mitochondrial function. https://doi.org/10.3390/antiox10111818	Mouse	Liver
Fang 2021 Cell Rep	2021	Fang H, Ye X, Xie J, Li Y, Li H, Bao X, Yang Y, Lin Z, Jia M, Han Q, Zhu J, Li X, Zhao Q, Yang Y, Lyu J (2021) A membrane arm of mitochondrial complex I sufficient to promote respirasome formation. Cell Rep 35:108963.
Schumann 2021 Commun Biol	2021	Schumann T, Koenig J, von Loeffelholz C, Vatner DF, Zhang D, Perry RJ, Bernier M, Chami J, Henke C, Kurzbach A, El-Agroudy NN, Willmes DM, Pesta D, de Cabo R, O Sullivan JF, Simon E, Shulman GI, Hamilton BS, Birkenfeld AL (2021) Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Commun Biol 4:826.	Mouse	Liver		Diabetes
Trinity 2021 J Appl Physiol	2021	Trinity JD, Craig JC, Fermoyle CC, McKenzie AI, Lewis MT, Park SH, Rondina MT, Richardson RS (2021) Impact of presymptomatic COVID-19 on vascular and skeletal muscle function: a case study. J Appl Physiol (1985) 130:1961-70.	Human	Skeletal muscle		Infectious
Honecker 2021 Int J Obes (Lond)	2021	Honecker J, Weidlich D, Heisz S, Lindgren CM, Karampinos DC, Claussnitzer M, Hauner H (2021) A distribution-centered approach for analyzing human adipocyte size estimates and their association with obesity-related traits and mitochondrial function. Int J Obes (Lond) [Ephub ahead of print].	Human	Fat		Obesity
Apostolopoulou 2021 Sci Adv	2021	Apostolopoulou M, Mastrototaro L, Hartwig S, Pesta D, Straßburger K, de Filippo E, Jelenik T, Karusheva Y, Gancheva S, Markgraf D, Herder C, Nair KS, Reichert AS, Lehr S, Müssig K, Al-Hasani H, Szendroedi J, Roden M (2021) Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males. https://doi.org/10.1126/sciadv.abi9551	Human	Skeletal muscle		Diabetes
Goncalves 2021 Redox Biol	2021	Goncalves LS, Sales LP, Saito TR, Campos JC, Fernandes AL, Natali J, Jensen L, Arnold A, Ramalho L, Bechara LRG, Esteca MV, Correa I, Sant'Anna D, Ceroni A, Michelini LC, Gualano B, Teodoro W, Carvalho VH, Vargas BS, Medeiros MHG, Baptista IL, Irigoyen MC, Sale C, Ferreira JCB, Artioli GG (2021) Histidine dipeptides are key regulators of excitation-contraction coupling in cardiac muscle: evidence from a novel CARNS1 knockout rat model. Redox Biol 44:102016.	Rat	Heart
Szczerbinski 2021 Cells	2021	Szczerbinski L, Taylor MA, Puchta U, Konopka P, Paszko A, Citko A, Szczerbinski K, Goscik J, Gorska M, Larsen S, Kretowski A (2021) The response of mitochondrial respiration and quantity in skeletal muscle and adipose tissue to exercise in humans with prediabetes. Cells 10:3013.	Human	Skeletal muscle Fat		Diabetes
Holody 2021 Mitochondrion	2021	Holody C, Anfray A, Mast H, Lessard M, Han WH, Carpenter R, Bourque S, Sauvé Y, Lemieux H (2021) Differences in relative capacities of oxidative phosphorylation pathways may explain sex- and tissue-specific susceptibility to vision defects due to mitochondrial dysfunction. Mitochondrion 56:102-10.	Rat	Nervous system		Other
Avin 2021 Sci Rep	2021	Avin KG, Hughes MC, Chen NX, Srinivasan S, O'Neill KD, Evan AP, Bacallao RL, Schulte ML, Moorthi RN, Gisch DL, Perry CGR, Moe SM, O'Connell TM (2021) Skeletal muscle metabolic responses to physical activity are muscle type specific in a rat model of chronic kidney disease. Sci Rep 11:9788.	Rat	Skeletal muscle		Other
Palzur 2021 Int J Mol Sci	2021	Palzur E, Edelman D, Sakas R, Soustiel JF (2021) Etifoxine restores mitochondrial oxidative phosphorylation and improves cognitive recovery following traumatic brain injury. Int J Mol Sci 22:12881. doi: 10.3390/ijms222312881	Rat	Nervous system
Dubinin 2021 Membranes (Basel)	2021	Dubinin MV, Semenova AA, Nedopekina DA, Davletshin EV, Spivak AY, Belosludtsev KN (2021) Effect of F16-betulin conjugate on mitochondrial membranes and its role in cell death initiation. Membranes (Basel) 11:352.	Rat	Liver
Wall 2021 Dis Model Mech	2021	Wall JM, Basu A, Zunica ERM, Dubuisson OS, Pergola K, Broussard JP, Kirwan JP, Axelrod CL, Johnson AE (2021) CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases. Dis Model Mech 14:dmm048603.	Drosophila	Skeletal muscle		Other
Rossetti 2021 Sci Adv	2021	Rossetti G, Ermer JA, Stentenbach M, Siira SJ, Richman TR, Milenkovic D, Perks KL, Hughes LA, Jamieson E, Xiafukaiti G, Ward NC, Takahashi S, Gray N, Viola HM, Hool LC, Rackham O, Filipovska A (2021) A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance. Sci Adv 7:eabi7514.	Mouse	Liver
Christiansen 2021 Sci Rep	2021	Christiansen LB, Dohlmann TL, Ludvigsen TP, Parfieniuk E, Ciborowski M, Szczerbinski L, Kretowski A, Desler C, Tiano L, Orlando P, Martinussen T, Olsen LH, Larsen S (2021) Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected. Sci Rep 11:2167.	Pig	Heart Skeletal muscle Liver
Daura 2021 Neurobiol Dis	2021	Daura E, Tegelberg S, Yoshihara M, Jackson C, Simonetti F, Aksentjeff K, Ezer S, Hakala P, Katayama S, Kere J, Lehesjoki AE, Joensuu T (2021) Cystatin B-deficiency triggers ectopic histone H3 tail cleavage during neurogenesis. Neurobiol Dis 156:105418.	Mouse	Stem cells Nervous system		Neurodegenerative
Sahl 2021 Adipocyte	2021	Sahl RE, Høy Helms EF, Schmücker M, Flensted-Jensen M, Ingersen A, Morville T, Dela F, Helge JW, Larsen S (2021) Reliability and variation in mitochondrial respiration in human adipose tissue. Adipocyte 10:605-11.	Human	Fat
Prieto-Carrasco 2021 Biology (Basel)	2021	Prieto-Carrasco R, Silva-Palacios A, Rojas-Morales P, Aparicio-Trejo OE, Medina-Reyes EI, Hernandez-Cruz EY, Sanchez-Garibay C, Salinas-Lara C, Pavon N, Roldan FJ, Zazueta C, Tapia E, Pedraza-Chaverri J (2021) Unilateral ureteral obstruction for 28 days in rats is not associated with changes in cardiac function or alterations in mitochondrial function. Biology (Basel) 10:671.	Rat	Heart		Other
Riguet 2021 Nat Commun	2021	Riguet N, Mahul-Mellier AL, Maharjan N, Burtscher J, Croisier M, Knott G, Hastings J, Patin A, Reiterer V, Farhan H, Nasarov S, Lashuel HA (2021) Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties. Nat Commun 12:6579.	Human	HEK		Neurodegenerative
Zhang 2021 Pharmaceutics	2021	Zhang H, Zhang A, Gupte AA, Hamilton DJ (2021) Plumbagin elicits cell-specific cytotoxic effects and metabolic responses in melanoma cells. Pharmaceutics 13:706.	Human	Endothelial;epithelial;mesothelial cell Other cell lines		Cancer
Wuest 2021 Int J Mol Sci	2021	Wüst RCI, Coolen BF, Held NM, Daal MRR, Alizadeh Tazehkandi V, Baks-Te Bulte L, Wiersma M, Kuster DWD, Brundel BJJM, van Weeghel M, Strijkers GJ, Houtkooper RH (2021) The antibiotic doxycycline impairs cardiac mitochondrial and contractile function. Int J Mol Sci 22:4100.	Mouse	Heart
Liang 2021 Biomed Pharmacother	2021	Liang L, Zhang G, Cheng C, Li H, Jin T, Su C, Xiao Y, Bradley J, Peberdy MA, Ornato JP, Mangino MJ, Tang W (2021) High-resolution respirometry for evaluation of mitochondrial function on brain and heart homogenates in a rat model of cardiac arrest and cardiopulmonary resuscitation. Biomed Pharmacother 142:111935.	Rat	Heart Nervous system	Ischemia-reperfusion	Cardiovascular
Cheng 2021 Comp Biochem Physiol B Biochem Mol Biol	2021	Cheng H, Munro D, Huynh K, Pamenter ME (2021) Naked mole-rat skeletal muscle mitochondria exhibit minimal functional plasticity in acute or chronic hypoxia. Comp Biochem Physiol B Biochem Mol Biol 255:110596.	Other mammals	Skeletal muscle	Hypoxia Oxidative stress;RONS
Hoene 2021 Mol Metab	2021	Hoene M, Kappler L, Kollipara L, Hu C, Irmler M, Bleher D, Hoffmann C, Beckers J, Hrabě de Angelis M, Häring HU, Birkenfeld AL, Peter A, Sickmann A, Xu G, Lehmann R, Weigert C (2021) Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability. Mol Metab 54:101359.	Mouse	Liver
Moon 2021 J Lipid Res	2021	Moon SH, Dilthey BG, Liu X, Guan S, Sims HF, Gross RW (2021) High-Fat diet activates liver iPLA₂γ generating eicosanoids that mediate metabolic stress. J Lipid Res 62:100052.	Mouse	Liver		Obesity
Kaspar 2021 Sci Adv	2021	Kaspar S, Oertlin C, Szczepanowska K, Kukat A, Senft K, Lucas C, Brodesser S, Hatzoglou M, Larsson O, Topisirovic I, Trifunovic A (2021) Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR. Sci Adv 7:0971.	Mouse	Heart
Sharma 2021 Cancer Cell Int	2021	Sharma P, Sharma V, Ahluwalia TS, Dogra N, Kumar S, Singh S (2021) Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4. Cancer Cell Int 21:629.	Human	Endothelial;epithelial;mesothelial cell
Goldberg 2021 Biochem J	2021	Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH (2021) Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform. Biochem J 476:1521-37.	Mouse	Heart Skeletal muscle Liver
Connell 2021 J Nutr	2021	Connell NJ, Grevendonk L, Fealy CE, Moonen-Kornips E, Bruls YMH, Schrauwen-Hinderling VB, de Vogel J, Hageman R, Geurts J, Zapata-Perez R, Houtkooper RH, Havekes B, Hoeks J, Schrauwen P (2021) NAD⁺-precursor supplementation with L-tryptophan, nicotinic acid, and nicotinamide does not affect mitochondrial function or skeletal muscle function in physically compromised older adults. J Nutr 151:2917-31	Human	Skeletal muscle
Zuccarelli 2021 J Physiol	2021	Zuccarelli L, Baldassarre G, Magnesa B, Degano C, Comelli M, Gasparini M, Manferdelli G, Marzorati M, Mavelli I, Pilotto A, Porcelli S, Rasica L, Šimunič B, Pišot R, Narici M, Grassi B (2021) Peripheral impairments of oxidative metabolism after a 10-day bed rest are upstream of mitochondrial respiration. J Physiol 599:4813-29.	Human	Skeletal muscle
Knapp-Wilson 2021 bioRxiv	2021	Knapp-Wilson A, Pereira GC, Buzzard E, Richardson A, Corey RA, Neal C, Verkade P, Halestrap AP, Gold VAM, Kuwabara P, Collinson I (2021) Maintenance of complex I and respiratory super-complexes by NDUF-11 is essential for respiratory function, mitochondrial structure and health in C. elegans. bioRxiv doi: https://doi.org/10.1101/2021.01.06.425530.	Caenorhabditis elegans
Figueira 2021 Arch Biochem Biophys	2021	Figueira TR, Francisco A, Ronchi JA, Dos Santos GRRM, Santos WD, Treberg JR, Castilho RF (2021) NADPH supply and the contribution of NAD(P)⁺ transhydrogenase (NNT) to H₂O₂ balance in skeletal muscle mitochondria. Arch Biochem Biophys 707:108934.	Mouse	Skeletal muscle	Oxidative stress;RONS
Zunica 2021 Cancer Metab	2021	Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP (2021) Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15. Cancer Metab 9:36.	Human Mouse	Endothelial;epithelial;mesothelial cell		Cancer
Thoral 2021 Biol Lett	2021	Thoral E, Roussel D, Chinopoulos C, Teulier L, Salin K (2021) Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish. Biol Lett 17:20200759.	Fishes	Skeletal muscle
Kakimoto 2021 Redox Biol	2021	Kakimoto PA, Serna JDC, de Miranda Ramos V, Zorzano A, Kowaltowski AJ (2021) Increased glycolysis is an early consequence of palmitate lipotoxicity mediated by redox signaling. Redox Biol 45:102026.	Human	Liver
Akinbiyi 2021 Sci Rep	2021	Akinbiyi EO, Abramowitz LK, Bauer BL, Stoll MSK, Hoppel CL, Hsiao CP, Hanover JA, Mears JA (2021) Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass. Sci Rep 11:22106.
Baldini 2021 Life Sci	2021	Baldini F, Fabbri R, Eberhagen C, Voci A, Portincasa P, Zischka H, Vergani L (2021) Adipocyte hypertrophy parallels alterations of mitochondrial status in a cell model for adipose tissue dysfunction in obesity. Life Sci 265:118812.	Mouse	Fibroblast		Obesity
James 2021 Nat Commun	2021	James OJ, Vandereyken M, Marchingo JM, Singh F, Bray SE, Wilson J, Love AG, Swamy M (2021) IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes. Nat Commun 12:4290.	Mouse	Lymphocyte
Galli 2021 Front Physiol	2021	Galli GLJ, Ruhr IM, Crossley J, Crossley DA 2nd (2021) The long-term effects of developmental hypoxia on cardiac mitochondrial function in snapping turtles. Front Physiol 12:689684. doi: 10.3389/fphys.2021.689684	Reptiles	Heart	Oxidative stress;RONS Hypoxia
Willis 2021 Sci Rep	2021	Willis JR, Hickey AJR, Devaux JBL (2021) Thermally tolerant intertidal triplefin fish (Tripterygiidae) sustain ATP dynamics better than subtidal species under acute heat stress. Sci Rep 11:11074.	Fishes	Nervous system
Mazzoli 2021 Nutrients	2021	Mazzoli A, Gatto C, Crescenzo R, Cigliano L, Iossa S (2021) Prolonged changes in hepatic mitochondrial activity and insulin sensitivity by high fructose intake in adolescent rats. Nutrients 13:1370.	Rat	Liver
Axelrod 2021 EMBO Mol Med	2021	Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP (2021) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol Med 12:12088.	Mouse	Skeletal muscle		Obesity
Correia 2021 Hum Mutat	2021	Correia SP, Moedas MF, Naess K, Bruhn H, Maffezzini C, Calvo-Garrido J, Lesko N, Wibom R, Schober FA, Jemt A, Stranneheim H, Freyer C, Wedell A, Wredenberg A (2021) Severe congenital lactic acidosis and hypertrophic cardiomyopathy caused by an intronic variant in NDUFB7. Hum Mutat 42:378-84.	Human	Fibroblast
Bandara 2021 Mitochondrion	2021	Bandara AB, Drake JC, James CC, Smyth JW, Brown DA (2021) Complex I protein NDUFS2 is vital for growth, ROS generation, membrane integrity, apoptosis, and mitochondrial energetics. Mitochondrion 58:160-68.	Human	HEK
Davies 2021 FASEB J	2021	Davies KL, Smith DJ, El-Bacha T, Stewart ME, Easwaran A, Wooding PFP, Forhead AJ, Murray AJ, Fowden AL, Camm EJ (2021) Development of cerebral mitochondrial respiratory function is impaired by thyroid hormone deficiency before birth in a region-specific manner. FASEB J 35:21591.	Other mammals	Nervous system
Avram 2021 Life (Basel)	2021	Avram VF, Bina AM, Sima A, Aburel OM, Sturza A, Burlacu O, Timar RZ, Muntean DM, Elmer E, Cretu OM (2021) Improvement of platelet respiration by cell-permeable succinate in diabetic patients treated with statins. Life (Basel) 11:288.	Human	Platelet		Diabetes
Klepinina 2021 PLoS One	2021	Klepinina L, Klepinin A, Truu L, Chekulayev V, Vija H, Kuus K, Teino I, Pook M, Maimets T, Kaambre T (2021) Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS One 16:e0245348.	Human	Endothelial;epithelial;mesothelial cell		Cancer
Vandenberg 2021 Neurochem Int	2021	Vandenberg GG, Dawson NJ, Head A, Scott GR, Scott AL (2021) Astrocyte-mediated disruption of ROS homeostasis in Fragile X mouse model. Neurochem Int 146:105036.	Mouse	Nervous system		Autism
Sarabhai 2021 Diabetologia	2021	Sarabhai T, Koliaki C, Mastrototaro L, Kahl S, Pesta D, Apostolopoulou M, Wolkersdorfer M, Bönner AC, Bobrov P, Markgraf DF, Herder C, Roden M (2021) Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle. Diabetologia 65:301-14.	Human	Skeletal muscle		Diabetes
Scalzo 2021 J Physiol	2021	Scalzo RL, Schauer IE, Rafferty D, Knaub LA, Kvaratskhelia N, Johnson TK, Pott GB, Abushamat LA, Whipple MO, Huebschmann AG, Cree-Green M, Reusch JEB, Regensteiner JG (2021) Single-leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes. J Physiol 600:963-78.	Human	Skeletal muscle		Diabetes
Chambers 2021 JCI Insight	2021	Chambers KT, Cooper MA, Swearingen AR, Brookheart RT, Schweitzer GG, Weinheimer CJ, Kovacs A, Koves TR, Muoio DM, McCommis KS, Finck BN (2021) Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations. JCI Insight 6:134340.	Mouse	Heart		Cardiovascular
Tallosy 2021 Sci Rep	2021	Tallósy SP, Poles MZ, Rutai A, Fejes R, Juhász L, Burián K, Sóki J, Szabó A, Boros M, Kaszaki J (2021) The microbial composition of the initial insult can predict the prognosis of experimental sepsis. Sci Rep 11:22772.	Rat	Liver		Sepsis
Davis 2021 J Appl Physiol	2021	Davis MS, Barrett MR (2021) Effect of conditioning and physiology hyperthermia on canine skeletal muscle mitochondrial oxygen consumption. J Appl Physiol. 130:1317-1325	Dog	Skeletal muscle	Temperature
MiPNet21.17 BloodCellsIsolation	2020-10-22	O2k-Protocols: Isolation of blood cells for HRR.	Human	Blood cells Platelet
Hassan 2020 MitoFit Preprint Arch	2020-04-30	Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. https://doi.org/10.26124/mitofit:200003	Human		Mitochondrial disease	Autism
Song 2020 Life Sci	2020	Song K, Zhang Y, Ga Q, Bai Z, Ge RL (2020) High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling. Life Sci 252:117633.	Mouse	Liver	Hypoxia	Obesity
Edmunds 2020 Mol Metab	2020	Edmunds LR, Xie B, Mills AM, Huckestein BR, Undamatla R, Murali A, Pangburn MM, Martin J, Sipula I, Kaufman BA, Scott I, Jurczak MJ (2020) Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance. Mol Metab 41:101051.	Mouse	Liver		Obesity
Kunz 2020 J Biol Chem	2020	Kunz HE, Dorschner JM, Berent TE, Meyer T, Wang X, Jatoi A, Kumar R, Lanza IR (2020) Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. J Biol Chem 295:17441-59.	Mouse	Skeletal muscle		Cancer
Frambach 2020 Biochim Biophys Acta Mol Basis Dis	2020	Frambach SJCM, van de Wal MAE, van den Broek PHH, Smeitink JAM, Russel FGM, de Haas R, Schirris TJJ (2020) Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165727.	Mouse	Skeletal muscle	Mitochondrial disease
Heinonen 2020 Sci Rep	2020	Heinonen I, Sorop O, van Dalen BM, Wüst RCI, van de Wouw J, de Beer VJ, Octavia Y, van Duin RWB, Hoogstrate Y, Blonden L, Alkio M, Anttila K, Stubbs A, van der Velden J, Merkus D, Duncker DJ (2020) Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement. Sci Rep 10:13173.	Pig	Heart		Cardiovascular Diabetes
Rodriguez de Yurre 2020 An Acad Bras Cienc	2020	Rodriguez de Yurre A, Martins EGL, Lopez-Alarcon M, Cabral B, Vera N, Lopes JA, Galina A, Takiya CM, Lindoso RS, Vieyra A, SÁenz OC, Medei E (2020) Type 2 diabetes mellitus alters cardiac mitochondrial content and function in a non-obese mice model. An Acad Bras Cienc 92:e20191340.	Mouse	Heart		Diabetes
Alston 2020 Am J Hum Genet	2020	Alston CL, Veling MT, Heidler J, Taylor LS, Alaimo JT, Sung AY, He L, Hopton S, Broomfield A, Pavaine J, Diaz J, Leon E, Wolf P, McFarland R, Prokisch H, Wortmann SB, Bonnen PE, Wittig I, Pagliarini DJ, Taylor RW (2020) Pathogenic bi-allelic mutations in NDUFAF8 cause Leigh syndrome with an isolated complex I deficiency. Am J Hum Genet 106:92-101.	Human	Fibroblast
Jayakumari 2020 J Diabetes	2020	Jayakumari NR, Rajendran RS, Sivasailam A, Vimala SS, Nanda S, Manjunatha S, Pillai VV, Karunakaran J, Gopala S (2020) Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians. J Diabetes 12:542-55.	Human	Heart		Diabetes
Chausse 2020 Brain Behav Immun	2020	Chausse B, Lewen A, Poschet G, Kann O (2020) Selective inhibition of mitochondrial respiratory complexes controls the transition of microglia into a neurotoxic phenotype in situ. Brain Behav Immun 88:802-14.	Mouse	Nervous system
Bundgaard 2020 J Exp Biol	2020	Bundgaard A, Qvortrup K, Rasmussen LJ, Fago A (2020) Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia. J Exp Biol 222:jeb200410.	Amphibians	Heart
Oellermann 2020 Sci Rep	2020	Oellermann M, Hickey AJR, Fitzgibbon QP, Smith G (2020) Thermal sensitivity links to cellular cardiac decline in three spiny lobsters. Sci Rep 10:202.	Crustaceans	Heart	Temperature
Hayes 2020 Nutrients	2020	Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan CJ, Tuorto F, Nolan DP, Kelly VP (2020) Queuine micronutrient deficiency promotes Warburg metabolism and reversal of the mitochondrial ATP synthase in HeLa cells. Nutrients 12:E871.	Human	HeLa		Cancer
Politis-Barber 2020 Am J Physiol Endocrinol Metab	2020	Politis-Barber V, Brunetta HS, Paglialunga S, Petrick HL, Holloway GP (2020) Long-term high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration. Am J Physiol Endocrinol Metab 319:E376-87.	Mouse	Fat		Obesity
Deleye 2020 J Biol Chem	2020	Deleye Y, Cotte AK, Hannou SA, Hennuyer N, Bernard L, Derudas B, Caron S, Legry V, Vallez E, Dorchies E, Martin N, Lancel S, Annicotte JS, Bantubungi K, Pourtier A, Raverdy V, Pattou F, Lefebvre P, Abbadie C, Staels B, Haas JT, Paumelle R (2020) CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway. J Biol Chem 295:17310-22.	Mouse	Liver
Pereira 2020 PLoS One	2020	Pereira GC, Lee L, Rawlings N, Ouwendijk J, Parker JE, Andrienko TN, Henley JM, Halestrap AP (2020) Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia. PLoS One 15:e0234653.	Rat	Heart	Ischemia-reperfusion Permeability transition
Risiglione 2020 Int J Mol Sci	2020	Risiglione P, Leggio L, Cubisino SAM, Reina S, Paternò G, Marchetti B, Magrì A, Iraci N, Messina A (2020) High-resolution respirometry reveals MPP⁺ mitochondrial toxicity mechanism in a cellular model of parkinson's disease. Int J Mol Sci 21:E7809.	Human	Neuroblastoma
Romeiro 2020 bioRxiv	2020	Romeiro NC, Ferreira CM, Oliveira MF (2020) Assessment of mitochondrial physiology of murine white adipose tissue by mechanical permeabilization and lipid depletion. bioRxiv doi: https://doi.org/10.1101/2020.02.19.956870.	Mouse	Fat
Krabbendam 2020 Cell Death Dis	2020	Krabbendam IE, Honrath B, Dilberger B, Iannetti EF, Branicky RS, Meyer T, Evers B, Dekker FJ, Koopman WJH, Beyrath J, Bano D, Schmidt M, Bakker BM, Hekimi S, Culmsee C, Eckert GP, Dolga AM (2020) SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans. Cell Death Dis 11:263.	Mouse	Nervous system	Cell death	Neurodegenerative
Pelster 2020 PLoS One	2020	Pelster B, Wood CM, Campos DF, Val AL (2020) Cellular oxygen consumption, ROS production and ROS defense in two different size-classes of an Amazonian obligate air-breathing fish (Arapaima gigas). PLoS One 15:e0236507.	Fishes	Kidney Lung;gill	Hypoxia
Cipullo 2020 Nucleic Acids Res	2020	Cipullo M, Pearce SF, Lopez Sanchez IG, Gopalakrishna S, Krüger A, Schober F, Busch JD, Li X, Wredenberg A, Atanassov I, Rorbach J (2020) Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly. Nucleic Acids Res 49:354-70.	Human	HEK
MitoEAGLE muscle 1	2020	Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. - Updated: 2020-03-08	Human	Skeletal muscle
Coppin 2020 Cell Death Dis	2020	Coppin L, Jannin A, Ait Yahya E, Thuillier C, Villenet C, Tardivel M, Bongiovanni A, Gaston C, de Beco S, Barois N, van Seuningen I, Durand E, Bonnefond A, Vienne JC, Vamecq J, Figeac M, Vincent A, Delacour D, Porchet N, Pigny P (2020) Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface. Cell Death Dis 11:360.	Human	Islet cell;pancreas;thymus Endothelial;epithelial;mesothelial cell		Cancer
Magnesa 2020 Thesis	2020	Magnesa B (2020) Skeletal muscle mitochondrial oxidative phosphorylation plasticity in two studies on humans: exercise training effect in obese subjects and bed rest effect in healthy subjects. PhD Thesis 81.	Human	Skeletal muscle		Obesity
Hardee 2020 Mol Metab	2020	Hardee JP, Martins KJB, Miotto PM, Ryall JG, Gehrig SM, Reljic B, Naim T, Chung JD, Trieu J, Swiderski K, Philp AM, Philp A, Watt MJ, Stroud DA, Koopman R, Steinberg GR, Lynch GS (2020) Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity. Mol Metab 45:101157.	Mouse	Skeletal muscle
Bloise 2020 Thyroid	2020	Bloise FF, Santos AT, Brito JT, Andrade CBV, Oliveira TS, Souza AF, Fontes KN, Silva JD, Blanco NG, Silva PL, Rocco PRM, Fliers E, Boelen A, da-Silva WS, Ortiga-Carvalho TM (2020) Sepsis impairs thyroid hormone signaling and mitochondrial function in the mouse diaphragm. Thyroid 30:1079-90.	Mouse	Skeletal muscle		Sepsis
Vaccari 2020 Eur J Appl Physiol	2020	Vaccari F, Passaro A, D'Amuri A, Sanz JM, Di Vece F, Capatti E, Magnesa B, Comelli M, Mavelli I, Grassi B, Fiori F, Bravo G, Avancini A, Parpinel M, Lazzer S (2020) Effects of 3-month high-intensity interval training vs. moderate endurance training and 4-month follow-up on fat metabolism, cardiorespiratory function and mitochondrial respiration in obese adults. Eur J Appl Physiol 120:1787-803.	Human	Skeletal muscle		Obesity
Lopez 2020 Function (Oxf)	2020	Lopez R, Marzban B, Gao X, Lauinger E, Van den Bergh F, Whitesall SE, Converso-Baran K, Burant CF, Michele DE, Beard DA (2020) Impaired myocardial energetics causes mechanical dysfunction in decompensated failing hearts. Function (Oxf) 1:zqaa018.	Rat	Heart		Cardiovascular
Hartmann 2020 Free Radic Res	2020	Hartmann DD, Gonçalves DF, Da Rosa PC, Martins RP, Courtes AA, Franco JL, A Soares FA, Puntel GO (2020) A single muscle contusion promotes an immediate alteration in mitochondrial bioenergetics response in skeletal muscle fibres with different metabolism. Free Radic Res 54:137-49.	Rat	Skeletal muscle		Other
Andrade 2020 Nutr Metab Cardiovasc Dis	2020	Andrade D, Oliveira G, Menezes L, Nascimento AL, Carvalho S, Stumbo AC, Thole A, Garcia-Souza É, Moura A, Carvalho L, Cortez E (2020) Insulin-like growth factor-1 short-period therapy improves cardiomyopathy stimulating cardiac progenitor cells survival in obese mice. Nutr Metab Cardiovasc Dis 30:151-61.	Mouse	Heart
Allen 2020 Commun Biol	2020	Allen ME, Pennington ER, Perry JB, Dadoo S, Makrecka-Kuka M, Dambrova M, Moukdar F, Patel HD, Han X, Kidd GK, Benson EK, Raisch TB, Poelzing S, Brown DA, Shaikh SR (2020) The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats. Commun Biol 3:389.	Rat	Heart	Ischemia-reperfusion
Rodriguez 2020 J Gerontol A Biol Sci Med Sci	2020	Rodríguez E, Hakkou M, Hagen TM, Lemieux H, Blier PU (2020) Divergences in the control of mitochondrial respiration are associated with lifespan variation in marine bivalves. J Gerontol A Biol Sci Med Sci 76:796-804.	Molluscs			Aging;senescence
Jian 2020 Cell Metab	2020	Jian C, Fu J, Cheng X, Shen LJ, Ji YX, Wang X, Pan S, Tian H, Tian S, Liao R, Song K, Wang HP, Zhang X, Wang Y, Huang Z, She ZG, Zhang XJ, Zhu L, Li H (2020) Low-dose sorafenib acts as a mitochondrial uncoupler and ameliorates nonalcoholic steatohepatitis. Cell Metab 31:892-908.	Mouse	Liver		Cancer
Visavadiya 2020 Mol Cell Biochem	2020	Visavadiya NP, Pena GS, Khamoui AV (2020) Mitochondrial dynamics and quality control are altered in a hepatic cell culture model of cancer cachexia. Mol Cell Biochem 476:23-34.	Mouse	Liver		Cancer
Wang 2020 J Mol Med (Berl)	2020	Wang SY, Zhu Siyu, Wu Jian, Zhang Maomao, Xu Yousheng, Xu Wei, Cui Jinjin, Yu Bo, Cao Wei, Liu Jingjin (2020) Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathy. J Mol Med (Berl) 98:245-61.	Mouse	Heart	Oxidative stress;RONS	Diabetes Cardiovascular Obesity
Khamoui 2020 Physiol Genomics	2020	Khamoui AV, Tokmina-Roszyk D, Rossiter HB, Fields GB, Visavadiya NP (2020) Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia. Physiol Genomics 52:203-16.	Mouse	Liver		Cancer
Serna 2020 J Bioenerg Biomembr	2020	Serna JDC, Caldeira da Silva CC, Kowaltowski AJ (2020) Functional changes induced by caloric restriction in cardiac and skeletal muscle mitochondria. J Bioenerg Biomembr 52:269-77.	Rat	Heart Skeletal muscle	Permeability transition	Aging;senescence
Hingst 2020 Mol Metab	2020	Hingst JR, Kjøbsted R, Birk JB, Jørgensen NO, Larsen MR, Kido K, Larsen JK, Kjeldsen SAS, Fentz J, Frøsig C, Holm S, Fritzen AM, Dohlmann TL, Larsen S, Foretz M, Viollet B, Schjerling P, Overby P, Halling JF, Pilegaard H, Hellsten Y, Wojtaszewski JFP (2020) Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise. Mol Metab 40:101028.	Mouse	Skeletal muscle
Liu 2020 Cell Death Dis	2020	Liu YF, Zhu Juan-Juan, Yu Tian X, Liu Han, Zhang Tao, Zhang Yun-Peng, Xie Si-An, Zheng Ming, Kong Wei, Yao Wei-Juan, Pang Wei, Zhao Chuan-Rong, Tang Yuan-Jun, Zhou Jing (2020) Hypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility. Cell Death Dis 11:35.	Mouse	Endothelial;epithelial;mesothelial cell
Mahul-Mellier 2020 Proc Natl Acad Sci U S A	2020	Mahul-Mellier AL, Burtscher J, Maharjan N, Weerens L, Croisier M, Kuttler F, Leleu M, Knott GW, Lashuel HA (2020) The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration. Proc Natl Acad Sci U S A 117:4971-82.	Mouse	Nervous system		Parkinson's
Eshima 2020 J Appl Physiol (1985)	2020	Eshima H, Siripoksup P, Mahmassani ZS, Johnson JM, Ferrara PJ, Verkerke ARP, Salcedo A, Drummond MJ, Funai K (2020) Neutralizing mitochondrial ROS does not rescue muscle atrophy induced by hindlimb unloading in female mice. J Appl Physiol (1985) 129:124-32.	Mouse	Skeletal muscle	Oxidative stress;RONS
Lensu 2020 Nutrients	2020	Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Lindén J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides ameliorate high-fat-diet-induced hepatic steatosis in rats . Nutrients 12:E3225.	Rat	Liver		Other
Almoiliqy 2020 Acta Pharmacol Sin	2020	Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y (2020) Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53. Acta Pharmacol Sin 41:1208-22.	Rat	Endothelial;epithelial;mesothelial cell	Ischemia-reperfusion
Wefers 2020 Mol Metab	2020	Wefers J, Connell NJ, Fealy CE, Andriessen C, de Wit V, van Moorsel D, Moonen-Kornips E, Jörgensen JA, Hesselink MKC, Havekes B, Hoeks J, Schrauwen P (2020) Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals. Mol Metab 41:101050.	Human	Skeletal muscle		Obesity
Contreras Mostazo 2020 Cancers (Basel)	2020	Mostazo MGC, Kurrle N, Casado M, Fuhrmann D, Alshamleh I, Häupl B, Martín-Sanz P, Brüne B, Serve H, Schwalbe H, Schnütgen F, Marin S, Cascante M (2020) Metabolic plasticity is an essential requirement of acquired tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Cancers (Basel) 12:E3443.	Human	Blood cells		Cancer
Hafstad 2020 Antioxidants (Basel)	2020	Hafstad AD, Hansen SS, Lund J, Santos CXC, Boardman NT, Shah AM, Aasum E (2020) NADPH oxidase 2 mediates myocardial oxygen wasting in obesity. Antioxidants (Basel) 9:E171.	Mouse	Heart	Oxidative stress;RONS	Obesity
Larsen 2020 Cardiovasc Drugs Ther	2020	Larsen AH, Wiggers H, Dollerup OL, Jespersen NR, Hansson NH, Frøkiær J, Brøsen K, Nørrelund H, Bøtker HE, Møller N, Jessen N (2020) Metformin lowers body weight but fails to increase insulin sensitivity in chronic heart failure patients without diabetes: a randomized, double-blind, placebo-controlled study. Cardiovasc Drugs Ther 35:491-503.	Human	Skeletal muscle		Cardiovascular Diabetes
Mezeiova 2020 Eur J Med Chem	2020	Mezeiova E, Janockova J, Andrys R, Soukup O, Kobrlova T, Muckova L, Pejchal J, Simunkova M, Handl J, Micankova P, Capek J, Rousar T, Hrabinova M, Nepovimova E, Marco-Contelles JL, Valko M, Korabecny J (2020) 2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease. Eur J Med Chem 211:113112.	Human	Neuroblastoma		Alzheimer's
Xia 2020 Biomed Res Int	2020	Xia W, Wang Q, Lu Y, Hu Y, Zhang X, Zhang J, Liu D, Song J, Zhu Z, Liu D, Zhang H (2020) Transient receptor potential channel canonical type 3 deficiency antagonizes myofibroblast transdifferentiation in vivo. Biomed Res Int 2020:1202189.	Human	Fibroblast	Oxidative stress;RONS
Russell 2020 Nutrients	2020	Russell JS, Griffith TA, Naghipour S, Vider J, Du Toit EF, Patel HH, Peart JN, Headrick JP (2020) Dietary α-linolenic acid counters cardioprotective dysfunction in diabetic mice: unconventional PUFA protection. Nutrients 12:E2679.	Mouse	Heart	Ischemia-reperfusion	Diabetes
Maeda 2020 J Cell Mol Med	2020	Maeda H, Kami D, Maeda R, Murata Y, Jo JI, Kitani T, Tabata Y, Matoba S, Gojo S (2020) TAT-dextran-mediated mitochondrial transfer enhances recovery from models of reperfusion injury in cultured cardiomyocytes. J Cell Mol Med 24:5007-20.	Rat	Heart	Ischemia-reperfusion
Falcao-Tebas 2020 J Physiol	2020	Falcão-Tebas F, Marin EC, Kuang J, Bishop DJ, McConell GK (2020) Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring. J Physiol 598:4251-70.	Rat	Skeletal muscle		Obesity
Kamarauskaite 2020 Biomed Res Int	2020	Kamarauskaite J, Baniene R, Trumbeckas D, Strazdauskas A, Trumbeckaite S (2020) Increased succinate accumulation induces ROS generation in in vivo ischemia/reperfusion-affected rat kidney mitochondria. Biomed Res Int 2020:8855585.	Rat	Kidney	Ischemia-reperfusion
Jespersen 2020 Sci Rep	2020	Jespersen NR, Hjortbak MV, Lassen TR, Støttrup NB, Johnsen J, Tonnesen PT, Larsen S, Kimose HH, Bøtker HE (2020) Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus. Sci Rep 10:10344.	Rat	Heart	Ischemia-reperfusion	Diabetes
Grewal 2020 Exp Neurol	2020	Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248.	Human	Neuroblastoma		Aging;senescence Alzheimer's
Chen 2020 Biochim Biophys Acta Mol Basis Dis	2020	Chen T, Hill JT, Moore TM, Cheung ECK, Olsen ZE, Piorczynski TB, Marriott TD, Tessem JS, Walton CM, Bikman BT, Hansen JM, Thomson DM (2020) Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance. Biochim Biophys Acta Mol Basis Dis 1866:165805.	Mouse	Skeletal muscle		Obesity
Marrocco 2020 Thesis	2020	Marrocco A (2020) Alterations of CCSP expression and macrophages metabolism in the development of silica-induced pulmonary inflammation and fibrosis. PhD Thesis 108.	Mouse	Macrophage-derived		Other
Brand 2020 J Clin Med	2020	Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout-an interventional pilot study. J Clin Med 9:E667.	Human	Lymphocyte		Other
Fuchs 2020 J Funct Foods	2020	Fuchs C, Bakuradze T, Steinke R, Grewal R, Eckert GP, Richling E (2020) Polyphenolic composition of extracts from winery by-products and effects on cellular cytotoxicity and mitochondrial functions in HepG2 cells. J Funct Foods 70:103988.	Human	Liver
D'Urso 2020 Surg Endosc	2020	D'Urso A, Agnus V, Barberio M, Seeliger B, Marchegiani F, Charles AL, Geny B, Marescaux J, Mutter D, Diana M (2020) Computer-assisted quantification and visualization of bowel perfusion using fluorescence-based enhanced reality in left-sided colonic resections. Surg Endosc 35:4321-31.	Human	Endothelial;epithelial;mesothelial cell	Ischemia-reperfusion
Cecatto 2020 Toxicol In Vitro	2020	Cecatto C, Amaral AU, Roginski AC, Castilho RF, Wajner M (2020) Impairment of mitochondrial bioenergetics and permeability transition induction caused by major long-chain fatty acids accumulating in VLCAD deficiency in skeletal muscle as potential pathomechanisms of myopathy. Toxicol In Vitro 62:104665.	Rat	Skeletal muscle	Permeability transition	Inherited Myopathy Other
Rondot 2020 Thesis	2020	Rondot A (2020) Fuels for winter: the role of proline in overwintering bumblebee queens (Bombus impatiens). Master's Thesis 41.	Hexapods	Skeletal muscle
Avila-Rojas 2020 Food Chem Toxicol	2020	Avila-Rojas SH, Aparicio-Trejo OE, Briones-Herrera A, Medina-Campos ON, Reyes-Fermín LM, Martínez-Klimova E, León-Contreras JC, Hernández-Pando R, Tapia E, Pedraza-Chaverri J (2020) Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin. Food Chem Toxicol 145:111774.	Rat	Kidney
Szibor 2020 J Cell Mol Med	2020	Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gaertner U, Hall AR, Pell V, Viscomi C, Krieg T, Murphy MP, Braun T, Gellerich FN, Schlueter KD, Jacobs HT(2020) Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia. J Cell Mol Med 24:3534-48.	Mouse	Heart	Ischemia-reperfusion
Briones-Herrera 2020 Free Radic Biol Med	2020	Briones-Herrera A, Ramírez-Camacho I, Zazueta C, Tapia E, Pedraza-Chaverri J (2020) Altered proximal tubule fatty acid utilization, mitophagy, fission and supercomplexes arrangement in experimental Fanconi syndrome are ameliorated by sulforaphane-induced mitochondrial biogenesis. Free Radic Biol Med 153:54-70.	Rat	Kidney
Seo 2020 J Clin Med	2020	Seo DY, Heo JW, No MH, Yoo SZ, Ko JR, Park DH, Kang JH, Kim CJ, Jung SJ, Han J, Kwak HB (2020) Exercise training protects against atorvastatin-induced skeletal muscle dysfunction and mitochondrial dysfunction in the skeletal muscle of rats. J Clin Med 9:E2292.	Rat	Skeletal muscle
Wen 2020 Biomedicines	2020	Wen JJ, Cummins CB, Williams TP, Radhakrishnan RS (2020) The genetic evidence of burn-induced cardiac mitochondrial metabolism dysfunction . Biomedicines 8:E566.	Rat	Heart
McCommis 2020 bioRxiv	2020	McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, Todd King M, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN (2020) Ketogenic diet prevents heart failure from defective mitochondrial pyruvate metabolism. bioRxiv doi: https://doi.org/10.1101/2020.02.21.959635 .	Mouse	Heart
Buch 2020 FASEB J	2020	Buch BT, Halling JF, Ringholm S, Gudiksen A, Kjøbsted R, Olsen MA, Wojtaszewski JFP, Pilegaard H (2020) Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner. FASEB J 34:8653-70.	Mouse	Skeletal muscle		Aging;senescence
Souza da Silva 2020 Mol Neurobiol	2020	Souza da Silva J, Nonose Y, Rohden F, Lukasewicz Ferreira PC, Fontella FU, Rocha A, Wigner Brochier A, Vieira Apel R, de Lima TM, Seminotti B, Amaral AU, Galina A, Souza DO (2020) Guanosine neuroprotection of presynaptic mitochondrial calcium homeostasis in a mouse study with amyloid-β oligomers. Mol Neurobiol 57:4790-809.	Mouse	Nervous system		Alzheimer's
Hraoui 2020 J Exp Biol	2020	Hraoui G, Bettinazzi S, Gendron AD, Boisclair D, Breton S (2020) Mitochondrial thermo-sensitivity in invasive and native freshwater mussels. J Exp Biol 223:jeb215921.	Molluscs	Lung;gill	Temperature
Gruenig 2020 Biochem Pharmacol	2020	Grünig D, Szabo L, Marbet M, Krähenbühl S (2020) Valproic acid affects fatty acid and triglyceride metabolism in HepaRG cells exposed to fatty acids by different mechanisms. Biochem Pharmacol 177:113860.	Mouse	Liver
Schleier 2020 J Cardiovasc Transl Res	2020	Schleier Y, Moreno-Loaiza O, López Alarcón MM, Lopes Martins EG, Braga BC, Ramos IP, Galina A, Medei EH (2020) NOD mice recapitulate the cardiac disturbances observed in type 1 diabetes. J Cardiovasc Transl Res 14:271-82.	Mouse	Heart		Diabetes
Agil 2020 J Clin Med	2020	Agil A, Chayah M, Visiedo L, Navarro-Alarcon M, Rodríguez Ferrer JM, Tassi M, Reiter RJ, Fernández-Vázquez G (2020) Melatonin improves mitochondrial dynamics and function in the kidney of Zücker diabetic fatty rats. J Clin Med 9:E2916.	Rat	Kidney		Diabetes Obesity
Al-Azab 2020 FEBS J	2020	Al-Azab M, Qaed E, Ouyang X, Elkhider A, Walana W, Li H, Li W, Tang Y, Adlat S, Wei J, Wang B, Li X (2020) TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation. FEBS J 287:3088-104.	Human	Other cell lines		Other
Burtscher 2020 Int J Mol Sci	2020	Burtscher J, Di Pardo A, Maglione V, Schwarzer C, Squitieri F (2020) Mitochondrial respiration changes in R6/2 Huntington's Disease model mice during aging in a brain region specific manner. Int J Mol Sci 21:5412.	Mouse	Nervous system
Woessner 2020 J Appl Physiol (1985)	2020	Woessner MN, Neil C, Saner NJ, Goodman CA, McIlvenna LC, Ortiz de Zevallos J, Garnham AP, Levinger I, Allen JD (2020) Effect of inorganic nitrate on exercise capacity, mitochondria respiration and vascular function in heart failure reduced ejection fraction. J Appl Physiol (1985) 128:1355-64.	Human	Skeletal muscle		Cardiovascular
Liepinsh 2020 Physiol Rep	2020	Liepinsh E, Makarova E, Plakane L, Konrade I, Liepins K, Videja M, Sevostjanovs E, Grinberga S, Makrecka-Kuka M, Dambrova M (2020) Low-intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults. Physiol Rep 8:e14489.	Human	Blood cells
McLaughlin 2020b Sci Rep	2020	McLaughlin KL, Hagen JT, Coalson HS, Nelson MAM, Kew KA, Wooten AR, Fisher-Wellman KH (2020) Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs. Sci Rep 10:17599.	Mouse	Heart Liver Kidney Fat
Li Puma 2020 Am J Physiol Regul Integr Comp Physiol	2020	Li Puma LC, Hedges M, Heckman JM, Mathias AB, Engstrom MR, Brown AB, Chicco AJ (2020) Experimental oxygen concentration influences rates of mitochondrial hydrogen peroxide release from cardiac and skeletal muscle preparations. Am J Physiol Regul Integr Comp Physiol 318:972-80.	Mouse	Heart Skeletal muscle	Oxidative stress;RONS
Macasoi 2020 Oncol Rep	2020	Macașoi I, Pavel IZ, Moacă AE, Avram S, David LV, Coricovac D, Mioc A, Spandidos DA, Tsatsakis A, Șoica C, Dumitrașcu V, Dehelean C (2020) Mechanistic investigations of antitumor activity of a Rhodamine B‑oleanolic acid derivative bioconjugate. Oncol Rep 44:1169-83.	Human	Endothelial;epithelial;mesothelial cell		Cancer
Piel 2020 FEBS J	2020	Piel MS, Masscheleyn S, Bouillaud F, Moncoq K, Miroux B (2020) Structural models of mitochondrial uncoupling proteins obtained in DPC micelles are not functionally relevant. FEBS J 288:3024-33.	Saccharomyces cerevisiae
Mohsin 2020 Arch Biochem Biophys	2020	Mohsin AA, Thompson J, Hu Y, Hollander J, Lesnefsky EJ, Chen Q (2020) Endoplasmic reticulum stress-induced complex I defect: Central role of calcium overload. Arch Biochem Biophys 683:108299.	Rat	Skeletal muscle	Oxidative stress;RONS
Sowton 2020 Mol Genet Metab Rep	2020	Sowton AP, Padmanabhan N, Tunster SJ, McNally BD, Murgia A, Yusuf A, Griffin JL, Murray AJ, Watson ED (2020) Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. Mol Genet Metab Rep 23:100580.	Mouse	Liver		Other
Marquez 2020 J Am Heart Assoc	2020	Marquez AM, Morgan RW, Ko T, Landis WP, Hefti MM, Mavroudis CD, McManus MJ, Karlsson M, Starr J, Roberts AL, Lin Y, Nadkarni V, Licht DJ, Berg RA, Sutton RM, Kilbaugh TJ (2020) Oxygen exposure during cardiopulmonary resuscitation is associated with cerebral oxidative injury in a randomized, blinded, controlled, preclinical trial. J Am Heart Assoc 9:015032.	Pig	Nervous system		Cardiovascular
Zhang 2020 Chemosphere	2020	Zhang Y, Li Y, Feng Q, Shao M, Yuan F, Liu F (2020) Polydatin attenuates cadmium-induced oxidative stress via stimulating SOD activity and regulating mitochondrial function in Musca domestica larvae. Chemosphere 248:126009.	Hexapods		Oxidative stress;RONS
Brunetta 2020 J Physiol	2020	Brunetta HS, Politis-Barber V, Petrick HL, Dennis KMJH, Kirsh AJ, Barbeau PA, Nunes EA, Holloway GP (2020) Nitrate attenuates HFD-induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial ROS emission. J Physiol 598:3357-71.	Mouse	Fat		Obesity
Simard 2020 Metabolites	2020	Simard C, Lebel A, Allain EP, Touaibia M, Hebert-Chatelain E, Pichaud N (2020) Metabolic characterization and consequences of mitochondrial pyruvate carrier deficiency in Drosophila melanogaster. Metabolites 109:E363.	Drosophila
Cassereau 2020 Exp Neurol	2020	Cassereau J, Chevrollier A, Codron P, Goizet C, Gueguen N, Verny C, Reynier P, Bonneau D, Lenaers G, Procaccio V (2020) Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K. Exp Neurol 323:113069.	Human	Fibroblast	Oxidative stress;RONS	Neurodegenerative
Cubizolle 2020 J Cell Mol Med	2020	Cubizolle A, Cia D, Moine E, Jacquemot N, Guillou L, Rosell M, Angebault-Prouteau C, Lenaers G, Meunier I, Vercauteren J, Durand T, Crauste C, Brabet P (2020) Isopropyl-phloroglucinol-DHA protects outer retinal cells against lethal dose of all-trans-retinal. J Cell Mol Med 24:5057-69.	Rat	Endothelial;epithelial;mesothelial cell
Dulac 2020 J Physiol	2020	Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation . J Physiol 598:3691-710.	Mouse	Skeletal muscle
Bose 2020 Aging Cell	2020	Bose C, Alves I, Singh P, Palade PT, Carvalho E, Børsheim E, Jun SR, Cheema A, Boerma M, Awasthi S, Singh SP (2020) Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell 19:e13261.	Mouse	Heart		Aging;senescence
Gnad 2020 Cell Metab	2020	Gnad T, Navarro G, Lahesmaa M, Reverte-Salisa L, Copperi F, Cordomi A, Naumann J, Hochhäuser A, Haufs-Brusberg S, Wenzel D, Suhr F, Jespersen NZ, Scheele C, Tsvilovskyy V, Brinkmann C, Rittweger J, Dani C, Kranz M, Deuther-Conrad W, Eltzschig HK, Niemi T, Taittonen M, Brust P, Nuutila P, Pardo L, Fleischmann BK, Blüher M, Franco R, Bloch W, Virtanen KA, Pfeifer A (2020) Adenosine/A2B receptor signaling ameliorates the effects of aging and counteracts obesity. Cell Metab 32:56-70.e7.	Mouse	Skeletal muscle		Aging;senescence Obesity
P-L control efficiency	2020	Gnaiger E (2020) Cell ergometry: OXPHOS-control and ET-coupling efficiency. Mitochondr Physiol Network (2015-01-18) last update 2020-11-12.
Cornelissen 2020 Hum Mol Genet	2020	Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet 29:1096-106.	Human	Fibroblast	Cell death Oxidative stress;RONS	Parkinson's
Feng 2020 Int J Biol Macromol	2020	Feng Q, Shao M, Han J, Tang T, Zhang Y, Liu F (2020) TFAM, a potential oxidative stress biomarker used for monitoring environment pollutants in Musca domestica. Int J Biol Macromol 155:524-34.	Hexapods		Oxidative stress;RONS
Lin 2020 Preprints	2020	Lin M, Fu T, Hsu C, Huang S, Lin Y, Wang J (2020) Cycling exercise training enhances mitochondrial bioenergetics of platelets in patients with peripheral arterial disease: a randomized controlled trial. Preprints 2020070567.	Human	Platelet		Other
Skemiene 2020 J Bioenerg Biomembr	2020	Skemiene K, Pampuscenko K, Rekuviene E, Borutaite V (2020) Protective effects of anthocyanins against brain ischemic damage. J Bioenerg Biomembr 52:71-82.	Rat	Nervous system	Ischemia-reperfusion
Abid 2020 FASEB J	2020	Abid H, Ryan ZC, Delmotte P, Sieck GC, Lanza IR (2020) Extramyocellular interleukin-6 influences skeletal muscle mitochondrial physiology through canonical JAK/STAT signaling pathways. FASEB J 34:14458-72.	Mouse	Skeletal muscle	Oxidative stress;RONS
Krajcova 2020 PLOS ONE	2020	Krajčová A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pokorná E, Duška F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142.	Human	Heart	Cryopreservation
Liu 2020 J Clin Invest	2020	Liu L, Ding C, Fu T, Feng Z, Lee JE, Xiao L, Xu Z, Yin Y, Guo Q, Sun Z, Sun W, Mao Y, Yang L, Zhou Z, Zhou D, Xu L, Zhu Z, Qiu Y, Ge K, Gan Z (2020) Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction. J Clin Invest 130:4710-25.	Mouse	Skeletal muscle
Nicolaisen 2020 FASEB J	2020	Nicolaisen TS, Klein AB, Dmytriyeva O, Lund J, Ingerslev LR, Fritzen AM, Carl CS, Lundsgaard AM, Frost M, Ma T, Schjerling P, Gerhart-Hines Z, Flamant F, Gauthier K, Larsen S, Richter EA, Kiens B, Clemmensen C (2020) Thyroid hormone receptor α in skeletal muscle is essential for T3-mediated increase in energy expenditure. FASEB J 34:15480-91.	Mouse	Skeletal muscle
De-Souza 2020 J Biol Chem	2020	De-Souza EA, Pimentel FSA, De-Queiroz ALFV, Camara H, Felix-Formiga ML, Machado CM, Pinto S, Galina A, Mori MA, Montero-Lomelí M, Masuda CA (2020) The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. J Biol Chem 295:3773-82.	Caenorhabditis elegans Saccharomyces cerevisiae
Piel 2020 PLoS One	2020	Piel S, Chamkha I, Dehlin AK, Ehinger JK, Sjövall F, Elmér E, Hansson MJ (2020) Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose. PLoS One 15:e0231173.	Human	Liver Platelet
Skemiene 2020 Biomolecules	2020	Skemiene K, Rekuviene E, Jekabsone A, Cizas P, Morkuniene R, Borutaite V (2020) Comparison of effects of metformin, phenformin, and inhibitors of mitochondrial complex I on mitochondrial permeability transition and ischemic brain injury. Biomolecules 10:E1400.	Rat	Nervous system	Ischemia-reperfusion Permeability transition
Ehrlicher 2020 FASEB J	2020	Ehrlicher SE, Stierwalt HD, Miller BF, Newsom SA, Robinson MM (2020) Mitochondrial adaptations to exercise do not require Bcl2-mediated autophagy but occur with BNIP3/Parkin activation. FASEB J 34:4602-18.	Mouse	Skeletal muscle
Ulgherait 2020 Nat Commun	2020	Ulgherait Matt, Chen Anna, McAllister Sophie F, Kim Han X, Delventhal Rebecca, Wayne Charlotte R, Garcia Christian J, Recinos Yocelyn, Oliva Miles, Canman Julie C, Picard Martin, Owusu-Ansah Edward, Shirasu-Hiza Mimi (2020) Circadian regulation of mitochondrial uncoupling and lifespan. Nat Commun 11:1927.	Drosophila			Aging;senescence
Brum 2020 Mol Neurobiol	2020	Brum EDS, Fialho MFP, Fischer SPM, Hartmann DD, Gonçalves DF, Scussel R, Machado-de-Ávila RA, Dalla Corte CL, Soares FAA, Oliveira SM (2020) Relevance of mitochondrial dysfunction in the reserpine-induced experimental fibromyalgia model. Mol Neurobiol 57:4202-17.	Mouse	Skeletal muscle Nervous system		Other
Makrecka-Kuka 2020 Sci Rep	2020	Makrecka-Kuka M, Dimitrijevs P, Domracheva I, Jaudzems K, Dambrova M, Arsenyan P (2020) Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production. Sci Rep 10:21595.	Mouse	Endothelial;epithelial;mesothelial cell		Cancer
Groennebaek 2020 Cells	2020	Groennebaek T, Billeskov TB, Schytz CT, Jespersen NR, Bøtker HE, Olsen RKJ, Eldrup N, Nielsen J, Farup J, De Paoli FV, Vissing K (2020) Mitochondrial structure and function in the metabolic myopathy accompanying patients with critical limb ischemia. Cells 9:E570.	Human	Skeletal muscle	Ischemia-reperfusion	Myopathy
Lozano 2020 Part Fibre Toxicol	2020	Lozano O, Silva-Platas C, Chapoy-Villanueva H, Pérez BE, Lees JG, Ramachandra CJA, Contreras-Torres FF, Lázaro-Alfaro A, Luna-Figueroa E, Bernal-Ramírez J, Gordillo-Galeano A, Benitez A, Oropeza-Almazán Y, Castillo EC, Koh PL, Hausenloy DJ, Lim SY, García-Rivas G (2020) Amorphous SiO₂ nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes. Part Fibre Toxicol 17:15.	Rat	Heart
Wu 2020 Chemosphere	2020	Wu F, Sokolov EP, Dellwig O, Sokolova IM (2020) Season-dependent effects of ZnO nanoparticles and elevated temperature on bioenergetics of the blue mussel Mytilus edulis. Chemosphere 263:127780.	Molluscs	Other cell lines	Temperature
Dirks 2020 J Physiol	2020	Dirks ML, Miotto PM, Goossens GH, Senden JM, Petrick HL, van Kranenburg J, van Loon LJC, Holloway GP (2020) Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H₂O₂ emission. J Physiol 598:123-37.	Human	Skeletal muscle	Oxidative stress;RONS
Yadav 2020 Cell Death Dis	2020	Yadav SK, Kambis TN, Kar S, Park SY, Mishra PK (2020) MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro. Cell Death Dis 11:186.	Human	Heart Stem cells	Cell death	Diabetes
Keppner 2020 Thesis	2020	Keppner G (2020) Impact of gut microbiota composition, liver metabolism and respiratory capacity of peripheral blood mononuclear cells on resting metabolic rate. PhD Thesis 100.	Human	Blood cells		Obesity
Rodrigues 2020 J Appl Physiol (1985)	2020	Rodrigues GC, Rocha NN, Maia LA, Melo I, Simões AC, Antunes MA, Bloise FF, Woyames J, da-Silva WS, Capelozzi VL, Abela G, Ball L, Pelosi P, Rocco PRM, Silva PL (2020) Impact of experimental obesity on diaphragm structure, function and bioenergetics. J Appl Physiol (1985) 129:1062-74.	Rat	Skeletal muscle		Obesity
Kawamura 2021 Mol Ther Nucleic Acids	2020	Kawamura E, Maruyama M, Abe J, Sudo A, Takeda A, Takada S, Yokota T, Kinugawa S, Harashima H, Yamada Y (2021) Validation of gene therapy for mutant mitochondria by delivering mitochondrial RNA using a MITO-porter. Mol Ther Nucleic Acids 20:687-98.	Human	Fibroblast	Mitochondrial disease
Nascimento-Dos-Santos 2020 Biochim Biophys Acta Mol Basis Dis	2020	Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis 1866:165686.	Rat	Liver Nervous system		Neurodegenerative
Dubinin 2020 Biochim Biophys Acta Bioenerg	2020	Dubinin MV, Talanov EY, Tenkov KS, Starinets VS, Mikheeva IB, Belosludtsev KN (2020) Transport of Ca²⁺ and Ca²⁺-dependent permeability transition in heart mitochondria in the early stages of duchenne muscular dystrophy. Biochim Biophys Acta Bioenerg 1861:148250.	Mouse	Heart	Permeability transition	Myopathy
Pena 2020 Int J Chronic Dis	2020	Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501.	Mouse	Nervous system		Alzheimer's
Carvalho 2020 BMC Nutr	2020	Carvalho E, Adams SH, Borsheim E, Blackburn ML, Ono-Moore KD, Cotter M, Bowlin AK, Yeruva L (2020) Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk. BMC Nutr 6:13.	Pig	Liver
Le 2020 J Biol Chem	2020	Le CH, Benage LG, Specht KS, Li Puma LC, Mulligan CM, Heuberger AL, Prenni JE, Claypool SM, Chatfield KC, Sparagna GC, Chicco AJ (2020) Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria. J Biol Chem 295:12485-97.	Human	Heart		Aging;senescence
Kupats 2020 Oxid Med Cell Longev	2020	Kupats E, Stelfa G, Zvejniece B, Grinberga S, Vavers E, Makrecka-Kuka M, Svalbe B, Zvejniece L, Dambrova M (2020) Mitochondrial-protective effects of R-phenibut after experimental traumatic brain injury. Oxid Med Cell Longev 2020:9364598.	Mouse	Nervous system		Other
Woessner 2020 Thesis	2020	Woessner MN (2020) BEET-HF: The effects of dietary inorganic nitrate supplementation on aerobic exercise performance, vascular function, cardiac performance and mitochondrial respiration in patients with heart failure with reduced ejection fraction. PhD Thesis 198.	Human	Skeletal muscle		Cardiovascular
Reutzel 2020 Oxid Med Cell Longev	2020	Reutzel M, Grewal R, Dilberger B, Silaidos C, Joppe A, Eckert GP (2020) Cerebral mitochondrial function and cognitive performance during aging: A longitudinal study in NMRI mice. Oxid Med Cell Longev 2020:4060769.	Mouse	Nervous system		Aging;senescence Neurodegenerative
Esselun 2020 Neuromolecular Med	2020	Esselun C, Dilberger B, Silaidos CV, Koch E, Schebb NH, Eckert GP (2020) A walnut diet in combination with enriched environment improves cognitive function and affects lipid metabolites in brain and liver of aged NMRI mice. Neuromolecular Med 23:140-60.	Mouse	Nervous system		Aging;senescence
Fecker 2020 Biomolecules	2020	Fecker R, Buda V, Alexa E, Avram S, Pavel IZ, Muntean D, Cocan I, Watz C, Minda D, Dehelean CA, Soica C, Danciu C (2020) Phytochemical and biological screening of Oenothera biennis L. hydroalcoholic extract. Biomolecules 10:E818.	Human	Endothelial;epithelial;mesothelial cell	Cell death
Musi 2020 Aging Cell	2020	Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME (2020) Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell 17:e12840.	Mouse	Nervous system		Aging;senescence Neurodegenerative
Baxter 2020 Elife	2020	Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D (2020) Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Elife 9:e50705.	Mouse	Heart
Gvozdjakova 2020 Diagnostics (Basel)	2020	Gvozdjáková A, Sumbalová Z, Kucharská J, Komlósi M, Rausová Z, Vančová O, Számošová M, Mojto V (2020) Platelet mitochondrial respiration, endogenous coenzyme Q₁₀ and oxidative stress in patients with chronic kidney disease. Diagnostics (Basel) 10:176.	Human	Platelet		Other
Miotto 2020 Am J Physiol Endocrinol Metab	2020	Miotto PM, Petrick HL, Holloway GP (2020) Acute insulin deprivation results in altered mitochondrial substrate sensitivity conducive to greater fatty acid transport. Am J Physiol Endocrinol Metab 319:E345-53.	Rat	Skeletal muscle		Diabetes
Cheng 2020 Am J Physiol Heart Circ Physiol	2020	Cheng TC, Philip JL, Tabima DM, Kumari S, Yakubov B, Frump AL, Hacker TA, Bellofiore A, Li R, Sun X, Goss KN, Lahm T, Chesler N (2020) Estrogen receptor alpha prevents right ventricular diastolic dysfunction and fibrosis in female rats . Am J Physiol Heart Circ Physiol 319:H1459-73.	Rat	Heart		Cardiovascular
Sharma 2020 Integr Cancer Ther	2020	Sharma P, Singh S (2020) Combinatorial effect of DCA and let-7a on triple-negative MDA-MB-231 cells: A metabolic approach of treatment. Integr Cancer Ther 19:1534735420911437.	Human	Endothelial;epithelial;mesothelial cell		Cancer
Macedo 2020 FASEB J	2020	Macedo F, Romanatto T, Gomes de Assis C, Buis A, Kowaltowski AJ, Aguilaniu H, Marques da Cunha F (2020) Lifespan-extending interventions enhance lipid-supported mitochondrial respiration in Caenorhabditis elegans. FASEB J 34:9972-81.	Caenorhabditis elegans			Aging;senescence
Palavicini 2020 JCI Insight	2020	Palavicini JP, Chen J, Wang C, Wang J, Qin C, Baeuerle E, Wang X, Woo JA, Kang DE, Musi N, Dupree JL, Han X (2020) Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. JCI Insight 5:137286.	Mouse	Nervous system		Diabetes Neurodegenerative Obesity
Doig 2020 Skelet Muscle	2020	Doig CL, Zielinska AE, Fletcher RS, Oakey LA, Elhassan YS, Garten A, Cartwright D, Heising S, Alsheri A, Watson DG, Prehn C, Adamski J, Tennant DA, Lavery GG (2020) Induction of the nicotinamide riboside kinase NAD⁺ salvage pathway in a model of sarcoplasmic reticulum dysfunction. Skelet Muscle 10:5.	Mouse	Skeletal muscle
Pajuelo 2020 Cells	2020	Pajuelo Reguera D, Čunátová K, Vrbacký M, Pecinová A, Houštěk J, Mráček T, Pecina P (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:443.	Human	HEK
Vulczak 2020 Cells	2020	Vulczak A, Souza AO, Ferrari GD, Azzolini AECS, Pereira-da-Silva G, Alberici LC (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:E628.	Mouse	Endothelial;epithelial;mesothelial cell		Cancer
Xiong 2020 Biomed Pharmacother	2020	Xiong Xiaowei, Lu Weihang, Qin Xuan, Luo Qingyu, Zhou Weimin (2020) Downregulation of the GLP-1/CREB/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction. Biomed Pharmacother 127:110218.	Human Rat	Endothelial;epithelial;mesothelial cell	Oxidative stress;RONS	Diabetes
Mahalingam 2020 J Physiol	2020	Mahalingam S, Cheviron ZA, Storz JF, McClelland GB, Scott GR (2020) Chronic cold exposure induces mitochondrial plasticity in deer mice native to high altitudes. J Physiol 598:5411-26.	Mouse	Skeletal muscle	Temperature Hypoxia
Roginski 2020 Biochim Biophys Acta Mol Basis Dis	2020	Roginski AC, Wajner A, Cecatto C, Wajner SM, Castilho RF, Wajner M, Amaral AU (2020) Disturbance of bioenergetics and calcium homeostasis provoked by metabolites accumulating in propionic acidemia in heart mitochondria of developing rats. Biochim Biophys Acta Mol Basis Dis 1866:165682.	Rat	Heart Other cell lines	Permeability transition	Inherited
Zhou 2020 Biomed Pharmacother	2020	Zhou J, Zhang Y, Li S, Zhou Q, Lu Y, Shi J, Liu J, Wu Q, Zhou S (2020) Dendrobium nobile Lindl. alkaloids-mediated protection against CCl4-induced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway. Biomed Pharmacother 129:110351.	Mouse	Liver	Oxidative stress;RONS
Duong 2020 Mitochondrion	2020	Duong QV, Hoffman A, Zhong K, Dessinger MJ, Zhang Y, Bazil JN (2020) Calcium overload decreases net free radical emission in cardiac mitochondria. Mitochondrion 51:126-39.	Guinea pig	Heart	Ischemia-reperfusion Oxidative stress;RONS
Vanweert 2020 J Clin Endocrinol Metab	2020	Vanweert F, de Ligt M, Hoeks J, Hesselink MKC, Schrauwen P, Phielix E (2020) Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances. J Clin Endocrinol Metab 106:e1827-36.	Human	Skeletal muscle		Diabetes
Ost 2020 EMBO Rep	2020	Ost M, Igual Gil C, Coleman V, Keipert S, Efstathiou S, Vidic V, Weyers M, Klaus S (2020) Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress. EMBO Rep 21:e48804.	Mouse	Skeletal muscle
Matsuo 2020 Am J Physiol Endocrinol Metab	2020	Matsuo FS, Araújo PHC, Mota RF, Carvalho AJR, Queiroz MS, Almeida BB, Ferreira KCOS, Metzner RJM, Ferrari GD, Alberici LC, Osako MK (2020) RANKL induces beige adipocyte differentiation in preadipocytes. Am J Physiol Endocrinol Metab 318:E866-77.	Mouse	Fat		Diabetes Obesity
Parker 2020 Thesis	2020	Parker EP (2020) The effect of isoleucine supplementation of peripheral blood mononuclear cell metabolism in subjects with type 2 diabetes. URS Thesis 31.	Human	Blood cells		Diabetes
Cruz 2020 Drug Alcohol Depend	2020	Cruz JV, Maba IK, Correia D, Kaziuk FD, Cadena SMSC, Zampronio AR (2020) Intermittent binge-like ethanol exposure during adolescence attenuates the febrile response by reducing brown adipose tissue thermogenesis in rats. Drug Alcohol Depend 209:107904.	Rat	Fat
Hoffmann 2020 J Clin Endocrinol Metab	2020	Hoffmann C, Schneeweiss P, Randrianarisoa E, Schnauder G, Kappler L, Machann J, Schick F, Fritsche A, Heni M, Birkenfeld A, Niess AM, Häring HU, Weigert C, Moller A (2020) Response of mitochondrial respiration in adipose tissue and muscle to 8 weeks of endurance exercise in obese subjects. J Clin Endocrinol Metab 105:dgaa571.	Human	Skeletal muscle		Obesity
Yurre 2020 Arq Bras Cardiol	2020	Yurre AR, Silva JDFD, Torres MKDS, Martins EL, Ramos IP, Silva WSFLD, Sarpa JDS, Guedes CCDS, Napoleão TH, Coelho LCBB, Paiva PMG, Medei E (2020) Evaluation of the cardiac effects of a water-soluble lectin (Wsmol) from Moringa oleifera seeds. Arq Bras Cardiol 114:1029-37.	Mouse	Heart
Liu 2020 Am J Physiol Heart Circ Physiol	2020	Liu R, Jagannathan R, Sun L, Li F, Yang P, Lee J, Negi V, Perez-Garcia EM, Shiva S, Yechoor VK, Moulik M (2020) Tead1 is essential for mitochondrial function in cardiomyocytes. Am J Physiol Heart Circ Physiol 319:H89-99.	Mouse	Heart		Cardiovascular
Lensu 2020 Preprints	2020	Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Linden J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides targeting Faecalibacterium prausnitzii prevent high fat diet-induced hepatic steatosis in rats. Preprints 2020:2020090241.	Rat	Liver
Tepp 2020 Biochim Biophys Acta Gen Subj	2020	Tepp K, Puurand M, Timohhina N, Aid-Vanakova J, Reile I, Shevchuk I, Chekulayev V, Eimre M, Peet N, Kadaja L, Paju K, Kaambre T (2020) Adaptation of striated muscles to Wolframin deficiency in mice: Alterations in cellular bioenergetics. Biochim Biophys Acta Gen Subj 1864:129523.	Mouse	Heart Skeletal muscle		Inherited Neurodegenerative
Irion 2020 Stem Cells Int	2020	Irion CI, Martins EL, Christie MLA, de Andrade CBV, de Moraes ACN, Ferreira RP, Pimentel CF, Suhett GD, Campos de Carvalho AC, Lindoso RS, Vieyra A, Galina A, Goldenberg RCS (2020) Acute myocardial infarction reduces respiration in rat cardiac fibers, despite adipose tissue mesenchymal stromal cell transplant. Stem Cells Int 2020:4327965 .	Rat	Heart		Cardiovascular
Silaidos 2020 Mitochondrion	2020	Silaidos C, Grube J, Muley C, Eckert GP (2020) Time-dependent melatonin secretion is associated with mitochondrial function in peripheral blood mononuclear cells (PBMC) of male volunteers. Mitochondrion 53:21-29.	Human	Blood cells
Courtes 2020 Brain Res Bull	2020	Courtes AA, Gonçalves DF, Hartmann DD, da Rosa PC, Cassol G, Royes LFF, de Carvalho NR, Soares FAA (2020) Guanosine protects against behavioural and mitochondrial bioenergetic alterations after mild traumatic brain injury. Brain Res Bull 163:31-39.	Rat	Nervous system		Other
Charles 2020 Nanomedicine (Lond)	2020	Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) 15:2917-32.	Human	Endothelial;epithelial;mesothelial cell
Madeo 2020 US Patent	2020	Madeo F, Eisenberg T, Stekovic S (2020) Use of spermidine for the enhancement of mitochondrial respiration. US Patent US20200054579 A1.	Mouse	Heart
Szibor 2020 J Biol Chem	2020	Szibor Marten, Gizatullina Zemfira, Gainutdinov Timur, Endres Thomas, Debska-Vielhaber Grazyna, Kunz Matthias, Karavasili Niki, Hallmann Kerstin, Schreiber Frank, Bamberger Alexandra, Schwarzer Michael, Doenst Torsten, Heinze Hans-Jochen, Leßmann Volkmar, Vielhaber Stefan, Kunz Wolfram S, Gellerich Frank Norbert (2020) Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply. J Biol Chem 295:4383-97.	Mouse	Nervous system
Aparicio-Trejo 2020 Free Radic Biol Med	2020	Aparicio-Trejo OE, Avila-Rojas SH, Tapia E, Rojas-Morales P, León-Contreras JC, Martínez-Klimova E, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2020) Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid. Free Radic Biol Med 154:18-32.	Rat	Kidney		Other
Boardman 2020 Am J Physiol Heart Circ Physiol	2020	Boardman NT, Pedersen TM, Rossvoll L, Hafstad AD, Aasum E (2020) Diet-induced obese mouse hearts tolerate an acute high fatty acid exposure that also increases ischemic tolerance. Am J Physiol Heart Circ Physiol 319:H682-93.	Mouse	Heart	Ischemia-reperfusion	Obesity
Zavadskis 2020 Pharmaceutics	2020	Zavadskis S, Weidinger A, Hanetseder D, Banerjee A, Schneider C, Wolbank S, Marolt Presen D, Kozlov AV (2020) Effect of diphenyleneiodonium chloride on intracellular reactive oxygen species metabolism with emphasis on NADPH oxidase and mitochondria in two therapeutically relevant human cell types. Pharmaceutics 13:E10.	Human	Other cell lines	Oxidative stress;RONS
Stepanova 2020 Methods Cell Biol	2020	Stepanova A, Galkin A (2020) Measurement of mitochondrial H₂O₂ production under varying O₂ tensions. https://doi.org/10.1016/bs.mcb.2019.12.008	Mouse	Nervous system	Oxidative stress;RONS
Pham 2020 Eur J Appl Physiol	2020	Pham T, MacRae CL, Broome SC, D'souza RF, Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Eur J Appl Physiol 120:1657-69.	Human	Skeletal muscle	Oxidative stress;RONS
Silva-Rodrigues 2020 Free Radic Biol Med	2020	Silva-Rodrigues T, De-Souza-Ferreira E, Machado CM, Cabral-Braga B, Rodrigues-Ferreira C, Galina A (2020) Hyperglycemia in a Type 1 Diabetes Mellitus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain. Free Radic Biol Med 160:796-806.	Rat	Nervous system	Oxidative stress;RONS	Diabetes
Rebane-Klemm 2020 Cancers (Basel)	2020	Rebane-Klemm E, Truu L, Reinsalu L, Puurand M, Shevchuk I, Chekulayev V, Timohhina N, Tepp K, Bogovskaja J, Afanasjev V, Suurmaa K, Valvere V, Kaambre T (2020) Mitochondrial respiration in KRAS and BRAF mutated colorectal tumors and polyps. Cancers (Basel) 12:E815.	Human	Endothelial;epithelial;mesothelial cell		Cancer
Vega 2020 Physiol Rep	2020	Vega RB, Brouwers B, Parsons SA, Stephens NA, Pino MF, Hodges A, Yi F, Yu G, Pratley RE, Smith SR, Sparks LM (2020) An improvement in skeletal muscle mitochondrial capacity with short-term aerobic training is associated with changes in Tribbles 1 expression. Physiol Rep 8:e14416.	Human	Skeletal muscle
Simard 2020b Metabolites	2020	Simard CJ, Touaibia M, Allain EP, Hebert-Chatelain E, Pichaud N (2020) Role of the mitochondrial pyruvate carrier in the occurrence of metabolic inflexibility in Drosophila melanogaster exposed to dietary sucrose. Metabolites 10:E411.	Drosophila
Venediktova 2020 Mitochondrion	2020	Venediktova NI, Mashchenko OV, Talanov EY, Belosludtseva NV, Mironova GD (2020) Energy metabolism and oxidative status of rat liver mitochondria in conditions of experimentally induced hyperthyroidism. Mitochondrion 52:190-96.	Rat	Liver		Other
McCommis 2020 Nat Metab	2020	McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, King MT, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN (2020) Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. Nat Metab 2:1232-47.	Mouse	Heart		Cardiovascular
Schneider 2020 PLoS One	2020	Schneider J, Han WH, Matthew R, Sauve Y, Lemieux H (2020) Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat. PLoS One 15:e0228710.	Rat	Heart		Diabetes Aging;senescence
Smith 2020 J Biol Chem	2020	Smith CD, Schmidt CA, Lin CT, Fisher-Wellman KH, Neufer PD (2020) Flux through mitochondrial redox circuits linked to nicotinamide nucleotide transhydrogenase generates counterbalance changes in energy expenditure. J Biol Chem 295:16207-16.	Mouse	Skeletal muscle	Oxidative stress;RONS
Ferreira 2020 PLoS Genet	2020	Ferreira N, Andoniou CE, Perks KL, Ermer JA, Rudler DL, Rossetti G, Periyakaruppiah A, Wong JKY, Rackham O, Noakes PG, Degli-Esposti MA, Filipovska A (2020) Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease. PLoS Genet 16:e1008604.	Mouse	Liver	Mitochondrial disease	Infectious
Bhaskaran 2020 Aging Cell	2020	Bhaskaran S, Pollock N, C Macpherson P, Ahn B, Piekarz KM, Staunton CA, Brown JL, Qaisar R, Vasilaki A, Richardson A, McArdle A, Jackson MJ, Brooks SV, Van Remmen H (2020) Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell 19:e13225.	Mouse	Skeletal muscle		Aging;senescence
Tichanek 2020 Sci Rep	2020	Tichanek F, Salomova M, Jedlicka J, Kuncova J, Pitule P, Macanova T, Petrankova Z, Tuma Z, Cendelin J (2020) Hippocampal mitochondrial dysfunction and psychiatric-relevant behavioral deficits in spinocerebellar ataxia 1 mouse model. Sci Rep 10:5418.	Mouse	Nervous system		Neurodegenerative
Kapser-Fischer 2020 Thesis	2020	Kapser-Fischer IP (2020) Dietary interventions in C57BL/6 mice and their interplay with selected metabolic and genetic parameters. PhD Thesis 120.	Mouse	Fat		Obesity
Wei 2020 Cell Rep	2020	Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing NADPH synthesis counteracts diabetic nephropathy through restoration of AMPK activity in type 1 diabetic rats. Cell Rep 32:108207.	Rat	Kidney		Diabetes
Dawson 2020 J Exp Biol	2020	Dawson NJ, Millet C, Selman C, Metcalfe NB (2020) Measurement of mitochondrial respiration in permeabilized fish gills. J Exp Biol 223:jeb216762.	Fishes	Lung;gill
Garcia 2020 Mol Hum Reprod	2020	Garcia BM, Machado TS, Carvalho KF, Nolasco P, Nociti RP, Del Collado M, Capo Bianco MJD, Grejo MP, Neto JDA, Sugiyama FHC, Tostes K, Pandey AK, Gonçalves LM, Perecin F, Meirelles FV, Ferraz JBS, Vanzela EC, Boschero AC, Guimarães FEG, Abdulkader F, Laurindo FRM, Kowaltowski AJ, Chiaratti MR (2020) Mice born to females with oocyte-specific deletion of mitofusin 2 have increased weight gain and impaired glucose homeostasis. Mol Hum Reprod 26:938-52.	Mouse	Liver		Diabetes Obesity
Stankova 2020 Int J Mol Sci	2020	Staňková P, Kučera O, Peterová E, Lotková H, Maseko TE, Nožičková K, Červinková Z (2020) Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease. Int J Mol Sci 21:E1101.	Mouse	Liver		Other
Remie 2020 Am J Clin Nutr	2020	Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, Lindeboom L, de Wit VHW, van de Weijer T, Aarts SABM, Lutgens E, Schomakers BV, Elfrink HL, Zapata-Pérez R, Houtkooper RH, Auwerx J, Hoeks J, Schrauwen-Hinderling VB, Phielix E, Schrauwen P (2020) Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr 112:413-26.	Human	Skeletal muscle		Obesity
Belosludtsev 2020 Biochimie	2020	Belosludtsev KN, Belosludtseva NV, Kosareva EA, Talanov EY, Gudkov SV, Dubinin MV (2020) Itaconic acid impairs the mitochondrial function by the inhibition of complexes II and IV and induction of the permeability transition pore opening in rat liver mitochondria. Biochimie 176:150-57.	Rat	Liver
Thome 2020 JCI Insight	2020	Thome T, Kumar RA, Burke SK, Khattri RB, Salyers ZR, Kelley RC, Coleman MD, Christou DD, Hepple RT, Scali ST, Ferreira LF, Ryan TE (2020) Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease. JCI Insight 6:e139826.	Mouse	Skeletal muscle		Myopathy Other
Anderson 2020 Cells	2020	Anderson Vulczak, de Oliveira Souza Anderson, Ferrari Gustavo Duarte, Caleiro Seixas Azzolini Ana Elisa, Pereira-da-Silva Gabriela, Alberici Luciane Carla (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:628.	Mouse			Cancer
Chang 2020 J Biol Chem	2020	Chang L, Liu X, Diggle CP, Boyle JP, Hopkins PM, Shaw MA, Allen PD (2020) Bioenergetic defects in muscle fibers of RYR1 mutant knock-in mice associated with malignant hyperthermia. J Biol Chem 295:15226-35.	Mouse	Skeletal muscle
Baggio 2020 Neurotoxicology	2020	Baggio S, Zenki K, Martins Silva A, Dos Santos TG, Rech G, Lazzarotto G, Dias RD, Mussulini BH, Rico EP, de Oliveira DL (2020) Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. Neurotoxicology 78:152-160.	Zebrafish	Nervous system		Other
Keller 2020 Oxid Med Cell Longev	2020	Keller Amy, Hull Sara E, Elajaili Hanan, Johnston Aspen, Knaub Leslie A, Chun Ji hye, Walker Lori, Nozik-Grayck Eva, Reusch Jane EB (2020) (–)-Epicatechin modulates mitochondrial redox in vascular cell models of oxidative stress. Oxid Med Cell Longev 2020:6392629.	Human	Endothelial;epithelial;mesothelial cell	Oxidative stress;RONS	Diabetes
Song 2020 Obes Facts	2020	Song K, Zhang Y, Ga Q, Bai Z, Ge RL (2020) Increased insulin sensitivity by high-altitude hypoxia in mice with high-fat diet-induced obesity is associated with activated AMPK signaling and subsequently enhanced mitochondrial biogenesis in skeletal muscles. Obes Facts 13:455-72.		Skeletal muscle	Hypoxia	Obesity
Friederich-Persson 2020 Am J Physiol Renal Physiol	2020	Friederich-Persson M, Persson P (2020) Mitochondrial angiotensin II receptors regulate oxygen consumption in kidney mitochondria from healthy and type 1 diabetic rats. Am J Physiol Renal Physiol 318:F683-88.	Rat	Kidney		Diabetes
Burtscher 2020 eNeuro	2020	Burtscher J, Copin JC, Sandi C, Lashuel HA (2020) Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala. eNeuro 7:ENEURO.0110-20.2020.	Mouse	Nervous system		Parkinson's
Dawid 2020 Biochim Biophys Acta Bioenerg	2020	Dawid C, Weber D, Musiol E, Janas V, Baur S, Lang R, Fromme T (2020) Comparative assessment of purified saponins as permeabilization agents during respirometry. Biochim Biophys Acta Bioenerg 1861:148251.	Human Mouse	Nervous system HEK
No 2020 Pflugers Arch	2020	No MH, Heo JW, Yoo SZ, Kim CJ, Park DH, Kang JH, Seo DY, Han J, Kwak HB (2020) Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 472:179-93.	Rat	Heart	Cell death	Aging;senescence
Fuller 2020 J Appl Physiol (1985)	2020	Fuller KNZ, McCoin CS, Allen J, Bell-Glenn S, Koestler DC, Dorn Ii GW, Thyfault JP (2020) Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice. J Appl Physiol (1985) 128:1251-61.	Mouse	Liver	Oxidative stress;RONS
Weber 2020 FASEB J	2020	Weber M, Mera P, Casas J, Salvador J, Rodríguez A, Alonso S, Sebastián D, Soler-Vázquez MC, Montironi C, Recalde S, Fucho R, Calderón-Domínguez M, Mir JF, Bartrons R, Escola-Gil JC, Sánchez-Infantes D, Zorzano A, Llorente-Cortes V, Casals N, Valentí V, Frühbeck G, Herrero L, Serra D (2020) Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD. FASEB J 34:11816-37.	Mouse	Liver		Obesity
Battaglia 2020 Cell Death Dis	2020	Battaglia CR, Cursano S, Calzia E, Catanese A, Boeckers TM (2020) Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons. Cell Death Dis 11:1004.	Rat	Nervous system
Cecatto 2020 Mitochondrion	2020	Cecatto C, Amaral AU, Wajner A, Wajner SM, Castilho RF, Wajner M (2020) Disturbance of mitochondrial functions associated with permeability transition pore opening induced by cis-5-tetradecenoic and myristic acids in liver of adolescent rats. Mitochondrion 50:1-13.	Rat	Liver Other cell lines	Permeability transition	Inherited Other
Bertero 2020 Circ Res	2020	Bertero E, O'Rourke B, Maack C (2020) Mitochondria do not survive calcium overload during transplantation. Circ Res 126:784-86.	Mouse	Skeletal muscle	Ischemia-reperfusion
Guo 2020 Hum Gene Ther	2020	Guo Y, Zhang K, Gao X, Zhou Z, Liu Z, Yang K, Huang K, Yang Q, Long Q (2020) Sustained oligomycin sensitivity conferring protein expression in cardiomyocytes protects against cardiac hypertrophy induced by pressure-overload via improving mitochondrial function. Hum Gene Ther 31:1178-89.	Mouse	Heart
MitoEAGLE blood cells 1	2020	Åsander Frostner Eleonor, Aburel Oana M, Avram Vlad F, Calabria Elisa, Castelo Rueda Maria Paulina, Chamkha Imen, Čižmárová Beata, Danila Maria-Daniela, Doerrier Carolina, Eckert Gunter P, Ehinger Johannes K, Elmer Eskil, Garcia-Souza Luiz F, Gnaiger Erich, Hoppel Florian, Karabatsiakis Alexander, Keppner Gloria, Kidere Dita, Krako Jakovljević Nina, Labieniec-Watala Magdalena, Lelcu Theia, Micankova Petra, Michalak Slawomir, Molina Anthony JA, Pavlovic Kasja, Pichler Irene, Piel Sarah, Rousar Tomas, Rybacka-Mossakowska Joanna, Schartner Melanie, Siewiera Karolina, Silaidos Carmina, Sjövall Fredrik, Sobotka Ondrej, Sumbalova Zuzana, Swiniuch Daria, Vernerova Andrea, Volani Chiara, Vujacic-Mirski Ksenija, Watala Cezary (2020) Interlaboratory guide to mitochondrial respiratory studies with peripheral blood mononuclear cells and platelets. - Updated: 2020-03-06 - *Confirmed	Human	Blood cells Platelet		Aging;senescence
Locatelli 2020 FASEB J	2020	Locatelli L, Cazzaniga A, De Palma C, Castiglioni S, Maier JAM (2020) Mitophagy contributes to endothelial adaptation to simulated microgravity. FASEB J 34:1833-45.	Human	Endothelial;epithelial;mesothelial cell
Schoepf 2020 Nat Commun	2020	Schöpf Bernd, Weissensteiner Hansi, Schäfer Georg, Fazzini Federica, Charoentong Pornpimol, Naschberger Andreas, Rupp Bernhard, Fendt Liane, Bukur Valesca, Giese Irina, Sorn Patrick, Sant’Anna-Silva Ana Carolina, Iglesias-Gonzalez Javier, Sahin Ugur, Kronenberg Florian, Gnaiger Erich, Klocker Helmut (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. https://doi.org/10.1038/s41467-020-15237-5	Human	Genital Other cell lines		Cancer
Fisher 2020 Placenta	2020	Fisher J, McKeating D, Pennell E, Cuffe J, Holland O, Perkins A (2020) Mitochondrial isolation, cryopreservation and preliminary biochemical characterisation from placental cytotrophoblast and syncytiotrophoblast. Placenta 82:1-4.	Human	Genital	Cryopreservation
Weaver 2020 Biol Lett	2020	Weaver RJ, Carrion G, Nix R, Maeda GP, Rabinowitz S, Iverson ENK, Thueson K, Havird JC (2020) High mitochondrial mutation rates in Silene are associated with nuclear-mediated changes in mitochondrial physiology. Biol Lett 16:20200450.	Plants
Purhonen 2020 Nat Commun	2020	Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J (2020) A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322.	Mouse	Liver Kidney	Mitochondrial disease
Kanellopoulos 2020 Cell	2020	Kanellopoulos AK, Mariano V, Spinazzi M, Woo YJ, McLean C, Pech U, Li KW, Armstrong JD, Giangrande A, Callaerts P, Smit AB, Abrahams BS, Fiala A, Achsel T, Bagni C (2020) Aralar sequesters GABA into hyperactive mitochondria, causing social behavior deficits. Cell 180:1178-97.	Drosophila	Nervous system Other cell lines
Severo 2020 Life Sci	2020	Severo L, Godinho D, Machado F, Hartmann D, Fighera MR, Soares FA, Furian AF, Oliveira MS, Royes LF (2020) The role of mitochondrial bioenergetics and oxidative stress in depressive behavior in recurrent concussion model in mice. Life Sci 257:117991.	Mouse	Nervous system		Other
He 2020 Clin Transl Med	2020	He C, Gao P, Cui Y, Li Q, Li Y, Lu Z, Ma H, Zhao Y, Li L, Sun F, Chen, X, Jia H, Liu D, Yang G, Zheng H, Zhu Z (2020) Low‐glucose‐sensitive TRPC6 dysfunction drives hypoglycemia‐induced cognitive impairment in diabetes. Clin Transl Med 10:e205.	Mouse	Nervous system		Diabetes Alzheimer's
Chabi 2019 MitoFit Preprint Arch EA	2019-10-10	Chabi Béatrice, Ost M, Gama-Perez P, Dahdah N, Lemieux H, Holody CD, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Pesta D, Calabria E, Casado M, Fernandez-Ortiz M, Acuña-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wüst R, Dayanidhi S, Gnaiger E, Doerrier C, Garcia-Roves PM (2019) Generating reference values on mitochondrial respiration in permeabilized muscle fibers. https://doi.org/10.26124/mitofit:ea19.MitoEAGLE.0001	Human	Skeletal muscle
Doerrier 2019 MitoFit Preprint Arch EA	2019-07-04	Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2019) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. https://doi.org/10.26124/mitofit:ea19.MiPSchool.0009	Human	Skeletal muscle
MiPNet18.05 Amplex-Mouse-heart	2019-06-24	O2k-Fluorometry: HRR and H₂O₂ production in mouse cardiac tissue homogenate.	Mouse	Heart
MiPNet20.14 AmplexRed H2O2-production	2019-06-24	O2k-FluoRespirometry: HRR and simultaneous determination of H₂O₂ production with Amplex UltraRed.	Mouse	Heart
Halbach 2019 Am J Physiol Regul Integr Comp Physiol	2019	Halbach JL, Prieto JM, Wang AW, Hawisher D, Cauvi DM, Reyes T, Okerblom J, Ramirez-Sanchez I, Villarreal F, Patel HH, Bickler SW, Perdrizet GA, De Maio A (2019) Early hyperbaric oxygen therapy improves survival in a model of severe sepsis. Am J Physiol Regul Integr Comp Physiol 317:R160-R168.	Mouse	Liver		Sepsis
Chao 2019 Am J Physiol Cell Physiol	2019	Chao T, Gomez BI, Heard TC, Smith BW, Dubick MA, Burmeister DM (2019) Burn-induced reductions in mitochondrial abundance and efficiency are more pronounced with small volumes of colloids in swine. Am J Physiol Cell Physiol 317:C1229-38.	Pig	Heart	Temperature
Zhu 2019 Aging Cell	2019	Zhu B, Li Y, Xiang L, Zhang J, Wang L, Guo B, Liang M, Chen L, Xiang L, Dong J, Liu M, Mei W, Li H, Xiang G (2019) Alogliptin improves survival and health of mice on a high-fat diet. Aging Cell 18:e12883.	Mouse	Liver		Aging;senescence Diabetes
Anton 2019 Front Physiol	2019	Anton L, DeVine A, Polyak E, Olarerin-George A, Brown AG, Falk MJ, Elovitz MA (2019) HIF-1α stabilization increases miR-210 eliciting first trimester extravillous trophoblast mitochondrial dysfunction. Front Physiol 10:699.	Human	Genital		Other
Powers 2019 Neurourol Urodyn	2019	Powers SA, Ryan TE, Pak ES, Fraser MO, McClung JM, Hannan JL (2019) Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions. Neurourol Urodyn 38:1524-32.	Mouse	Other cell lines
Grandoch 2019 Nat Metab	2019	Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M5, Haendeler J, Fischer JW (2019) 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. Nat Metab 1:546-59.	Mouse	Fat		Diabetes
Kwak 2019 Int J Environ Res Public Health	2019	Kwak HB, Woodlief TL, Green TD, Cox JH, Hickner RC, Neufer PD, Cortright RN (2019) Overexpression of long-chain acyl-CoA synthetase 5 increases fatty acid oxidation and free radical formation while attenuating insulin signaling in primary human skeletal myotubes. Int J Environ Res Public Health 16:E1157.	Human	Skeletal muscle	Oxidative stress;RONS
Wolf 2019 Cells	2019	Wolf C, Zimmermann R, Thaher O, Bueno D, Wüllner V, Schäfer MKE, Albrecht P, Methner A (2019) The Charcot-Marie tooth disease mutation R94Q in MFN2 decreases ATP production but increases mitochondrial respiration under conditions of mild oxidative stress. Cells 8:E1289.	Mouse	Fibroblast		Inherited
Kharechkina 2019 Biochim Biophys Acta Gen Subj	2019	Kharechkina ES, Nikiforova AB, Teplova VV, Odinokova IV, Krestinina OV, Baburina YL, Kruglova SA, Kruglov AG (2019) Regulation of permeability transition pore opening in mitochondria by external NAD(H). Biochim Biophys Acta Gen Subj 1863:771-83.	Rat	Liver	Permeability transition
Bertolini 2019 MBio	2019	Bertolini MS, Chiurillo MA, Lander N, Vercesi AE, Docampo R (2019) MICU1 and MICU2 play an essential role in mitochondrial Ca²⁺ uptake, growth, and infectivity of the human pathogen Trypanosoma cruzi. MBio 10:e00348-19.	Protists			Infectious
Garnham 2019 J Cachexia Sarcopenia Muscle	2019	Garnham JO, Roberts LD, Caspi T, Al-Owais MM, Bullock M, Swoboda PP, Koshy A, Gierula J, Paton MF, Cubbon RM, Kearney MT, Bowen TS, Witte KK (2019) Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure. J Cachexia Sarcopenia Muscle 11:79-88.	Human	Skeletal muscle		Cardiovascular
Lau 2019 Comp Biochem Physiol B Biochem Mol Biol	2019	Lau GY, Milsom WK, Richards JG, Pamenter ME (2019) Heart mitochondria from naked mole-rats (Heterocephalus glaber) are more coupled, but similarly susceptible to anoxia-reoxygenation stress than in laboratory mice (Mus musculus). Comp Biochem Physiol B Biochem Mol Biol 240:110375.	Mouse Other mammals	Heart	Hypoxia
Poudel 2019 Can J Physiol Pharmacol	2019	Poudel A, Zhou JY, Mekala N, Welchko R, Rosca MG, Li L (2019) Berberine hydrochloride protects against cytokine-induced inflammation through multiple pathways in undifferentiated C2C12 myoblast cells. Can J Physiol Pharmacol 97:699-707.	Mouse	Skeletal muscle		Obesity
Lerchner 2019 Anal Bioanal Chem	2019	Lerchner J, Sartori MR, Volpe POL, Lander N, Mertens F, Vercesi AE (2019) Direct determination of anaerobe contributions to the energy metabolism of Trypanosoma cruzi by chip calorimetry. Anal Bioanal Chem 411:3763-68.	Protists
Boardman 2019 Can J Physiol Pharmacol	2019	Boardman NT, Falck AT, Lund T, Chu X, Martin-Armas M, Norvik JV, Jenssen TG, Ytrehus K (2019) Human concentrations of uric acid scavenges adaptive and maladaptive ROS in isolated rat hearts subjected to ischemic stress. Can J Physiol Pharmacol 98:139-46.	Rat	Heart	Ischemia-reperfusion Oxidative stress;RONS
Qaed 2019 Oxid Med Cell Longev	2019	Qaed E, Wang J, Almoiliqy M, Song Y, Liu W, Chu P, Alademi S, Alademi M, Li H, Alshwmi M, Al-Azab M, Ahsan A, Mahdi S, Han G, Niu M, Ali A, Shopit A, Wang H, Li X, Qaid A, Ma X, Li T, Peng J, Ma J, Zhang J, Tang Z (2019) Phosphocreatine improves cardiac dysfunction by normalizing mitochondrial respiratory function through JAK2/STAT3 signaling pathway in vivo and in vitro. Oxid Med Cell Longev 2019:6521218.	Rat	Heart		Cardiovascular Diabetes
Petrick 2019 Biochem J	2019	Petrick HL, Holloway GP (2019) High intensity exercise inhibits carnitine palmitoyltransferase-I sensitivity to L-carnitine. Biochem J 476:547-58.	Mouse	Skeletal muscle
Petrick 2019 J Physiol	2019	Petrick HL, Pignanelli C, Barbeau PA, Churchward-Venne TA, Dennis KMJH, van Loon LJC, Burr JF, Goossens GH, Holloway GP (2019) Blood flow restricted resistance exercise and reductions in oxygen tension attenuate mitochondrial H₂O₂ emission rates in human skeletal muscle. J Physiol 597:3985-97.	Human	Skeletal muscle	Oxidative stress;RONS
Brunetta 2019 J Funct Foods	2019	Brunetta HS, de Paula GC, Fritzen M, Cecchini MS, dos Santos GJ, Nazari EM, Rafacho A, de Bem AF, Nunes EA (2019) Leucine increases muscle mitochondrial respiration and attenuates glucose intolerance in diet-induced obesity in Swiss mice. J Funct Foods 62:103544.	Mouse	Skeletal muscle		Obesity
Bodis 2019 J Clin Endocrinol Metab	2019	Bodis K, Jelenik T, Lundbom J, Markgraf DF, Strom A, Zaharia OP, Karusheva Y, Burkart V, Muessig K, Kupriyanova Y, Ouni M, Wolkersdorfer M, Hwang JH, Ziegler D, Schuermann A, Roden M, Szendroedi J (2019) Expansion and impaired mitochondrial efficiency of deep subcutaneous adipose tissue in recent-onset type 2 diabetes. J Clin Endocrinol Metab 105:dgz267.	Human	Fat		Diabetes
Hughes 2019 J Physiol	2019	Hughes MC, Ramos SV, Turnbull PC, Edgett BA, Huber JS, Polidovitch N, Schlattner U, Backx PH, Simpson JA, Perry CGR (2019) Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodelling in Duchenne muscular dystrophy. J Physiol 598:1377-92.	Mouse	Heart		Myopathy
Azevedo 2019 Food Chem Toxicol	2019	Azevedo LF, Porto Dechandt CR, Cristina de Souza Rocha C, Hornos Carneiro MF, Alberici LC, Barbosa F Jr (2019) Long-term exposure to bisphenol A or S promotes glucose intolerance and changes hepatic mitochondrial metabolism in male Wistar rats. Food Chem Toxicol 132:110694.	Rat	Liver
Aguilar 2019 Cell Rep	2019	Aguilar E, Esteves P, Sancerni T, Lenoir V, Aparicio T, Bouillaud F, Dentin R, Prip-Buus C, Ricquier D, Pecqueur C, Guilmeau S, Alves-Guerra MC (2019) UCP2 deficiency increases colon tumorigenesis by promoting lipid synthesis and depleting NADPH for antioxidant defenses. Cell Rep 28:2306-16.	Mouse	Endothelial;epithelial;mesothelial cell		Cancer
Skrivergaard 2019 Viruses	2019	Skrivergaard S, Jensen MS, Rolander TB, Nguyen TBN, Bundgaard A, Nejsum LN, Martensen PM (2019) The cellular localization of the p42 and p46 oligoadenylate synthetase 1 isoforms and their impact on mitochondrial respiration. Viruses 11:E1122.	Human	Other cell lines HeLa
Pedrotti 2019 Sci Adv	2019	Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D (2019) The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli. Sci Adv 5:eaav1472.	Mouse	Fat	Temperature	Obesity
Gururaja Rao 2019 Cells	2019	Gururaja Rao S, Bednarczyk P, Towheed A, Shah K, Karekar P, Ponnalagu D, Jensen HN, Addya S, Reyes BAS, Van Bockstaele EJ, Szewczyk A, Wallace DC, Singh H (2019) BK_Ca (Slo) channel regulates mitochondrial function and lifespan in Drosophila melanogaster. Cells 8:E945.	Drosophila			Aging;senescence
Datzmann 2019 Pharmacol Res	2019	Datzmann T, Hoffmann A, McCook O, Merz T, Wachter U, Preuss J, Vettorazzi S, Calzia E, Gröger M, Kohn F, Schmid A, Denoix N, Radermacher P, Wepler M (2019) Effects of sodium thiosulfate (Na₂S₂O₃) during resuscitation from hemorrhagic shock in swine with preexisting atherosclerosis. Pharmacol Res 151:104536.	Pig	Heart Liver Kidney	Ischemia-reperfusion	Cardiovascular
Madlala 2019 Integr Food Nutr Metab	2019	Madlala HP, Maarman GJ, Ojuka E (2019) Fructose impairs mitochondrial respiration and substrate utilization in hepatocytes via the enzyme, glutamate oxaloacetate transaminase. Integr Food Nutr Metab doi: 10.15761/IFNM.1000228.	Human	Liver
Seo 2019 Exp Neurol	2019	Seo JH, Park HS, Park SS, Kim CJ, Kim DH, Kim TW (2019) Physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorder. Exp Neurol 322:113043.	Rat	Nervous system		Other
Glombik 2019 Neurotox Res	2019	Głombik K, Detka J, Góralska J, Kurek A, Solnica B, Budziszewska B (2019) Brain metabolic alterations in rats showing depression-like and obesity phenotypes. Neurotox Res 37:406-24.	Rat	Nervous system		Obesity Other
Doig 2019 bioRxiv	2019	Doig CD, Zelinska AE, Oakey LA, Fletcher RS, El Hassan Y, Garten A, Cartwright D, Heising S, Tennant DA, Watson D, Adamski J, Lavery GG (2019) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice. bioRxiv doi: https://doi.org/10.1101/567297 .	Mouse	Skeletal muscle
Paradis 2019 Antioxidants (Basel)	2019	Paradis S, Charles AL, Georg I, Goupilleau F, Meyer A, Kindo M, Laverny G, Metzger D, Geny B (2019) Aging exacerbates ischemia-reperfusion-induced mitochondrial respiration impairment in skeletal muscle. Antioxidants (Basel) 8:E168.	Mouse	Skeletal muscle	Ischemia-reperfusion	Aging;senescence
Turnbull 2019 Am J Physiol Cell Physiol	2019	Turnbull PC, Hughes MC, Perry CGR (2019) The fatty acid derivative palmitoylcarnitine abrogates colorectal cancer cell survival by depleting glutathione. Am J Physiol Cell Physiol 317:C1278-88.	Human	Endothelial;epithelial;mesothelial cell		Cancer
Shrum 2019 Biomolecules	2019	Shrum S, Rusch NJ, MacMillan-Crow LA (2019) Specific BK channel activator NS11021 protects rat renal proximal tubular cells from cold storage-induced mitochondrial injury in vitro. Biomolecules 9:E825.	Rat	Kidney	Temperature
Rawat 2019 J Mol Biol	2019	Rawat S, Anusha V, Jha M, Sreedurgalakshmi K, Raychaudhuri S (2019) Aggregation of respiratory complex subunits marks the onset of proteotoxicity in proteasome inhibited cells. J Mol Biol 431:996-1015.	Mouse	Nervous system Other cell lines
Miranda Mendonca 2019 Neurochem Int	2019	Miranda Mendonça AP, Hoppe LY, Gaviraghi A, Araújo-Jorge TC, de Oliveira GM, Felippe RM, Oliveira MF, da Silva Fragoso VM (2019) Highly aggressive behavior induced by social stress is associated to reduced cytochrome c oxidase activity in mice brain cortex. Neurochem Int 126:210-17.	Mouse	Nervous system
Teulier 2019 Comp Biochem Physiol A Mol Integr Physiol	2019	Teulier L, Thoral E, Queiros Q, McKenzie DJ, Roussel D, Dutto G, Gasset E, Bourjea J, Saraux C (2019) Muscle bioenergetics of two emblematic Mediterranean fish species: Sardina pilchardus and Sparus aurata. Comp Biochem Physiol A Mol Integr Physiol 235:174-79.	Fishes	Skeletal muscle
Berru 2019 Sci Rep	2019	Berru FN, Gray SE, Thome T, Kumar RA, Salyers ZR, Coleman M, Dennis Le, O'Malley K, Ferreira LF, Berceli SA, Scali ST, Ryan TE (2019) Chronic kidney disease exacerbates ischemic limb myopathy in mice via altered mitochondrial energetics. Sci Rep 9:15547.	Mouse	Skeletal muscle	Ischemia-reperfusion	Myopathy Other
Gaviraghi 2019 Anal Biochem	2019	Gaviraghi A, Oliveira MF (2019) A method for assessing mitochondrial physiology using mechanically permeabilized flight muscle of Aedes aegypti mosquitoes. Anal Biochem 576:33-41.	Hexapods	Skeletal muscle
Rodinova 2019 Dis Model Mech	2019	Rodinova M, Krizova J, Stufkova H, Bohuslavova B, Askeland G, Dosoudilova Z, Juhas S, Juhasova J, Ellederova Z, Zeman J, Eide L, Motlik J, Hansikova H (2019) Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease. Dis Model Mech 12:dmm038737.	Pig	Skeletal muscle		Other
Wang 2019 Life Sci	2019	Wang JW, Xue ZY, Wu AS (2019) Mechanistic insights into δ-opioid-induced cardioprotection: Involvement of caveolin translocation to the mitochondria. Life Sci 247:116942.	Mouse	Heart	Ischemia-reperfusion
Devaux 2019 Front Physiol	2019	Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2019) Acidosis maintains the function of brain mitochondria in hypoxia-tolerant triplefin fish: a strategy to survive acute hypoxic exposure? Front Physiol 9:1941.	Fishes	Nervous system	Oxidative stress;RONS Hypoxia
Dent 2019 J Appl Physiol (1985)	2019	Dent JR, Hetrick B, Tahvilian S, Sathe A, Greyslak K, LaBarge SA, Svensson K, McCurdy CE, Schenk S (2019) Skeletal muscle mitochondrial function and exercise capacity is not impaired in mice with knockout of STAT3. J Appl Physiol (1985) 127:1117-27.	Mouse	Skeletal muscle
Thome 2019 Am J Physiol Cell Physiol	2019	Thome T, Salyers ZR, Kumar RA, Hahn D, Berru FN, Ferreira LF, Scali ST, Ryan TE (2019) Uremic metabolites impair skeletal muscle mitochondrial energetics through disruption of the electron transport system and matrix dehydrogenase activity. Am J Physiol Cell Physiol 317:C701-13.	Mouse	Skeletal muscle		Other
Teh 2019 Mol Cancer Ther	2019	Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M (2019) Respiratory capacity and reserve predict cell sensitivity to mitochondria inhibitors: mechanism-based markers to identify metformin-responsive cancers. Mol Cancer Ther 18:693-705.	Human Mouse	Other cell lines		Cancer
Fiorenza 2019 FASEB J	2019	Fiorenza M, Lemminger AK, Marker M, Eibye K, Iaia FM, Bangsbo J, Hostrup M (2019) High-intensity exercise training enhances mitochondrial oxidative phosphorylation efficiency in a temperature-dependent manner in human skeletal muscle: implications for exercise performance. FASEB J 33:8976-89.	Human	Skeletal muscle
Ruegsegger 2019 JCI Insight	2019	Ruegsegger GN, Vanderboom PM, Dasari S, Klaus KA, Kabiraj P, McCarthy CB, Lucchinetti CF, Nair KS (2019) Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain. JCI Insight 4:130681.	Mouse	Nervous system		Diabetes
Svensson 2019 Am J Physiol Endocrinol Metab	2019	Svensson K, Tahvilian S, Martins VF, Dent JR, Lemanek A, Barooni N, Greyslak K, McCurdy CE, Schenk S (2019) Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice. Am J Physiol Endocrinol Metab 318:E145-51.	Mouse	Skeletal muscle
Mann 2019 Oncogene	2019	Mann J, Githaka JM, Buckland TW, Yang N, Montpetit R, Patel N, Li L, Baksh S, Godbout R, Lemieux H, Goping IS (2019) Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism. Oncogene 38:3325-39.	Human	Endothelial;epithelial;mesothelial cell	Cell death	Cancer
Berg 2019 Front Physiol	2019	Berg J, Undebakke V, Rasch-Halvorsen Ø, Aakerøy L, Sandbakk Ø, Tjønna AE (2019) Comparison of mitochondrial respiration in M. triceps brachii and M. vastus lateralis between elite cross-country skiers and physically active controls. Front Physiol 10:365.	Human	Skeletal muscle
Driescher 2019 Heliyon	2019	Driescher N, Joseph DE, Human VR, Ojuka E, Cour M, Hadebe N, Bester D, Marnewick JL, Lecour S, Lochner A, Essop MF (2019) The impact of sugar-sweetened beverage intake on rat cardiac function. Heliyon 5:e01357.	Rat	Heart
Jiang 2019 EMBO Rep	2019	Jiang S, Koolmeister C, Misic J, Siira S, Kühl I, Silva Ramos E, Miranda M, Jiang M, Posse V, Lytovchenko O, Atanassov I, Schober FA, Wibom R, Hultenby K, Milenkovic D, Gustafsson CM, Filipovska A, Larsson NG (2019) TEFM regulates both transcription elongation and RNA processing in mitochondria. EMBO Rep 20:e48101.	Mouse	Heart
Zhang 2019 Nephron	2019	Zhang R, Wang X, Gao Q, Jiang H, Zhang S, Lu M, Liu F, Xue X (2019) Taurine supplementation reverses diabetes-induced podocytes injury via modulation of the CSE/TRPC6 axis and improvement of mitochondrial function. Nephron 144:84-95.	Mouse	Kidney		Diabetes
Electron-transfer-pathway state	2019	Gnaiger E (2019) ET-pathway states. Mitochondr Physiol Network 2019-06-11 (last edit since 2016-11-08).
Latham 2019 J Anim Sci	2019	Latham CM, Fenger CK, White SH (2019) Rapid Communication: Differential skeletal muscle mitochondrial characteristics of weanling racing-bred horses. J Anim Sci [Epub ahead of print].	Horse	Skeletal muscle
Weinstein 2019 bioRxiv	2019	Weinstein RN, Crawford DL (2019) Effect of EBV-transformation on oxidative phosphorylation physiology in human cell lines. bioRxiv doi: https://doi.org/10.1101/2019.12.16.878025 .	Human	Other cell lines Lymphocyte
Spinazzi 2019 Proc Natl Acad Sci U S A	2019	Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B (2019) PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proc Natl Acad Sci U S A 116:277-86.	Mouse	Nervous system		Neurodegenerative
Hafen 2019 J Appl Physiol (1985)	2019	Hafen PS, Abbott K, Bowden JA, Lopiano R, Hancock CR, Hyldahl RD (2019) Daily heat treatment maintains mitochondrial function and attenuates atrophy in human skeletal muscle subjected to immobilization. J Appl Physiol (1985) 127:47-57.	Human	Skeletal muscle	Temperature
Jaiswal 2019 Mol Metab	2019	Jaiswal N, Gavin MG, Quinn WJ 3rd, Luongo TS, Gelfer RG, Baur JA, Titchenell PM (2019) The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis. Mol Metab 28:1-13.	Mouse	Skeletal muscle
Fang 2019 Nat Commun	2019	Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Morevati M, Lee HJ, Kato H, Kassahun H, Lee JH, Filippelli D, Okur MN, Mangerich A, Croteau DL, Maezawa Y, Lyssiotis CA, Tao J, Yokote K, Rusten TE, Mattson MP, Jasper H, Nilsen H, Bohr VA (2019) NAD⁺ augmentation restores mitophagy and limits accelerated aging in Werner syndrome. Nat Commun 10:5284.	Mouse	Heart Nervous system Liver		Other Aging;senescence
Rojas-Morales 2019 Free Radic Biol Med	2019	Rojas-Morales P, León-Contreras JC, Aparicio-Trejo OE, Reyes- Ocampo JG, Medina-Campos ON, Jiménez-Osorio AS, González-Reyes S, Marquina- Castillo B, Hernández-Pando R, Barrera-Oviedo D, Sánchez-Lozada LG, Pedraza-Chaverri J, Tapia E (2019) Fasting reduces oxidative stress, mitochondrial dysfunction and fibrosis induced by renal ischemia-reperfusion injury. Free Radic Biol Med 135:60-67.	Rat	Kidney	Ischemia-reperfusion Oxidative stress;RONS
Gonzalez-Armenta 2019 J Nutr	2019	Gonzalez-Armenta JL, Gao Z, Appt SE, Vitolins MZ, Michalson KT, Register TC, Shively CA, Molina AJA (2019) Skeletal muscle mitochondrial respiration is elevated in female cynomolgus macaques fed a western compared with a mediterranean diet. J Nutr 149:1493-502.	Other mammals	Skeletal muscle
Lefranc 2019 Hypertension	2019	Lefranc C, Friederich-Persson M, Braud L, Palacios-Ramirez R, Karlsson S, Boujardine N, Motterlini R, Jaisser F, Nguyen Dinh Cat A (2019) MR (mineralocorticoid receptor) induces adipose tissue senescence and mitochondrial dysfunction leading to vascular dysfunction in obesity. Hypertension 73:458-68.	Mouse	Fat		Aging;senescence Obesity
Rodriguez-Enriquez 2019 Toxicol Appl Pharmacol	2019	Rodríguez-Enríquez S, Pacheco-Velázquez SC, Marín-Hernández Á, Gallardo-Pérez JC, Robledo-Cadena DX, Hernández-Reséndiz I, García-García JD, Belmont-Díaz J, López-Marure R, Hernández-Esquivel L, Sánchez-Thomas R, Moreno-Sánchez R (2019) Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress. Toxicol Appl Pharmacol 370:65-77.	Rat	Heart Liver	Oxidative stress;RONS	Cancer
Kappler 2019 Am J Physiol Endocrinol Metab	2019	Kappler L, Hoene M, Hu C, von Toerne C, Li J, Bleher D, Hoffmann C, Böhm A, Kollipara L, Zischka H, Königsrainer A, Häring HU, Peter A, Xu G, Sickmann A, Hauck SM, Weigert C, Lehmann R (2019) Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints. Am J Physiol Endocrinol Metab 317:E374-E387.	Human Mouse	Skeletal muscle Liver
Miranda-Silva 2019 Acta Physiologica	2019	Miranda-Silva D, Wüst RCI, Conceição G, Gonçalves-Rodrigues P, Gonçalves N, Gonçalves A, Kuster DWD, Leite-Moreira AF, van der Velden J, de Sousa Beleza JM, Magalhães J, Stienen GJM, Falcão-Pires I (2019) Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction. Acta Physiol e13378.	Rat	Heart		Cardiovascular Obesity
Rudler 2019 Sci Adv	2019	Rudler DL, Hughes LA, Perks KL, Richman TR, Kuznetsova I, Ermer JA, Abudulai LN, Shearwood AJ, Viola HM, Hool LC, Siira SJ, Rackham O, Filipovska A (2019) Fidelity of translation initiation is required for coordinated respiratory complex assembly. Sci Adv 5:eaay2118.	Mouse	Heart
Sukovas 2019 J Bioenerg Biomembr	2019	Sukovas A, Silkuniene G, Trumbeckaite S, Jasukaitiene A, Degutyte-Fomins L, Mildaziene V, Gulbinas A, Baniene R, Dambrauskas Z, Paskauskas S (2019) Hyperthermia potentiates cisplatin cytotoxicity and negative effects on mitochondrial functions in OVCAR-3 cells. J Bioenerg Biomembr 51:301-10.	Human	Genital	Temperature	Cancer
Mazzoli 2019 Nutrients	2019	Mazzoli A, Crescenzo R, Cigliano L, Spagnuolo MS, Cancelliere R, Gatto C, Iossa S (2019) Early hepatic oxidative stress and mitochondrial changes following western diet in middle aged rats. Nutrients 11:E2670.	Rat	Liver	Oxidative stress;RONS
Johnson 2019 Mol Metab	2019	Johnson JM, Verkerke ARP, Maschek JA, Ferrara PJ, Lin CT, Kew KA, Neufer PD, Lodhi IJ, Cox JE, Funai K (2019) Alternative splicing of UCP1 by non-cell-autonomous action of PEMT. Mol Metab 31:55-66.	Mouse	Fat
Gonzalez-Mariscal 2019 FASEB J	2019	González-Mariscal I, Montoro RA, O'Connell JF, Kim Y, Gonzalez-Freire M, Liu QR, Alfaras I, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Hardivillé S, Ghosh P, Egan JM (2019) Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism. FASEB J 33:5850-63.	Mouse	Skeletal muscle		Obesity
Bettinazzi 2019 Cryobiology	2019	Bettinazzi S, Gendron AD, Breton S (2019) The effect of cryopreservation on mitochondrial function in freshwater mussel tissue samples (Bivalvia: Unionida). Cryobiology 88:106-109.	Molluscs	Lung;gill	Cryopreservation
Zhang 2019 Biochem Biophys Res Commun	2019	Zhang WY, Hu XF, Wan N, Zhang JF, Yang P, Wen Q, Chen WJ, Zhu F, Liang ML, Cheng LX, Shu YW (2019) Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice. Biochem Biophys Res Commun 514:386-92.	Mouse	Liver		Other
Lewis 2019 Am J Physiol Regul Integr Comp Physiol	2019	Lewis MT, Kasper JD, Bazil JN, Frisbee JC, Wiseman RW (2019) Skeletal muscle energetics are compromised only during high-intensity contractions in the Goto-Kakizaki rat model of type 2 diabetes. Am J Physiol Regul Integr Comp Physiol 317:R356-68.	Rat	Skeletal muscle		Diabetes
Esteves 2019 Oncogene	2019	Esteves P, Dard L, Brillac A, Hubert C, Sarlak S, Rousseau B, Dumon E, Izotte J, Bonneu M, Lacombe D, Dupuy JW, Amoedo N, Rossignol R (2019) Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F. Oncogene 39:617-36.	Human	Endothelial;epithelial;mesothelial cell		Cancer
Shao 2019 Cardiovasc Diabetol	2019	Shao Q, Meng L, Lee S, Tse G, Gong M, Zhang Z, Zhao J, Zhao Y, Li G, Liu T (2019) Empagliflozin, a sodium glucose co-transporter-2 inhibitor, alleviates atrial remodeling and improves mitochondrial function in high-fat diet/streptozotocin-induce diabetic rats. Cardiovasc Diabetol 18:165.	Rat	Heart		Diabetes
Carteri 2019 Toxicol Lett	2019	Carteri RB, Kopzynski A, Menegassi LN, Rodolphi MS, Strogulski NR, Portela LV (2019) Anabolic-androgen steroids effects on bioenergetics responsiveness of synaptic and extrasynaptic mitochondria. Toxicol Lett 307:72-80.	Mouse	Nervous system
Desquiret-Dumas 2019 Biochim Biophys Acta Mol Basis Dis	2019	Desquiret-Dumas V, Leman G, Wetterwald C, Chupin S, Lebert A, Khiati S, Le Mao M, Geffroy G, Kane MS, Chevrollier A, Goudenege D, Gadras C, Tessier L, Barth M, Leruez S, Amati-Bonneau P, Henrion D, Bonneau D, Procaccio V, Reynier P, Lenaers G, Gueguen N (2019) Warburg-like effect is a hallmark of complex I assembly defects. Biochim Biophys Acta Mol Basis Dis 1865:2475-89.	Human	Fibroblast		Other
Pino 2019 Physiol Genomics	2019	Pino MF, Stephens NA, Eroshkin AM, Yi F, Hodges A, Cornnell HH, Pratley RE, Smith SR, Wang M, Han X, Coen PM, Goodpaster BH, Sparks LM (2019) Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with type 2 diabetes. Physiol Genomics 51:586-95.	Human	Skeletal muscle		Diabetes
Havird 2019 Philos Trans R Soc Lond B Biol Sci	2019	Havird JC, Shah AA, Chicco AJ (2019) Powerhouses in the cold: mitochondrial function during thermal acclimation in montane mayflies. Philos Trans R Soc Lond B Biol Sci 375:20190181.	Hexapods
Paumelle 2019 J Hepatol	2019	Paumelle R, Haas J, Hennuyer N, Bauge E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi A, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B (2019) Hepatic PPARα is critical in the metabolic adaptation to sepsis. J Hepatol 70:963-73.	Human	Liver		Infectious Sepsis
Chang 2019 Br J Anaesth	2019	Chang L, Daly C, Miller DM, Allen PD, Boyle JP, Hopkins PM, Shaw MA (2019) Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals. Br J Anaesth 122:613-21.	Human	Skeletal muscle	Temperature
Kunz 2019 Am J Physiol Endocrinol Metab	2019	Kunz HE, Dasari S, Lanza IR (2019) EPA and DHA elicit distinct transcriptional responses to high-fat feeding in skeletal muscle and liver. Am J Physiol Endocrinol Metab 317:E460-E472.	Mouse	Skeletal muscle Liver
Cannon 2019 J Appl Physiol (1985)	2019	Cannon DT, Rodewohl L, Adams V, Breen EC, Bowen TS (2019) Skeletal myofiber VEGF deficiency leads to mitochondrial, structural and contractile alterations in mouse diaphragm. J Appl Physiol (1985) 127:1360-69.	Mouse	Skeletal muscle
Fisher-Wellman 2019 Cell Rep	2019	Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM (2019) Respiratory phenomics across multiple models of protein hyperacylation in cardiac mitochondria reveals a marginal impact on bioenergetics. Cell Rep 26:1557-72.	Mouse	Heart Skeletal muscle
Miotto 2019 FASEB J	2019	Miotto PM, McGlory C, Bahniwal R, Kamal M, Phillips SM, Holloway GP (2019) Supplementation with dietary ω-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women. FASEB J 33:8232-40.	Human	Skeletal muscle
Ling 2019 Am J Clin Nutr	2019	Ling Y, Carayol J, Galusca B, Canto C, Montaurier C, Matone A, Vassallo I, Minehira K, Alexandre V, Cominetti O, Núñez Galindo A, Corthésy J, Dayon L, Charpagne A, Métairon S, Raymond F, Descombes P, Casteillo F, Peoc'h M, Palaghiu R, Féasson L, Boirie Y, Estour B, Hager J, Germain N, Gheldof N (2019) Persistent low body weight in humans is associated with higher mitochondrial activity in white adipose tissue. Am J Clin Nutr 110:605-16.	Human	Skeletal muscle Fat
Dechandt 2019 Front Neurol	2019	Dechandt CRP, Ferrari GD, Dos Santos JR, de Oliveira JAC, da Silva-Jr RMP, Cunha AOS, Garcia-Cairasco N, Alberici LC (2019) Energy metabolism and redox state in brains of wistar audiogenic rats, a genetic model of epilepsy. Front Neurol 10:1007.	Rat	Nervous system		Other
Stepanova 2019 Antioxid Redox Signal	2019	Stepanova Anna, Sosunov S, Niatsetskaya Z, Konrad Csaba, Starkov AA, Manfredi G, Wittig I, Ten V, Galkin Alexander (2019) Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury. Antioxid Redox Signal 31:608-22.	Mouse	Nervous system	Ischemia-reperfusion
Rutai 2019 Shock	2019	Rutai A, Fejes R, Juhász L, Tallósy SP, Poles MZ, Földesi I, Mészáros AT, Szabó A, Boros M, Kaszaki J (2019) Endothelin A and B receptors: Potential pargets for microcirculatory-mitochondrial therapy in experimental sepsis. Shock 54:87-95.	Rat	Liver		Sepsis
Vaka 2019 Am J Physiol Regul Integr Comp Physiol	2019	Vaka VR, Mcmasters KM, Cornelius DC, Ibrahim T, Jayaram A, Usry N, Cunningham MW Jr, Amaral LM, LaMarca BD (2019) Natural killer cells contribute to mitochondrial dysfunction in response to placental ischemia in Reduced Uterine Perfusion Pressure (RUPP) rats. Am J Physiol Regul Integr Comp Physiol 316:R441-R447.	Human Rat	Endothelial;epithelial;mesothelial cell Genital	Ischemia-reperfusion Oxidative stress;RONS
Chroeis 2019 Eur J Sport Sci	2019	Chrøis KM, Dohlmann TL, Søgaard D, Hansen CV, Dela F, Helge JW, Larsen S (2019) Mitochondrial adaptations to high intensity interval training in older females and males. Eur J Sport Sci 20:135-45.	Human	Skeletal muscle		Aging;senescence
Oakey 2019 Wellcome Open Res	2019	Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG (2019) Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD⁺ depletion. Wellcome Open Res 3:147.	Mouse	Skeletal muscle
Gratl 2019 Eur J Vasc Endovasc Surg	2019	Gratl A, Frese J, Speichinger F, Pesta D, Frech A, Omran S, Greiner A (2019) Regeneration of mitochondrial function in gastrocnemius muscle in peripheral arterial disease after successful revascularisation. Eur J Vasc Endovasc Surg 59:109-15.	Human	Skeletal muscle	Ischemia-reperfusion	Cardiovascular
McBride 2019 Arch Biochem Biophys	2019	McBride S, Wei-LaPierre L, McMurray F, MacFarlane M, Qiu X, Patten DA, Dirksen RT, Harper ME (2019) Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3. Arch Biochem Biophys 663:239-48.	Mouse	Skeletal muscle	Oxidative stress;RONS
Ferey 2019 Am J Physiol Heart Circ Physiol	2019	Ferey J, Boudoures AL, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch BJ, Thompson MD, Diwan A, Moley KH (2019) Maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independent of maternal mitochondrial inheritance. Am J Physiol Heart Circ Physiol 316:H1202-H1210.	Mouse	Heart		Obesity
Campos 2019 Thesis	2019	Campos DF (2019) Os peixes amazônicos vivem perto dos seus limites térmicos? O efeito das mudanças climáticas sobre a ecofisiologia de peixes de Igarapé da Amazônia Central. PhD Thesis 106.	Fishes	Lung;gill	Temperature
Zhang 2019 Redox Biol	2019	Zhang Y, Bharathi SS, Beck ME, Goetzman ES (2019) The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase can be a source of mitochondrial hydrogen peroxide. Redox Biol 26:101253.	Mouse	Liver	Oxidative stress;RONS
Kim 2019 Biochim Biophys Acta Mol Basis Dis	2019	Kim HK, Jeon J, Song IS, Heo HJ, Jeong SH, Long LT, Thu VT, Ko TH, Kim M, Kim N, Lee SR, Yang JS, Kang MS, Ahn JM, Cho JY, Ko KS, Rhee BD, Nilius B, Ha NC, Shimizu I, Minamino T, Cho KI, Park YS, Kim S, Han J (2019) Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling. Biochim Biophys Acta Mol Basis Dis 1865:165524.	Mouse	Heart		Cardiovascular
Datzmann 2019 J Neurosurg	2019	Datzmann T, Kapapa T, Scheuerle A, McCook O, Merz T, Unmuth S, Hoffmann A, Mathieu R, Mayer S, Mauer UM, Roehrer S, Yilmazer-Hanke D, Moeller P, Nussbaum BL, Calzia E, Groeger M, Hartmann C, Radermacher P, Wepler M (2019) In-depth characterization of a long-term, resuscitated model of acute subdural hematoma-induced brain injury. J Neurosurg [Epub ahead of print].	Pig	Nervous system		Other
Courtes 2019 Biomed Pharmacother	2019	Courtes AA, de Carvalho NR, Gonçalves DF, Hartmann DD, da Rosa PC, Dobrachinski F, Franco JL, de Souza DOG, Soares FAA (2019) Guanosine protects against Ca²⁺-induced mitochondrial dysfunction in rats. Biomed Pharmacother 111:1438-46.	Rat	Liver
Fisar 2019 Clin Biochem	2019	Fišar Z, Jirák R, Zvěřová M, Setnička V, Habartová L, Hroudová J, Vaníčková Z, Raboch J (2019) Plasma amyloid beta levels and platelet mitochondrial respiration in patients with Alzheimer's disease. Clin Biochem 72:71-80.	Human	Platelet Blood cells		Alzheimer's
Scavuzzo 2019 J Neurophysiol	2019	Scavuzzo CJ, Leblancq MJ, Nargang F, Lemieux H, Hamilton TJ, Dickson CT (2019) The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics. J Neurophysiol 122:1123-35.	Rat	Nervous system
Tomasic 2019 Biochim Biophys Acta Mol Basis Dis	2019	Tomašić N, Kotarsky H, de Oliveira Figueiredo R, Hansson E, Mörgelin M, Tomašić I, Kallijärvi J, Elmér E, Jauhiainen M, Eklund EA, Fellman V (2019) Fasting reveals largely intact systemic lipid mobilization mechanisms in respiratory chain complex III deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165573.	Mouse	Liver
McCoin 2019 Am J Physiol Endocrinol Metab	2019	McCoin CS, Von Schulze A, Allen J, Fuller KN, Xia Q, Koestler DC, Houchen CJ, Maurer A, Dorn Ii GW, Shankar K, Morris EM, Thyfault JP (2019) Sex modulates hepatic mitochondrial adaptations to high fat diet and physical activity. Am J Physiol Endocrinol Metab 317:E298-E311.	Mouse	Liver		Other
Papadimitriou 2019 Sci Rep	2019	Papadimitriou ID, Eynon N, Yan X, Munson F, Jacques M, Kuang J, Voisin S, North KN, Bishop DJ (2019) A "human knockout" model to investigate the influence of the α-actinin-3 protein on exercise-induced mitochondrial adaptations. Sci Rep 9:12688.	Human	Skeletal muscle
Ferreira 2019 EMBO J	2019	Ferreira N, Perks KL, Rossetti G, Rudler DL, Hughes LA, Ermer JA, Scott LH, Kuznetsova I, Richman TR, Narayana VK, Abudulai LN, Shearwood AJ, Cserne Szappanos H, Tull D, Yeoh GC, Hool LC, Filipovska A, Rackham O (2019) Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation. EMBO J 38:e102155.	Mouse	Heart Liver
Bundgaard 2019 Sci Rep	2019	Bundgaard A, James AM, Gruszczyk AV, Martin J, Murphy MP, Fago A (2019) Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury. Sci Rep 9:2850.	Mouse Reptiles	Heart	Ischemia-reperfusion Oxidative stress;RONS
Robinson 2019 Am J Physiol Cell Physiol	2019	Robinson MM, Sather BK, Burney ER, Ehrlicher SE, Stierwalt HD, Franco MC, Newsom SA (2019) Robust intrinsic differences in mitochondrial respiration and H₂O₂ emission between L6 and C2C12 cells. Am J Physiol Cell Physiol 317:C339-C347.	Mouse Rat	Skeletal muscle
Cooper 2019 Exp Physiol	2019	Cooper MA, McCoin C, Pei D, Thyfault JP, Koestler D, Wright DE (2019) Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet. Exp Physiol 103:1206-12.	Mouse	Nervous system
Cormier 2019 Sci Rep	2019	Cormier RPJ, Champigny CM, Simard CJ, St-Coeur PD, Pichaud N (2019) Dynamic mitochondrial responses to a high-fat diet in Drosophila melanogaster. Sci Rep 9:4531.	Drosophila	Skeletal muscle
Belosludtsev 2019 Biochim Biophys Acta Biomembr	2019	Belosludtsev KN, Belosludtseva NV, Talanov EY, Tenkov KS, Starinets VS, Agafonov AV, Pavlik LL, Dubinin MV (2019) Effect of bedaquiline on the functions of rat liver mitochondria. Biochim Biophys Acta Biomembr 1861:288-97.	Rat	Liver
Martines 2019 Sci Rep	2019	Martines AMF, Gerding A, Stolle S, Vieira-Lara MA, Wolters JC, Jurdzinski A, Bongiovanni L, de Bruin A, van der Vlies P, van der Vries G, Bloks VW, Derks TGJ, Reijngoud DJ, Bakker BM (2019) Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD⁺ in medium-chain acyl-CoA dehydrogenase knockout mice. Sci Rep 9:14539.	Mouse	Liver
Naszai 2019 Sci Rep	2019	Nászai A, Terhes E, Kaszaki J, Boros M, Juhász L (2019) Ca⁽²⁺⁾N it be measured? Detection of extramitochondrial calcium movement with high-resolution FluoRespirometry. Sci Rep 9:19229.	Rat	Liver
Dall 2019 J Biol Chem	2019	Dall M, Trammell SAJ, Asping M, Hassing AS, Agerholm M, Vienberg SG, Gillum MP, Larsen S, Treebak JT (2019) Mitochondrial function in liver cells is resistant to perturbations in NAD⁺ salvage capacity. J Biol Chem 294:13304-26.	Mouse	Liver
Mueller 2019 Neurochem Int	2019	Mueller TE, Nunes MEM, Rodrigues NR, Fontana BD, Hartmann DD, Franco JL, Rosemberg DB (2019) Neurochemical mechanisms underlying acute and chronic ethanol-mediated responses in zebrafish: The role of mitochondrial bioenergetics. Neurochem Int 131:104584.	Zebrafish	Nervous system
Bettinazzi 2019 Proc Biol Sci	2019	Bettinazzi S, Rodríguez E, Milani L, Blier PU, Breton S (2019) Metabolic remodelling associated with mtDNA: insights into the adaptive value of doubly uniparental inheritance of mitochondria. Proc Biol Sci 286:20182708.	Molluscs	Lung;gill Genital
Li 2019 Int Urol Nephrol	2019	Li Z, Zhou J, Li Y, Yang F, Lian X, Liu W (2019) Mitochondrial TRPC3 promotes cell proliferation by regulating the mitochondrial calcium and metabolism in renal polycystin-2 knockdown cells. Int Urol Nephrol 51:1059-70.	Human	Endothelial;epithelial;mesothelial cell		Inherited
Grauso 2019 Sci Rep	2019	Grauso M, Lan A, Andriamihaja M, Bouillaud F, Blachier F (2019) Hyperosmolar environment and intestinal epithelial cells: impact on mitochondrial oxygen consumption, proliferation, and barrier function in vitro. Sci Rep 9:11360.	Human	Endothelial;epithelial;mesothelial cell Other cell lines		Cancer
Axton 2019 J Nutr	2019	Axton ER, Beaver LM, St Mary L, Truong L, Logan CR, Spagnoli S, Prater MC, Keller RM, Garcia-Jaramillo M, Ehrlicher SE, Stierwalt HD, Newsom SA, Robinson MM, Tanguay RL, Stevens JF, Hord NG (2019) Treatment with nitrate, but not nitrite, lowers the oxygen cost of exercise and decreases glycolytic intermediates while increasing fatty acid metabolites in exercised zebrafish. J Nutr 00:1–13.	Zebrafish	Skeletal muscle
Esselun 2019 Oxid Med Cell Longev	2019	Esselun C, Bruns B, Hagl S, Grewal R, Eckert GP (2019) Differential effects of silibinin A on mitochondrial function in neuronal PC12 and HepG2 liver cells. Oxid Med Cell Longev 2019:1652609.	Human Rat	Nervous system Liver
Wiberg 2019 Eur Heart J Acute Cardiovasc Care	2019	Wiberg S, Stride N, Bro-Jeppesen J, Holmberg MJ, Kjærgaard J, Larsen S, Donnino MW, Hassager C, Dela F (2019) Mitochondrial dysfunction in adults after out-of-hospital cardiac arrest. Eur Heart J Acute Cardiovasc Care 9:S138-44.	Human	Skeletal muscle	Ischemia-reperfusion	Cardiovascular
Cadiz 2019 Comp Biochem Physiol B Biochem Mol Biol	2019	Cadiz L, Bundgaard A, Malte H, Fago A (2019) Hypoxia enhances blood O₂ affinity and depresses skeletal muscle O₂ consumption in zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol 234:18-25.	Zebrafish	Skeletal muscle	Hypoxia
Ederle 2019 J Clin Med	2019	Ederle C, Charles AL, Khayath N, Poirot A, Meyer A, Clere-Jehl R, Andres E, De Blay F, Geny B (2019) Mitochondrial function in peripheral blood mononuclear cells (PBMC) is enhanced, together with increased reactive oxygen species, in severe asthmatic patients in exacerbation. J Clin Med 8:E1613.	Human	Blood cells	Oxidative stress;RONS	Other
Heden 2019 Sci Adv	2019	Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K (2019) Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Sci Adv 5:eaax8352.	Mouse	Skeletal muscle
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MitoPedia concepts: Respiratory control ratio

MitoPedia methods: Respirometry

L/P coupling-control ratio

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List of publications: LEAK and OXPHOS

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