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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
MitoEAGLE data: muscle
WG2
- MITOEAGLE data repository in muscle and other tissues
WG2 Description
- During the past 10 years, a dramatically increasing number of studies report respirometric data on human muscle tissue (e.g. Christiansen 2015 Am J Physiol). Muscle mitochondrial function is particularly studied in genetically engineered mouse models of human diseases (e.g. Jelenik 2014 Diabetes). However, despite the many published data, lack of consistency often precludes quantitative comparison among data sets with permeabilized or homogenized muscle fibres or isolated mitochondria, normalized to either tissue wet weight, dry weight, protein content, citrate synthase activity or other mitochondrial markers. In the absence of validated conversion factors, these data remain largely unconnected and can only be qualitatively linked.
- The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.
WG2 Participants
Country | City | Contact |
---|---|---|
Australia | Melbourne | Bishop David J |
Austria | Salzburg | Mayr JA |
Austria | Innsbruck | Doerrier Carolina |
Austria | Innsbruck | Laner Verena |
Austria | Innsbruck | Gnaiger Erich |
Belgium | Liege | Votion Dominique-Marie |
Belgium | Leuven | Bird Matthew |
Brazil | São Paulo | Ferreira Julio Cesar B |
Brazil | Jaboticabal, SP | Garcia Geovana S |
Canada | Antigonish | Kane Daniel A |
Canada | Rimouski | Blier Pierre U |
Canada | Rimouski | Vandermeeren E |
Canada | Vancouver | Boushel Robert C |
Canada | Edmonton (Alberta) | Lemieux Helene |
Croatia | Zagreb | Saric A |
Croatia | Split | Mihanovic I |
Czech Republic | Prague 10 | Krajcova Adela |
Czech Republic | Prague | Elkalaf Moustafa |
Czech Republic | Pilsen | Kuncova J |
Czech Republic | Hradec Králové | Waldauf P |
Czech Republic | Pilsen | Markova Michaela |
Denmark | Copenhagen | Larsen Steen |
Denmark | Copenhagen | Gonzalez-Franquesa Alba |
Denmark | Malov | Hey-Mogensen M |
Denmark | Hvidovre | Nehlin Jan O |
Denmark | Copenhagen N | Mortensen OH |
Denmark | Copenhagen | Dela Flemming |
Estonia | Tallinn | Tepp Kersti |
Estonia | Tallinn | Vendelin Marko |
Estonia | Tallinn | Aid-Vanakova Jekaterina |
Estonia | Tallinn | Karro N |
Estonia | Tallinn | Puurand Marju |
Estonia | Tartu | Paju Kalju |
Estonia | Tallinn | Truu Laura |
Estonia | Tallinn | Kaambre Tuuli |
Finland | Helsinki | Pirinen E |
Finland | Jyvaeskylae | Lehti Maarit |
France | Montpellier Cedex 1 | Chabi Beatrice |
France | Paris | Ventura-Clapier R |
France | Grenoble cedex 9 | Dubouchaud Herve |
France | Montpellier | Cortade F |
France | Bordeaux cedex | Mourier A |
France | Paris | Armand Anne-Sophie |
France | Paris | Petit Patrice X |
France | Grenoble Cedex 9 | Schlattner Uwe |
Germany | Leipzig | Ost Mario |
Germany | Cologne | Pesta Dominik |
Germany | Bremerhaven | Mark Felix Christopher |
Germany | Rostock | Haider F |
Germany | Nuthetal | Klaus S |
Germany | Munich | Jastroch M |
Germany | Bochum | Platen P |
Germany | Düsseldorf | Granata Cesare |
Germany | Duesseldorf | Roden Michael |
Germany | Duesseldorf | Jelenik T |
Germany | Köln | Kimoloi Sammy |
Greece | Athens | Trougakos Ioannis P |
Greece | Heraklion | Tavernarakis Nektarios |
Greece | Heraklio | Sidiropoulou K |
India | Haryana | Sharma Vipin |
Ireland | Dublin | O'Gorman Donal |
Ireland | Dublin | Porter Richard K |
Ireland | Sligo | Murphy J |
Israel | Jerusalem | Saada Reisch Ann |
Israel | Rishon Le Zion | Hachmo Yafit |
Israel | Zrifin | Sova Marina |
Italia | Udine | Salvadego Desy |
Italy | Pisa | Gastaldelli Amalia |
Italy | Rome | Scatena Roberto |
Italy | Novara | Reano Simone |
Italy | Milan | De Palma Clara |
Italy | Milan | Giovarelli Matteo |
Italy | Bologna | Genova Maria Luisa |
Japan | Sapporo | Nambu H |
Japan | Sapporo | Maekawa S |
Japan | Sapporo | Shirakawa R |
Latvia | Riga | Kuka Janis |
Latvia | Riga | Zvejniece Liga |
Latvia | Riga | Inashkina I |
Latvia | Riga | Liepins Edgars |
Luxembourg | Strassen | Devaux Yvan |
Malta | Msida | Vella Joanna |
Netherlands | Wageningen | Keijer Jaap |
Netherlands | Maastricht | Van Polanen N |
Netherlands | BT Amsterdam | Jaspers Richard T |
Netherlands | Amsterdam | De Goede Paul |
Netherlands | Maastricht | Hoeks Joris |
Netherlands | Maastricht | Grevendonk L |
Niederlande | ER Masstricht | De Wit-Verheggen V |
Niederlande | ER Masstricht | De Theije C |
Norway | Oslo | Eide L |
Norway | Tromsoe | Jansen Kirsten M |
Norway | Bergen | Tronstad Karl Johan |
Norway | Tromsoe | Larsen Terje S |
Norway | Tromsoe | Schots Pauke C |
Norway | Tromsoe | Aasum E |
Norway | Ullevål | Heiestad Christina |
Norway | Oslo | Lund Jenny |
Norway | Oslo | Nikolic N |
Norway | Oslo | Torp May-Kristin |
Norway | Oslo | Rustan AC |
Poland | Warsaw | Sek Aleksandra |
Poland | Warsaw | Kampa Rafal Pawel |
Poland | Warsaw | Dymkowska Dorota |
Poland | Lodz | Watala Cezary |
Poland | Lodz | Labieniec-Watala Magdalena |
Portugal | Porto | Beleza Jorge |
Portugal | Cantanhede | Martins Joao D |
Portugal | Coimbra | Palmeira Carlos |
Portugal | Cantanhede | Ferreira LL |
Portugal | Coimbra | Martins Marques T |
Portugal | Porto | Coxito Pedro |
Portugal | Coimbra | Carvalho Eugenia |
Portugal | Porto | Magalhaes Jose |
Portugal | Coimbra | Pereira Susana P |
Romania | Timisoara | Lighezan R |
Romania | Timisoara | Muntean Danina M |
Singapore | Singapore | Hausenloy Derek J |
Slovakia | Bratislava | Ukropcova B |
Slovakia | Bratislava | Maderova D |
Slovakia | Bratislava | Nemec Michal |
Slovakia | Bratislava | Ukropec J |
Slovakia | Bratislava | Sumbalova Zuzana |
Slovenia | Ljubljana | Pirkmajer Sergej |
Slovenia | Ljubljana | Dolinar K |
Slovenia | Ljubljana | Mars T |
South Africa | Smith James | |
Spain | Granada | Lopez Garcia Luis Carlos |
Spain | Madrid | Cadenas S |
Spain | Madrid | Moran M |
Spain | Barcelona | Sebastian D |
Spain | Barcelona | Zorzano Antonio |
Spain | Barcelona | Catalan M |
Spain | Barcelona | De la Torre Lara J |
Spain | Sevilla | Bustos Matilde |
Spain | Armilla (Granada) | Acuna-Castroviejo Dario |
Spain | Barcelona | Batlle M |
Spain | Barcelona | Gama Perez Pau |
Spain | Armilla (Granada) | Fernandez-Ortiz Marisol |
Spain | Armilla, Granada | Escames Germaine |
Spain | A Coruña | Blanco FJ |
Spain | Barcelona | Guitart M |
Spain | Barcelona | Garcia-Roves Pablo Miguel |
Sweden | Linköping | Fontes-Oliveira CC |
Sweden | Stockholm | Cardinale Daniele A |
Switzerland | Lausanne | Zalachoras I |
Switzerland | Lausanne | Gebara E |
Switzerland | Lausanne | Morato Fornaguera L |
Switzerland | Lausanne | Sandi Carmen |
Switzerland | Lausanne | Weger M |
Switzerland | Bern | Nuoffer Jean-Marc |
The Netherlands | Wageningen | Van der Ende Miranda |
The Netherlands | BT Amsterdam | Wuest Rob CI |
Turkey | Ankara | Tuncay Erkan |
USA | Torrance | Rossiter Harry B |
USA | Fort Collins | Chicco Adam J |
USA | Chicago | Dayanidhi Sudarshan |
USA | Fairbanks | O'Brien Kristin |
USA | Colorado Springs | Jacobs RA |
USA | Baltimore | Gonzalez-Freire Marta |
USA | Norfolk | Lai Nicola |
USA | College Station | White-Springer Sarah H |
USA | Seattle | Marcinek DJ |
USA | Gainesville | Hepple Russell T |
USA | Baltimore | Fang Evandro F |
USA | Orlando | Distefano Giovanna |
USA | Ann Arbor | Beard Daniel A |
USA | Little Rock | Porter Craig |
USA | St Louis | Welch R |
USA | Gainesville | Wohlgemuth Stephanie E |
USA | Gainesville | Neyroud D |
USA | College Station | Latham C |
USA | Boca Raton | Khamoui Andy V |
USA | Baton Rouge | Irving Brian A |
USA | Baton Rouge | Axelrod Christopher L |
USA | Orlando | Coen Paul M |
United Kingdom | London | Szabadkai Gyorgy |
United Kingdom | Manchester | Giakoumaki I |
United Kingdom | Birmingham | Thakker A |
United Kingdom | Leeds | Boyle JP |
United Kingdom | Loughborough | Ebanks Brad |
United Kingdom | Plymouth, Devon | McKenna Helen T |
United Kingdom | Birmingham | Garten Antje |
United Kingdom | Nottingham | Chakrabarti Lisa |
United Kingdom | Birmingham | Ashcroft S |
United Kingdom | Oxford | Makrecka-Kuka Marina |
United Kingdom | Cambridge | Shiroma Jonathan G |
United Kingdom | Brighton | Moore Anthony L |
United Kingdom | Cambridge | Murray Andrew James |
United Kingdom | Birmingham | Joanisse S |
United States | Providence | Siamwala J |
WG2 Management
Tasks
- Call for participating labs to deliver relevant experimental data on already published studies and to report them in a standardized format.
- Collection and indexing of the data sets as required for statistical analysis.
- Discussion of procedures, protocols and general guidelines.
- Draft a comprehensive review on mt-function in muscle tissue (registration at PROSPERO, link with EQUATOR).
- Opening of the database to the research public for data search and moderated entry of new data sets.
Milestones
- Call for data report delivered.
- Data sets entered in standardized format.
- Summary, interpretation and discussion of data for review.
Deliverables
- A MITOEAGLE database on muscle tissue from humans and model organisms.
- A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue.
- Draft of review manuscript.
Projects in progress
- » MiPMap