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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
MitoEAGLE data: muscle
WG2
- MITOEAGLE data repository in muscle and other tissues
WG2 Description
- During the past 10 years, a dramatically increasing number of studies report respirometric data on human muscle tissue (e.g. Christiansen 2015 Am J Physiol). Muscle mitochondrial function is particularly studied in genetically engineered mouse models of human diseases (e.g. Jelenik 2014 Diabetes). However, despite the many published data, lack of consistency often precludes quantitative comparison among data sets with permeabilized or homogenized muscle fibres or isolated mitochondria, normalized to either tissue wet weight, dry weight, protein content, citrate synthase activity or other mitochondrial markers. In the absence of validated conversion factors, these data remain largely unconnected and can only be qualitatively linked.
- The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.
WG2 Participants
Country | City | Contact |
---|---|---|
Australia | Melbourne | Bishop David J |
Austria | Innsbruck | Doerrier Carolina |
Austria | Innsbruck | Laner Verena |
Austria | Innsbruck | Gnaiger Erich |
Austria | Salzburg | Mayr JA |
Belgium | Leuven | Bird Matthew |
Belgium | Liege | Votion Dominique-Marie |
Brazil | São Paulo | Ferreira Julio Cesar B |
Brazil | Jaboticabal, SP | Garcia Geovana S |
Canada | Rimouski | Vandermeeren E |
Canada | Vancouver | Boushel Robert C |
Canada | Edmonton (Alberta) | Lemieux Helene |
Canada | Rimouski | Blier Pierre U |
Canada | Antigonish | Kane Daniel A |
Croatia | Split | Mihanovic I |
Croatia | Zagreb | Saric A |
Czech Republic | Pilsen | Kuncova J |
Czech Republic | Hradec Králové | Waldauf P |
Czech Republic | Pilsen | Markova Michaela |
Czech Republic | Prague 10 | Krajcova Adela |
Czech Republic | Prague | Elkalaf Moustafa |
Denmark | Copenhagen | Gonzalez-Franquesa Alba |
Denmark | Hvidovre | Nehlin Jan O |
Denmark | Malov | Hey-Mogensen M |
Denmark | Copenhagen | Dela Flemming |
Denmark | Copenhagen | Larsen Steen |
Denmark | Copenhagen N | Mortensen OH |
Estonia | Tallinn | Aid-Vanakova Jekaterina |
Estonia | Tallinn | Karro N |
Estonia | Tallinn | Puurand Marju |
Estonia | Tartu | Paju Kalju |
Estonia | Tallinn | Truu Laura |
Estonia | Tallinn | Kaambre Tuuli |
Estonia | Tallinn | Vendelin Marko |
Estonia | Tallinn | Tepp Kersti |
Finland | Helsinki | Pirinen E |
Finland | Jyvaeskylae | Lehti Maarit |
France | Grenoble cedex 9 | Dubouchaud Herve |
France | Montpellier | Cortade F |
France | Paris | Armand Anne-Sophie |
France | Paris | Petit Patrice X |
France | Bordeaux cedex | Mourier A |
France | Grenoble Cedex 9 | Schlattner Uwe |
France | Montpellier Cedex 1 | Chabi Beatrice |
France | Paris | Ventura-Clapier R |
Germany | Bochum | Platen P |
Germany | Düsseldorf | Granata Cesare |
Germany | Duesseldorf | Jelenik T |
Germany | Duesseldorf | Roden Michael |
Germany | Köln | Kimoloi Sammy |
Germany | Leipzig | Ost Mario |
Germany | Bremerhaven | Mark Felix Christopher |
Germany | Rostock | Haider F |
Germany | Cologne | Pesta Dominik |
Germany | Nuthetal | Klaus S |
Germany | Munich | Jastroch M |
Greece | Heraklio | Sidiropoulou K |
Greece | Athens | Trougakos Ioannis P |
Greece | Heraklion | Tavernarakis Nektarios |
India | Haryana | Sharma Vipin |
Ireland | Dublin | Porter Richard K |
Ireland | Sligo | Murphy J |
Ireland | Dublin | O'Gorman Donal |
Israel | Rishon Le Zion | Hachmo Yafit |
Israel | Zrifin | Sova Marina |
Israel | Jerusalem | Saada Reisch Ann |
Italia | Udine | Salvadego Desy |
Italy | Novara | Reano Simone |
Italy | Milan | De Palma Clara |
Italy | Milan | Giovarelli Matteo |
Italy | Bologna | Genova Maria Luisa |
Italy | Pisa | Gastaldelli Amalia |
Italy | Rome | Scatena Roberto |
Japan | Sapporo | Shirakawa R |
Japan | Sapporo | Nambu H |
Japan | Sapporo | Maekawa S |
Latvia | Riga | Liepins Edgars |
Latvia | Riga | Inashkina I |
Latvia | Riga | Kuka Janis |
Latvia | Riga | Zvejniece Liga |
Luxembourg | Strassen | Devaux Yvan |
Malta | Msida | Vella Joanna |
Netherlands | Amsterdam | De Goede Paul |
Netherlands | Maastricht | Grevendonk L |
Netherlands | Maastricht | Hoeks Joris |
Netherlands | Maastricht | Van Polanen N |
Netherlands | Wageningen | Keijer Jaap |
Netherlands | BT Amsterdam | Jaspers Richard T |
Niederlande | ER Masstricht | De Wit-Verheggen V |
Niederlande | ER Masstricht | De Theije C |
Norway | Tromsoe | Aasum E |
Norway | Tromsoe | Schots Pauke C |
Norway | Ullevål | Heiestad Christina |
Norway | Oslo | Nikolic N |
Norway | Oslo | Lund Jenny |
Norway | Oslo | Torp May-Kristin |
Norway | Oslo | Rustan AC |
Norway | Tromsoe | Jansen Kirsten M |
Norway | Bergen | Tronstad Karl Johan |
Norway | Oslo | Eide L |
Norway | Tromsoe | Larsen Terje S |
Poland | Warsaw | Kampa Rafal Pawel |
Poland | Warsaw | Dymkowska Dorota |
Poland | Lodz | Watala Cezary |
Poland | Lodz | Labieniec-Watala Magdalena |
Poland | Warsaw | Sek Aleksandra |
Portugal | Porto | Coxito Pedro |
Portugal | Coimbra | Carvalho Eugenia |
Portugal | Porto | Magalhaes Jose |
Portugal | Coimbra | Pereira Susana P |
Portugal | Porto | Beleza Jorge |
Portugal | Coimbra | Palmeira Carlos |
Portugal | Cantanhede | Martins Joao D |
Portugal | Cantanhede | Ferreira LL |
Portugal | Coimbra | Martins Marques T |
Romania | Timisoara | Muntean Danina M |
Romania | Timisoara | Lighezan R |
Singapore | Singapore | Hausenloy Derek J |
Slovakia | Bratislava | Nemec Michal |
Slovakia | Bratislava | Ukropec J |
Slovakia | Bratislava | Sumbalova Zuzana |
Slovakia | Bratislava | Ukropcova B |
Slovakia | Bratislava | Maderova D |
Slovenia | Ljubljana | Mars T |
Slovenia | Ljubljana | Pirkmajer Sergej |
Slovenia | Ljubljana | Dolinar K |
South Africa | Smith James | |
Spain | Barcelona | Catalan M |
Spain | Barcelona | Zorzano Antonio |
Spain | Sevilla | Bustos Matilde |
Spain | Barcelona | De la Torre Lara J |
Spain | Armilla (Granada) | Acuna-Castroviejo Dario |
Spain | Barcelona | Gama Perez Pau |
Spain | Armilla (Granada) | Fernandez-Ortiz Marisol |
Spain | A Coruña | Blanco FJ |
Spain | Barcelona | Batlle M |
Spain | Barcelona | Guitart M |
Spain | Armilla, Granada | Escames Germaine |
Spain | Barcelona | Garcia-Roves Pablo Miguel |
Spain | Granada | Lopez Garcia Luis Carlos |
Spain | Madrid | Moran M |
Spain | Madrid | Cadenas S |
Spain | Barcelona | Sebastian D |
Sweden | Stockholm | Cardinale Daniele A |
Sweden | Linköping | Fontes-Oliveira CC |
Switzerland | Lausanne | Morato Fornaguera L |
Switzerland | Lausanne | Sandi Carmen |
Switzerland | Lausanne | Weger M |
Switzerland | Bern | Nuoffer Jean-Marc |
Switzerland | Lausanne | Zalachoras I |
Switzerland | Lausanne | Gebara E |
The Netherlands | BT Amsterdam | Wuest Rob CI |
The Netherlands | Wageningen | Van der Ende Miranda |
Turkey | Ankara | Tuncay Erkan |
USA | Baltimore | Fang Evandro F |
USA | Colorado Springs | Jacobs RA |
USA | Norfolk | Lai Nicola |
USA | Ann Arbor | Beard Daniel A |
USA | Gainesville | Hepple Russell T |
USA | Orlando | Distefano Giovanna |
USA | St Louis | Welch R |
USA | Gainesville | Neyroud D |
USA | College Station | Latham C |
USA | Boca Raton | Khamoui Andy V |
USA | Little Rock | Porter Craig |
USA | Gainesville | Wohlgemuth Stephanie E |
USA | Orlando | Coen Paul M |
USA | Baton Rouge | Axelrod Christopher L |
USA | Torrance | Rossiter Harry B |
USA | Baton Rouge | Irving Brian A |
USA | Fort Collins | Chicco Adam J |
USA | Chicago | Dayanidhi Sudarshan |
USA | Fairbanks | O'Brien Kristin |
USA | Baltimore | Gonzalez-Freire Marta |
USA | College Station | White-Springer Sarah H |
United Kingdom | Oxford | Makrecka-Kuka Marina |
United Kingdom | Cambridge | Shiroma Jonathan G |
United Kingdom | Brighton | Moore Anthony L |
United Kingdom | Birmingham | Joanisse S |
United Kingdom | Cambridge | Murray Andrew James |
United Kingdom | London | Szabadkai Gyorgy |
United Kingdom | Manchester | Giakoumaki I |
United Kingdom | Birmingham | Thakker A |
United Kingdom | Birmingham | Garten Antje |
United Kingdom | Loughborough | Ebanks Brad |
United Kingdom | Nottingham | Chakrabarti Lisa |
United Kingdom | Birmingham | Ashcroft S |
United Kingdom | Leeds | Boyle JP |
United Kingdom | Plymouth, Devon | McKenna Helen T |
United States | Providence | Siamwala J |
WG2 Management
Tasks
- Call for participating labs to deliver relevant experimental data on already published studies and to report them in a standardized format.
- Collection and indexing of the data sets as required for statistical analysis.
- Discussion of procedures, protocols and general guidelines.
- Draft a comprehensive review on mt-function in muscle tissue (registration at PROSPERO, link with EQUATOR).
- Opening of the database to the research public for data search and moderated entry of new data sets.
Milestones
- Call for data report delivered.
- Data sets entered in standardized format.
- Summary, interpretation and discussion of data for review.
Deliverables
- A MITOEAGLE database on muscle tissue from humans and model organisms.
- A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue.
- Draft of review manuscript.
Projects in progress
- » MiPMap