Difference between revisions of "MitoEAGLE data: muscle"
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:::: The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types. | :::: The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types. | ||
== WG2 Participants == | |||
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== WG2 Management == | |||
=== Tasks === | === Tasks === | ||
Revision as of 14:52, 27 April 2016
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News and Events |  |
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Working Groups | Short-Term Scientific Missions | Management Committee | Members |  |
COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
MitoEAGLE data: muscle
WG2
- MITOEAGLE data repository in muscle and other tissues
WG2 Description
- During the past 10 years, a dramatically increasing number of studies report respirometric data on human muscle tissue (e.g. Christiansen 2015 Am J Physiol). Muscle mitochondrial function is particularly studied in genetically engineered mouse models of human diseases (e.g. Jelenik 2014 Diabetes). However, despite the many published data, lack of consistency often precludes quantitative comparison among data sets with permeabilized or homogenized muscle fibres or isolated mitochondria, normalized to either tissue wet weight, dry weight, protein content, citrate synthase activity or other mitochondrial markers. In the absence of validated conversion factors, these data remain largely unconnected and can only be qualitatively linked.
- The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.
WG2 Participants
| Country | City | Contact |
|---|---|---|
| Australia | Melbourne | Bishop David J |
| Austria | Innsbruck | Gnaiger Erich |
| Austria | Salzburg | Mayr JA |
| Austria | Innsbruck | Doerrier Carolina |
| Austria | Innsbruck | Laner Verena |
| Belgium | Liege | Votion Dominique-Marie |
| Belgium | Leuven | Bird Matthew |
| Brazil | São Paulo | Ferreira Julio Cesar B |
| Brazil | Jaboticabal, SP | Garcia Geovana S |
| Canada | Vancouver | Boushel Robert C |
| Canada | Rimouski | Blier Pierre U |
| Canada | Edmonton (Alberta) | Lemieux Helene |
| Canada | Antigonish | Kane Daniel A |
| Canada | Rimouski | Vandermeeren E |
| Croatia | Zagreb | Saric A |
| Croatia | Split | Mihanovic I |
| Czech Republic | Hradec Králové | Waldauf P |
| Czech Republic | Pilsen | Markova Michaela |
| Czech Republic | Prague 10 | Krajcova Adela |
| Czech Republic | Pilsen | Kuncova J |
| Czech Republic | Prague | Elkalaf Moustafa |
| Denmark | Copenhagen | Dela Flemming |
| Denmark | Copenhagen N | Mortensen OH |
| Denmark | Copenhagen | Larsen Steen |
| Denmark | Hvidovre | Nehlin Jan O |
| Denmark | Copenhagen | Gonzalez-Franquesa Alba |
| Denmark | Malov | Hey-Mogensen M |
| Estonia | Tallinn | Truu Laura |
| Estonia | Tallinn | Kaambre Tuuli |
| Estonia | Tallinn | Aid-Vanakova Jekaterina |
| Estonia | Tallinn | Karro N |
| Estonia | Tallinn | Tepp Kersti |
| Estonia | Tartu | Paju Kalju |
| Estonia | Tallinn | Vendelin Marko |
| Estonia | Tallinn | Puurand Marju |
| Finland | Jyvaeskylae | Lehti Maarit |
| Finland | Helsinki | Pirinen E |
| France | Bordeaux cedex | Mourier A |
| France | Grenoble Cedex 9 | Schlattner Uwe |
| France | Grenoble cedex 9 | Dubouchaud Herve |
| France | Montpellier Cedex 1 | Chabi Beatrice |
| France | Montpellier | Cortade F |
| France | Paris | Ventura-Clapier R |
| France | Paris | Armand Anne-Sophie |
| France | Paris | Petit Patrice X |
| Germany | Cologne | Pesta Dominik |
| Germany | Leipzig | Ost Mario |
| Germany | Rostock | Haider F |
| Germany | Nuthetal | Klaus S |
| Germany | Köln | Kimoloi Sammy |
| Germany | Munich | Jastroch M |
| Germany | Bochum | Platen P |
| Germany | Duesseldorf | Roden Michael |
| Germany | Düsseldorf | Granata Cesare |
| Germany | Bremerhaven | Mark Felix Christopher |
| Germany | Duesseldorf | Jelenik T |
| Greece | Heraklion | Tavernarakis Nektarios |
| Greece | Heraklio | Sidiropoulou K |
| Greece | Athens | Trougakos Ioannis P |
| India | Haryana | Sharma Vipin |
| Ireland | Dublin | O'Gorman Donal |
| Ireland | Dublin | Porter Richard K |
| Ireland | Sligo | Murphy J |
| Israel | Rishon Le Zion | Hachmo Yafit |
| Israel | Zrifin | Sova Marina |
| Israel | Jerusalem | Saada Reisch Ann |
| Italia | Udine | Salvadego Desy |
| Italy | Pisa | Gastaldelli Amalia |
| Italy | Bologna | Genova Maria Luisa |
| Italy | Novara | Reano Simone |
| Italy | Rome | Scatena Roberto |
| Italy | Milan | De Palma Clara |
| Italy | Milan | Giovarelli Matteo |
| Japan | Sapporo | Shirakawa R |
| Japan | Sapporo | Nambu H |
| Japan | Sapporo | Maekawa S |
| Latvia | Riga | Zvejniece Liga |
| Latvia | Riga | Inashkina I |
| Latvia | Riga | Liepins Edgars |
| Latvia | Riga | Kuka Janis |
| Luxembourg | Strassen | Devaux Yvan |
| Malta | Msida | Vella Joanna |
| Netherlands | Maastricht | Hoeks Joris |
| Netherlands | Maastricht | Grevendonk L |
| Netherlands | Wageningen | Keijer Jaap |
| Netherlands | Maastricht | Van Polanen N |
| Netherlands | Amsterdam | De Goede Paul |
| Netherlands | BT Amsterdam | Jaspers Richard T |
| Niederlande | ER Masstricht | De Theije C |
| Niederlande | ER Masstricht | De Wit-Verheggen V |
| Norway | Oslo | Rustan AC |
| Norway | Oslo | Eide L |
| Norway | Tromsoe | Schots Pauke C |
| Norway | Ullevål | Heiestad Christina |
| Norway | Bergen | Tronstad Karl Johan |
| Norway | Oslo | Lund Jenny |
| Norway | Tromsoe | Larsen Terje S |
| Norway | Oslo | Torp May-Kristin |
| Norway | Tromsoe | Aasum E |
| Norway | Tromsoe | Jansen Kirsten M |
| Norway | Oslo | Nikolic N |
| Poland | Lodz | Watala Cezary |
| Poland | Warsaw | Sek Aleksandra |
| Poland | Warsaw | Kampa Rafal Pawel |
| Poland | Lodz | Labieniec-Watala Magdalena |
| Poland | Warsaw | Dymkowska Dorota |
| Portugal | Cantanhede | Ferreira LL |
| Portugal | Coimbra | Martins Marques T |
| Portugal | Porto | Coxito Pedro |
| Portugal | Porto | Magalhaes Jose |
| Portugal | Coimbra | Palmeira Carlos |
| Portugal | Coimbra | Pereira Susana P |
| Portugal | Coimbra | Carvalho Eugenia |
| Portugal | Porto | Beleza Jorge |
| Portugal | Cantanhede | Martins Joao D |
| Romania | Timisoara | Lighezan R |
| Romania | Timisoara | Muntean Danina M |
| Singapore | Singapore | Hausenloy Derek J |
| Slovakia | Bratislava | Ukropcova B |
| Slovakia | Bratislava | Maderova D |
| Slovakia | Bratislava | Nemec Michal |
| Slovakia | Bratislava | Ukropec J |
| Slovakia | Bratislava | Sumbalova Zuzana |
| Slovenia | Ljubljana | Pirkmajer Sergej |
| Slovenia | Ljubljana | Dolinar K |
| Slovenia | Ljubljana | Mars T |
| South Africa | Smith James | |
| Spain | A Coruña | Blanco FJ |
| Spain | Barcelona | Guitart M |
| Spain | Granada | Lopez Garcia Luis Carlos |
| Spain | Sevilla | Bustos Matilde |
| Spain | Madrid | Cadenas S |
| Spain | Barcelona | De la Torre Lara J |
| Spain | Madrid | Moran M |
| Spain | Barcelona | Batlle M |
| Spain | Armilla (Granada) | Fernandez-Ortiz Marisol |
| Spain | Barcelona | Sebastian D |
| Spain | Barcelona | Zorzano Antonio |
| Spain | Barcelona | Catalan M |
| Spain | Armilla (Granada) | Acuna-Castroviejo Dario |
| Spain | Barcelona | Garcia-Roves Pablo Miguel |
| Spain | Armilla, Granada | Escames Germaine |
| Spain | Barcelona | Gama Perez Pau |
| Sweden | Stockholm | Cardinale Daniele A |
| Sweden | Linköping | Fontes-Oliveira CC |
| Switzerland | Lausanne | Weger M |
| Switzerland | Lausanne | Zalachoras I |
| Switzerland | Lausanne | Gebara E |
| Switzerland | Bern | Nuoffer Jean-Marc |
| Switzerland | Lausanne | Morato Fornaguera L |
| Switzerland | Lausanne | Sandi Carmen |
| The Netherlands | Wageningen | Van der Ende Miranda |
| The Netherlands | BT Amsterdam | Wuest Rob CI |
| Turkey | Ankara | Tuncay Erkan |
| USA | Fairbanks | O'Brien Kristin |
| USA | Gainesville | Wohlgemuth Stephanie E |
| USA | Gainesville | Neyroud D |
| USA | College Station | Latham C |
| USA | Baltimore | Gonzalez-Freire Marta |
| USA | College Station | White-Springer Sarah H |
| USA | Orlando | Coen Paul M |
| USA | Baton Rouge | Irving Brian A |
| USA | Torrance | Rossiter Harry B |
| USA | Fort Collins | Chicco Adam J |
| USA | Colorado Springs | Jacobs RA |
| USA | Norfolk | Lai Nicola |
| USA | Boca Raton | Khamoui Andy V |
| USA | Gainesville | Hepple Russell T |
| USA | Seattle | Marcinek DJ |
| USA | Baltimore | Fang Evandro F |
| USA | Ann Arbor | Beard Daniel A |
| USA | Orlando | Distefano Giovanna |
| USA | Baton Rouge | Axelrod Christopher L |
| USA | Little Rock | Porter Craig |
| USA | St Louis | Welch R |
| USA | Chicago | Dayanidhi Sudarshan |
| United Kingdom | Loughborough | Ebanks Brad |
| United Kingdom | Plymouth, Devon | McKenna Helen T |
| United Kingdom | Birmingham | Garten Antje |
| United Kingdom | London | Szabadkai Gyorgy |
| United Kingdom | Cambridge | Shiroma Jonathan G |
| United Kingdom | Brighton | Moore Anthony L |
| United Kingdom | Cambridge | Murray Andrew James |
| United Kingdom | Birmingham | Thakker A |
| United Kingdom | Leeds | Boyle JP |
| United Kingdom | Nottingham | Chakrabarti Lisa |
| United Kingdom | Birmingham | Ashcroft S |
| United Kingdom | Oxford | Makrecka-Kuka Marina |
| United Kingdom | Manchester | Giakoumaki I |
| United Kingdom | Birmingham | Joanisse S |
| United States | Providence | Siamwala J |
WG2 Management
Tasks
- Call for participating labs to deliver relevant experimental data on already published studies and to report them in a standardized format.
- Collection and indexing of the data sets as required for statistical analysis.
- Discussion of procedures, protocols and general guidelines.
- Draft a comprehensive review on mt-function in muscle tissue (registration at PROSPERO, link with EQUATOR).
- Opening of the database to the research public for data search and moderated entry of new data sets.
Milestones
- Call for data report delivered.
- Data sets entered in standardized format.
- Summary, interpretation and discussion of data for review.
Deliverables
- A MITOEAGLE database on muscle tissue from humans and model organisms.
- A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue.
- Draft of review manuscript.
Projects in progress
- » MiPMap
