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• O2k-Publications: Inhibitor
  ...:[[Category:Publications]] [[Instrument and method::Oxygraph-2k]] [[Topic::Inhibitor]] == O2k-Publications: Inhibitor - Abstracts ==
  1 KB (186 words) - 11:44, 11 November 2016
• Substrate-uncoupler-inhibitor titration
  |description=Mitochondrial '''Substrate-uncoupler-inhibitor titration''' ('''SUIT''') [[MitoPedia: SUIT |protocols]] are used with [[mi {{#ask:[[Additional label::Substrate-uncoupler-inhibitor titration]]
  3 KB (339 words) - 08:57, 27 May 2020
• Substrate-uncoupler-inhibitor-titration
  #REDIRECT [[Substrate-uncoupler-inhibitor titration]]
  53 bytes (3 words) - 22:41, 31 August 2015

Page text matches

• Phenylsuccinate
  |description='''Phenylsuccinate''' is a competitive inhibitor of succinate transport (20 mM). |type=Inhibitor
  227 bytes (24 words) - 15:56, 2 May 2014
• Bongkrekik acid
  |description='''Bongkrekik acid''' is a selective and potent inhibitor of the [[adenine nucleotide translocator]] (ANT). Bka binds to the matrix ( |type=Inhibitor PS
  366 bytes (47 words) - 20:51, 23 August 2015
• Hydroxycinnamate
  ...cription='''Hydroxycinnamate''' (alpha-cyano-4-hydroxycinnamic acid) is an inhibitor of the [[pyruvate carrier]] (0.65 mM). Above 10 mM [[pyruvate]], hydroxyci |type=Inhibitor ETS
  537 bytes (63 words) - 15:53, 2 May 2014
• N-ethylmaleimide
  |type=Inhibitor PS {{MitoPedia methods|type=Inhibitor PS
  409 bytes (52 words) - 12:58, 12 February 2021
• MitoPedia: Inhibitors
  »[[O2k-Publications: Inhibitor]] {{#ask:[[MitoPedia topic::Inhibitor]]
  210 bytes (21 words) - 16:18, 10 February 2015
• Hydroxylamine
  |description='''Hydroxylamine''' is an inhibitor of [[catalase]]. |mitopedia topic=Inhibitor
  2 KB (312 words) - 12:19, 21 April 2021
• Mersalyl
  ...iption='''Mersalyl''' (C₁₃H₁₇HgNO₆) is an inhibitor of the [[Pi symporter]]. |type=Inhibitor
  768 bytes (122 words) - 12:55, 12 February 2021
• Thenoyltrifluoroacetone
  |description='''Thenoyltrifluoroacetone''' TTFA is a noncompetitive inhibitor of CII binding on the quinone-binding (SDHC/SDHD). |mitopedia topic=Inhibitor
  332 bytes (37 words) - 23:25, 2 April 2023
• Amytal
  ...mobarbital; 5-Ethyl-5-isoamylbarbituric acid) is a barbiturate drug and an inhibitor of [[Complex I]]. |type=Inhibitor ETS
  920 bytes (127 words) - 11:53, 22 June 2021
• 2-mercaptoacetate
  ...of [[octanoylcarnitine]] oxidation. 2-mercaptoacetate has been used as an inhibitor of [[fatty acid oxidation]] ([[F-pathway control state]]). In permeabilized |mitopedia topic=Inhibitor
  723 bytes (84 words) - 17:08, 18 January 2022
• Substrate-uncoupler-inhibitor-titration
  #REDIRECT [[Substrate-uncoupler-inhibitor titration]]
  53 bytes (3 words) - 22:41, 31 August 2015
• Tartronic acid
  ...artronic acid (hydroxymalonic acid, C3H4O5; molecular weight 120.06) is an inhibitor of [[malic enzyme]]. |mitopedia topic=Inhibitor
  650 bytes (76 words) - 10:37, 11 September 2020
• Citreoviridin
  ...tor of the [[ATP synthase]] which, differently from the FO subunit binding inhibitor oligmycin, binds to the F1 subunit of the ATP synthase. |mitopedia topic=Inhibitor
  910 bytes (125 words) - 10:15, 11 September 2020
• Atractyloside
  |description='''Atractyloside''' is an inhibitor of the [[Adenine nucleotide translocator|adenine nucleotide translocator (A |type=Inhibitor PS
  1 KB (199 words) - 12:47, 12 February 2021
• O2k-Publications: Inhibitor
  ...:[[Category:Publications]] [[Instrument and method::Oxygraph-2k]] [[Topic::Inhibitor]] == O2k-Publications: Inhibitor - Abstracts ==
  1 KB (186 words) - 11:44, 11 November 2016
• Oxalomalic acid
  |description='''Oxalomalic acid''' is an inhibitor of aconitase (and of cytoplasmic NADP-dependent isocitrate dehydrogenase). |mitopedia topic=Inhibitor
  680 bytes (89 words) - 11:18, 2 June 2016
• Dinitrochlorobenzene
  ...lorobenzene (1-chloro-2,4-dinitrobenzene)''' (DNCB) is a glutathione (GSH) inhibitor. ...cavenging H₂O₂. Additionally, [[auranofin]] (AF), an inhibitor of thioredoxin reductase (TrxR) can be used to quantified the contribution
  2 KB (217 words) - 10:20, 11 September 2020
• Kuznetsov 1997 Biochim Biophys Acta
  ...V, Winkler K, Kirches E, Lins H, Feistner H, Kunz WS (1997) Application of inhibitor titrations for the detection of oxidative phosphorylation defects in saponi ...of flux control was observed. We conclude, therefore, that application of inhibitor titrations and the quantitative description of the titration curve can be a
  2 KB (327 words) - 17:24, 16 January 2021
• Krishnathas 2017 Med Chem Comm
  ...henyl)ethyl]quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I. Med Chem Comm 8:657-61. ...r results challenge the postulated primary mode-of-action of EVP4593 as an inhibitor of NF-κB pathway activation and/or store-operated calcium influx.
  2 KB (232 words) - 13:49, 4 June 2018
• Metabolic control variable
  ...kground to reference steady state (Y to Z). Alternatively, ''X'' may be an inhibitor of flux, absent in the reference state but present in the background state |mitopedia topic=Inhibitor, Substrate and metabolite, Uncoupler
  858 bytes (123 words) - 18:19, 10 November 2020
• Cyanide
  |description='''Cyanide''' (usually added as KCN) is a competitive inhibitor of [[Complex_IV| cytochcrome ''c'' oxidase (CIV)]]. Inhibition is reversed {{MitoPedia O2k and high-resolution respirometry|type=Inhibitor ETS
  3 KB (360 words) - 09:51, 10 June 2021
• Sun 2012 Front Mol Neurosci
  ...ylketone completely inhibited caspase activation, while treatment with the inhibitor of calpains- and papain-like cathepsins (2S,3S)-trans-epoxysuccinyl-leucyla
  2 KB (278 words) - 13:52, 29 July 2016
• Azide
  |description='''Sodium azide''' is an inhibitor of [[Complex IV]]/cytochrome ''c'' oxidase (CIV, COX, CcO). |type=Inhibitor ETS
  2 KB (337 words) - 17:28, 16 December 2021
• Belosludtsev 2018 Biochemistry (Mosc)
  ...s of dequalinium (≤10 μM), this swelling is inhibited by cyclosporin A, an inhibitor of the mitochondrial permeability transition pore. At the same time, at hig |topics=Inhibitor, Ion;substrate transport
  2 KB (282 words) - 09:04, 5 October 2018
• Hildyard 2003 Biochem J
  ...ily (MCF). Only mitochondria from the YIL006w deletion mutant exhibited no inhibitor-sensitive pyruvate transport, but otherwise behaved normally. YIL006w encod
  1 KB (138 words) - 17:17, 16 January 2021
• Degli Esposti 1998 Biochim Biophys Acta
  ...compounds and their potency is related to that of rotenone, the classical inhibitor of complex I. Among commercial products, particular attention is dedicated |keywords=NADH–ubiquinone reductase; Respiratory inhibitor; Ubiquinone
  1 KB (158 words) - 13:55, 12 March 2021
• Auranofin
  ...itochondria: Trx system. Additionally, [[dinitrochlorobenzene]] (DNCB), an inhibitor of glutathione (GSH) can be used to obtain the GSH contribution scavenging ...H, Kim GY, Moon SK, Cheong J, Kim WJ, Yoo YH, Choi YH (2017) Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep
  2 KB (282 words) - 10:11, 11 September 2020
• Strobilurin
  |mitopedia topic=Inhibitor
  498 bytes (64 words) - 02:46, 23 January 2023
• Mathiyazakan 2023 Antimicrob Agents Chemother
  ...cobacterium tuberculosis'' cytochrome ''bcc:aa''3 supercomplex and a novel inhibitor targeting subunit cytochrome ''c''I. Antimicrob Agents Chemother 67:e015312 ...ion via the cIcII head. The successful identification of a new cyt-bcc:aa3 inhibitor demonstrates the potential of a structure-mechanism-based approach for nove
  2 KB (335 words) - 18:10, 17 September 2023
• Becker 1999 Am J Physiol
  ...dase inhibitor diphenyleneiodonium (0.9 +/- 0.1). By contrast, the site IV inhibitor cyanide, as well as inhibitors of xanthine oxidase (allopurinol), nitric ox
  2 KB (242 words) - 17:49, 13 April 2022
• Stoner 1984 J Bioenerg Biomembr
  ...ill make the other more rate limiting and thus will decrease the amount of inhibitor of the other required for half-maximal inhibition. These two types of "coup
  3 KB (369 words) - 22:45, 16 February 2021
• Grefte 2015 Biochim Biophys Acta
  ...bited by Rot (10-100 nM), but not by piericidin A (PA; 100 nM), another CI inhibitor. At 100 nM, both Rot and PA fully blocked myoblast oxygen consumption. Knoc |topics=Inhibitor
  2 KB (244 words) - 10:43, 9 November 2016
• Razak 2018 RUMeS
  ...s measured using OROBOROS HRR Oxygraph-2k according to substrate-uncoupler-inhibitor titration (SUIT) protocol. ...d following the addition of complex I inhibitor (rotenone) and complex III inhibitor (antimycin A).
  2 KB (322 words) - 11:47, 8 April 2019
• Briston 2016 Sci Rep
  ...owney B (2016) Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in ...dependent of CypD inhibition. Here we identified a novel, CypD-independent inhibitor of the mPTP. The screening approach and compound described provides a workf
  2 KB (331 words) - 14:25, 21 September 2021
• Kunz 1993 FEBS Lett
  ...or EGTA, the inhibitor of Ca²⁺ transport Ruthenium red and the inhibitor of the myosin ATPase vanadate. The caffeine concentration dependency of res
  1 KB (185 words) - 11:00, 27 March 2018
• Qvit 2022 Pharmaceuticals (Basel)
  ...A, Ostberg NP, Campos JC, Ferreira JCB, Mochly-Rosen D (2022) A selective inhibitor of cardiac troponin I phosphorylation by delta protein kinase C (δPKC) as ...ylation of cTnI is critical in IR injury, and that a cTnI/δPKC interaction inhibitor should be considered as a therapeutic target to reduce cardiac injury after
  2 KB (280 words) - 18:55, 6 December 2022
• Kopitar-Jerala 2017 Abstract MITOEAGLE Barcelona
  ...nes in macrophages. It was reported that metformin, mitochondria complex I inhibitor, decreased production of the pro-form of the inflammatory cytokine IL-1β a Stefin B (cystatin B) is an endogenous cysteine cathepsin inhibitor, and the loss-of-function mutations in the stefin B gene were reported in p
  2 KB (289 words) - 08:17, 21 February 2020
• Gottfried 2013 PLoS One
  ..., diclofenac holds potential as a clinically applicable MYC and glycolysis inhibitor supporting established tumor therapies.
  3 KB (382 words) - 08:54, 21 February 2020
• Vanden Hoek 1998 J Biol Chem
  ...y myxothiazol, but not by diphenyleneiodonium or the nitric-oxide synthase inhibitor L-nitroarginine. We conclude that hypoxia increases mitochondrial superoxid
  2 KB (263 words) - 20:58, 11 April 2022
• Etomoxir
  ...(Eto; 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate) is an irreversible inhibitor of [[carnitine palmitoyltransferase I]] (CPT-I) on the outer face of the mi |mitopedia topic=Inhibitor
  1 KB (184 words) - 06:35, 20 April 2023
• Palmeira 2019 MiP2019
  ...tion of ischemia/reperfusion injury: effects of a soluble adenylyl cyclase inhibitor LRE1. ...a setting of rodent model of hepatic IR. Therefore, we tested LRE1 (a sAC inhibitor) administration before I/R.
  2 KB (344 words) - 16:01, 7 October 2019
• Lambertucci 2008 J Cell Physiol
  ...tion induced by PA was observed by treatment with diphenylene iodonium, an inhibitor of NADPH oxidase. The participation of this enzyme complex was confirmed th
  2 KB (278 words) - 23:16, 5 July 2021
• 3-Mercaptopropionic acid
  |mitopedia topic=Inhibitor
  521 bytes (61 words) - 08:41, 17 March 2023
• Triethyltin bromide
  |description=Triethyltin bromide (TET) is a lipophilic [1] inhibitor of the mitochondrial [[ATP synthase]] [2] which is used to induce [[LEAK st |mitopedia topic=Inhibitor
  1 KB (195 words) - 10:37, 11 September 2020
• Teplova 2017 Toxicol Lett
  ...its capability of acting as both a protonophore and an unusual complex II inhibitor, which interferes with the mitochondrial respiration by blocking the electr |keywords=Complex II inhibitor, Mitochondria, Q(d)-binding site, Superoxide anion, Triclosan, Uncoupler
  2 KB (297 words) - 08:48, 27 June 2019
• Torres-Quesada 2022 Cancers (Basel)
  ...nveiled mitochondrial dysfunction upon exposure to the FDA-approved kinase inhibitor sunitinib. This seemingly context-dependent side effect of this drug highli ...cells, cell bioenergetics, cell culture media, cell proliferation, kinase inhibitor, mitochondrial function
  2 KB (314 words) - 15:16, 9 December 2022
• Kraft 2004 Thesis Universität Halle-Wittenberg - Germany
  ...cooling was without interruption. The newly established multiple substrate-inhibitor titration provides the possibility to measure complex I dependent functiona ...r technique, respirometry, mitochondria, mitochondrial function, substrate-inhibitor-titration, mitochondrial encephalomyopathy, shipment of samples
  2 KB (197 words) - 17:56, 7 November 2016
• Antal 2013 Planta
  ...of mitochondrial respiration, FCCP, a protonophore, nor propyl gallate, an inhibitor of the plastid terminal oxidase, induced such a strong effect like antimyci
  1 KB (216 words) - 15:00, 8 August 2023
• Hsu 2004 Biochemistry
  ...act=Human mitochondrial malic enzyme is a regulatory enzyme with ATP as an inhibitor. Structural studies reveal that the enzyme has two ATP-binding sites, one a |topics=ATP, Inhibitor
  1 KB (220 words) - 15:40, 1 August 2014
• Galina 2014 Int J Biochem Cell Biol
  |keywords=3-Bromopyruvate, Glycolytic inhibitor, Mitochondrial respiration inhibitor, Alkylation,Tumor cell metabolism
  2 KB (210 words) - 14:06, 12 June 2022
• Larsen 2011 Acta Physiol (Oxf)
  ..., ADP and glutamate (GMO(3) ), + succinate (GMOS(3) ), + uncoupler (U) and inhibitor (rotenone) of complex I respiration. Citrate synthase (CS) activity was mea |keywords=AMPKα2 kinase-dead (KD) mice; substrate-uncoupler-inhibitor-titration (SUIT) protocol
  2 KB (338 words) - 15:43, 5 March 2019
• Takada 2016 Cardiovasc Res
  ...ma S, Yokota T, Tanaka S, Okita K, Tsutsui H (2016) Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart ...igated the effects of the administration of a dipeptidyl peptidase (DPP)-4 inhibitor on the exercise capacity and skeletal muscle abnormalities in an HF mouse m
  3 KB (439 words) - 17:28, 8 March 2021
• Cumero 2012 Br J Pharmacol
  ...d soluble F₁-ATPase. Activity assays and immunodetection of the inhibitor protein IF₁ were used and combined with molecular docking analys ''Key Results'': T1AM is a non-competitive inhibitor of F₀F₁-ATPsynthase whose binding is mutually exclusi
  3 KB (456 words) - 09:10, 27 January 2020
• Pasdois 2007 Am J Physiol Heart Circ Physiol
  ...r), ODQ (a GC inhibitor), PP2 (a src kinase inhibitor), and KT-5823 (a PKG inhibitor) abolished preconditioning by BK and blocked the inotropic response to ouab |topics=Cyt c, Inhibitor, Ion;substrate transport
  3 KB (436 words) - 12:42, 16 February 2018
• Hollis 2003 Biochim Biophys Acta
  ...O(2)(-) generation in control cells, or those treated with the NO synthase inhibitor, when incubated at 21% O(2). However, after 30-min exposure of control cell |topics=Cyt c, Flux control, Inhibitor, Oxygen kinetics, Redox state
  2 KB (314 words) - 14:45, 1 December 2015
• Lu 2018 ACS Infect Dis
  ...Wang Z, Rhee KY, Ding K, Zhang T, Cook GM (2018) A pyrazolo[1,5-a]pyridine inhibitor of the respiratory cytochrome bcc complex for the treatment of drug-resista ...infection. Here, we characterize a putative respiratory complex III (QcrB) inhibitor, TB47: a pyrazolo[1,5-a]pyridine-3-carboxamide. TB47 is active (MIC between
  3 KB (360 words) - 11:03, 11 August 2021
• Ahn 2010 Biochim Biophys Acta
  ...ediated pAkt while increased pAMPK regardless of insulin. Reciprocally, an inhibitor of Akt, triciribine (TCN), decreased cellular ATP contents. Overexpression
  2 KB (293 words) - 17:25, 25 February 2020
• Aroor 2015 Diabetes
  ...) and diacylglycerol (DAG) content was significantly attenuated with DPP-4 inhibitor treatment. In addition, MK0626 significantly reduced mitochondrial incomple ...rds=Lipidomics, NAFLD, Obesity, Hepatic insulin resistance, MK-0626 (DPP-4 inhibitor)
  3 KB (364 words) - 16:16, 19 March 2019
• Laboratory titration sheet
  ...et''' contains the sequential titrations in a specific Substrate-uncoupler-inhibitor titration (SUIT) protocol. The laboratory titration sheets for different SU
  522 bytes (60 words) - 11:54, 25 March 2022
• Bastian 2016 Cancer Lett
  ...GA, Doshi A, Zaware N, Gangjee A, Ihnat MA (2016) AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization. Cancer Lett pii: S0 ...nd animals with AG311 and dichloroacetate, a pyruvate dehydrogenase kinase inhibitor that increases oxidative metabolism, resulted in synergistic cell kill and
  2 KB (310 words) - 09:30, 23 December 2016
• Nambu 2019 Eur J Pharmacol
  ...were divided into 2 groups, i.e., with or without treatment with the SGLT2 inhibitor empagliflozin (Empa, 300 mg/kg of food). Consistent with previous studies, ..., Ketone body, Mitochondria, Muscle strength, Myocardial infarction, SGLT2 inhibitor
  3 KB (402 words) - 11:35, 3 March 2020
• Ap5A
  |description='''P1,P5-Di(adenosine-5')pentaphosphate (Ap5A)''' is an inhibitor of [[adenylate kinase]] (ADK), the enzyme which rephosphorylates AMP to ADP |mitopedia topic=Inhibitor
  2 KB (227 words) - 10:25, 21 June 2021
• Hiltunen 1981 Biochim Biophys Acta
  ...hydroxymalonate (an inhibitor of malic enzymes) and mercaptopicolinate (an inhibitor of phosphoenolpyruvate carboxykinase) as tools. Hydroxymalonate inhibited t
  2 KB (209 words) - 17:26, 7 November 2016
• Vamecq 1987 Biochem J
  ...xidase]] was inhibited by micromolar concentrations of [[antimycin A]], an inhibitor of mitochondrial respiration. The inhibition was observed with all three su |topics=Inhibitor
  2 KB (233 words) - 19:05, 16 January 2021
• Jaber 2020 BM Exp Neurol
  ...nd cytochrome c release induced by the anti-apoptotic BCL-2 family protein inhibitor ABT-737.
  2 KB (326 words) - 03:19, 24 August 2021
• Bentebibel 2006 Biochemistry
  ...were within the same range as those observed for etomoxiryl-CoA, a potent inhibitor of CPT I. When a pancreatic INS(823/13), muscle L6E9, or kidney HEK293 cell
  2 KB (349 words) - 10:18, 6 July 2021
• Ganguly 2022 MitoFit
  ...uly U, Bir A, Chakrabarti S (2022) Cytotoxicity of mitochondrial Complex I inhibitor rotenone: a complex interplay of cell death pathways. https://doi.org/10.26 ...ages/6/64/Ganguly_2022_MitoFit.pdf Cytotoxicity of mitochondrial Complex I inhibitor rotenone: a complex interplay of cell death pathways]<br/>
  4 KB (503 words) - 07:47, 8 January 2023
• Malonyl-CoA synthase
  ...ACSF3) with enzymatic activity in the presence of [[malonate]] (Complex II inhibitor) and methylmalonate.
  593 bytes (71 words) - 17:50, 11 November 2016
• Glutamate-aspartate carrier
  ...oneutal and may be impaired by [[uncoupling]]. [[Aminooxyacetate]] is an [[inhibitor]] of the glutamate-aspartate carrier.
  623 bytes (82 words) - 14:54, 25 July 2016
• Tesori 2015 Sci Rep
  ...nk JN, Maulucci G, Puglisi MA, Pani G, Gasbarrini A (2015) The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for c ...oxicity was dramatically increased by glucose withdrawal or the glycolytic inhibitor 2-DG. Under metabolic stress, activation of the AMP dependent Protein Kinas
  2 KB (326 words) - 16:16, 13 November 2017
• Loomis 1948 J Biol Chem
  |topics=Coupling efficiency;uncoupling, Inhibitor
  645 bytes (76 words) - 17:44, 16 January 2021
• Declercq 1987 J Biol Chem
  ...atory subunit). The hepatic monomer is larger than the muscle enzyme. Each inhibitor interacts via its thioester group at the palmitoyl-CoA binding site of the
  3 KB (384 words) - 10:30, 6 July 2021
• Shim 2022 Cancer Cell Int
  ...JH, Yook JI, Kang SG. (2022) Etomoxir, a carnitine palmitoyltransferase 1 inhibitor, combined with temozolomide reduces stemness and invasiveness in patient-de ...being realized. Etomoxir (ETO), a carnitine palmitoyltransferase 1 (CPT1) inhibitor exerts cytotoxic effects in GBM, which involve interrupting the FAO pathway
  2 KB (357 words) - 10:58, 18 January 2023
• Oxaloacetate
  ...the inner [[mitochondrial|mt]]-membrane of various tissues. Oa is a potent inhibitor of [[succinate dehydrogenase]].
  725 bytes (96 words) - 19:31, 1 January 2021
• Piel 2015 Abstract MiPschool London 2015
  |title=The novel Cyclophilin D inhibitor NVP019 reduces mitochondrial permeability transition in isolated rat and hu ...as to assess the potential of NVP019, a novel, non-immunosuppressive Cyp-D inhibitor with minimal off-target effects [3], to inhibit mitochondrial permeability
  3 KB (423 words) - 09:10, 16 June 2015
• Shao 2019 Cardiovasc Diabetol
  ...hao Y, Li G, Liu T (2019) Empagliflozin, a sodium glucose co-transporter-2 inhibitor, alleviates atrial remodeling and improves mitochondrial function in high-f ...patients are less well-explored. We tested the hypothesis that the SGLT-2 inhibitor, empagliflozin, can prevent atrial remodeling in a diabetic rat model.
  2 KB (340 words) - 14:19, 5 December 2019
• Respiratory state
  ::::* Mitochondrial preparations: specific substrate-inhibitor combinations for selectively stimulating electron entry through Complex I ( ::::* Kinetic inhibitor control: Kinetic studies with variation of a specific inhibitor yield apparent kinetic constants, such as the ''K''_I'.
  3 KB (400 words) - 15:50, 15 August 2021
• Zeng 2019 Toxicol Appl Pharmacol
  ...ective effects of ICA on ROT-treated cells was markedly abolished by SIRT3 inhibitor 3-TYP. Our findings demonstrate that ICA exerts a neuroprotective role thro |topics=Inhibitor
  3 KB (360 words) - 15:22, 15 October 2019
• Ganguly 2022 BEC
  ...uly U, Bir A, Chakrabarti S (2022) Cytotoxicity of mitochondrial Complex I inhibitor rotenone: a complex interplay of cell death pathways. Bioenerg Commun 2022. ...iseases including Parkinson’s disease. Because the mitochondrial Complex I inhibitor rotenone is widely used to develop experimental models of Parkinson’s dis
  3 KB (418 words) - 07:00, 8 January 2023
• Worth 2014 J Biol Chem
  |abstract=Rotenone is a naturally occurring mitochondrial complex I inhibitor with a known association with parkinsonian phenotypes in both human populat |topics=Inhibitor
  2 KB (254 words) - 05:33, 22 March 2023
• Substrate-uncoupler-inhibitor titration
  |description=Mitochondrial '''Substrate-uncoupler-inhibitor titration''' ('''SUIT''') [[MitoPedia: SUIT |protocols]] are used with [[mi {{#ask:[[Additional label::Substrate-uncoupler-inhibitor titration]]
  3 KB (339 words) - 08:57, 27 May 2020
• TPP+ inhibitory effect
  |mitopedia topic=Inhibitor
  773 bytes (102 words) - 00:03, 18 February 2020
• Taroni 1987 Biochim Biophys Acta
  ...ce of succinate the Km value for malate was 1.9 mM. ATP was found to be an inhibitor competitive with malate, with a Ki (ATP) of 0.2 mM. This is the first repor
  2 KB (272 words) - 15:10, 27 May 2020
• Myxothiazol
  |description='''Myxothiazol''' Myx is an inhibitor of [[Complex III]] (CIII). CIII also inhibits [[Complex I|CI]]. Myxothiazol ..., Xia D, Yu C-A, Xia J-Z, Kachurin AM, Zhang L, Yu L, Deisenhofer J (1998) Inhibitor binding changes domain mobility in the iron–sulfur protein of the mitocho
  3 KB (443 words) - 18:23, 9 April 2022
• Gellerich 2009 PLoS One
  .../sub>= 360 nM Ca²⁺). This regulation was not affected by RR, an inhibitor of the mitochondrial Ca²⁺ uniporter. Active respiration is regul |topics=Calcium, Inhibitor
  2 KB (270 words) - 09:28, 7 May 2020
• Danylovych 2016 Ukr Biochem J
  ...se in FAD fluorescence in comparison to control. NaN3 (5 mM), a complex IV inhibitor, and CCCP (10 μM), a protonophore, caused decrease in NADH and FAD fluores
  2 KB (300 words) - 13:18, 14 February 2022
• Bociaga-Jasik 2013 Pharmacol Rep
  ...i A, Mach T, Dembińska-Kieć A (2013) Metabolic effects of the HIV protease inhibitor – saquinavir in differentiating human preadipocytes. Pharmacol Rep 65:93 Methods: The aim of the study was to characterize effects of the protease inhibitor (PI) - saquinavir (SQV) on metabolic functions, and gene expression during
  2 KB (262 words) - 21:08, 18 March 2018
• Siebels 2013 Biochim Biophys Acta
  |title=Siebels I, Dröse S (2013) Q-site inhibitor induced ROS production of mitochondrial complex II is attenuated by TCA cyc ...ccupied flavin site. Importantly, the ROS production induced by the Q-site inhibitor atpenin A5 was largely unaffected by the redox state of the Q pool and the
  2 KB (278 words) - 10:39, 27 March 2018
• Moreno-Sanchez 2013 FEBS J
  ...dicating that CII, not CIII, is the ROS-producing site. The complex I (CI) inhibitor rotenone partially reduces the ROS production driven by high succinate leve
  3 KB (404 words) - 14:40, 26 March 2018
• Zeng 2017 J Biol Chem
  ...oxygen species (ROS) metabolism remains unclear. In this study a specific inhibitor for the rate-limiting enzyme involved in peroxisomal FAO, [[acyl-CoA oxidas |topics=Inhibitor
  2 KB (251 words) - 15:38, 28 March 2018
• Bukowska 2019 Eur J Pharmacol
  ...neration, which was effectively prevented by edoxaban, vorapaxar and GB83 (inhibitor of protease-activated receptor 2). Of note, exposure to FXa did not initiat
  3 KB (376 words) - 11:19, 3 March 2020
• Antimycin A
  ...e transfer of electrons from heme ''b''_H to oxidized Q (Qi site inhibitor). High concentrations of antimycin A also inhibit acyl-CoA oxidase and D-am * [[Myxothiazol]] - this CIII inhibitor induces less ROS production but is more expensive than Ama.
  3 KB (462 words) - 13:23, 15 March 2022
• Covi 2007 Physiol Biochem Zool
  ...energy-producing pathways in the developing embryo. However, the V-ATPase inhibitor exhibits a concentration-dependent inhibition of oxygen consumption in aero
  2 KB (283 words) - 09:35, 9 November 2016
• Kuhnt 2007 Neurochem Res
  ...l muscles. For that purpose skinned fiber technique and multiple substrate inhibitor titration were adapted to tumor samples. In our animal tumor model (R1H) fu ...Skinned fiber technique, High-resolution respirometry, Multiple substrate inhibitor titration, Rat rhabdomyosarcoma R1H
  2 KB (259 words) - 10:57, 27 March 2018
• MiPNet09.12 O2k-Titrations
  |topics=ADP, Inhibitor, Substrate, Uncoupler, Amino acid
  974 bytes (128 words) - 22:23, 9 April 2022
• Quiles 2006 Plant Cell Environ
  ...lectron donation by NADPH and ferredoxin to plastoquinone. Antimycin A (an inhibitor of cyclic electron flow) increased the NADH DH activity and preserved the
  2 KB (321 words) - 09:38, 11 September 2021
• Morota 2009 Exp Neurol
  ...ate from direct mPT inhibition. We conclude that a clinically relevant mPT inhibitor should have a mitochondrial target and increase mitochondrial calcium reten
  3 KB (371 words) - 17:34, 25 February 2020
• Ali 2019 MiP2019
  ...s with glycolytic inhibitors. Indeed, iodoacetate (IA), an effective GAPDH inhibitor, caused about 70% drop in MDA-MB-231 cell viability at 20 μM while 40 μM |topics=Inhibitor
  2 KB (285 words) - 15:29, 19 August 2019
• Kopitar-Jerala 2015 Front Cell Neurosci
  ...l loss in the brain of the stefin B-deficient mice, implying a role of the inhibitor at the cross-talk between microglia and cerebellar cells. Detailed analysis
  2 KB (286 words) - 13:40, 27 July 2016
• Dawson 1993 Am J Physiol
  ...greater after azide than after myxothiazol or cyanide. Desferrioxamine, an inhibitor of iron-catalyzed hydroxyl radical formation, delayed cell killing after ea
  2 KB (288 words) - 16:31, 3 February 2022
• Takahashi 2017 Exp Gerontol
  ...OCR in the isolated mitochondria was not inhibited by Mdivi-1, a selective inhibitor of DRP1. Thus, we propose a novel function of OPA1 in regulating the CIV ac
  2 KB (304 words) - 17:37, 25 February 2020
• Krumschnabel 1999 Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
  ...rophenol. Similarly, oxygen consumption sensitive to the protein synthesis inhibitor cycloheximide was transiently increased by A23187, but returned to control
  2 KB (288 words) - 12:05, 23 January 2019
• Scaduto 1994 Eur J Biochem
  ...in both heart and liver mitochondria. In liver, 2-oxoglutarate is a potent inhibitor of oxalacetate transamination to aspartate and activation of this enzyme by |topics=Calcium, Inhibitor, Redox state, Substrate
  2 KB (319 words) - 07:52, 17 December 2018
• Sodium orthovanadate
  ...='''Sodium vanadate (Na₃VO₄)''' is used as an ATPase inhibitor. |mitopedia topic=Inhibitor
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• Rudnicki 2014 United States Patent Application Publication
  ...enting and treating obesity, as well as related diseases, using a microRNA inhibitor.
  814 bytes (104 words) - 15:52, 13 November 2017
• Xue 1996 Plant Physiol
  ...presence of this compound (Trebst, 1980). Glycolaldehyde is a Calvin cycle inhibitor that prevents the regeneration of ribulose-1,5-bisphosphate from triose pho ...iratory pathway to LEDR was examined by the use of the alternative oxidase inhibitor propyl gallate (Weger and Dasgupta, 1993). Addition of propyl gallate, adde
  3 KB (460 words) - 10:47, 3 August 2022
• Ferreira 2019 Nat Commun
  ...isatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D (2019) A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. ...and dysfunctional mitochondria in heart failure. βIIPKC siRNA or a βIIPKC inhibitor mitigates mitochondrial fragmentation and cell death. We confirm that Mfn1-
  2 KB (273 words) - 12:58, 18 March 2019
• O'Connor 2018 Sci Rep
  ...B, Trefely S, Nunez-Cruz S, Blair IA, June CH, Milone MC (2018) The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. |abstract=Etomoxir (ETO) is a widely used small-molecule inhibitor of fatty acid oxidation (FAO) through its irreversible inhibitory effects o
  2 KB (282 words) - 10:09, 6 July 2021
• Kiorpes 2021 J Biol Chem
  ...oxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat liver mitochondria. J B ...M (R)-TDGA-CoA). TDGA-CoA was identified as a complexing type irreversible inhibitor (Ki approximately 0.27 microM) by the double reciprocal relationship betwee
  2 KB (269 words) - 22:54, 5 July 2021
• Hyunhee 2015 Abstract MiPschool Greenville 2015
  ...ondrial permeability transition pore inhibitor) and Ca-074 Me (cathepsin B inhibitor) did not. TMRE and mitoSOX experiments revealed that 18 h of CIT and reperf
  3 KB (472 words) - 15:34, 20 July 2015
• Konjar 2010 Immunology
  ...ells and primary antigen-restricted mouse CTLs with the cathepsin L (CatL) inhibitor L1 resulted in a marked inhibition of perforin-dependent target cell death
  2 KB (290 words) - 14:30, 29 July 2016
• Rosenfeld 2010 Abstract IOC60
  ...en bacterium ''Pseudomonas aeruginosa'' is known to produce the Complex IV inhibitor HCN and a blue phenazine pigment, pyocyanin (PCN), which harbors many poten |topics=Aerobic glycolysis, Inhibitor, Oxygen kinetics, Redox state
  2 KB (291 words) - 16:37, 26 March 2018
• Wiedemann 1998 J Neurol Sci
  ...oxidoreductase amytal revealed a higher sensitivity of respiration to this inhibitor indicating an elevated flux control coefficient of this enzyme. (iii) Apply
  2 KB (297 words) - 18:07, 16 January 2021
• Mohazzab 1995 Am J Physiol
  ...g NAD(P)H oxidoreductases, diphenyliodonium (DPI), could be employed as an inhibitor of O2-. production by NADH oxidoreductase, which functions as a selective p
  2 KB (277 words) - 15:32, 11 February 2022
• Chakrabarti 2022 Abstract Bioblast
  ...<u>Chakrabarti Sasanka</u> (2022) Cytotoxicity of mitochondrial Complex I inhibitor rotenone: a complex interplay of cell death pathways. Bioblast 2022: BEC In ...early established. We show here that the classical mitochondrial Complex I inhibitor rotenone (0.5 µM) causes death of SH-SY5Y cells (a human neuroblastoma cel
  3 KB (441 words) - 16:23, 20 June 2022
• Gammon 2019 Cells
  ...ca-Worms D (2019) Mechanism-specific pharmacodynamics of a novel Complex-I inhibitor quantified by imaging reversal of consumptive hypoxia with [18F]FAZA PET '' ...itable vulnerability. In this regard, IACS-010759 is a novel high affinity inhibitor of OxPhos targeting mitochondrial complex-I that has recently completed a P
  3 KB (420 words) - 13:09, 14 October 2023
• Maher 2014 J Biol Chem
  ...enhanced IL-1β processing. Pretreatment of macrophages with the cathepsin inhibitor E-64d did not affect secretion of IL-1β, suggesting that the increased cat
  2 KB (292 words) - 15:32, 27 July 2016
• Wang 2010 J Biol Chem
  ...st step of FAO), but was only partially inhibited by rotenone (a complex I inhibitor). Although palmitoyl-CoA and octanoyl-CoA provided reducing equivalents to |topics=Cyt c, Inhibitor
  4 KB (564 words) - 21:45, 10 September 2023
• Niu 2018 Cancer Metab
  ...vity in purified mitochondria. GSK-2837808A, in contrast, is a competitive inhibitor of NAD, which cannot cross the inner mitochondrial membrane. GSK-2837808A d |topics=Inhibitor
  2 KB (329 words) - 11:22, 29 July 2019
• Traufeller 2004 Biochim Biophys Acta
  ...d fibers was inhibited by high concentrations of L-AC, indicating that the inhibitor can be transported via the acyl-carnitine transporter, too. The combined us
  2 KB (350 words) - 10:53, 23 January 2019
• Domenis 2012 Int J Mol Sci
  ...ulated mitochondria adaptation in tumor cells: a focus on ATP synthase and inhibitor factor 1. Int J Mol Sci 13:1933-50. ...tion and a rise in the expression levels of the ATP synthase β subunit and Inhibitor Factor 1 (IF1). Hyperglycemia, on the other hand, led to a markedly decreas
  2 KB (318 words) - 10:14, 13 March 2015
• Dikova 2020 Free Radic Biol Med
  ...e. According to our experiments with the glucose-6-phosphate dehydrogenase inhibitor 6-Aminonicotinamide, this was attributable to the pentose phosphate pathway
  2 KB (337 words) - 10:09, 31 May 2023
• Wei 2019 Biochem Biophys Res Commun
  ...itochondrial biogenesis. The inhibition of CREB activation by its specific inhibitor H89 obscures the induction of PGC-1α, NRF1, and TFAM by aminophylline, and
  2 KB (319 words) - 14:58, 12 January 2022
• Delport 2017 Metab Brain Dis
  ...target for antidepressant action. MB is also recognized as a non-selective inhibitor of nitric oxide synthase (NOS) and guanylate cyclase. Dysfunction of the ni
  2 KB (335 words) - 23:18, 23 April 2023
• Lagoutte 2010 Biochim Biophys Acta
  |abstract=Sulfide (H₂S) is an inhibitor of mitochondrial cytochrome oxidase comparable to cyanide. In this study, p |topics=Inhibitor
  2 KB (343 words) - 13:30, 13 November 2017
• Hawley 2016 Diabetes
  ...EA, Salt IP, Steinberg GR, Hardie DG (2016) The Na+/glucose cotransporter inhibitor canagliflozin activates AMPK by inhibiting mitochondrial function and incre |topics=Inhibitor
  2 KB (311 words) - 15:52, 9 November 2016
• Hegazy 2022 Biomedicines
  ...the nanomolar range that were up to 7-fold more potent than the canonical inhibitor UK-5099. These novel compounds possess drug-like properties and complied wi
  2 KB (319 words) - 13:39, 5 December 2022
• Brown 2008 Am J Physiol Endocrinol Metab
  ...d by incubating human skeletal muscle cell cultures with the mitochondrial inhibitor sodium azide and examining the effects on insulin action. Incubation of hum |topics=Inhibitor
  2 KB (327 words) - 11:08, 27 March 2018
• Johnson 2000 Arthritis Rheum
  ...beta from increasing intracellular ATP and elaboration of PPi, a critical inhibitor of hydroxyapatite deposition. Antimycin and oligomycin also abrogated the a |topics=Inhibitor
  3 KB (333 words) - 16:34, 23 February 2015
• Fink 2022 FASEB Bioadv
  ...and consequently ΔΨ, were perturbed both by GDP, a well-recognized potent inhibitor of UCP1 and by the chemical uncoupler carbonyl cyanide m-chlorophenyl hydra |topics=Inhibitor, mt-Membrane potential
  2 KB (331 words) - 01:29, 3 April 2023
• Martin 2012 Osteoarthritis Cartilage
  ...were treated with rotenone, an ET inhibitor; or oligomycin an ATP synthase inhibitor; or 2-fluoro-2-deoxy-D-glucose, a glycolysis inhibiter; or peroxide, an exo
  2 KB (329 words) - 15:52, 25 November 2015
• Sugimura 2012 J Reprod Dev
  ...coupled to ATP synthesis, as determined by sensitivity to an ATP synthase inhibitor, and the remaining 37% was attributed to proton leak. In contrast, 50% and
  2 KB (345 words) - 16:13, 13 November 2017
• Patyal 2022 Int J Mol Sci
  ...X, Azhar G, Ameer FS, Verma A, Crane J, Kc G, Che Y, Wei JY (2022) Rho/SRF inhibitor modulates mitochondrial functions. https://doi.org/10.3390/ijms231911536 |abstract=CCG-1423 is a Rho A pathway inhibitor that has been reported to inhibit Rho/SRF-mediated transcriptional regulati
  2 KB (309 words) - 16:07, 20 December 2023
• Malic enzyme
  ...heart and skeletal muscle. [[Tartronic acid]] (hydroxymalonic acid) is an inhibitor of ME. ...fumarate and to some extent by succinate as an activator, and by ATP as an inhibitor ([[Sauer 1973 Biochem Biophys Res Commun]]).
  4 KB (531 words) - 20:38, 30 April 2022
• Simonin 2012 Biochem J
  ...much the same way as thenoyltrifluoroacetone (TTFA), a noncompetitive SDH inhibitor. We suggest that NO inhibits SDH in its ubiquinone site or its Fe-S centers
  2 KB (337 words) - 10:17, 9 November 2016
• Gomez 2008 Circulation
  ...usion), the mPTP inhibitor cyclosporine A (CsA; 10 mg/kg IV), or the GSK3β inhibitor SB216763 (SB21; 70 µg/kg IV). Infarct size was assessed by triphenyltetraz
  2 KB (329 words) - 16:45, 26 March 2018
• Carnitine palmitoyltransferase I
  ...different kinetic and regulatory properties. Malonyl-CoA is an endogenous inhibitor of CPT-I.
  946 bytes (123 words) - 16:47, 13 April 2023
• Malagrino 2019 Oxid Med Cell Longev
  |abstract=Hydrogen sulfide (H₂S), a known inhibitor of cytochrome c oxidase (CcOX), plays a key signaling role in human (patho) |topics=Inhibitor
  2 KB (333 words) - 11:18, 21 January 2020
• Fisar 2017 Indian J Biochem Biophys
  ...lonate, oligomycin, rotenone), and uncoupler. Multiple substrate-uncoupler-inhibitor titration (SUIT) protocols were proposed for Complex I-, Complex II-, Compl |topics=ADP, Inhibitor, Substrate
  2 KB (327 words) - 12:38, 29 May 2018
• Wang 2023 Clin Exp Pharmacol Physiol
  ...but numerous challenges remain. 3-nitro-N-methyl salicylamide (3-NNMS), an inhibitor of mitochondrial electron transport chain complex III, can be used to reduc |keywords=3-NNMS, Heart preservation solution, Mitochondrial inhibitor, Myocardial ischaemia-reperfusion injury, Oxidative stress
  2 KB (330 words) - 15:22, 6 December 2023
• Blebbistatin
  ...'Blebbistatin''' is a widely used muscle and non-muscle myosin II-specific inhibitor that block contractile activity. Blebbistatin shows selectivity and high af |mitopedia topic=Inhibitor
  2 KB (338 words) - 10:21, 27 September 2021
• Krumschnabel 2003 J Exp Biol
  ...was insensitive to EIPA, an inhibitor of Na(+)/H(+) exchange, and SITS, an inhibitor of Cl(-)/HCO(3)(-) exchange, but was prevented in Cl(-)-free medium. In hyp
  2 KB (339 words) - 13:28, 21 June 2019
• Walker 1994 Curr Opin Struct Biol
  ...ts have different mechanisms for inhibition of ATP synthase: by binding an inhibitor protein, and by stabilization of the ADP-inhibited state by making an intra
  884 bytes (122 words) - 09:18, 5 April 2022
• Rekuviene 2017 Neurosci Lett
  ...olved in regulation of mPTP opening during ischemia and whether a specific inhibitor of this complex - rotenone can protect against ischemia-induced cell death |topics=Inhibitor
  2 KB (338 words) - 11:46, 11 June 2018
• Flux control efficiency
  ...X''); then ''Y_X'' is the background rate in the presence of the inhibitor. ...'', acts on ''Y_X'' (substrate, activator) or is removed from Y (inhibitor) to yield ''Z_X''. The ''X''-specific (in contrast to general) [[
  8 KB (1,272 words) - 18:27, 1 January 2021
• Zholobenko 2017 PLOS ONE
  ...ered by increased [ADP] and is increased by adenine nucleotide transporter inhibitor, atractyloside, but not bongkrekic acid. Both quercetin and dehydrosilybin |topics=ADP, Coupling efficiency;uncoupling, Inhibitor
  3 KB (381 words) - 13:38, 29 May 2018
• Stepanova 2016 Biochim Biophys Acta
  ...etate (OAA) is an intermediate of the TCA cycle and at the same time is an inhibitor of complex II with high affinity (Kd~10-8M). Whether or not OAA inhibition |topics=Inhibitor
  3 KB (384 words) - 10:02, 24 September 2018
• Piericidin
  |mitopedia topic=Inhibitor
  1 KB (151 words) - 09:28, 2 November 2020
• Salicylhydroxamic acid
  ...HAM; synonym: 2-Hydroxybenzohydroxamic acid N,2-Dihydroxybenzamide) is an inhibitor of the [[alternative oxidase]] (AOX). When AOX is blocked by SHAM, electron |mitopedia topic=Inhibitor
  2 KB (337 words) - 22:29, 9 April 2022
• Pon 2011 Malar J
  ...y the enzyme and evaluate its activity in terms of cofactor dependency and inhibitor preference. |topics=Inhibitor
  3 KB (370 words) - 10:05, 9 November 2016
• Timon-Gomez 2023 GIBB
  ...rrier C, Garcia-Souza LF, Gnaiger E (2023) A reference substrate-uncoupler-inhibitor titration protocol to create a mitochondrial pathway and coupling control d ...diseases. To address these challenges, we developed a substrate-uncoupler-inhibitor titration reference protocol (SUIT-RP) for measuring metabolic fluxes by hi
  3 KB (337 words) - 13:18, 31 May 2023
• Felser 2013 Toxicol Sci
  ...odarone at 20µM. Similar to amiodarone, dronedarone is an uncoupler and an inhibitor of the mitochondrial respiratory chain and of β-oxidation both acutely and |topics=Inhibitor, mt-Membrane potential, Fatty acid
  3 KB (363 words) - 16:28, 7 November 2016
• Davis 2017 Tissue Eng Part C Methods
  ...ial O2k system to measure oxygen consumption. In response to the complex I inhibitor rotenone, myobundle basal respiration decreased dose dependently with an IC |topics=Inhibitor
  3 KB (338 words) - 13:22, 4 June 2018
• Seitaj 2020 Cells
  ...tler U, Tenzer S, Parys JB, Bultynck G, Methner A (2020) Transmembrane BAX inhibitor-1 motif containing protein 5 (TMBIM5) sustains mitochondrial structure, sha |abstract=The Transmembrane Bax Inhibitor-1 motif (TMBIM)-containing protein family is evolutionarily conserved and h
  3 KB (353 words) - 20:58, 1 October 2020
• Kupsch 2009 FEBS J
  inhibitor of IMM-linked K⁺-transport) and tributyltin (an inhibitor of the
  3 KB (378 words) - 10:58, 23 January 2019
• Silva 2019 ESCI2019
  ...iger E (2019) Can fatty acid oxidation be specifically blocked by the CPT1 inhibitor etomoxir? |abstract=Etomoxir is an irreversible inhibitor of the mitochondrial transport of long-chain fatty acids via blockage of ca
  5 KB (697 words) - 19:11, 10 January 2022
• Hedges 2020 Biosci Rep
  ...ey AJR, Shepherd PR, Merry TL (2020) Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does n ...and female mice were fed a diet containing 0.3 g/kg of the p110α-selective inhibitor BYL-719 (BYL) or a vehicle diet (VEH) for 6 weeks. Mice consuming BYL-719 h
  2 KB (352 words) - 14:49, 17 January 2023
• Rouet 2017 US Patent
  ...e for treating a pathophysiological situation, wherein said compound is an inhibitor of the ApoO activity or of the ApoO gene expression.
  1 KB (157 words) - 12:47, 5 February 2018
• Bredholt T 2009 Mol Cancer
  ...ro''. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with khat in a panel of acute myeloid leukemia cel |topics=ADP, Inhibitor
  3 KB (331 words) - 18:19, 31 January 2020
• Grefte 2014 Abstract MiP2014
  ...hibited by high concentrations of [[rotenone]] (Rot; 10 µM), a widely used inhibitor of OXPHOS [[Complex I]] (CI), suggesting that activity of this complex is r ...two CI inhibitors (Rot or piericidin A, PA) or in the presence of the CIII inhibitor [[antimycin A]] (Ama). For all inhibitors, the lowest concentration that fu
  4 KB (565 words) - 16:30, 23 February 2015
• Chicco 2022 MitoFit
  ...rein, we demonstrate inhibitory effects of >1 mM malate or malonate (a CII inhibitor) on ''J''_O₂ supported by pyruvate and/or glutamate, s
  3 KB (372 words) - 07:52, 8 January 2023
• Amaral 2016 J Neurochem
  .... Taken together, our data strongly indicate that 2MCA behaves as a potent inhibitor of glutamate oxidation by inhibiting GDH activity and as a PT inducer, dist |topics=Calcium, Inhibitor
  3 KB (361 words) - 11:22, 3 March 2020
• Chicco 2022 Abstract Bioblast
  ..., Garcia-Roves PM (2022) Elucidating the complexity of substrate-uncoupler-inhibitor titration protocols. '''Bioblast 2022: BEC Inaugural Conference.''' In: htt ...n of succinate exerts a stimulatory effect (NS > N). Then the selective CI inhibitor rotenone is utilized to eliminate the contribution of the N-pathway to NS-p
  4 KB (625 words) - 08:33, 28 July 2022
• Malonate
  |description='''Malonate''' (malonic acid) is a competitive inhibitor of [[succinate dehydrogenase]] ([[Complex II]]). Malonate is a substrate of |mitopedia topic=Inhibitor
  3 KB (357 words) - 11:12, 10 June 2021
• Doucet 2018 Mol Pharmacol
  ...fication of peracetylated quercetin as a selective 12-lipoxygenase pathway inhibitor in human platelets. Mol Pharmacol 95:139-50. ...racetylated quercetin (compound 6) as a more selective platelet-type 12-LO inhibitor than baicalein, with no measurable non-targeted effects on the platelet's a
  3 KB (364 words) - 23:46, 29 February 2020
• Gellerich 1995 HRR
  ...eiter R, Sperl W (1995) Hochauflösende Respirometrie und multiple Substrat/Inhibitor-Titration zum funktionellen Nachweis mitochondrialer Defekte in permeabilis
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• Goudie 2017 Abstract IOC122
  ...istically significant result. Thus, systemic administration of a selective inhibitor of mitochondrial fission reduced the severity of disease in two different,
  2 KB (341 words) - 16:46, 27 March 2018
• Fisher-Wellman 2023 Cancers (Basel)
  ...ility in the drug-resistant phenotype, a potential therapeutic avenue. The inhibitor regimen showed efficacy in an ''in vivo'' model and in primary AML cells fr
  3 KB (455 words) - 13:58, 19 July 2023
• Lisak 2015 Cell Death Differ
  ...ms-Quack P, Hahn M, Waisman A, Reed JC, Hövelmeyer N, Methner A (2015) BAX inhibitor-1 is a Ca²⁺ channel critically important for immune cell functio ...in the synthesis and folding of proteins. BAX (BCL2-associated X protein) inhibitor-1 (BI-1) is a Ca²⁺ leak channel also implicated in the response
  2 KB (358 words) - 15:11, 13 November 2017
• Ballot 2010 Apoptosis
  ...potential, swelling and cytochrome c release. Cyclosporin A, a well-known inhibitor of MPT, completely prevents mitochondrial signs of apoptosis. The drug decr |topics=Inhibitor, Substrate
  3 KB (387 words) - 11:49, 22 December 2020
• Hoejeberg 1977 Biochem Biophys Res Commun
  |topics=Inhibitor
  1 KB (148 words) - 12:45, 24 February 2015
• Ale-Agha 2018 PLOS Biol
  ...pendent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endotheli
  3 KB (376 words) - 15:45, 23 August 2018
• 2-Deoxyglucose
  |mitopedia topic=Inhibitor
  990 bytes (130 words) - 11:16, 21 June 2021
• Perry 2011 Biochem J
  ...ulated respiratory kinetics. BLEB ('''blebbistatin'''), a myosin II ATPase inhibitor, blocked contraction under all conditions and yielded high ''K''<sub>m</sub |topics=ADP, Inhibitor, Temperature
  3 KB (378 words) - 16:12, 6 March 2020
• Kosenko 2010 Biology Bull
  ...MB, Venediktova NI, Popova II, Kaminskii YG (2010) The drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases. Biology Bull 37:346-50.
  1 KB (161 words) - 15:50, 26 May 2015
• Woyda-Ploszczyca 2017 IOC124
  ...gical significance and consequently GDP should not be used as a diagnostic inhibitor of UCPs.
  3 KB (355 words) - 13:50, 28 August 2017
• Pless-Petig 2018 Cell Transplant
  ...ed hepatocytes confirmed that impaired energy production-as elicited by an inhibitor of the respiratory chain, antimycin A-can decrease cell attachment without
  3 KB (386 words) - 12:22, 16 March 2018
• Kanner 1976 Biochem Biophys Res Commun
  |abstract=Coupling factor 6 (F6) and mitochondrial ATPase inhibitor were isolated from the rutamycin-sensitive ATPase complex of bovine heart m
  1 KB (150 words) - 13:03, 24 February 2015
• Marshall 1996 Am J Respir Cell Mol Biol
  ...nhibitor diphenyleneiodonium (DPI: 10 microM) but not by the mitochondrial inhibitor myxathiazole (10 microM). The hypoxic superoxide increase was significantly
  3 KB (377 words) - 17:48, 20 April 2022
• Schoeckel 2015 Cancer Metab
  ...evidence that inhibition of mutated BRAF using the specific small molecule inhibitor vemurafenib increased the OXPHOS dependency of BRAF mutant melanoma cells. ...ve phosphorylation (OXPHOS), Reactive oxygen species (ROS), Small molecule inhibitor, Human melanoma SK-MEL-28 cells, Human skin A-375 cells
  3 KB (381 words) - 15:07, 9 November 2016
• Osiki 2016 FASEB J
  ...ith 1mM oxalomalic acid (aconitase inhibitor) or 1mM 2-mercaptoacetate, an inhibitor of MCAD – the rate-limiting enzyme of octanoylcarnitine oxidation. Respir
  3 KB (373 words) - 16:15, 26 March 2018
• Beryllium sulfate
  |mitopedia topic=Inhibitor
  1 KB (136 words) - 12:57, 26 April 2024
• Lim 2011 PloS One
  ...r AG18051 would also confer protection from HA toxicity. We found that the inhibitor conferred only partial protection from HA toxicity indicating distinct path
  3 KB (416 words) - 15:10, 13 November 2017
• Background state
  ...reference state. Alternatively, the metabolic control variable ''X'' is an inhibitor, which is present in the background state Y, but absent in the reference st
  1 KB (177 words) - 18:19, 10 November 2020
• Sodium fluoride
  |mitopedia topic=Inhibitor
  1 KB (140 words) - 12:59, 26 April 2024
• Reference state
  ...in the reference state but absent in the background state. If ''X'' is an inhibitor of flux, it is absent in the reference state but present in the background
  1 KB (179 words) - 18:14, 10 November 2020
• Jaskiewicz 2019 J Clin Med
  ...does not do so in conjunction with caspase-3. It appears that the calpain inhibitor, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal (ALLM), restored the viability th
  3 KB (374 words) - 12:28, 21 June 2019
• Warne 2015 J Biol Chem
  ...We therefore designed and synthesised a new mitochondrially-targeted CypD inhibitor, JW47, using a quinolinium cation tethered to cyclosporine (CsA). X-ray ana |topics=Inhibitor
  3 KB (349 words) - 20:10, 7 March 2020
• Vielhaber 2013 Acta Neuropathol
  ...of active state oxygen consumption to azide, a cytochrome c oxidase (CIV) inhibitor, was increased. The observed dysfunction of the mitochondrial respiratory c |topics=Inhibitor, Threshold;excess capacity
  3 KB (400 words) - 12:18, 8 November 2016
• Nagy 2014 Abstract MiP2014
  ...In the presence of glucose, adding a mitochondrial fatty acid transporter inhibitor further increased the ECAR.
  3 KB (403 words) - 13:04, 23 January 2019
• Cyclosporin A
  ...ransition and from CsA inhibition. Moreover, it is also a is a calcineurin inhibitor and potent immunosuppressive agent used largely as a means of prophylaxis a |mitopedia topic=Inhibitor
  3 KB (370 words) - 11:04, 14 June 2022
• Ouabain
  |mitopedia topic=Inhibitor
  1 KB (157 words) - 13:05, 12 February 2021
• Goo 2012 PLoS One
  ...rdinated regulation by PTEN/Akt. Using LY294002 (a PI3K inhibitor) and Akt inhibitor IV, we showed that the regulation of enzyme activities and protein expressi
  3 KB (426 words) - 14:24, 13 November 2017
• Cockova 2017 Thesis
  ..., we managed to observe increased ROS production in cells treated with FTO inhibitor. |topics=Inhibitor
  3 KB (415 words) - 11:23, 22 January 2018
• Zhang 2017 J Am Heart Assoc
  ...X, Wang X, Tse G, Li G, Liu T (2017) Alogliptin, a dipeptidyl peptidase-4 inhibitor, alleviates atrial remodeling and improves mitochondrial function and bioge ...n. In this study, we explored whether alogliptin, a dipeptidyl peptidase-4 inhibitor, can prevent mitochondrial dysfunction and atrial remodeling in a diabetic
  3 KB (381 words) - 11:58, 27 June 2019
• Ruas 2016 PLOS ONE
  ...red when oxidative phosphorylation was fully inhibited by the ATP synthase inhibitor citreoviridin. Further experiments indicated that oligomycin cannot be repl |topics=Inhibitor, Substrate
  3 KB (421 words) - 12:08, 9 December 2021
• He 2005 Am J Physiol Lung Cell Mol Physiol
  ...crease in DHE fluorescence. This response was blocked by the NADPH oxidase inhibitor diphenyleneiodonium (10 microM). KO neutrophils did not respond; however, a
  3 KB (379 words) - 18:01, 13 April 2022
• Schiller 2022 Pharmaceuticals (Basel)
  ...sources. The structure of complex I is determined at high resolution, and inhibitor binding sites are described in detail. In this review, we summarize the sta
  1 KB (177 words) - 15:58, 22 March 2023
• Kampjut 2020 Science
  ...ys. Quinone binds at three positions along the quinone cavity, as does the inhibitor rotenone that also binds within subunit ND4. Dramatic conformational change
  1 KB (174 words) - 19:49, 6 November 2023
• Parvez 2010 Biochim Biophys Acta
  |topics=Calcium, Inhibitor ...hrome c; FCCP, carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone; IC50, inhibitor concentration causing 50% inhibition; mtPTP, mitochondrial permeability tra
  3 KB (397 words) - 10:43, 23 January 2019
• Sumbalova 2014 Abstract MiP2014
  ...ger [2], and the effect was attributed to accumulation of oxaloacetate, an inhibitor of succinate dehydrogenase (SDH) and fumarate [1,3]. |topics=Inhibitor, Substrate, Uncoupler
  4 KB (587 words) - 13:46, 5 January 2023
• Krajcova 2016 Abstract MitoFit Science Camp 2016
  ...consumption rate (OCR) was measured at baseline, after addition of ATPase inhibitor and subsequently after incubation in a range of propofol concentrations (fo ...fter addition of ATPase inhibitor, mitochondrial uncoupler and complex III inhibitor. Injection of these agents enabled to calculate baseline OCR, ATP turnover
  5 KB (679 words) - 15:19, 23 January 2019
• Doerrier 2017 MiPschool C2
  |title=[[File:DoerrierC.JPG|left|90px]] Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles. ...monized states differ in terms of the sequence of substrate, uncoupler and inhibitor titrations (Figure 2). RP1 includes respiratory states that can be compared
  5 KB (706 words) - 12:00, 27 May 2019
• Goretzki 2022 Int J Mol Sci
  ...ine IL 1β was unaffected. Interestingly, pretreatment with the glutaminase inhibitor BPTES resulted in an increase in IL-1β, but decreased IL-12p70 secretion w
  3 KB (428 words) - 10:57, 19 January 2023
• George 2015 Abstract MiPschool Greenville 2015
  ...idation was inhibited with addition of oxamate, a membrane impermeable LDH inhibitor. Similar observations were made within rat hippocampal (cornu ammonis 1; CA
  3 KB (403 words) - 16:41, 7 November 2016
• Pereira da Silva Grilo da Silva 2018 MiP2018
  ...d to evaluate mitochondrial fitness in the course of disease. Etomoxir, an inhibitor of carnitine palmitoyltransferase-I, is often used (40-400 μm) in commerci ...lated from mouse liver and brain mitochondria. We used substrate-uncoupler-inhibitor titration (SUIT) protocols to analyze oxidative phosphorylation (OXPHOS) an
  6 KB (816 words) - 19:07, 10 January 2022
• Peleli 2016 Free Radic Biol Med
  ...ed with wt, and this augmented response was abolished by the selective XOR inhibitor febuxostat. Livers from eNOS^-/- displayed higher nitrite reducin
  3 KB (479 words) - 10:52, 2 August 2017
• Hand 2013 Abstract MiP2013
  ...ict that the F1Fo-ATP synthase is blocked during diapause by the F1-ATPase inhibitor protein IF1. This 9.6 kDa protein binds to the ATP synthase at the F1 catal |keywords=Diapause, Inhibitor protein IF1
  4 KB (563 words) - 14:30, 13 November 2017
• S/NS pathway control ratio
  ...nate in the absence of Rot, since [[oxaloacetate]] accumulates as a potent inhibitor of [[succinate dehydrogenase]] (CII).
  1 KB (163 words) - 18:28, 1 January 2021
• McKee 2010 Abstract IOC60
  ...ems. In this regard we have already demonstrated that AZT is a competitive inhibitor of thymidine phosphorylation in mitochondria isolated from heart, liver, an ...Lynx MD, McKee EE (2006) 3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria.
  3 KB (469 words) - 14:37, 8 November 2016
• Busanello 2017 Front Pharmacol
  ...(Ca²⁺ chelator), cyclosporin A (MPT inhibitor), ruthenium red (inhibitor of mitochondria Ca²⁺ uptake) and coenzyme Q10 (antioxidant), ind
  3 KB (445 words) - 11:16, 25 June 2019
• Rapamycin
  |description='''Rapamycin''' is an inhibitor of the mammalian/mechanistic target of rapamycin, complex 1 (mTORC1). Rapam
  1 KB (154 words) - 14:10, 24 September 2023
• Yang 2018 Cell Death Dis
  ...asome system as a part of the protective leptin pathway. In addition, GSK3 inhibitor (SB216763) was also involved in the degradation of OMA1. In conclusion, in
  3 KB (433 words) - 00:23, 1 March 2020
• MitoKit-CII/Succinate-nv
  |mitopedia topic=Inhibitor
  1 KB (154 words) - 12:08, 27 July 2021
• Carboxyatractyloside
  |description='''Carboxyatractyloside''' CAT is a highly selective and potent inhibitor of the [[adenine nucleotide translocator]] (ANT). CAT stabilizes the nucleo |mitopedia topic=Inhibitor
  3 KB (491 words) - 14:55, 7 February 2024
• Fandrey 1994 Biochem J
  ...ion of endogenous H2O2 levels by the addition of menadione or the catalase inhibitor, aminotriazole, dose-dependently lowered Epo production. The inhibitory eff
  1 KB (194 words) - 09:29, 12 April 2022
• Koizumi 2023 Front Cardiovasc Med
  |keywords=SGLT2 inhibitor; diabetes; empagliflozin; mitochondria; reactive oxygen species |topics=ADP, Inhibitor, Substrate
  3 KB (454 words) - 14:46, 20 August 2023
• Volska 2013 Abstract MiP2013
  |title=Volska K, Makrecka-Kuka M, Svalbe B, Dambrova M (2013) The inhibitor of L-carnitine biosynthesis protects brain mitochondria against anoxia-reox ...cellular energy metabolism. Recently it has been shown that mildronate, an inhibitor of L-carnitine biosynthesis, improves the neurological outcome after ischem
  3 KB (413 words) - 14:24, 27 March 2018
• Arandarcikaite 2013 Abstract MiP2013
  ...o PKG activation before inducing ischemia in vena cava, we infused the PKG inhibitor KT5823 (1 µM) and NOC-18. ...brain mitochondria. Pre-treatment of brain in the ischemic group with PKG inhibitor and NO donor resulted in no statistically significant differences to contro
  3 KB (436 words) - 11:02, 28 April 2017
• Aspirin
  ...equires dosage adjusted to individual body mass. It is a non-selective COX inhibitor and exerts an effect on long-chain fatty acid transport into mitochondria.
  1 KB (156 words) - 17:19, 24 September 2023
• Porter 2018 MiP2018b
  ...ration, P<0.001). The response to the adenine nucleotide translocase (ANT) inhibitor bongkrekic acid during state 4 respiration was similar in healthy and burne
  3 KB (434 words) - 08:11, 13 September 2018
• Scott 2016 Thesis
  ...d fructose-fed rats was measured in response to different substrate and/or inhibitor combinations using the Oroboros Oxygraph-2K high-resolution respirometry sy ...ased mitochondrial expression of CD36, (iv) the reduced presence of CPT1’s inhibitor malonyl-CoA, (v) the reduced sensitivity of CPT1 to malonyl-CoA, and (vi) t
  3 KB (455 words) - 16:00, 23 January 2019
• Ethanol
  | mitopedia topic=Inhibitor, Substrate and metabolite, Uncoupler, Permeabilization agent
  1 KB (221 words) - 11:29, 27 May 2021
• Oligomycin
  |description='''Oligomycin''' (Omy) is an inhibitor of [[ATP synthase]] by blocking its proton channel (Fo subunit), which is n |mitopedia topic=Inhibitor
  6 KB (917 words) - 12:57, 29 April 2024
• Daura 2021 Neurobiol Dis
  ...the molecular pathogenesis of CSTB deficiency.Cystatin B (CSTB) acts as an inhibitor of cysteine proteases of the cathepsin family and loss-of-function mutation
  3 KB (447 words) - 12:32, 27 March 2023
• Ling 2023 EBioMedicine
  ...; an mTORC1-inhibitor, rapamycin; a SIRT1-activator, resveratrol; or SIRT1-inhibitor, EX-527. Malnutrition enteropathy was induced in enteric organoids through
  3 KB (431 words) - 15:03, 14 November 2023
• Wieser 2001 Biochem J
  ...tion to be functionally related to the concentration of cycloheximide, the inhibitor used. It was found that at 15 mM cycloheximide [three orders of magnitude h |topics=ATP production, Inhibitor, Ion;substrate transport
  4 KB (522 words) - 12:08, 23 January 2019
• Chowdhury 2017 Blood
  ...g NAMPT contributes to the prolonged survival of CLL cells. Idelalisib, an inhibitor of phosphatidylinositol-3-kinase-delta (PI3Kδ) is an approved therapy for ...o each individual drug after 48 hours. Preliminary data with another NAMPT-inhibitor, GMX-1778 at 1nM also showed similar effect to FK866 and in combination wit
  5 KB (673 words) - 18:30, 31 January 2020
• Succinate
  ...nate alone may lead to accumulation of [[oxaloacetate]], which is a potent inhibitor of Complex II (compare [[Succinate and rotenone]]). High activities of mt-[ :::: In the absence of CI-linked substrates, add the CI-inhibitor [[rotenone]] before addition of succinate, to avoid accumulation of [[oxalo
  3 KB (467 words) - 15:06, 17 December 2022
• Campanella 2009 Trends Biochem Sci
  ...limited by the mitochondrial protein IF(1), an endogenous F(1)F(o)-ATPase inhibitor. IF(1), therefore, preserves ATP at the expense of Deltapsi(m). Despite a w
  1 KB (182 words) - 10:37, 3 April 2022
• Timon-Gomez 2023 MiP2023
  ...=[[File:Timon-Gomez A.jpg|left|100px|Timon-Gomez Alba]]Substrate-uncoupler-inhibitor titration protocol for analyzing carbohydrate and fatty acid metabolism ...l defects using high-resolution respirometry [2]. This substrate-uncoupler-inhibitor titration (SUIT) protocol analyzes fatty acid oxidation (FAO) by adding 0.1
  4 KB (456 words) - 16:47, 12 July 2023
• Sundstroem 2019 Acta Neuropathol Commun
  ...hondrial respiration, β-sitosterol represents a promising adjuvant to BRAF inhibitor therapy in patients with, or at risk for, melanoma brain metastases.
  3 KB (453 words) - 06:14, 20 April 2020
• Sauer 1973 Biochem Biophys Res Commun
  ...entration. Succinate was an allosteric activator and ATP was a competitive inhibitor of malate. The second peak showed hyperbolic kinetics in plots of activity
  1 KB (206 words) - 12:44, 29 May 2015
• Groeger 2010 Crit Care
  |abstract='''Introduction:''' Hydrogen sulfide (H₂S) is a potent inhibitor of cytochrome c oxidase (COX) and, thus, of mitochondrial respiration [1]. ...donor Na₂S (1 to 64 μM). In the parallel chamber, the identical inhibitor titration sequence was preceded by the inhibition of the respiratory chain
  3 KB (463 words) - 14:26, 13 November 2017
• Cottingham 1983 Biochim Biophys Acta
  ...fferent activities of the NADH dehydrogenase. In the absence of a specific inhibitor, the turnover of the external NADH dehydrogenase was adjusted using a novel
  2 KB (216 words) - 09:44, 1 April 2021
• Komlodi 2018 Methods Mol Biol
  ...d Buffer Z), and MiRK03 (KCl). Respiration in a simple substrate-uncoupler-inhibitor titration protocol was identical in MiR05, Buffer Z, and MiR07, whereas oxy ...solution respirometry, Oxygraph-2k, Respiration media, Substrate-uncoupler-inhibitor titration, HEK 293T cells, Permeabilized muscle fibers, DTPA, Buffer z
  3 KB (453 words) - 12:33, 25 October 2023
• Giulivi 2008 Biochem J
  ...confirm the involvement of malic enzyme, the effect of tartronic acid, an inhibitor of this enzyme, was tested on malate only or on malate- and pyruvate-supple
  4 KB (555 words) - 18:53, 15 March 2021
• Hoppel 2016c Abstract MitoFit Science Camp 2016
  ...acquire the noncoupled ET capacity; Antimycin A is used as the Complex III inhibitor.
  3 KB (480 words) - 15:32, 23 January 2019
• Galemou Yoga 2021 Front Chem
  |keywords=NADH dehydrogenase, Electron transfer, Inhibitor, Oxidative phosphorylation, Proton pumping, Respiratory chain, Semiquinone
  2 KB (216 words) - 16:15, 22 March 2023
• Nemeth 2016 FASEB J
  ...taconyl-CoA at the expense of ATP (or GTP), and is also a weak competitive inhibitor of complex II. Here, we investigated specific bioenergetic effects of incre |topics=ADP, Inhibitor
  3 KB (443 words) - 13:30, 2 August 2023
• Schaefer 2016 Abstract MitoFit Science Camp 2016
  (HEK APP) ± gamma secretase inhibitor treatment. In the upper panel the whole cells were analysed, the lower pane
  3 KB (494 words) - 15:19, 23 January 2019
• Spurway 1997 FEBS Letters
  |abstract=The effects of etomoxir, an inhibitor of mitochondrial long-chain fatty acid oxidation, on triacylglycerol metabo
  1 KB (183 words) - 23:07, 5 July 2021
• Garcia-Souza 2018 Life Sciences Meeting 2018 Innsbruck AT
  ...ting procedures have to be established. We developed a substrate-uncoupler-inhibitor titration protocol to measure respiratory control in intact cells and cell ...measured before and after addition of pyruvate. Oligomycin (0.05 – 2.5 µM, inhibitor of F-ATPase) was added to obtain LEAK respiration. Electron transfer-capaci
  3 KB (477 words) - 19:10, 10 January 2022
• SUIT reference protocol
  |description=The '''substrate-uncoupler-inhibitor titration ([[SUIT]]) reference protocol''', SUIT RP, provides a common base
  2 KB (204 words) - 10:38, 29 July 2022
• Djafarzadeh 2017 J Vis Exp
  ...stopper with injection ports, which makes it ideal for substrate-uncoupler-inhibitor titrations or detergent titration protocols for determining effective and o
  2 KB (204 words) - 16:28, 27 March 2018
• Hill 2015 Abstract MiPschool London 2015
  |title=A novel inhibitor of the mitochondrial permeability transition pore is beneficial in an exper ...ted mPTP opening. Compounds were compared to cyclosporin A – the canonical inhibitor of pore opening. Two of the compounds inhibited pore opening with significa
  3 KB (455 words) - 20:08, 7 March 2020
• Munro 2016 Free Radic Biol Med
  ...) and/or glutathione (GSH)-dependent enzymatic pathways. The Trx-reductase inhibitor auranofin (2µM), and a pre-treatment of mitochondria with 35µM of 1-chlor |topics=Inhibitor, Substrate
  4 KB (588 words) - 09:35, 8 November 2016
• Gariani 2016 J Hepatol
  ...o do this, we examined the preventive and therapeutic benefits of the PARP inhibitor (PARPi), olaparib, in different models of NAFLD. ...ds=Non-alcoholic fatty liver disease, Poly-ADP ribosylation, Sirtuin, PARP inhibitor
  3 KB (499 words) - 14:08, 2 August 2017
• MitoKit-CII/Malonate-nv
  |mitopedia topic=Inhibitor
  1 KB (174 words) - 12:06, 27 July 2021
• Maher 2014 FEBS Lett
  ...al role in preventing inflammation. Stefin B (cystatin B) is an endogenous inhibitor of cysteine proteinases. In stefin B-deficient bone marrow-derived macropha
  1 KB (183 words) - 16:09, 9 November 2016

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