Template:SUIT KCN: Difference between revisions

Latest revision as of 15:39, 9 April 2019

Cyanide (usually added as KCN) is a competitive inhibitor of cytochrome c oxidase (CIV).

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	[[Cyanide]] (usually added as KCN) is a competitive inhibitor of [[Complex_IV\| cytochrome ''c'' oxidase (CIV)]]. In the presence of an active [[alternative oxidase]] (AOX) pathway, after the inhibition of CIV, cells remain in the physiological coupling state [[ROUTINE]]. In those occasions where the AOX is not active, after the inhibition of CIV, the (ROX state) is normally achieved, where ''Rox'' is the [[residual oxygen consumption]] due to oxidative side reactions estimated either after inhibition of CIII, CIV or in the absence of endogenous fuel-substrates. ''Rox'' is subtracted from oxygen flux as a baseline for all respiratory states, to obtain mitochondrial respiration. [[Cyanide]] inhibition is reversed by pyruvate and high oxygen levels.		[[Cyanide]] (usually added as KCN) is a competitive inhibitor of [[Complex_IV\| cytochrome ''c'' oxidase (CIV)]].