Prosthetic group: Difference between revisions
From Bioblast
No edit summary |
No edit summary ย |
||
(One intermediate revision by the same user not shown) | |||
Line 1: | Line 1: | ||
{{MitoPedia | {{MitoPedia | ||
|description=A '''prosthetic group''' is [[cofactor]] that is attached permanently and tightly or even covalently to an enzyme and that is regenerated in each enzymatic turnover. Thus a prostethic group is distinguished from a [[coenzyme]] or cosubstrate that is attached loosely and transiently. Like a coenzyme, the prosthetic group is required by an enzyme for its activity. A prosthetic group is 'a tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity' (IUPAC definition). | |description=A '''prosthetic group''' is a [[cofactor]] that is attached permanently and tightly or even covalently to an enzyme and that is regenerated in each enzymatic turnover. Thus a prostethic group is distinguished from a [[coenzyme]] or cosubstrate that is attached loosely and transiently. Like a coenzyme, the prosthetic group is required by an enzyme for its activity. A prosthetic group is 'a tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity' (IUPAC definition). | ||
FMN/FMNH<sub>2</sub> and FAD/FADH<sub>2</sub> are prosthetic groups of [[Complex I]] and [[Complex II]], respectively. ย | FMN/FMNH<sub>2</sub> and FAD/FADH<sub>2</sub> are prosthetic groups of [[Complex I]] and [[Complex II]], respectively. ย | ||
|info=https://www.ebi.ac.uk/chebi/searchId.do?chebiId=26348 | |info=https://www.ebi.ac.uk/chebi/searchId.do?chebiId=26348 | ||
}} | }} | ||
{{Template:Keywords: Substrates and cofactors}} | |||
{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Enzyme, Substrate and metabolite | |mitopedia topic=Enzyme, Substrate and metabolite | ||
}} | }} |
Latest revision as of 22:01, 7 May 2023
Description
A prosthetic group is a cofactor that is attached permanently and tightly or even covalently to an enzyme and that is regenerated in each enzymatic turnover. Thus a prostethic group is distinguished from a coenzyme or cosubstrate that is attached loosely and transiently. Like a coenzyme, the prosthetic group is required by an enzyme for its activity. A prosthetic group is 'a tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity' (IUPAC definition).
FMN/FMNH2 and FAD/FADH2 are prosthetic groups of Complex I and Complex II, respectively.
Reference: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=26348
- Bioblast links: Substrates and cofactors - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- Cofactor
- ยป Cofactor
- ยป Coenzyme, cosubstrate
- ยป Nicotinamide adenine dinucleotide
- ยป Coenzyme Q2
- ยป Prosthetic group
- ยป Flavin adenine dinucleotide
- Cofactor
- Referennces
- ยป Gnaiger E (2023) Complex II ambiguities โ FADH2 in the electron transfer system. MitoFit Preprints 2023.3.v6. https://doi.org/10.26124/mitofit:2023-0003.v6
- Referennces
MitoPedia topics: Enzyme, Substrate and metabolite