Difference between revisions of "Noncoupled respiration"
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Noncoupled respiration is maximum [[electron flow]] in an open-transmembrane proton circuit mode of operation (see [[ETS capacity]]). | Noncoupled respiration is maximum [[electron flow]] in an open-transmembrane proton circuit mode of operation (see [[ETS capacity]]). | ||
|info=[[Gnaiger 2014 MitoPathways]], [[MitoPedia: Respiratory states]] | |info=[[Gnaiger 2014 MitoPathways]], [[MitoPedia: Respiratory states]] | ||
}} | }} | ||
{{MitoPedia concepts | {{MitoPedia concepts | ||
|mitopedia concept=Respiratory state | |mitopedia concept=Respiratory state, Recommended | ||
}} | }} | ||
{{MitoPedia methods | {{MitoPedia methods | ||
|mitopedia method=Respirometry | |mitopedia method=Respirometry | ||
}} | }} | ||
{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=EAGLE | |mitopedia topic=EAGLE | ||
}} | }} | ||
Contributed by [[Gnaiger E]] 2010-08-15, edited 2015-01-19. | |||
== Is respiration uncoupled - noncoupled - dyscoupled? == | == Is respiration uncoupled - noncoupled - dyscoupled? == | ||
::::» ''More details:'' [[Uncoupler]] | |||
== Biochemical coupling efficiency: from 0 to <1 == | == Biochemical coupling efficiency: from 0 to <1 == | ||
::::» ''More details:'' [[OXPHOS coupling efficiency]] and [[ETS coupling efficiency]] | |||
Revision as of 13:06, 19 November 2016
- high-resolution terminology - matching measurements at high-resolution
Noncoupled respiration
Description
Noncoupled respiration is distinguished from general (pharmacological or mechanical) uncoupled respiration, to give a label to an effort to reach the state of maximum uncoupler-activated respiration without inhibiting respiration. Noncoupled respiration, therefore, yields an estimate of ETS capacity. Experimentally uncoupled respiration may fail to yield an estimate of ETS capacity, due to inhibition of respiration above optimum uncoupler concentrations or insufficient stimulation by sub-optimal uncoupler concentrations. Optimum uncoupler concentrations for evaluation of (noncoupled) ETS capacity require inhibitor titrations (Steinlechner-Maran 1996 Am J Physiol Cell Physiol; Huetter 2004 Biochem J; Gnaiger 2008 POS).
Noncoupled respiration is maximum electron flow in an open-transmembrane proton circuit mode of operation (see ETS capacity).
Abbreviation: E
Reference: Gnaiger 2014 MitoPathways, MitoPedia: Respiratory states
MitoPedia concepts:
Respiratory state,
Recommended
MitoPedia methods:
Respirometry
MitoPedia topics:
EAGLE
Contributed by Gnaiger E 2010-08-15, edited 2015-01-19.
Is respiration uncoupled - noncoupled - dyscoupled?
- » More details: Uncoupler
Biochemical coupling efficiency: from 0 to <1
- » More details: OXPHOS coupling efficiency and ETS coupling efficiency
