Kotiadis 2012 J Cell Sci: Difference between revisions
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Latest revision as of 09:23, 9 November 2016
Kotiadis VN, Leadsham JE, Bastow EL, Gheeraert A, Whybrew JM, Bard M, Lappalainen P, Gourlay CW (2012) Identification of new surfaces of Cofilin that link mitochondrial function to the control of multi-drug resistance. J Cell Sci 125:2288-99. |
Kotiadis VN, Leadsham JE, Bastow EL, Gheeraert A, Whybrew JM, Bard M, Lappalainen P, Gourlay CW (2012) J Cell Sci
Abstract: ADF/cofilin family proteins are essential regulators of actin cytoskeletal dynamics. Recent evidence also implicates cofilin in the regulation of mitochondrial function. Here, we identify new functional surfaces of cofilin that are linked with mitochondrial function and stress responses in the budding yeast S. cerevisiae. Our data links surfaces of cofilin that are involved in separable activities of actin filament disassembly or stabilisation, to the regulation of mitochondrial morphology and the activation status of Ras respectively. Importantly, charge alterations to conserved surfaces of cofilin that do not interfere with its actin regulatory activity leads to a dramatic increase in respiratory function that triggers a retrograde signal to up-regulate a battery of ABC transporters and concurrent metabolic changes that support multi-drug resistance. We hypothesise that cofilin functions within a novel bio-sensing system that connects the cytoskeleton and mitochondrial function to environmental challenge. โข Keywords: ADF/cofilin, S. cerevisiae, Ras
โข O2k-Network Lab: UK Canterbury Gourlay CW
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