Hildebrandt 2008 FEBS J: Difference between revisions
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{{Labeling | {{Labeling | ||
|area=Respiration, Comparative MiP; environmental MiP | |||
|organism=Rat | |organism=Rat | ||
|taxonomic group=Annelids | |taxonomic group=Annelids | ||
|tissues=Liver | |tissues=Liver | ||
|preparations=Isolated Mitochondria | |||
|injuries=Hypoxia | |||
|topics=Inhibitor, Substrate | |||
|couplingstates=OXPHOS | |couplingstates=OXPHOS | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional=Sulfide | |additional=Sulfide | ||
|discipline=Mitochondrial Physiology, Pharmacology; Biotechnology | |discipline=Mitochondrial Physiology, Pharmacology; Biotechnology | ||
}} | }} | ||
Revision as of 13:15, 11 August 2013
| Hildebrandt TM, Grieshaber MK (2008) Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria. FEBS J 275: 3352-3356. |
Hildebrandt TM, Grieshaber MK (2008) FEBS J
Abstract: Hydrogen sulfide is a potent toxin of aerobic respiration, but also has physiological functions as a signalling molecule and as a substrate for ATP production. A mitochondrial pathway catalyzing sulfide oxidation to thiosulfate in three consecutive reactions has been identified in rat liver as well as in the body-wall tissue of the lugworm, Arenicola marina. A membrane-bound sulfide : quinone oxidoreductase converts sulfide to persulfides and transfers the electrons to the ubiquinone pool. Subsequently, a putative sulfur dioxygenase in the mitochondrial matrix oxidizes one persulfide molecule to sulfite, consuming molecular oxygen. The final reaction is catalyzed by a sulfur transferase, which adds a second persulfide from the sulfide : quinone oxidoreductase to sulfite, resulting in the final product thiosulfate. This role in sulfide oxidation is an additional physiological function of the mitochondrial sulfur transferase, rhodanese. • Keywords: Mitochondria, Sulfide oxidation, Sulfide : quinone oxidoreductase, Sulfur dioxygenase, Sulfur transferase
Labels: MiParea: Respiration, Comparative MiP; environmental MiP"Comparative MiP; environmental MiP" is not in the list (Respiration, Instruments;methods, mt-Biogenesis;mt-density, mt-Structure;fission;fusion, mt-Membrane, mtDNA;mt-genetics, nDNA;cell genetics, Genetic knockout;overexpression, Comparative MiP;environmental MiP, Gender, ...) of allowed values for the "MiP area" property.
Stress:Hypoxia Organism: Rat Tissue;cell: Liver Preparation: Isolated Mitochondria"Isolated Mitochondria" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property.
Regulation: Inhibitor, Substrate Coupling state: OXPHOS
HRR: Oxygraph-2k
Sulfide
