Difference between revisions of "E-R control efficiency"

Revision as of 18:51, 7 November 2020

high-resolution terminology - matching measurements at high-resolution

E-R control efficiency

Description

The apparent ET-reserve coupling efficiency (E-R coupling control efficiency), j_E-R = (E-R)/E = 1-R/E, is an expression of the relative scope of increasing ROUTINE respiration in living cells by uncoupling. j_E-R = 0.0 for zero excess capacity when R=E; j_E-R = 1.0 for the maximum limit when R=0. The ROUTINE state of living cells is stimulated to Electron transfer pathway by uncoupler titration, which yields the excess E-R capacity, E-R. Since ET-capacity is significantly higher than OXPHOS capacity in various cell types (as shown by cell ergometry), ExR or j_ExR is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent excess E-P capacity, E-P, is not a respiratory reserve in the sense of oxidative phosphorylation.

Abbreviation: j_ExR

Reference: Flux control efficiency

Compare

» ROUTINE-control ratio, R/E

» ET-excess coupling efficiency, j_E-P = (E-P)/E = 1-P/E

» ET-coupling efficiency, j_E-L = 1-L/E

MitoPedia concepts: Respiratory control ratio

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 {{MitoPedia
 |abbr=''j<sub>ExR</sub>''
-|description=[[Image:jExR.jpg|50 px|Excess ''E-R'' capacity factor]] The apparent '''excess ''E-R'' capacity factor''' (''E-R'' coupling control factor), ''j<sub>ExR</sub>'' = (''E-R'')/''E'' = 1-''R/E'', is an expression of the relative scope of increasing [[ROUTINE respiration]] in living cells by uncoupling. ''j<sub>ExR</sub>'' = 0.0 for zero excess capacity when ''R''=''E''; ''j<sub>ExR</sub>'' = 1.0 for the maximum limit when ''R''=0. The [[ROUTINE]] state of living cells is stimulated to [[Electron transfer pathway]] by [[uncoupler]] titration, which yields the [[Excess E-R capacity |excess ''E-R'' capacity]], ''ExR''=''E-R''. Since ET-capacity is significantly higher than OXPHOS capacity in various cell types (as shown by '''[[cell ergometry]]'''), ''ExR'' or ''j<sub>ExR</sub>'' is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent [[Excess E-P capacity |excess ''E-P'' capacity]], ''ExP''=''E-P'', is not a respiratory reserve in the sense of oxidative phosphorylation.
+|description=[[Image:jExR.jpg|50 px|ET-reserve coupling efficiency]] The apparent '''ET-reserve coupling efficiency''' (''E-R'' coupling control efficiency), ''j<sub>E-R</sub>'' = (''E-R'')/''E'' = 1-''R/E'', is an expression of the relative scope of increasing [[ROUTINE respiration]] in living cells by uncoupling. ''j<sub>E-R</sub>'' = 0.0 for zero excess capacity when ''R''=''E''; ''j<sub>E-R</sub>'' = 1.0 for the maximum limit when ''R''=0. The [[ROUTINE]] state of living cells is stimulated to [[Electron transfer pathway]] by [[uncoupler]] titration, which yields the [[Excess E-R capacity |excess ''E-R'' capacity]], ''E-R''. Since ET-capacity is significantly higher than OXPHOS capacity in various cell types (as shown by '''[[cell ergometry]]'''), ''ExR'' or ''j<sub>ExR</sub>'' is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent [[Excess E-P capacity |excess ''E-P'' capacity]], ''E-P'', is not a respiratory reserve in the sense of oxidative phosphorylation.
-|info=[[Flux control factor]]
+|info=[[Flux control efficiency]]
 }}
+== Compare ==
+:::» [[ROUTINE-control ratio]], ''R/E''
+:::» [[ET-excess coupling efficiency]], ''j<sub>E-P</sub>'' = (''E-P'')/''E'' = 1-''P/E''
+:::» [[ET-coupling efficiency]], ''j<sub>E-L</sub>'' = 1-''L/E''
 {{MitoPedia concepts
 |mitopedia concept=Respiratory control ratio
 }}
-{{MitoPedia methods}}
-{{MitoPedia O2k and high-resolution respirometry}}
-{{MitoPedia topics}}
-== Compare ==
-:::» [[ROUTINE-control ratio]], ''R/E''
-:::» [[Excess E-P capacity factor |Excess ''E-P'' capacity factor]], ''j<sub>ExP</sub>'' = (''E-P'')/''E'' = 1-''P/E''
-:::» [[ET-coupling efficiency]], ''j<sub>≈E</sub>'' = 1-''L/E''
 [[Category:Coupling control]]