Difference between revisions of "E-R control efficiency"
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{{MitoPedia | {{MitoPedia | ||
|abbr=''j<sub>ExR</sub>'' | |abbr=''j<sub>ExR</sub>'' | ||
|description=[[Image:jExR.jpg|50 px|Excess ''E-R'' capacity factor]] The apparent '''excess ''E-R'' capacity factor''' (''E-R'' coupling control factor), ''j<sub>ExR</sub>'' = (''E-R'')/''E'' = 1-''R/E'', is an expression of the relative scope of increasing [[ROUTINE respiration]] in intact cells by uncoupling. ''j<sub>ExR</sub>'' = 0.0 for zero excess capacity when ''R''=''E''; ''j<sub>ExR</sub>'' = 1.0 for the maximum limit when ''R''=0. The [[ROUTINE]] state of intact cells is stimulated to [[ | |description=[[Image:jExR.jpg|50 px|Excess ''E-R'' capacity factor]] The apparent '''excess ''E-R'' capacity factor''' (''E-R'' coupling control factor), ''j<sub>ExR</sub>'' = (''E-R'')/''E'' = 1-''R/E'', is an expression of the relative scope of increasing [[ROUTINE respiration]] in intact cells by uncoupling. ''j<sub>ExR</sub>'' = 0.0 for zero excess capacity when ''R''=''E''; ''j<sub>ExR</sub>'' = 1.0 for the maximum limit when ''R''=0. The [[ROUTINE]] state of intact cells is stimulated to [[ET-pathway]] by [[uncoupler]] titration, which yields the [[Excess E-R capacity |excess ''E-R'' capacity]], ''ExR''=''E-R''. Since ET capacity is significantly higher than OXPHOS capacity in various cell types (as shown by '''[[cell ergometry]]'''), ''ExR'' or ''j<sub>ExR</sub>'' is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent [[Excess E-P capacity |excess ''E-P'' capacity]], ''ExP''=''E-P'', is not a respiratory reserve in the sense of oxidative phosphorylation. | ||
|info=[[Flux control factor]] | |info=[[Flux control factor]] | ||
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:::» [[ROUTINE control ratio]], ''R/E'' | :::» [[ROUTINE control ratio]], ''R/E'' | ||
:::» [[Excess E-P capacity factor |Excess ''E-P'' capacity factor]], ''j<sub>ExP</sub>'' = (''E-P'')/''E'' = 1-''P/E'' | :::» [[Excess E-P capacity factor |Excess ''E-P'' capacity factor]], ''j<sub>ExP</sub>'' = (''E-P'')/''E'' = 1-''P/E'' | ||
:::» [[ | :::» [[ET-pathway coupling efficiency]], ''j<sub>≈E</sub>'' = 1-''L/E'' |
Revision as of 08:35, 20 October 2017
Description
The apparent excess E-R capacity factor (E-R coupling control factor), jExR = (E-R)/E = 1-R/E, is an expression of the relative scope of increasing ROUTINE respiration in intact cells by uncoupling. jExR = 0.0 for zero excess capacity when R=E; jExR = 1.0 for the maximum limit when R=0. The ROUTINE state of intact cells is stimulated to ET-pathway by uncoupler titration, which yields the excess E-R capacity, ExR=E-R. Since ET capacity is significantly higher than OXPHOS capacity in various cell types (as shown by cell ergometry), ExR or jExR is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent excess E-P capacity, ExP=E-P, is not a respiratory reserve in the sense of oxidative phosphorylation.
Abbreviation: jExR
Reference: Flux control factor
MitoPedia concepts:
Respiratory control ratio
Compare
- » ROUTINE control ratio, R/E
- » Excess E-P capacity factor, jExP = (E-P)/E = 1-P/E
- » ET-pathway coupling efficiency, j≈E = 1-L/E