Difference between revisions of "E-P control efficiency"
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|abbr=''j<sub>ExP</sub>'' | |abbr=''j<sub>ExP</sub>'' | ||
|description=[[Image:jExP.jpg|50 px|Excess ''E-P'' capacity factor]] The apparent '''excess ''E-P'' capacity factor''' (''E-P'' coupling control factor), ''j<sub>ExP</sub>'' = (''E-P'')/''E'' = 1-''P/E'', is an expression of the relative limitation of [[OXPHOS capacity]] by the capacity of the [[phosphorylation system]]. ''j<sub>ExP</sub>'' = 0.0 when OXPHOS is not limited by the phosphorylation system at zero ETS excess capacity, ''P''=''E'', when the phosphorylation system does not exert any control over OXPHOS capacity. ''j<sub>ExP</sub>'' increases with increasing control of the phosphorylation system over OXPHOS capacity. ''j<sub>ExP</sub>'' = 1 at the limit of zero phosphorylation capacity. The [[OXPHOS]] state of mt-preparations is stimulated to [[ETS]] by [[uncoupler]] titration, which yields the [[Excess E-P capacity |excess ''E-P'' capacity]], ''ExP''=''E-P''. | |description=[[Image:jExP.jpg|50 px|Excess ''E-P'' capacity factor]] The apparent '''excess ''E-P'' capacity factor''' (''E-P'' coupling control factor), ''j<sub>ExP</sub>'' = (''E-P'')/''E'' = 1-''P/E'', is an expression of the relative limitation of [[OXPHOS capacity]] by the capacity of the [[phosphorylation system]]. ''j<sub>ExP</sub>'' = 0.0 when OXPHOS is not limited by the phosphorylation system at zero ETS excess capacity, ''P''=''E'', when the phosphorylation system does not exert any control over OXPHOS capacity. ''j<sub>ExP</sub>'' increases with increasing control of the phosphorylation system over OXPHOS capacity. ''j<sub>ExP</sub>'' = 1 at the limit of zero phosphorylation capacity. The [[OXPHOS]] state of mt-preparations is stimulated to [[ETS]] by [[uncoupler]] titration, which yields the [[Excess E-P capacity |excess ''E-P'' capacity]], ''ExP''=''E-P''. | ||
|info=[[Flux control factor]], [[Gnaiger 2014 MitoPathways]] | |info=[[Flux control factor]], [[Gnaiger 2014 MitoPathways]] | ||
}} | }} | ||
{{MitoPedia | {{MitoPedia concepts | ||
|mitopedia | |mitopedia concept=Respiratory control ratio | ||
}} | }} | ||
{{MitoPedia methods}} | |||
{{MitoPedia O2k and high-resolution respirometry}} | |||
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== Compare == | == Compare == | ||
:::» [[OXPHOS control ratio]], ''P/E'' | :::» [[OXPHOS control ratio]], ''P/E'' | ||
Revision as of 12:58, 8 February 2016
- high-resolution terminology - matching measurements at high-resolution
E-P control efficiency
Description
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The apparent excess E-P capacity factor (E-P coupling control factor), jExP = (E-P)/E = 1-P/E, is an expression of the relative limitation of OXPHOS capacity by the capacity of the phosphorylation system. jExP = 0.0 when OXPHOS is not limited by the phosphorylation system at zero ETS excess capacity, P=E, when the phosphorylation system does not exert any control over OXPHOS capacity. jExP increases with increasing control of the phosphorylation system over OXPHOS capacity. jExP = 1 at the limit of zero phosphorylation capacity. The OXPHOS state of mt-preparations is stimulated to ETS by uncoupler titration, which yields the excess E-P capacity, ExP=E-P.
Abbreviation: jExP
Reference: Flux control factor, Gnaiger 2014 MitoPathways
MitoPedia concepts:
Respiratory control ratio
Compare
- » OXPHOS control ratio, P/E
- » Excess E-R capacity factor, jExR = (E-R)/E = 1-R/E
- » ETS coupling efficiency, j≈E = 1-L/E
