Oxidative phosphorylation

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Oxidative phosphorylation

Description

P.jpg Oxidative phosphorylation (OXPHOS) is the oxidation of reduced fuel substrates by electron transfer to oxygen, chemiosmotically coupled to the phosphorylation of ADP to ATP (P») and accompanied by an intrinsically uncoupled component of respiration. The OXPHOS state of respiration provides a measure of OXPHOS capacity (P), which is frequently corrected for residual oxygen consumption (ROX).

Abbreviation: OXPHOS

Reference: OXPHOS capacity

Contributed by Gnaiger E 2010-09-10, edited 2014-11-02.
Energy transformation in coupled fluxes, J, and forces, F and Δp, of oxidative phosphorylation. 2[H] indicates the reduced hydrogen equivalents of CHO fuel substrates and electron transfer to oxygen. JH+out is coupled output flux. Proton leaks dissipate energy of translocated protons from low pH in the positive to the negative compartment (BEC 2020.1).

OXPHOS

Figure: Energy transformation in coupled fluxes, J, and forces, F and Δp, of oxidative phosphorylation. 2[H] indicates the reduced hydrogen equivalents of CHO fuel substrates and electron transfer to oxygen. JH+out is coupled output flux. Proton leaks dissipate energy of translocated protons from low pH in the positive to the negative compartment (from Gnaiger 2014).


Related terms in Bioblast

P.jpg OXPHOS; P
R.jpg ROUTINE; R
E.jpg ET capacity; E
L.jpg LEAK; L
ROX.jpg ROX; Rox


SUITbrowser question: OXPHOS respiration

» OXPHOS capacity
OXPHOS respiration is the focus of several SUIT protocols. The SUITbrowser can be used to find SUIT protocols for this and other research questions.


References

Bioblast linkReferenceYear
Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837-45.2009
Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v6.2019
Gnaiger Erich et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. doi:10.26124/bec:2020-0001.v1.2020


MitoPedia concepts: Respiratory state, Recommended 


MitoPedia methods: Respirometry 


MitoPedia topics: EAGLE