Rigoni 2016 Abstract Mito Xmas Meeting Innsbruck: Difference between revisions
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{{Abstract | {{Abstract | ||
|title= | |title=Nucleoids and mtDNA dynamics regulation by mitochondrial ultrastructure. | ||
|authors= | |authors=Rigoni G, Mehrotra A, Glytsou C, Anastasia I and Soriano ME | ||
|year=2016 | |year=2016 | ||
|event=Mito Xmas Meeting 2016 Innsbruck AT | |event=Mito Xmas Meeting 2016 Innsbruck AT | ||
|abstract= | |abstract=Alteration of mitochondrial ultrastructure has emerged as phenotypical marker of dysfunction. In particular, changes in cristae shape and number regulate the respiratory efficiency of the cell and the release of proapoptotic factors. Moreover, in the last years a growing number of studies have observed a loss of mtDNA associated to mitochondrial related disorders but whether and how mtDNA and nucleoids regulation is influenced by mitochondrial ultrastructure is unknown. To address this question we studied nucleoids distribution and mtDNA copynumber in cellular models where the mitochondrial ultrastructure has been altered. We show that nucleoids distribution vary depending on mitochondrial ultrastructure and accordingly also mtDNA copy number. Furthermore, we have identified a mitochondrial complex that decrease with nucleoids suggesting a relevant role of this complex for nucleoids and mtDNA stability. Our results suggest that nucleoids and mtDNA stability is regulated by mitochondrial ultrastructure. | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|event=Poster | |||
}} | }} | ||
== Affiliations == | == Affiliations == | ||
:::: | :::: Rigoni G(1), Mehrotra A(1), Glytsou C(1,2), Anastasia I(1) and Soriano ME(1) | ||
::::# | ::::# Dept Biology, Univ Padova, Padova 35121, Italy | ||
::::# Dulbecco-Telethon Inst, Venetian Inst Molecular Medicine, Padova 35129, Italy | |||
Revision as of 12:32, 7 December 2016
| Nucleoids and mtDNA dynamics regulation by mitochondrial ultrastructure. |
Link:
Rigoni G, Mehrotra A, Glytsou C, Anastasia I and Soriano ME (2016)
Event: Mito Xmas Meeting 2016 Innsbruck AT
Alteration of mitochondrial ultrastructure has emerged as phenotypical marker of dysfunction. In particular, changes in cristae shape and number regulate the respiratory efficiency of the cell and the release of proapoptotic factors. Moreover, in the last years a growing number of studies have observed a loss of mtDNA associated to mitochondrial related disorders but whether and how mtDNA and nucleoids regulation is influenced by mitochondrial ultrastructure is unknown. To address this question we studied nucleoids distribution and mtDNA copynumber in cellular models where the mitochondrial ultrastructure has been altered. We show that nucleoids distribution vary depending on mitochondrial ultrastructure and accordingly also mtDNA copy number. Furthermore, we have identified a mitochondrial complex that decrease with nucleoids suggesting a relevant role of this complex for nucleoids and mtDNA stability. Our results suggest that nucleoids and mtDNA stability is regulated by mitochondrial ultrastructure.
Labels:
Event: Poster
Affiliations
- Rigoni G(1), Mehrotra A(1), Glytsou C(1,2), Anastasia I(1) and Soriano ME(1)
- Dept Biology, Univ Padova, Padova 35121, Italy
- Dulbecco-Telethon Inst, Venetian Inst Molecular Medicine, Padova 35129, Italy
