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PL Lodz Watala C

From Bioblast


PL Lodz Watala C

Oroboros O2k-Network

O2k-Network Lab Department of Haemostasis and Haemostatic Disorders

Medical University of Lodz

Address 6/8 Mazowiecka Str., 92-215
City Lodz
Country Poland
Weblink flawopiryna
Contact Watala Cezary
Team Dudzinska Dominika, Labieniec-Watala Magdalena, Siewiera Karolina
Team previous
Status 2 Power-O2k 2010-
Oroboros Events MitoEAGLE 2019 AT, MiPschool 2018, MitoEAGLE 2018 SE, MitoEAGLE 2018 AT, IOC126, MitoEAGLE 2017 CZ, MiPschool 2017, MitoEAGLE 2017 ES, MitoEAGLE 2016, IOC109, Bioblast 2012, IOC72, IOC61, IOC56, IOC55, MiPschool 2007


Siewiera 2022 Int J Mol Sci2022Siewiera K, Labieniec-Watala M, Kassassir H, Wolska N, Polak D, Watala C (2022) Potential role of mitochondria as modulators of blood platelet activation and reactivity in diabetes and effect of metformin on blood platelet bioenergetics and platelet activation.
Wigner 2021 Sci Rep2021Wigner P, Zielinski K, Labieniec-Watala M, Marczak A, Szwed M (2021) Doxorubicin-transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells. Sci Rep 11:4544.
Siewiera 2021 Int J Mol Sci2021Siewiera K, Labieniec-Watala M, Wolska N, Kassassir H, Watala C (2021) Sample preparation as a critical aspect of blood platelet mitochondrial respiration measurements - The impact of platelet activation on mitochondrial respiration.
Jaskiewicz 2019 J Clin Med2019Jaśkiewicz A, Pająk B, Łabieniec-Watała M, De Palma C, Orzechowski A (2019) Diverse action of selected statins on skeletal muscle cells - An attempt to explain the protective effect of geranylgeraniol (GGOH) in statin-associated myopathy (SAM). J Clin Med 8:694.
Bialas 2018 Int J Chron Obstruct Pulmon Dis2018Białas AJ, Siewiera K, Watała C, Rybicka A, Grobelski B, Kośmider L, Kurek J, Miłkowska-Dymanowska J, Piotrowski WJ, Górski P (2018) Mitochondrial functioning abnormalities observed in blood platelets of chronic smoke-exposed guinea pigs – a pilot study. Int J Chron Obstruct Pulmon Dis 13:3707—17 .
Siewiera 2016 Life Sci2016Siewiera K, Kassassir H, Talar M, Wieteska L, Watala C (2016) Higher mitochondrial potential and elevated mitochondrial respiration are associated with excessive activation of blood platelets in diabetic rats. Life Sci 148:293-304.
Watala 2016 Int J Pharm2016Watala C, Karolczak K, Kassassir H, Siewiera K, Maczynska K, Pieniazek A, Labieniec-Watala M (2016) How do the full-generation poly(amido)amine (PAMAM) dendrimers activate blood platelets? Platelet membrane zeta potential and other membrane-associated phenomena. Int J Pharm 500:379-89.
Kassassir 2016 Chem Biol Interact2016Kassassir H, Siewiera K, Talar M, Stec-Martyna E, Pawlowska Z, Watala C (2016) Non-enzymatic modifications of prostaglandin H synthase 1 affect bifunctional enzyme activity - Implications for the sensitivity of blood platelets to acetylsalicylic acid. Chem Biol Interact 253:78-92.
Labieniec-Watala 2015 Int J Pharm Sci Res2015Labieniec-Watala M, Przygodzki T, Siewiera K, Podsedek A, Watala C (2015) Facts and artifacts in the evaluation of the anti-diabetic activity of spent hop extract in rat hearts in the “experimental model of diabetes. Int J Pharm Sci Res 1:106.
Siewiera 2015 Platelets2015Siewiera K, Kassassir H, Talar M, Wieteska L, Watala C (2015) Long-term untreated streptozotocin-diabetes leads to increased expression and elevated activity of prostaglandin H2 synthase in blood platelets. Platelets 27:203-11.
Siewiera 2012 Int J Pharm2012Siewiera K, Labieniec-Watala M (2012) Ambiguous effect of dendrimer PAMAM G3 on rat heart respiration in a model of an experimental diabetes - Objective causes of laboratory misfortune or unpredictable G3 activity?. Int J Pharm 430:258-65.
Labieniec 2011 Int J Mol Sci2011Labieniec M, Siewiera K, Jozwiak Z (2011) Resorcylidene aminoguanidine (RAG) improves cardiac mitochondrial bioenergetics impaired by hyperglycaemia in a model of experimental diabetes. Int J Mol Sci 12:8013-26.
Labieniec 2009 Chem Biol Interact2009Labieniec M, Przygodzki T, Cársky J, Malinska D, Rysz J, Watala C (2009) Effects of resorcylidene aminoguanidine (RAG) on selected parameters of isolated rat liver mitochondria. Chem Biol Interact 179:280-7.


Calabria 2019 MiPschool Coimbra2019
Elisa Calabria
Investigating mitochondrial function in blood cells by high-resolution respirometry: contribution to an interlaboratory study. MitoEAGLE WG4.
Siewiera 2018 MiPschool Tromso E22018
Karolina Siewiera
Effect of metformin treatment on blood platelet bioenergetics and platelet function in STZ-diabetic and non-diabetic rats.
Siewiera 2017 MiPschool Obergurgl2017
Karolina Siewiera
Blood platelets as bioenergetic markers of brain damage in STZ-diabetes.
Labieniec-Watala 2017 MiP20172017
Magda Labieniec-Watala
Lack of the effect of low metformin concentrations on the response of breast cancer cell mitochondria to radiotherapy under conditions of the in vitro experimental hyperglycemia. Labieniec-Watala_Presentation
Siewiera 2017 MiP20172017
Karolina Siewiera
Changes in blood platelet and brain mitochondrial respiration during short and long-lasting STZ-induced diabetes.
Siewiera 2017 Abstract MITOEAGLE Barcelona2017
The effect of metformin on blood platelet bioenergetics and platelet function.
Labieniec-Watala 2012 Abstract Bioblast2012Labieniec-Watala M, Siewiera K, Watala C (2012) Seasonal fluctuations affect the physiology of laboratory animals – facts and artifacts from the perspective of heart mitochondrial respiratory response to tested compounds. Mitochondr Physiol Network 17.12.
Watala 2012 Abstract Bioblast2012Watala C, Przygodzki T, Siewiera K, Kassassir H, Talar M, Labieniec-Watala M (2012) Oxygen consumption in resting and activated blood platelets: platelet mitochondria and cyclooxygenases as compounding targets for high-resolution respirometry. Mitochondr Physiol Network 17.12.

Areas of interest

  • Mitochondrial respiratory capacity under normal and pathophysiological conditions (diabetes mellitus, atherothrombosis, brain-blood barrier disruption, cancerogenesis)
  • Pharmacological modulation of mitochondrial function by selected pharmaceuticals of anti-diabetic activity
  • Targeting of biochemical and molecular burden of diabetes

Gentle Science


  • Everything what concerns OROBOROS company (oxygraphs, company staff, workshops, conferences, scientific discussions, the quality of information, etc.) works at the highest level !!!!!!! BRAVO for you :) - Magdalena Labieniec-Watala (2013)
  • It is great that you develop the Oxygraph-2k in so wonderful directions.. excellent :))). - Magdalena Labieniec-Watala (2011)

Visiting scientist in the Oroboros O2k-Laboratory

Magdalena Labieniec-Watala: Visiting scientist at the Oroboros O2k-Laboratory from January 21 to February 03 2018
Karolina Siewiera: Visiting scientist at the Oroboros O2k-Laboratory from January 21 to February 03 2018
Karolina Siewiera: Visiting scientist at the Oroboros O2k-Laboratory within the framework of the ERASMUS-programme from July 1 to August 31 2015