|News and Events
|Short-Term Scientific Missions
COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
MitoPedia topics: EAGLE
COST WG4: WG4
|Mracek Tomas, RNDr.
Head of laboratory
Institute of Physiology,
Czech Academy of Sciences, CZ
|Videnska 1083, 142 20
|CZ Prague Houstek J
|Pecina 2017 MiP2017
|Brazdova 2017 MiP2017
|Pecinova 2017 MiP2017
|Cunatova 2017 MiP2017
|Mracek 2017 MiP2017
|Efimova 2017 MiP2017
|Kovalcikova 2017 MiP2017
|Pajuelo-Reguera 2017 MiP2017
|Alan 2017 MiP2017
|Tauchmannova 2015 Abstract MiP2015
|Assembly of subunit Fo-a into mammalian ATP synthase.
|Nuskova 2015 Abstract MiPschool London 2015
|Insufficient energy provision or increased oxidative stress – what matters more in ATP synthase deficiencies?
|Kovarova 2015 Abstract MiP2015
|Tissue- and species-specific differences in cytochrome c oxidase assembly induced by SURF1 defects.
|Rohlena 2015 Abstract MiP2015
|Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.
|Karbanova 2015 Abstract MiP2015
|CD36 does not directly participate in mitochondrial fatty acid transport and oxidation.
|Mracek 2015 Abstract MiP2015
|Myocardial iron and mitochondrial function in failing and non-failing human heart: direct tissue analysis.
|Pecinova 2015 Abstract MiP2015
|Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue.
|Kovalcikova 2015 Abstract MiP2015
|Derangements of myocardial mitochondrial function in patients with end-stage heart failure is associated with reduced endonuclease G.
|Pecina 2015 Abstract MiP2015
|Pharmacological inhibition of fatty-acid oxidation synergistically enhances the effect of L-asparaginase in childhood ALL cells.
|Mracek 2014 Abstract MiP2014
|Function of mitochondrial energy provision apparatus is compromised in patients with chronic heart failure. Mitochondr Physiol Network 19.13.
|Houstek 2014 Abstract MiP2014
|Alteration of structure and function of ATP synthase and cytochrome c oxidase by lack of Fo-a and Cox3 subunits caused by mitochondrial DNA 9205delTA mutation.
|Pecina 2014 Abstract MiP2014
|Manifestation of mitochondrial disorders of nuclear origin in lymphocytes.
|Pecina 2013 Abstract MiP2013
|Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08.
- Benefits for COST and for the COST Action MitoEAGLE
- Thinking about our potential involvement, I would propose following:
- WG3 - we can easily squeeze here with comparison of Oroboros and Seahorse, which we try to do anyway in order to establish the value of Seahorse. Here, we can join N. Larssons group, if it joins mtEAGLE (did not find them here yet).
- WG3/WG1 – Measurement of lymphocytes and using lymphocytes for cross-laboratory validation –as we now have quite extensive experience with lymphoid cells, we can participate in protocol development and so on. We are also happy to host some visiting researchers and teach them our expertise.
- WG1 – we have just about started screening of mito phenotypes in rat RI strains (SHRxBN). In the end, data will be available in http://www.genenetwork.org/ database, but most likely as some ratios of various respiratory states to make them usable for QTL mapping. We can deposit original data into mitoEAGLE database as well. It will be more genotype x phenotype study than age, gender etc. x phenotype and it would include rats, which would require broadening the mitoEAGLE scope to laboratory rodents in general and not to keep it focussed on mice only.
- If there would be any chance to utilise “Short-Term Scientific Missions” to send young team members to other participating labs and learn some new techniques (just looking at the participant list, e.g. fluorescent measuring of ATP in the lab of C. Chinopoulos springs into mind), it would be great added value of this COST project for us. And of course, we are also happy to host others in our lab, as I proposed with lymphocyte programme (and it does not have to be limited to it).