Curcumin

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Curcumin

Description

Curcumin has been shown to possess significant anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-mutagenic, anti-coagulant and anti-infective effects. The protective effects of curcumin on rat heart mitochondrial injuries induced by in vitro anoxia–reoxygenation were evaluated by Xu et al 2013. It was found that curcumin added before anoxia or immediately prior to reoxygenation exhibited remarkable protective effects against anoxia–reoxygenation induced oxidative damage to mitochondria.


Reference: Xu et al 2013

Communicated by Doerrier C (2015-03-03).

Curcumin and mitObesity

Work in progress by Gnaiger E 2020-02-09 linked to a preprint in preparation on BME and mitObesity.

References: Curcumin

 YearReferenceOrganismTissue;cell
Kener 2018 J Vis Exp2018Kener KB, Munk DJ, Hancock CR, Tessem JS (2018) High-resolution respirometry to measure mitochondrial function of intact beta cells in the presence of natural compounds. J Vis Exp 131.Islet cell;pancreas;thymus
Ortega-Dominguez 2017 Food Chem Toxicol2017Ortega-Domínguez B, Aparicio-Trejo OE, García-Arroyo FE, León-Contreras JC, Tapia E, Molina-Jijón E, Hernández-Pando R, Sánchez-Lozada LG, Barrera-Oviedo D, Pedraza-Chaverri J (2017) Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic. Food Chem Toxicol 107:373-85.
Tueller 2017 Biochem Biophys Res Commun2017Tueller DJ, Harley JS, Hancock CR (2017) Effects of curcumin and ursolic acid on the mitochondrial coupling efficiency and hydrogen peroxide emission of intact skeletal myoblasts. Biochem Biophys Res Commun 492:368-72.Skeletal muscle
Hagl 2015 Neurochem Int2015Hagl S, Kocher A, Schiborr C, Kolesova N, Frank J, Eckert GP (2015) Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice - Impact on bioavailability. Neurochem Int 89:234-42.MouseNervous system
Hagl 2014 J Alzheimers Dis b2014Hagl S, Heinrich M, Kocher A, Schiborr C, Frank J, Eckert GP (2014) Curcumin micelles improve mitochondrial function in a mouse model of Alzheimer’s disease. J Alzheimers Dis 1:80-3.MouseNervous system
Hirzel 2013 J Recept Signal Transduct Res2013Hirzel E, Lindinger PW, Maseneni S, Giese M, Rhein VV, Eckert A, Hoch M, Krähenbühl S, Eberle AN (2013) Differential modulation of ROS signals and other mitochondrial parameters by the antioxidants MitoQ, resveratrol and curcumin in human adipocytes. J Recept Signal Transduct Res 33:304-12.HumanFat
Other cell lines
Eckert 2013 Neurochem Int2013Eckert GP, Schiborr C, Hagl S, Abdel-Kader R, Müller WE, Rimbach G, Frank J (2013) Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8. Neurochem Int 62:595-602.Mouse
Eckert 2012 Mol Neurobiol2012Eckert GP, Renner K, Eckert SH, Eckmann J, Hagl S, Abdel-Kader RM, Kurz C, Leuner K, Muller WE (2012) Mitochondrial dysfunction - a pharmacological target in Alzheimer's disease. Mol Neurobiol 46:136-50.Human


  1. Shehzad A1, Rehman G, Lee YS (2013) Curcumin in inflammatory diseases. Biofactors 39:69-77. - https://www.ncbi.nlm.nih.gov/pubmed/23281076
  2. Den Hartogh DJ, Gabriel A, Tsiani E (2020) Antidiabetic properties of Curcumin I: Evidence from in vitro studies. Nutrients 12 pii:E118. - https://www.ncbi.nlm.nih.gov/pubmed/31906278
  3. Den Hartogh DJ, Gabriel A, Tsiani E (2020) Antidiabetic properties of Curcumin II: Evidence from in vivo studies. Nutrients 12 pii:E58. - https://www.ncbi.nlm.nih.gov/pubmed/31881654
  4. Lee ES, Kwon MH, Kim HM, Woo HB, Ahn CM, Chung CH (2019) Curcumin analog CUR5-8 ameliorates nonalcoholic fatty liver disease in mice with high-fat diet-induced obesity. Metabolism 103:154015. - https://www.ncbi.nlm.nih.gov/pubmed/31758951
  5. Liu Y, Weng W, Gao R, Liu Y (2019) New insights for cellular and molecular mechanisms of aging and aging-related diseases: herbal medicine as potential therapeutic approach. Oxid Med Cell Longev 2019:4598167. - https://www.ncbi.nlm.nih.gov/pubmed/31915506
  6. Tizabi Y, Getachew B, Csoka AB, Manaye KF, Copeland RL (2019) Novel targets for parkinsonism-depression comorbidity. Prog Mol Biol Transl Sci 167:1-24. - https://www.ncbi.nlm.nih.gov/pubmed/31601399
  7. Voulgaropoulou SD, van Amelsvoort TAMJ, Prickaerts J, Vingerhoets C (2019) The effect of curcumin on cognition in Alzheimer's disease and healthy aging: A systematic review of pre-clinical and clinical studies. Brain Res 1725:146476. - https://www.ncbi.nlm.nih.gov/pubmed/31560864
  8. Yang YSH, Li ZL, Shih YJ, Bennett JA, Whang-Peng J, Lin HY, Davis PJ, Wang K (2019) Herbal medicines attenuate PD-L1 expression to induce anti-proliferation in obesity-related cancers. Nutrients 11 pii: E2979. - https://www.ncbi.nlm.nih.gov/pubmed/31817534
  9. Rocha-Ferreira E, Sisa C, Bright S, Fautz T, Harris M, Contreras Riquelme I, Agwu C, Kurulday T, Mistry B, Hill D, Lange S, Hristova M (2019) Curcumin: novel treatment in neonatal hypoxic-ischemic brain injury. Front Physiol 10:1351. - https://www.ncbi.nlm.nih.gov/pubmed/31798458
  10. Feng D, Zou J, Su D, Mai H, Zhang S, Li P, Zheng X (2019) Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE-/- mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-κB inflammation. Nutr Metab (Lond) 16:79. - https://www.ncbi.nlm.nih.gov/pubmed/31788011
  11. Zhao Y, Chen B, Shen J, Wan L, Zhu Y, Yi T, Xiao Z (2017) The beneficial effects of Quercetin, Curcumin, and Resveratrol in obesity. Oxid Med Cell Longev 2017:1459497. - https://www.ncbi.nlm.nih.gov/pubmed/29138673
  12. Jin T, Song Z, Weng J, Fantus IG (2018) Curcumin and other dietary polyphenols: potential mechanisms of metabolic actions and therapy for diabetes and obesity. Am J Physiol Endocrinol Metab 314:E201-5. - https://www.ncbi.nlm.nih.gov/pubmed/29089337
  13. Tsuda T (2018) Curcumin as a functional food-derived factor: degradation products, metabolites, bioactivity, and future perspectives. Food Funct 9:705-14. - https://www.ncbi.nlm.nih.gov/pubmed/29206254
  14. Sanches-Silva A, Testai L, Nabavi SF, Battino M, Devi KP, Tejada S, Sureda A, Xu S, Yousefi B, Majidinia M, Russo GL, Efferth T, Nabavi SM, Farzaei MH (2020) Therapeutic potential of polyphenols in cardiovascular diseases: regulation of mTOR signaling pathway. Pharmacol Res. 2020 Jan 2:104626. - https://www.ncbi.nlm.nih.gov/pubmed/31904507
  15. Baziar N, Parohan M (2019) The effects of curcumin supplementation on body mass index, body weight, and waist circumference in patients with nonalcoholic fatty liver disease: A systematic review and dose-response meta-analysis of randomized controlled trials. Phytother Res. 2019 Dec 4. doi: 10.1002/ptr.6542. - https://www.ncbi.nlm.nih.gov/pubmed/31799714
  16. Saraf-Bank S, Ahmadi A, Paknahad Z, Maracy M, Nourian M (2019) Effects of curcumin on cardiovascular risk factors in obese and overweight adolescent girls: a randomized clinical trial. Sao Paulo Med J 2019 Nov 4. pii: S1516-31802019005008101. - https://www.ncbi.nlm.nih.gov/pubmed/31691723
  17. Fleenor BS, Carlini NA, Campbell MS (2019) Curcumin and arterial function in health and disease: impact on oxidative stress and inflammation. Curr Opin Clin Nutr Metab Care 22:459-64. - https://www.ncbi.nlm.nih.gov/pubmed/31577640
  18. Li H, Qi J, Li L (2019) Phytochemicals as potential candidates to combat obesity via adipose non-shivering thermogenesis. Pharmacol Res 147:104393. - https://www.ncbi.nlm.nih.gov/pubmed/31401211

MitoPedia: mitObesity drugs

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TermAbbreviationDescription
CurcuminCurcumin has been shown to possess significant anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-mutagenic, anti-coagulant and anti-infective effects. The protective effects of curcumin on rat heart mitochondrial injuries induced by in vitro anoxia–reoxygenation were evaluated by Xu et al 2013. It was found that curcumin added before anoxia or immediately prior to reoxygenation exhibited remarkable protective effects against anoxia–reoxygenation induced oxidative damage to mitochondria.
ElamipretideBendaviaBendavia (Elamipretide) was developed as a mitochondria-targeted drug against degenerative diseases, including cardiac ischemia-reperfusion injury. Clinical trials showed variable results. It is a cationic tetrapeptide which readily passes cell membranes, associates with cardiolipin in the mitochondrial inner membrane. Supercomplex-associated CIV activity significantly improved in response to elamipretide treatment in the failing human heart.
FlavonoidsFlavonoids are a group of bioactive polyphenols with potential antioxidant and anti-inflammatory effects, abundant in fruits and vegetables, and in some medicinal herbs. Flavonoids are synthesized in plants from phenylalanine. Dietary intake of flavonoids as nutraceuticals is discussed for targeting T2D and other degenerative diseases.
MelatoninaMTMelatonin (N-acetyl-5-methoxytryptamine, aMT) is a highly conserved molecule present in unicellular to vertebrate organisms. Melatonin is synthesized from tryptophan in the pinealocytes by the pineal gland and also is produced in other organs, tissues and fluids (extrapineal melatonin). Melatonin has lipophilic and hydrophilic nature which allows it to cross biological membranes. Therefore, melatonin is present in all subcellular compartments predominantly in the nucleus and mitochondria. Melatonin has pleiotropic functions with powerful antioxidant, anti-inflammatory and oncostatic effects with a wide spectrum of action particularly at the level of mitochondria. » MiPNet article
MetforminMetformin is mainly known as an important antidiabetic drug which is effective, however, in a wide spectrum of degenerative diseases. It is an inhibitor of Complex I.
RapamycinRapamycin is an inhibitor of the mammalian/mechanistic target of rapamycin, complex 1 (mTORC1). Rapamycin induces autophagy and dyscouples mitochondrial respiration. Rapamycin delays senescence in human cells, and extends lifespan in mice without detrimental effects on mitochondrial fitness in skeletal muscle.
ResveratrolResveratrol is a natural bioactive phenol prouced by several plants with antioxidant and anti-inflammatory effects. Dietary intake as nutraceutical is discussed for targeting mitochondria with a wide spectrum of action in degenerative diseases.
SpermidineSpermidine is a polycationic bioactive polyamine mainly found in wheat germ, soybean and various vegetables, involved in the regulation of mitophagy, cell growth and cell death. Like other caloric restriction mimetics, spermidine is effective in cardioprotection, neuroprotection and anticancer immunosuppression by preserving mitochondrial function and control of autophagy.
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