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Ceja-Galicia 2022 Antioxidants (Basel)

From Bioblast
Publications in the MiPMap
Ceja-Galicia ZA, García-Arroyo FE, Aparicio-Trejo OE, El-Hafidi M, Gonzaga-Sánchez G, León-Contreras JC, Hernández-Pando R, Guevara-Cruz M, Tovar AR, Rojas-Morales P, Aranda-Rivera AK, Sánchez-Lozada LG, Tapia E, Pedraza-Chaverri J (2022) Therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia: association with the improvement of renal mitochondrial β-oxidation and lipid metabolism in kidney and liver. https://doi.org/10.3390/antiox11112195

» Antioxidants (Basel) 11:2195. PMID: 36358567 Open Access

Ceja-Galicia Zeltzin Alejandra, Garcia-Arroyo Fernando Enrique, Aparicio-Trejo Omar Emiliano, El-Hafidi Mohammed, Gonzaga-Sánchez Guilleromo, Leon-Contreras Juan Carlos, Hernandez-Pando Rogelio, Guevara-Cruz Martha, Tovar Armando R, Rojas-Morales Pedro, Aranda-Rivera Ana Karina, Sanchez-Lozada Laura Gabriela, Tapia Edilia, Pedraza-Chaverri Jose (2022) Antioxidants (Basel)

Abstract: Chronic kidney disease (CKD) prevalence is constantly increasing, and dyslipidemia in this disease is characteristic, favoring cardiovascular events. However, the mechanisms of CKD dyslipidemia are not fully understood. The use of curcumin (CUR) in CKD models such as 5/6 nephrectomy (5/6Nx) has shown multiple beneficial effects, so it has been proposed to correct dyslipidemia without side effects. This work aimed to characterize CUR's potential therapeutic effect on dyslipidemia and alterations in lipid metabolism and mitochondrial ß-oxidation in the liver and kidney in 5/6Nx. Male Wistar rats were subjected to 5/6Nx and progressed by 4 weeks; meanwhile, CUR (120 mg/kg) was administered for weeks 5 to 8. Our results showed that CUR reversed the increase in liver and kidney damage and hypertriglyceridemia induced by 5/6Nx. CUR also reversed mitochondrial membrane depolarization and β-oxidation disorders in the kidney and the increased lipid uptake and the high levels of proteins involved in fatty acid synthesis in the liver and kidney. CUR also decreased lipogenesis and increased mitochondrial biogenesis markers in the liver. Therefore, we concluded that the therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia is associated with the restoration of renal mitochondrial ß-oxidation and the reduction in lipid synthesis and uptake in the kidneys and liver. Keywords: Antioxidant, Chronic kidney disease (CKD), Curcumin, Dyslipidemia, Fatty acids ß-oxidation, Hypertriglyceridemia, Lipid metabolism, Liver alteration in CKD, Mitochondrial dysfunction, Triglycerides Bioblast editor: Plangger M O2k-Network Lab: MX Mexico City Pedraza Chaverri J


Labels: MiParea: Respiration, Pharmacology;toxicology  Pathology: Other 

Organism: Rat  Tissue;cell: Kidney  Preparation: Isolated mitochondria 

Regulation: mt-Membrane potential  Coupling state: LEAK, OXPHOS  Pathway: F, N, ROX  HRR: Oxygraph-2k, O2k-Fluorometer 

2022-11