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• Cyanide
  |description='''Cyanide''' (usually added as KCN) is a competitive inhibitor of [[Complex_IV| cytochcrome ''c'' oxidase (CIV)]]. Inhibition is reversed {{MitoPedia O2k and high-resolution respirometry|type=Inhibitor ETS
  3 KB (360 words) - 09:51, 10 June 2021
• Sun 2012 Front Mol Neurosci
  ...ylketone completely inhibited caspase activation, while treatment with the inhibitor of calpains- and papain-like cathepsins (2S,3S)-trans-epoxysuccinyl-leucyla
  2 KB (278 words) - 13:52, 29 July 2016
• Azide
  |description='''Sodium azide''' is an inhibitor of [[Complex IV]]/cytochrome ''c'' oxidase (CIV, COX, CcO). |type=Inhibitor ETS
  2 KB (337 words) - 17:28, 16 December 2021
• Belosludtsev 2018 Biochemistry (Mosc)
  ...s of dequalinium (≤10 μM), this swelling is inhibited by cyclosporin A, an inhibitor of the mitochondrial permeability transition pore. At the same time, at hig |topics=Inhibitor, Ion;substrate transport
  2 KB (282 words) - 09:04, 5 October 2018
• Hildyard 2003 Biochem J
  ...ily (MCF). Only mitochondria from the YIL006w deletion mutant exhibited no inhibitor-sensitive pyruvate transport, but otherwise behaved normally. YIL006w encod
  1 KB (138 words) - 17:17, 16 January 2021
• Degli Esposti 1998 Biochim Biophys Acta
  ...compounds and their potency is related to that of rotenone, the classical inhibitor of complex I. Among commercial products, particular attention is dedicated |keywords=NADH–ubiquinone reductase; Respiratory inhibitor; Ubiquinone
  1 KB (158 words) - 13:55, 12 March 2021
• Auranofin
  ...itochondria: Trx system. Additionally, [[dinitrochlorobenzene]] (DNCB), an inhibitor of glutathione (GSH) can be used to obtain the GSH contribution scavenging ...H, Kim GY, Moon SK, Cheong J, Kim WJ, Yoo YH, Choi YH (2017) Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep
  2 KB (282 words) - 10:11, 11 September 2020
• Strobilurin
  |mitopedia topic=Inhibitor
  498 bytes (64 words) - 02:46, 23 January 2023
• Mathiyazakan 2023 Antimicrob Agents Chemother
  ...cobacterium tuberculosis'' cytochrome ''bcc:aa''3 supercomplex and a novel inhibitor targeting subunit cytochrome ''c''I. Antimicrob Agents Chemother 67:e015312 ...ion via the cIcII head. The successful identification of a new cyt-bcc:aa3 inhibitor demonstrates the potential of a structure-mechanism-based approach for nove
  2 KB (335 words) - 18:10, 17 September 2023
• Becker 1999 Am J Physiol
  ...dase inhibitor diphenyleneiodonium (0.9 +/- 0.1). By contrast, the site IV inhibitor cyanide, as well as inhibitors of xanthine oxidase (allopurinol), nitric ox
  2 KB (242 words) - 17:49, 13 April 2022
• Stoner 1984 J Bioenerg Biomembr
  ...ill make the other more rate limiting and thus will decrease the amount of inhibitor of the other required for half-maximal inhibition. These two types of "coup
  3 KB (369 words) - 22:45, 16 February 2021
• Grefte 2015 Biochim Biophys Acta
  ...bited by Rot (10-100 nM), but not by piericidin A (PA; 100 nM), another CI inhibitor. At 100 nM, both Rot and PA fully blocked myoblast oxygen consumption. Knoc |topics=Inhibitor
  2 KB (244 words) - 10:43, 9 November 2016
• Razak 2018 RUMeS
  ...s measured using OROBOROS HRR Oxygraph-2k according to substrate-uncoupler-inhibitor titration (SUIT) protocol. ...d following the addition of complex I inhibitor (rotenone) and complex III inhibitor (antimycin A).
  2 KB (322 words) - 11:47, 8 April 2019
• Briston 2016 Sci Rep
  ...owney B (2016) Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in ...dependent of CypD inhibition. Here we identified a novel, CypD-independent inhibitor of the mPTP. The screening approach and compound described provides a workf
  2 KB (331 words) - 14:25, 21 September 2021
• Kunz 1993 FEBS Lett
  ...or EGTA, the inhibitor of Ca²⁺ transport Ruthenium red and the inhibitor of the myosin ATPase vanadate. The caffeine concentration dependency of res
  1 KB (185 words) - 11:00, 27 March 2018
• Qvit 2022 Pharmaceuticals (Basel)
  ...A, Ostberg NP, Campos JC, Ferreira JCB, Mochly-Rosen D (2022) A selective inhibitor of cardiac troponin I phosphorylation by delta protein kinase C (δPKC) as ...ylation of cTnI is critical in IR injury, and that a cTnI/δPKC interaction inhibitor should be considered as a therapeutic target to reduce cardiac injury after
  2 KB (280 words) - 18:55, 6 December 2022
• Kopitar-Jerala 2017 Abstract MITOEAGLE Barcelona
  ...nes in macrophages. It was reported that metformin, mitochondria complex I inhibitor, decreased production of the pro-form of the inflammatory cytokine IL-1β a Stefin B (cystatin B) is an endogenous cysteine cathepsin inhibitor, and the loss-of-function mutations in the stefin B gene were reported in p
  2 KB (289 words) - 08:17, 21 February 2020
• Gottfried 2013 PLoS One
  ..., diclofenac holds potential as a clinically applicable MYC and glycolysis inhibitor supporting established tumor therapies.
  3 KB (382 words) - 08:54, 21 February 2020
• Vanden Hoek 1998 J Biol Chem
  ...y myxothiazol, but not by diphenyleneiodonium or the nitric-oxide synthase inhibitor L-nitroarginine. We conclude that hypoxia increases mitochondrial superoxid
  2 KB (263 words) - 20:58, 11 April 2022
• Etomoxir
  ...(Eto; 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate) is an irreversible inhibitor of [[carnitine palmitoyltransferase I]] (CPT-I) on the outer face of the mi |mitopedia topic=Inhibitor
  1 KB (184 words) - 06:35, 20 April 2023

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