Difference between revisions of "Malic enzyme"
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== ME, aging and cancer == | |||
* http://www.uphs.upenn.edu/news/News_Releases/2013/01/yang/ | |||
= List of publications: Malic enzyme = | = List of publications: Malic enzyme = | ||
{{#ask:[[Category:Publications]] [[Additional label::Malic enzyme]] | {{#ask:[[Category:Publications]] [[Additional label::Malic enzyme]] | ||
Revision as of 19:28, 30 July 2014
- high-resolution terminology - matching measurements at high-resolution
Malic enzyme
Description
Malic enzyme (ME; EC 1.1.1.40) catalyzes the oxidative decarboxylation of L-malate to pyruvate with the concomitant reduction of the dinucleotide cofactor NAD+ or NADP+ and a requirement for divalent cations (Mg2+ or Mn2+) as cofactors.
NAD(P)+ + L-malate2- <--> NAD(P)H + pyruvate- + CO2
Three groups of ME are distinguished (i) NAD+- and (ii) NADP+-dependent ME specific for NAD+ or NADP+, respectively, and (iii) NAD(P)+- dependent ME with dual specificity for NAD+ or NADP+ as cofactor. Three isoforms of ME have been identified in mammals: cytosolic NADP+-dependent ME (cNADP-ME), mitochondrial NADP+-dependent ME (mtNADP-ME), and mitochondrial NAD(P)+-dependent ME (mtNAD-ME; with NAD+ or NADP+ as cofactor, preference for NAD+ under physiological conditions). mtNAD-ME plays an important role in anaplerosis when glucose is limiting.
Abbreviation: mtME
Reference: Sauer 1980 J Biol Chem
MitoPedia topics: Enzyme
ME, aging and cancer
List of publications: Malic enzyme
| Year | Reference | Mammal and model | Tissue and cell | Stress | Diseases | |
|---|---|---|---|---|---|---|
| Gnaiger 2020 BEC MitoPathways | 2020 | Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002 | Human Mouse | Heart Skeletal muscle Fibroblast | ||
| Gaude 2014 Cancer Metab | 2014 | Gaude E, Frezza C (2014) Defects in mitochondrial metabolism and cancer. Cancer Metab 2:10. | Human | Cancer | ||
| Ren 2014 Sci Rep | 2014 | Ren JG, Seth P, Clish CB, Lorkiewicz PK, Higashi RM, Lane AN, Fan TW, Sukhatme VP (2014) Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling. Sci Rep 4:5414. | Human | Lung;gill Other cell lines | Cancer | |
| Jiang 2013 Nature | 2013 | Jiang P, Du W, Mancuso A, Wellen KE, Yang X (2013) Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature 493:689-93. | Human Mouse | Cell death Oxidative stress;RONS | Aging;senescence Cancer | |
| Pon 2011 Malar J | 2011 | Pon J, Napoli E, Luckhart S, Giulivi C (2011) Mitochondrial NAD+-dependent malic enzyme from Anopheles stephensi: a possible novel target for malaria mosquito control. Malar J Oct 26;10:318. doi: 10.1186/1475-2875-10-318. | Hexapods | |||
| Henry 2011 Bioprocess Biosyst Eng | 2011 | Henry O, Jolicoeur M, Kamen A (2011) Unraveling the metabolism of HEK-293 cells using lactate isotopomer analysis. Bioprocess Biosyst Eng 34:263-73. | Human | HEK | ||
| Giulivi 2008 Biochem J | 2008 | Giulivi C, Ross-Inta C, Horton AA, Luckhart S (2008) Metabolic pathways in Anopheles stephensi mitochondria. Biochem J 415:309-16. | Human Rat Birds Hexapods | Skeletal muscle | ||
| Pongratz 2007 J Biol Chem | 2007 | Pongratz RL, Kibbey RG, Shulman GI, Cline GW (2007) Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion. J Biol Chem 282:200-7. | Rat | Islet cell;pancreas;thymus Other cell lines | Diabetes | |
| Hsu 2004 Biochemistry | 2004 | Hsu WC, Hung HC, Tong L, Chang GG (2004) Dual functional roles of ATP in the human mitochondrial malic enzyme. Biochemistry 43: 7382-90. | ||||
| Hassel 2000 Mol Neurobiol | 2000 | Hassel B (2000) Carboxylation and anaplerosis in neurons and glia. Mol Neurobiol 22: 21-40. | Nervous system | |||
| Xu 1999 Structure | 1999 | Xu Y, Bhargava G, Wu H, Loeber G, Tong L (1999) Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme: a new class of oxidative decarboxylases. Structure 7: R877-89. | Human | |||
| McKenna 1995 Neurochem Res | 1995 | McKenna MC, Tildon JT, Stevenson JH, Huang X, Kingwell KG (1995) Regulation of mitochondrial and cytosolic malic enzymes from cultured rat brain astrocytes. Neurochem Res 20: 1491-501. | Nervous system | |||
| Loeber 1994 Biochem J | 1994 | Loeber G, Maurer-Fogy I, Schwendenwein R (1994) Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme. Biochem J 304:687-92. | Human Bovines | Heart | ||
| Zelewski 1991 Eur J Biochem | 1991 | Zelewski M, Swierczyński J (1991) Malic enzyme in human liver. Intracellular distribution, purification and properties of cytosolic isozyme. Eur J Biochem 201:339-45. | Human Rat | Liver | ||
| Russell 1991 Am J Physiol | 1991 | Russell RR, Taegtmeyer H (1991) Pyruvate carboxylation prevents the decline in contractile function of rat hearts oxidizing acetoacetate. Am J Physiol 261:H1756-62. | Rat | Heart | ||
| Taroni 1987 Biochim Biophys Acta | 1987 | Taroni F, Gellera C, Di Donato S (1987) Evidence for two distinct mitochondrial malic enzymes in human skeletal muscle: Purification and properties of the NAD(P)+-dependent enzyme. Biochim Biophys Acta 916: 446-454. | Human | Skeletal muscle | ||
| Skorkowski 1984 Comp Biochem Physiol | 1984 | Skorkowski EF, Aleksandrowicz Z, Scisłowski PW, Swierczyński J (1984) Evidence for the role of malic enzyme in the rapid oxidation of malate by cod heart mitochondria. Comp Biochem Physiol B 77:379-84. | Rat Rabbit Fishes | Heart | ||
| Nagel 1982 J Biol Chem | 1982 | Nagel WO, Sauer LA (1982) Mitochondrial malic enzymes. Purification and properties of the NAD(P)-dependent malic enzyme from canine small intestinal mucosa. J Biol Chem 257: 12405-11. | Dog | |||
| McKeehan 1982 Cell Biol Int Rep | 1982 | McKeehan WL (1982) Glycolysis, glutaminolysis and cell proliferation. Cell Biol Int Rep 6:635-50. | Aging;senescence Cancer | |||
| Hiltunen 1981 Biochim Biophys Acta | 1981 | Hiltunen JK, Davis EJ (1981) The disposition of citric acid cycle intermediates by isolated rat heart mitochondria. Biochim Biophys Acta 678:115-21. | Rat | Heart | ||
| Sauer 1980 J Biol Chem | 1980 | Sauer LA, Dauchy RT, Nagel WO, Morris HP (1980) Mitochondrial malic enzymes. Mitochondrial NAD(P)+-dependent malic enzyme activity and malate-dependent pyruvate formation are progression-linked in Morris hepatomas. J Biol Chem 255:3844-8. | Rat | Liver | Cancer | |
| Nagel 1980 J Biol Chem | 1980 | Nagel WO, Dauchy RT, Sauer LA (1980) Mitochondrial malic enzymes. An association between NAD(P)+-dependent malic enzyme and cell renewal in Sprague-Dawley rat tissues. J Biol Chem 255:3849-54. | Rat | Heart Skeletal muscle Nervous system Liver Kidney Lung;gill Islet cell;pancreas;thymus Genital | ||
| Sauer 1979 Biochem J | 1979 | Sauer LA, Dauchy RT, Nagel WO (1979) Identification of an NAD(P)+-dependent 'malic' enzyme in small-intestinal-mucosal mitochondria. Biochem J 184:185-8. | Human Bovines Dog Cat Chicken | |||
| Sauer 1978 Cancer Res | 1978 | Sauer LA, Dauchy RT (1978) Identification and properties of the nicotinamide adenine dinucleotide (phosphate)+-dependent malic enzyme in mouse ascites tumor mitochondria. Cancer Res 38:1751-6. | Cancer | |||
| Gnaiger 1977 Invertebrate anoxibiosis | 1977 | Gnaiger E (1977) Thermodynamic considerations of invertebrate anoxibiosis. In: Applications of calorimetry in life sciences. Lamprecht I, Schaarschmidt B (eds), de Gruyter, Berlin:281-303. | Annelids Molluscs | Ischemia-reperfusion | ||
| Mandella 1975 J Biol Chem | 1975 | Mandella RD, Sauer LA (1975) The mitochondrial malic enzymes. I. Submitochondrial localization and purification and properties of the NAD(P)+-dependent enzyme from adrenal cortex. J Biol Chem 250:5877-84. | Rat Bovines | Nervous system | ||
| Sauer 1973 Biochem Biophys Res Commun | 1973 | Sauer LA (1973) An NAD- and NADP-dependent malic enzyme with regulatory properties in rat liver and adrenal cortex mitochondrial fractions. Biochem Biophys Res Commun 50:524-31. | Rat | Nervous system Liver |
