Nagel 1980 J Biol Chem

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Nagel WO, Dauchy RT, Sauer LA (1980) Mitochondrial malic enzymes. An association between NAD(P)+-dependent malic enzyme and cell renewal in Sprague-Dawley rat tissues. J Biol Chem 255:3849-54.

» PMID: 7372653 Open Access

Nagel WO, Dauchy RT, Sauer LA (1980) J Biol Chem

Abstract: The activities of the mitochondrial NAD(P)+- and NADP+-dependent malic enzymes were measured in 11 tissues of the male Sprague-Dawley rat. The NAD(P)+-dependent malic enzyme was present in small intestinal mucosa, spleen, thymus, lung, and testis. Each of these tissues contain cells that are undergoing active rates of renewal. The NADP+-dependent malic enzyme was not confined to tissues undergoing cell renewal, and was present in mitochondria from brain, skeletal, and heart muscle, kidney, and lung and testis. Both enzymes were absent or at a low activity in normal and regenerating liver. The results support, and extent to nonneoplastic tissues, our proposal that cells which show active and sustained rates of renewal contain the NAD(P)+-dependent malic enzyme and have a unique intramitochondrial pathway for malate oxidation (Sauer 1980 J Biol Chem).


Labels: MiParea: Respiration 


Organism: Rat  Tissue;cell: Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Genital  Preparation: Isolated mitochondria, Enzyme  Enzyme: TCA cycle and matrix dehydrogenases 



Malic enzyme