Sauer 1980 J Biol Chem

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Sauer LA, Dauchy RT, Nagel WO, Morris HP (1980) Mitochondrial malic enzymes. Mitochondrial NAD(P)+-dependent malic enzyme activity and malate-dependent pyruvate formation are progression-linked in Morris hepatomas. J Biol Chem 255:3844-8.

» PMID: 7372652 Open Access

Sauer LA, Dauchy RT, Nagel WO, Morris HP (1980) J Biol Chem

Abstract:
Sauer 1980 J Biol Chem.jpg
In the presence of ADP, pyruvate formed from malate was rapidly oxidized to CO2 by pyruvate dehydrogenase. The production and oxidation of pyruvate occurred entirely within the mitochondrial matrix space. The results are consistent with a role for the NAD(P)+-dependent malic enzyme in net glutamine oxidation in undifferentiated hepatomas.


Labels: MiParea: Respiration  Pathology: Cancer 

Organism: Rat  Tissue;cell: Liver  Preparation: Isolated mitochondria 


Coupling state: OXPHOS 


Malic enzyme