Zverova 2019 Neuropsychiatr Dis Treat: Difference between revisions
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Revision as of 09:49, 14 August 2019
ZvΔΕovΓ‘ M, HroudovΓ‘ J, FiΕ‘ar Z, HansΓkovΓ‘ H, KaliΕ‘ovΓ‘ L, KitzlerovΓ‘ E, LambertovΓ‘ A, Raboch J (2019) Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder. Neuropsychiatr Dis Treat 15:233-40. |
Zverova M, Hroudova J, Fisar Z, Hansikova H, Kalisova L, Kitzlerova E, Lambertova A, Raboch J (2019) Neuropsychiatr Dis Treat
Abstract: Mitochondrial dysfunctions are implicated in the pathophysiology of mood disorders. We measured and examined the following selected mitochondrial parameters: citrate synthase (CS) activity, electron transport system (ETS) complex (complexes I, II, and IV) activities, and mitochondrial respiration in blood platelets.
The analyses were performed for 24 patients suffering from a depressive episode of bipolar affective disorder (BD), compared to 68 patients with MDD and 104 healthy controls. BD and unipolar depression were clinically evaluated using well-established diagnostic scales and questionnaires.
The CS, complex II, and complex IV activities were decreased in the depressive episode of BD patients; complex I and complex I/CS ratio were significantly increased compared to healthy controls. We observed significantly decreased complex II and CS activities in patients suffering from MDD compared to controls. Decreased respiration after complex I inhibition and increased residual respiration were found in depressive BD patients compared to controls. Physiological respiration and capacity of the ETS were decreased, and respiration after complex I inhibition was increased in MDD patients, compared to controls. Increased complex I activity can be a compensatory mechanism for decreased CS and complex II and IV activities.
We can conclude that complex I and its abnormal activity contribute to the defects in cellular energy metabolism during a depressive episode of BD. The observed parameters could be used in a panel of biomarkers that could selectively distinguish BD depression from MDD and can be easily examined from blood elements. β’ Keywords: Affective disorder, Biomarker, Mitochondrial enzyme, Oxidative phosphorylation, Platelet β’ Bioblast editor: Plangger M β’ O2k-Network Lab: CZ Prague Fisar Z, CZ Prague Zeman J
Labels: MiParea: Respiration, Patients
Pathology: Other
Organism: Human Tissue;cell: Platelet Preparation: Intact cells Enzyme: Complex I, Complex II;succinate dehydrogenase, Complex IV;cytochrome c oxidase
Coupling state: LEAK, ROUTINE, ET Pathway: ROX HRR: Oxygraph-2k
2019-01