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Electron transfer-pathway state will depend on the substrate added to fuel the mitochondrial respiration. To obtain the NADH electron transfer-pathway state (N), NADH-linked substrates (CI-linked), feeding electrons into the N-junction catalyzed by various mt-dehydrogenases. The most commonly applied N-junction substrate combinations are: PM, GM, PGM. The Succinate pathway control state (S), succinate-linked respiration or S-pathway is achieved with succinate as the single substrate, at ET-pathway level 3.