Difference between revisions of "TissueModels"
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== TissueModels: FFG BRIDGE Young Scientists == | |||
::::* Open postdoc position: [https://www.i-med.ac.at/biochemgen/documents/Biochemical-Genetics_Experimental-Postdoc_01.2022.pdf Biochemical-Genetics_Experimental-Postdoc_01.2022.pdf] | |||
::::* BRIDGE Young Scientists 2. Call - Project No. 878654, Medical University Innsbruck, Institute of Human Genetics | ::::* BRIDGE Young Scientists 2. Call - Project No. 878654, Medical University Innsbruck, Institute of Human Genetics | ||
::::* '''Duration''': 36 months | ::::* '''Duration''': 36 months | ||
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:::::* To evaluate the metabolic consequences of incubation with selected media with emphasis on mitochondrial energetics. | :::::* To evaluate the metabolic consequences of incubation with selected media with emphasis on mitochondrial energetics. | ||
:::::* To assess the membrane lipid architecture of cells exposed to selected media to evaluate to which extent the remodeling and/or ''de novo'' synthesis of cell lipids were altered and to compare the lipidome with that of the original tissue. | :::::* To assess the membrane lipid architecture of cells exposed to selected media to evaluate to which extent the remodeling and/or ''de novo'' synthesis of cell lipids were altered and to compare the lipidome with that of the original tissue. | ||
=== Reference === | |||
::::* Oemer G, Lackner L, Muigg K, Krumschnabel G, Watschinger K, Sailer S, Lindner H, Gnaiger E, Wortmann SB, Werner ER, Zschocke J, Keller MA (2018) The molecular structural diversity of mitochondrial cardiolipins. Proc Nat Acad Sci U S A 115:4158-63. - » [[Oemer 2018 Proc Nat Acad Sci U S A |Bioblast link]]« | |||
| Line 29: | Line 32: | ||
== Network == | == Network == | ||
=== Participants === | === Participants === | ||
::::'''Institute of Human Genetics, Medical University Innsbruck''' - | ::::'''Institute of Human Genetics, Medical University Innsbruck''' - [https://www.i-med.ac.at/biochemgen/ www.biochemgen.at] | ||
::::* [[Keller Markus A| '''Dr. Markus A. Keller''']] - Project Coordinator, WP 1 & 5 Leader | ::::* [[Keller Markus A| '''Dr. Markus A. Keller''']] - Project Coordinator, WP 1 & 5 Leader | ||
::::* [[Wohlfarter Y |'''Yvonne Wohlfarter''']] - WP 2 Leader | ::::* [[Wohlfarter Y |'''Yvonne Wohlfarter''']] - WP 2 Leader | ||
| Line 43: | Line 45: | ||
::::* [[Laner V| '''Verena Laner''']] - Oroboros project management | ::::* [[Laner V| '''Verena Laner''']] - Oroboros project management | ||
::::* [[Tindle-Solomon L| '''Lisa Tindle-Solomon''']] - Oroboros project management | ::::* [[Tindle-Solomon L| '''Lisa Tindle-Solomon''']] - Oroboros project management | ||
== Oroboros project involvement == | == Oroboros project involvement == | ||
:::: Oroboros Instruments | :::: Oroboros Instruments provides both infrastructure and the expertise required to conduct the respirometric measurements of the project. | ||
:::: The Institute for Human Genetics has been equipped with 2 O2ks for the duration of the project. | |||
== | == TissueModels Events == | ||
{{#ask:[[Category:Publications]] [[Additional label::TissueModels]] | {{#ask:[[Category:Publications]] [[Additional label::TissueModels events]] | ||
|?Was published in year=When | |?Was published in year=When | ||
|?Has title=Where | |?Has title=Where | ||
| Line 60: | Line 59: | ||
|offset=0 | |offset=0 | ||
|sort=Was published in year | |sort=Was published in year | ||
|order= | |order=descending | ||
}} | }} | ||
== TissueModels Publications == | |||
{{#ask:[[Additional label::TissueModels]] | |||
| mainlabel=Link | |||
|?Has title=Reference | |||
|?Has info=View | |||
|?Was published in year=Year | |||
|format=broadtable | |||
|limit=5000 | |||
|offset=0 | |||
|sort=Has title | |||
|order=descending | |||
}} | |||
== Links == | == Links == | ||
:::: | '''News and articles''' | ||
:::: [https://www.i-med.ac.at/mypoint/thema/745912.html Bridge-Projekt „Tissue Models“ erforscht das Potential gewebsspezifischer Zellkultur], www.i-med.ac.at, 2020-06-04 | |||
== Support == | == Support == | ||
This project has received funding from the Austrian | :::: This project has received funding from the Austrian Research Promotion Funding Agency (FFG). [[File:FFG-logo.png|left|100px]] | ||
Latest revision as of 16:09, 27 January 2022
TissueModels
TissueModels - Establishing tissue-specific cell models with culture medium additives
TissueModels: FFG BRIDGE Young Scientists
- Open postdoc position: Biochemical-Genetics_Experimental-Postdoc_01.2022.pdf
- BRIDGE Young Scientists 2. Call - Project No. 878654, Medical University Innsbruck, Institute of Human Genetics
- Duration: 36 months
- Start: 2020-04-01
About TissueModels
- Led by the Institute of Human Genetics at the Medical University Innsbruck, the TissueModels project aims to establish physiological models for the specific tissue type under investigation by defining medium compositions that preserve or re-establish structural and metabolic characteristics of cells during in vitro culture.
Aims
- The specific aims are:
- To identify medium composition with emphasis on the levels of selected fatty acids and of glucose that support growth and viability of cell lines originally derived from different tissues.
- To evaluate the metabolic consequences of incubation with selected media with emphasis on mitochondrial energetics.
- To assess the membrane lipid architecture of cells exposed to selected media to evaluate to which extent the remodeling and/or de novo synthesis of cell lipids were altered and to compare the lipidome with that of the original tissue.
- The specific aims are:
Reference
- Oemer G, Lackner L, Muigg K, Krumschnabel G, Watschinger K, Sailer S, Lindner H, Gnaiger E, Wortmann SB, Werner ER, Zschocke J, Keller MA (2018) The molecular structural diversity of mitochondrial cardiolipins. Proc Nat Acad Sci U S A 115:4158-63. - » Bioblast link«
Coordinator
- Dr. Markus A. Keller - Dr. Markus A. Keller, Institute of Human Genetics, Medical University Innsbruck- https://www.i-med.ac.at/imcbc/staff_doc/Keller_Markus.html
Network
Participants
- Institute of Human Genetics, Medical University Innsbruck - www.biochemgen.at
- Dr. Markus A. Keller - Project Coordinator, WP 1 & 5 Leader
- Yvonne Wohlfarter - WP 2 Leader
- Jakob Koch - WP 4 Leader
- Institute of Human Genetics, Medical University Innsbruck - www.biochemgen.at
- Oroboros Instruments GmbH - www.oroboros.at
- Erich Gnaiger, Ph.D. - PI
- Luiza Cardoso, Ph.D. - WP 3 Leader
- Verena Laner - Oroboros project management
- Lisa Tindle-Solomon - Oroboros project management
- Oroboros Instruments GmbH - www.oroboros.at
Oroboros project involvement
- Oroboros Instruments provides both infrastructure and the expertise required to conduct the respirometric measurements of the project.
- The Institute for Human Genetics has been equipped with 2 O2ks for the duration of the project.
TissueModels Events
TissueModels Publications
| Link | Reference | View | Year |
|---|---|---|---|
| Oemer 2021 J Lipid Res | Oemer G, Edenhofer ML, Wohlfarter Y, Lackner K, Leman G, Koch J, Cardoso LHD, Lindner HH, Gnaiger E, Dubrac S, Zschocke J, Keller MA (2021) Fatty acyl availability modulates cardiolipin composition and alters mitochondrial function in HeLa cells. https://doi.org/10.1016/j.jlr.2021.100111 | J Lipid Res 100111. PMID: 34450173 Open Access | 2021 |
Links
News and articles
- Bridge-Projekt „Tissue Models“ erforscht das Potential gewebsspezifischer Zellkultur, www.i-med.ac.at, 2020-06-04
Support
- This project has received funding from the Austrian Research Promotion Funding Agency (FFG).
- This project has received funding from the Austrian Research Promotion Funding Agency (FFG).
