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• Samardzic 2016 Abstract Mito Xmas Meeting Innsbruck
  |title=Increased Opa1 levels aggravate B cell lymphoma. ...le to apoptosis, whereas cellular and animal models of Opa1 overexpression display a resistance to apoptosis.
  2 KB (317 words) - 15:20, 14 December 2016
• Simard 2020b Metabolites
  ...haud N (2020) Role of the mitochondrial pyruvate carrier in the occurrence of metabolic inflexibility in ''Drosophila melanogaster'' exposed to dietary s ...pendently of the diet provided. This study thus highlights the involvement of MPC as an essential protein in ''Drosophila'' to maintain proper metabolic
  2 KB (328 words) - 22:33, 22 October 2020
• Lamberti 2015 Cold Spring Harb Protoc
  |title=Lamberti G, de Araújo ME, Huber LA (2015) Isolation of macrophage early and late endosomes by latex bead internalization and densi ...ls at different time points after internalization permits the purification of different organelle fractions, particularly early and late endosomes.
  1 KB (146 words) - 16:10, 9 November 2016
• Wagenaars 2014 Abstract IOC 2014-04 Schroecken
  |title=Wagenaars J, Willems PHGM, Koopman WJ (2014) Oxygen consumption in OXPHOS-d ...tein complex of the ETC and couples the oxidation of NADH to the reduction of ubiquinone.
  3 KB (352 words) - 15:46, 9 November 2016
• Aon 2010 Biochim Biophys Acta
  |title=Aon MA, Cortassa S, O'Rourke B (2010) Redox-optimized ROS balance: a unifyi ...mitochondrial membrane potential, Psim), whereas intact cardiac cells can display oxidative stress either when mitochondria become more uncoupled (i.e., low
  2 KB (323 words) - 21:46, 24 September 2021
• Plotegher 2017 Trends Mol Med
  |title=Plotegher N, Duchen MR (2017) Mitochondrial dysfunction and neurodegenerati ...ochondrial pathways represent a new therapeutic frontier in the management of LSDs.
  1 KB (180 words) - 13:45, 28 November 2017
• Postma 2018 bioRxiv
  |title=Postma M, Goedhart J (2018) PlotsOfData - a web app for visualizing data to ...inferences. By adjusting the transparency of the layers, the visualization of the raw data together with the summary can be tuned for optimal presentatio
  2 KB (247 words) - 19:57, 13 December 2018
• Samardzic 2015 Abstract MiPschool London 2015
  |title=''In vitro'' and ''in vivo'' study of the mitochondria shaping protein Opa1 in cancer. ...le to apoptosis, whereas cellular and animal models of Opa1 overexpression display a resistance to apoptosis.
  3 KB (406 words) - 15:06, 9 November 2016
• Ehrenberg 1988 Biophys J
  ...tial can be determined in individual cells from the nernstian distribution of cationic dyes. Biophys J 53: 785-789. ...ters are nontoxic, highly fluorescent dyes which do not form aggregates or display binding-dependent changes in fluorescence efficiency. Thus, their reversibl
  2 KB (267 words) - 10:06, 21 March 2014
• Rej 1993 Arch Pathol Lab Med
  ...yme activity measurements: Two decades of development in the commutability of enzyme quality control materials. Arch Pathol Lab Med 117(4):352-64. ...ferase, alpha-amylase, and alkaline phosphatase to judge the commutability of quality control materials for these enzymes.
  2 KB (254 words) - 11:53, 26 January 2021
• Brunelle 2005 Cell Metab
  |title=Brunelle JK, Bell EL, Quesada NM, Vercauteren K, Tiranti V, Zeviani M, Scar ...t on mitochondrial-generated reactive oxygen species (ROS) but independent of oxidative phosphorylation.
  2 KB (223 words) - 13:37, 31 May 2019
• Dubinski 2018 Biochim Biophys Acta
  ...=Dubinski AF, Camasta R, Soule TGB, Reed BH, Glerum DM (2018) Consequences of cytochrome c oxidase assembly defects for the yeast stationary phase. Bioch ...ary phase. Our results suggest that mitochondria may not be a major source of reactive oxygen species at stationary phase in cells lacking an intact resp
  2 KB (233 words) - 13:10, 25 April 2018
• Rodrigues 2016 Biochem J
  ...HOS, glutaminolysis and beta-oxidation constitute the metastatic phenotype of melanoma cells. https://doi.org/10.1042/BJ20150645 ...results presented here have centered on how the multiple metabolic inputs of tumor cells may converge to compose the so called metastatic phenotype.
  3 KB (425 words) - 14:10, 12 June 2022
• Anoar 2021 Front Neurosci
  |title=Anoar S, Woodling NS, Niccoli T (2021) Mitochondria dysfunction in frontote ...ted with FTD/ALS disrupt mitochondrial function, and we review how the use of ''Drosophila'' models has been pivotal to our current knowledge in this fie
  2 KB (268 words) - 15:12, 5 October 2023
• Kuznetsov 1998 BTK
  ...znetsov AV, Lassnig B, Margreiter R, Gnaiger E (1998) Diffusion limitation of oxygen versus ADP in permeabilized muscle fibers. In BioThermoKinetics in t ...eabilized muscle fibers [8]. In the present study we addressed the problem of oxygen limited respiration by comparing the oxygen kinetics in permeabilize
  2 KB (222 words) - 04:27, 23 November 2021
• Dufour 2013 Appl Environ Microbiol
  ..., Rosenfeld E, Stintzi A, Baysse C (2013) Insights into the mode of action of benzylisothiocyanate on ''Campylobacter jejuni''. Appl Environ Microbiol 79 ...e affects ''C. jejuni'' by targeting proteins, resulting in the disruption of major metabolic processes and eventually leading to cell death.
  2 KB (248 words) - 16:36, 26 March 2018
• Jimenez-Marco 2022 Platelets
  |title=Jimenez-Marco T, Castrillo A, Hierro-Riu F, Vicente V, Rivera J (2022) Froz ...n centers explore the possibility of split platelet inventories consisting of platelets stored at room temperature and cryopreserved and cold-stored plat
  2 KB (233 words) - 08:57, 9 November 2023
• Wolf 2019 EMBO J
  ...esa M, Shirihai OS (2019) Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. EMBO J 38:e ...chondrion behave as independent bioenergetic units, preventing the failure of specific cristae from spreading dysfunction to the rest.
  2 KB (268 words) - 10:20, 3 April 2022
• Amoedo 2013 Biosci Rep
  ...umjanek FD (2013) How does the metabolism of tumour cells differ from that of normal cells. Biosci Rep 33:e00080 ...argets for inhibitors. In this respect, a case study describing the effect of a metabolite analogue, the alkylating agent 3-bromopyruvate, on glycolytic
  2 KB (303 words) - 15:34, 22 February 2018
• Gabrielova 2011 Abstract IOC61
  ...k M, Gazak R, Vostalova J, Jezek J, Kren V, Modriansky M (2011) Evaluation of an oxygen consumption in rat heart mitochondria treatment by polyphenol com ...l aging and means have been sought to attenuate ROS formation with the aim of extending the cell lifespan.
  2 KB (289 words) - 14:24, 13 February 2015
• Iannetti 2016 Nat Protoc
  ...Beyrath J, Willems PH, Koopman WJ (2016) Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy. Nat Protoc 11:1693 ...variate and multivariate analysis. The protocol requires a time investment of ∼4 h distributed over 2 d. Although it is specifically developed for PHSF
  2 KB (218 words) - 14:33, 27 March 2018
• Han 2017 MiP2017
  |title=[[Image:MiPsocietyLOGO.JPG|left|90px|Mitochondrial Physiology Society|MiPso ...underlying retinal pigment epithelium (RPE) might precede the development of hyperglycemia and associated vascular changes in metabolic syndrome.
  4 KB (512 words) - 23:55, 17 March 2019
• Spinelli 2021 Science
  |title=Spinelli JB, Rosen PC, Sprenger HG, Puszynska AM, Mann JL, Roessler JM, Can ...ch net reverse the SDH complex under hypoxia. Thus, we delineate a circuit of electron flow in the mammalian ETC that maintains mitochondrial functions u
  2 KB (224 words) - 09:03, 2 April 2023
• Honzik 2006 Placenta
  ...T, Paul J, Zeman J, Houstek J (2006) Specific properties of heavy fraction of mitochondria from human-term placenta - Glycerophosphate-dependent hydrogen ...an additional source of reactive oxygen species participating in induction of oxidative stress in placenta.
  2 KB (256 words) - 14:30, 26 March 2018
• Pereira 2014 Sci Rep
  ...r Waerden A, Li B, Radivojac P, Samuels DC (2014) Global human frequencies of predicted nuclear pathogenic variants and the role played by protein hydrop ...A genes were restricted to a single continental population. The proportion of individuals having at least one potential pathogenic mutation in this gene
  2 KB (281 words) - 14:54, 23 March 2016
• Mancini 2017 Thesis
  |title=Mancini G (2017) Colesterol dietético e doença de Alzheimer em modelos ex ...benefits that resulted in a better quality of life during the advancement of the age.
  4 KB (569 words) - 08:40, 5 May 2020
• Grefte 2015 Biochim Biophys Acta
  |title=Grefte S, Wagenaars JA, Jansen R, Willems PH, Koopman WJ (2015) Rotenone in ...support a model in which Rot reduces primary myotube formation independent of its inhibitory effect on CI-driven mitochondrial ATP production, but via a
  2 KB (244 words) - 10:43, 9 November 2016
• Piel 2020 FEBS J
  ...S, Masscheleyn S, Bouillaud F, Moncoq K, Miroux B (2020) Structural models of mitochondrial uncoupling proteins obtained in DPC micelles are not function ...activation and inhibition. The K56S, K269S and K56S/K269S mutants did not display any default in activation, which shows that the NMR titration experiments i
  2 KB (269 words) - 15:49, 19 October 2021
• MiPNet10.05 O2-Concentration-Flux
  |title=Gnaiger E (2005-2010) From oxygen concentration to oxygen flux. Mitochondr ...text of chemical reactions? The rationale is based on fundamental concepts of physical chemistry and non-equilibrium thermodynamics.
  2 KB (303 words) - 10:54, 11 January 2018
• Amoedo 2015 Abstract MiP2015
  |title=The energy requirement of metastatic cells. ...results presented here have centered on how the multiple metabolic inputs of tumor cells may converge to compose the so called metastatic phenotype.
  4 KB (532 words) - 10:30, 9 November 2016
• O2k-Fluo LED2-Module
  ...serted through the front window of the O2k-glass chambers, for measurement of hydrogen peroxide production (Amplex® UltraRed), ATP production (Magnesiu == Scope of application ==
  6 KB (848 words) - 07:02, 29 March 2024
• Amoedo 2014 Abstract MiP2014
  |title=The metabolic panorama during tumor progression towards malignancy. ...tion. Our research, centered on cell lines that display increasing degrees of malignancy, focuses on metabolic events, especially those involving mitocho
  4 KB (559 words) - 10:30, 9 November 2016
• Svenkrtova 2016 Biogerontology
  ...ation of yeast cells during chronological aging by size points to the role of trehalose in cell vitality. Biogerontology 17:395-408. ...latter. We compare our XS- and L-fraction cell characteristics with those of cells isolated from stationary cultures by others based on density. This co
  2 KB (349 words) - 13:24, 3 August 2017
• Jinich 2020 Proc Natl Acad Sci U S A
  ..., Noor E, Sanders JN, Segrè D, Aspuru-Guzik A (2020) A thermodynamic atlas of carbon redox chemical space. Proc Natl Acad Sci U S A 117:32910-18. doi: 10 ...ve prebiotic molecules will provide a crucial reference for future origins-of-life models.
  2 KB (323 words) - 23:40, 13 February 2022
• Gomez-Duran 2012 Biochim Biophys Acta
  ...rylation differences between mitochondrial DNA haplogroups modify the risk of Leber's hereditary optic neuropathy. Biochim Biophys Acta 1822:1216-22. ...ations causing Leber's hereditary optic neuropathy and for the association of the disease with particular mitochondrial DNA haplogroups.
  2 KB (293 words) - 14:23, 13 November 2017
• Berger 2016 Nat Commun
  |title=Berger E, Rath E, Yuan D, Waldschmitt N, Khaloian S, Allgäuer M, Staszewsk ...ly impaired IEC to be pivotal in the control of the proliferative capacity of the stem cell niche.
  2 KB (288 words) - 11:26, 27 August 2018
• Crombie 2015 Biochem Biophys Rep
  ...T, Trouncea IA, Peraf MF, Delatyckid MB, Pébaya A (2015) Characterization of the retinal pigment epithelium in ''Friedreich ataxia''. Biochem Biophys Re ...DA-iPSCs showed normal OXPHOS and we did not observe functional impairment of the RPE in humans.
  2 KB (282 words) - 17:27, 9 November 2017
• Simard 2020 Metabolites
  ...-Chatelain E, Pichaud N (2020) Metabolic characterization and consequences of mitochondrial pyruvate carrier deficiency in ''Drosophila melanogaster''. M ...rulline, and arginosuccinate. This study therefore reveals the flexibility of mitochondrial substrate oxidation allowing Drosophila to maintain cellular
  2 KB (309 words) - 20:53, 18 September 2020
• Chao 2019 J Appl Physiol (1985)
  |title=Chao T, Burmeister DM, Corona BT, Greising SM (2019) Oxidative pathophysiol ...e VML injury in a porcine model that may be influential to the development of insidious pathophysiology and regenerative and rehabilitative therapies.
  2 KB (302 words) - 12:12, 9 July 2019
• SUIT-014
  |info='''A: Cells or tissue types that display a preference for [[GM_pathway_control_state |GM]] over [[PM_pathway_control ...contribution of two pathways which are most important in the mitochondria of many species, tissues and cell types.
  4 KB (634 words) - 15:21, 8 June 2020
• Hand 2000 Thermochim Acta
  |title=Hand SC, Podrabsky JE (2000) Bioenergetics of diapause and quiescence in aquatic animals. Thermochim. Acta 349:31-42. ...nated depression of catabolic and anabolic processes is a hallmark feature of both diapause and quiescence. However, the adenylate energy status and time
  3 KB (339 words) - 09:41, 9 November 2016
• Petroutsos 2016 Nature
  ...agawa J (2016) A blue-light photoreceptor mediates the feedback regulation of photosynthesis. https://doi.org/10.1038/nature19358 ...process that plays a vital role in microalgal acclimation to environments of variable light intensities.
  2 KB (295 words) - 14:36, 21 March 2023
• Ye 2011 J Biol Chem
  |title=Ye F, Lemieux H, Hoppel CL, Hanson RW, Hakimi P, Croniger CM, Puchowicz M, ...own PPARγ in Ski-CEFs by RNA interference reversed the elevated expression of these PPARγ target genes, as well as the shift to oxidative metabolism and
  2 KB (270 words) - 15:47, 9 November 2016
• Arnold 2022 Nature
  |title=Arnold PK, Jackson BT, Paras KI, Brunner JS, Hart ML, Newsom OJ, Alibeckoff ...blasts and embryonic stem cells revealed that changes in the configuration of the TCA cycle accompany cell fate transitions. During exit from pluripotenc
  2 KB (291 words) - 19:56, 22 July 2023
• Szelechowski 2018 Sci Rep
  |title=Szelechowski M, Amoedo N, Obre E, Léger C, Allard L, Bonneu M, Claverol S, ...of ALS bioenergetics linking FAO and UCP2. Lastly, we provide a unique set of data comparing the molecular alterations found in human ALS patients' skin
  2 KB (296 words) - 14:19, 17 April 2018
• Tar 2014 J Biol Chem
  ...m10 activator protein antagonize mitochondrial fission through degradation of the fission protein Dnm1. J Biol Chem 114:1114-8. ...Blm10-proteasome mediated turnover of Dnm1 is required for the maintenance of mitochondrial function and provides cytoprotection under conditions that in
  2 KB (342 words) - 00:09, 1 March 2020
• Ramkumar 2019 Mitochondrion
  |title=Ramkumar B, Dharaskar SP, Mounika G, Paithankar K, Sreedhar AS (2019) Mitoc ...alternate strategy to combat cancer, we propose pharmacological targeting of TRAP1 to target alternate energy metabolism.
  2 KB (339 words) - 11:24, 25 November 2019
• Croston 2014 Am J Physiol Heart Circ Physiol
  ...DM, Olfert IM, Jagannathan R, Hollander JM (2014) Functional deficiencies of subsarcolemmal mitochondria in the type 2 diabetic human heart. Am J Physio ...betes and the degree of dysfunction is consistent regardless of the extent of elevated HbA1c or blood glucose levels.
  2 KB (343 words) - 00:15, 16 February 2020
• Gao 2022 Biochim Biophys Acta Bioenerg
  ..., Braz GRF, Cannon B, Yang G, Nedergaard J (2022) Establishing the potency of N-acyl amino acids versus conventional fatty acids as thermogenic uncoupler ...eral tissues, and it is therefore unlikely that the N-acyl amino acids are of specific physiological relevance as UCP1-independent thermogenic compounds.
  3 KB (356 words) - 10:26, 5 December 2022
• Grimm 2015 Exp Gerontol
  |title=Grimm C, Osiewacz HD (2015) Manganese rescues adverse effects on lifespan a ...de and suggests that a manganese-dependent activity leads to the induction of ROS scavenging components.
  3 KB (358 words) - 09:20, 9 November 2016

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