Sazanov 2015 Nat Rev Mol Cell Biol: Difference between revisions
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|title=Sazanov LA (2015) A giant molecular proton pump: structure and mechanism of respiratory complex I. Nat Rev Mol Cell Biol 16:375-88. | |title=Sazanov LA (2015) A giant molecular proton pump: structure and mechanism of respiratory complex I. Nat Rev Mol Cell Biol 16:375-88. | ||
|info=[https://www.ncbi.nlm.nih.gov/pubmed/25991374 PMID: 25991374] | |info=[https://www.ncbi.nlm.nih.gov/pubmed/25991374 PMID: 25991374] | ||
|authors=Sazanov | |authors=Sazanov Leonid A | ||
|year=2015 | |year=2015 | ||
|journal=Nat Rev Mol Cell Biol | |journal=Nat Rev Mol Cell Biol |
Revision as of 16:02, 20 January 2023
Sazanov LA (2015) A giant molecular proton pump: structure and mechanism of respiratory complex I. Nat Rev Mol Cell Biol 16:375-88. |
Sazanov Leonid A (2015) Nat Rev Mol Cell Biol
Abstract: The mitochondrial respiratory chain, also known as the electron transport chain (ETC), is crucial to life, and energy production in the form of ATP is the main mitochondrial function. Three proton-translocating enzymes of the ETC, namely complexes I, III and IV, generate proton motive force, which in turn drives ATP synthase (complex V). The atomic structures and basic mechanisms of most respiratory complexes have previously been established, with the exception of complex I, the largest complex in the ETC. Recently, the crystal structure of the entire complex I was solved using a bacterial enzyme. The structure provided novel insights into the core architecture of the complex, the electron transfer and proton translocation pathways, as well as the mechanism that couples these two processes.
โข Bioblast editor: Gnaiger E
Cited by
- Gnaiger E et al โ MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. doi:10.26124/bec:2020-0001.v1.
Labels:
Enzyme: Complex I Regulation: ATP production, Coupling efficiency;uncoupling
BEC 2020.1