Difference between revisions of "OctPM pathway control state"
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{{MitoPedia | {{MitoPedia | ||
|abbr=PMOct | |abbr=PMOct | ||
|description=''' | |description='''PMOct''': [[Pyruvate]] & [[Malate]] & [[Octanoylcarnitine]]. | ||
'''MitoPathway control:''' CI<small>&</small>FAO | '''MitoPathway control:''' CI<small>&</small>FAO | ||
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This substrate combination supports CI-linked flux which is typically higher than FAO capacity. In SUIT-RP1, PMOct is induced after PM(E), to evaluate any additive effect of adding Oct. In SUIT-RP2, FAO OXPHOS capacity is measured first, testing for the effect of increasing malate concentration (compare [[Malate alone]], and pyruvate is added to compare FAO as the background state with CI&FAO as the reference state. | This substrate combination supports CI-linked flux which is typically higher than FAO capacity. In SUIT-RP1, PMOct is induced after PM(E), to evaluate any additive effect of adding Oct. In SUIT-RP2, FAO OXPHOS capacity is measured first, testing for the effect of increasing malate concentration (compare [[Malate alone]], and pyruvate is added to compare FAO as the background state with CI&FAO as the reference state. | ||
|info=[[MiPNet21.06 SUIT reference assay]] | |info=[[MiPNet21.06 SUIT reference assay]] | ||
}} | }} | ||
Revision as of 14:04, 24 January 2016
- high-resolution terminology - matching measurements at high-resolution
OctPM pathway control state
Description
PMOct: Pyruvate & Malate & Octanoylcarnitine.
MitoPathway control: CI&FAO
SUIT protocol: SUIT-RP1, SUIT-RP1
This substrate combination supports CI-linked flux which is typically higher than FAO capacity. In SUIT-RP1, PMOct is induced after PM(E), to evaluate any additive effect of adding Oct. In SUIT-RP2, FAO OXPHOS capacity is measured first, testing for the effect of increasing malate concentration (compare Malate alone, and pyruvate is added to compare FAO as the background state with CI&FAO as the reference state.
Abbreviation: PMOct
Reference: MiPNet21.06 SUIT reference assay
MitoPedia topics: "Respiratory substrate-coupling state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory substrate-coupling state"Respiratory substrate-coupling state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
