NS-pathway control state: Difference between revisions
No edit summary |
No edit summary |
||
Line 6: | Line 6: | ||
{{MitoPedia methods}} | {{MitoPedia methods}} | ||
{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Respiratory state, Substrate and metabolite | |mitopedia topic=Respiratory state, Respiratory substrate-coupling state, Substrate and metabolite | ||
}} | }} | ||
= List of publications: CI<small>&</small>II-linked substrate state = | = List of publications: CI<small>&</small>II-linked substrate state = |
Revision as of 05:17, 20 January 2016
Description
The Complex I&II-linked substrate state is induced in mt-preparations by addition of NADH-generating substrates (CI-linked) in combination with succinate (CII-linked). This physiological substrate combination is required for partial reconstiturion of TCA cycle function and convergent electron-input into the Q-junction to compensate for metabolite depletion into the incubation medium. An Additive effect of convergent CI&II electron flow is observed in most types of mitochondria.
Abbreviation: CI&II-linked
Reference: Gnaiger 2014 MitoPathways
MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property., "Respiratory substrate-coupling state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory substrate-coupling state"Respiratory substrate-coupling state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property., Substrate and metabolite