Mahapatra 2023 MiP2023
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Link: MiPschool Obergurgl 2023
Mahapatra Gargi (2023)
Event: MiPschool Obergurgl 2023
Authors: Gargi Mahapatra, Zhengrong Gao, James R. Bateman III, Samuel Neal Lockhart, Jaclyn Bergstrom, Suzanne Craft, Anthony J. A. Molina
Impaired glucose tolerance (IGT), including prediabetes and diabetes, increases risk of developing age related disorders, including Alzheimer’s disease (AD). We analyzed mitochondrial bioenergetics in platelets collected from 208 adults, 55 years and older, with or without insulin sensitivities (112 normoglycemics (NG), 96 IGTs). Platelets from IGT participants exhibited unique bioenergetic profiles exemplified by higher mitochondrial respiration than NG. IGT platelets exhibited higher glucose-dependent maximal (Max) and spare respiratory (SRC) capacities compared to NG, and higher fatty acid oxidation-dependent maximal coupled (MaxOXPHOS) and uncoupled (MaxETS) respiration compared to NG. Correlating bioenergetics from all 208 participants combined with glucose measures (OGTT_120, OGTT_AUC, and HbA1c) revealed significant positive associations. Most associations were unaltered with age, sex, and BMI adjustments. Further separating NG and IGT participants and correlating platelet respiration with glucose measures revealed distinct trends in NG versus IGT group. In NG, previously observed associations remained intact, and new significant positive associations emerged between platelet bioenergetics and HbA1c. Associations in IGT group were overall negative. Identifying systemic mitochondrial mechanisms that associate with glucose intolerance in older adults will help in monitoring pathological progression of AD in relation to comorbidities such as insulin sensitivity, and supports the development of minimally invasive biomarkers of AD.
• Keywords: Platelets, Glucose tolerance, Mitochondrial bioenergetics, Maximal respiration, Fatty acid oxidation
• O2k-Network Lab: US CA San Diego Molina AJA
Labels:
Event: E2
