Difference between revisions of "Jansen 2017 MiP2017"
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{{Abstract | {{Abstract | ||
|title=[[Image:MiPsocietyLOGO.JPG|left|90px|Mitochondrial Physiology Society|MiPsociety]] | |title=[[Image:MiPsocietyLOGO.JPG|left|90px|Mitochondrial Physiology Society|MiPsociety]] Dietary and pharmacological anti-obesogenic treatments improve myocardial metabolism in diet-induced obese mice. | ||
Dietary and pharmacological anti-obesogenic treatments improve myocardial metabolism in diet-induced obese mice. | |||
|info=[[MiP2017]] | |info=[[MiP2017]] | ||
|authors=Jansen KM, Larsen TS | |authors=Jansen KM, Larsen TS | ||
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|event=MiP2017 | |event=MiP2017 | ||
|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]] | |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]] | ||
Calanus oil (a novel marine oil), as well exenatide (GLP-1 agonist), | Calanus oil (a novel marine oil), as well as exenatide (GLP-1 agonist), reduces the deposition of intra-abdominal fat in adipose tissue during high-fat feeding. To test the hypothesis that targeted reduction of intra-abdominal fat can recover metabolic flexibility of the heart, which is otherwise lost in obesity. | ||
Female C57bl/6J | Female C57bl/6J mice received high-fat diet (HFD) or normal chow for 12 wks in order to induce obesity. Thereafter, the HFD mice were treated for 8 wks with Calanus oil (2%), exenatide (10 µg/kg/day), or the two treatments combined. Non-treated chow- and HFD-fed mice served as lean and obese controls, respectively. At the end of the treatment period, substrate oxidation (radioisotope technique) and tolerance to ischemia-reperfusion were examined, using Langendorff-perfused hearts. | ||
Both Calanus oil and exenatide had a clear anti-obesogenic effect, as demonstrated by significantly reduced intra-abdominal fat stores at the end of the treatment period. This was associated with improved myocardial glucose oxidation, relative to non-treated obese controls. Pre-ischemic left ventricular (LV) function was not different between the groups, but hearts from Calanus oil-treated obese | Both Calanus oil and exenatide had a clear anti-obesogenic effect, as demonstrated by significantly reduced intra-abdominal fat stores at the end of the treatment period. This was associated with improved myocardial glucose oxidation, relative to non-treated obese controls. Pre-ischemic left ventricular (LV) function was not different between the groups, but hearts from Calanus oil-treated obese mice showed increased post-ischemic functional recovery relative to hearts from non-treated obese mice. No synergism between Calanus oil and exenatide treatment was observed. | ||
In conclusion, obesity-related loss of myocardial metabolic flexibility was counteracted both by Calanus oil and exenatide treatment. In Calanus oil-treated | In conclusion, obesity-related loss of myocardial metabolic flexibility was counteracted both by Calanus oil and exenatide treatment. In Calanus oil-treated mice, this was associated with increased post-ischemic recovery of LV function. | ||
|editor=[[Beno M]] | |editor=[[Beno M]], [[Kandolf G]], | ||
|mipnetlab=NO Tromsoe Larsen TS | |mipnetlab=NO Tromsoe Larsen TS | ||
}} | }} | ||
{{Labeling}} | {{Labeling | ||
|area=Exercise physiology;nutrition;life style | |||
|diseases=Obesity | |||
|organism=Mouse | |||
}} | |||
== Affiliations == | == Affiliations == | ||
:::: Dept Medical Biol, Fac Health Sc, UiT The Arctic Univ Norway | :::: Dept Medical Biol, Fac Health Sc, UiT The Arctic Univ Norway, Norway. - [email protected] | ||
Latest revision as of 10:03, 7 November 2017
 |
Link: MiP2017
Event: MiP2017
Calanus oil (a novel marine oil), as well as exenatide (GLP-1 agonist), reduces the deposition of intra-abdominal fat in adipose tissue during high-fat feeding. To test the hypothesis that targeted reduction of intra-abdominal fat can recover metabolic flexibility of the heart, which is otherwise lost in obesity.
Female C57bl/6J mice received high-fat diet (HFD) or normal chow for 12 wks in order to induce obesity. Thereafter, the HFD mice were treated for 8 wks with Calanus oil (2%), exenatide (10 µg/kg/day), or the two treatments combined. Non-treated chow- and HFD-fed mice served as lean and obese controls, respectively. At the end of the treatment period, substrate oxidation (radioisotope technique) and tolerance to ischemia-reperfusion were examined, using Langendorff-perfused hearts.
Both Calanus oil and exenatide had a clear anti-obesogenic effect, as demonstrated by significantly reduced intra-abdominal fat stores at the end of the treatment period. This was associated with improved myocardial glucose oxidation, relative to non-treated obese controls. Pre-ischemic left ventricular (LV) function was not different between the groups, but hearts from Calanus oil-treated obese mice showed increased post-ischemic functional recovery relative to hearts from non-treated obese mice. No synergism between Calanus oil and exenatide treatment was observed.
In conclusion, obesity-related loss of myocardial metabolic flexibility was counteracted both by Calanus oil and exenatide treatment. In Calanus oil-treated mice, this was associated with increased post-ischemic recovery of LV function.
• Bioblast editor: Beno M, Kandolf G
• O2k-Network Lab: NO Tromsoe Larsen TS
Labels: MiParea: Exercise physiology;nutrition;life style Pathology: Obesity
Organism: Mouse
Affiliations
- Dept Medical Biol, Fac Health Sc, UiT The Arctic Univ Norway, Norway. - [email protected]
