Difference between revisions of "Jang 2016 J Intensive Care Med"
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|title=Jang DH, Greenwood JC, Spyres MB, Eckmann D (2016) Measurement of mitochondrial respiration and motility in acute care: sepsis, trauma, and poisoning. J Intensive Care Med [Epub ahead of print]. | |title=Jang DH, Greenwood JC, Spyres MB, Eckmann D (2016) Measurement of mitochondrial respiration and motility in acute care: sepsis, trauma, and poisoning. J Intensive Care Med [Epub ahead of print]. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/27443317 PMID: 27443317] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/27443317 PMID: 27443317] | ||
|authors=Jang DH, Greenwood JC, Spyres MB, Eckmann D | |authors=Jang DH, Greenwood JC, Spyres MB, Eckmann D | ||
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© The Author(s) 2016. | © The Author(s) 2016. | ||
|keywords=Bioenergetics, Medical toxicology, Mitochondria, Mitochondrial motility, Resuscitation, Sepsis | |keywords=Bioenergetics, Medical toxicology, Mitochondria, Mitochondrial motility, Resuscitation, Sepsis | ||
|mipnetlab=US PA Philadelphia Jang DH | |mipnetlab=US PA Philadelphia Jang DH, US PA Philadelphia Wallace DC | ||
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{{Labeling | {{Labeling | ||
Revision as of 14:09, 1 August 2016
| Jang DH, Greenwood JC, Spyres MB, Eckmann D (2016) Measurement of mitochondrial respiration and motility in acute care: sepsis, trauma, and poisoning. J Intensive Care Med [Epub ahead of print]. |
Jang DH, Greenwood JC, Spyres MB, Eckmann D (2016) J Intensive Care Med
Abstract: Metabolic biomarkers have potentially wider use in disease diagnosis and prognosis as well as in monitoring disease response to treatment. While biomarkers such as interleukins, microRNA, and lactate have been proposed for disease surveillance, there are still conflicting results regarding their clinical utility. Treatment of commonly encountered disease of acute care such as sepsis, trauma, and poisoning often relies on clinical diagnosis and therapy guided by use of surrogate markers of illness severity. The measurement of mitochondrial function, including respiration and motility, may offer superior alternatives to such markers. Assessing mitochondrial function in a clinical context has the potential to impact the area of acute care in terms of diagnosis, prognosis, and treatment. The study of mitochondrial bioenergetics has become critical in understanding the pathophysiology and treatment of complex diseases such as diabetes and cardiovascular disorders.
© The Author(s) 2016. • Keywords: Bioenergetics, Medical toxicology, Mitochondria, Mitochondrial motility, Resuscitation, Sepsis
• O2k-Network Lab: US PA Philadelphia Jang DH, US PA Philadelphia Wallace DC
Labels: MiParea: Respiration, Instruments;methods, mt-Structure;fission;fusion, mt-Medicine, Pharmacology;toxicology, mt-Awareness
Pathology: Sepsis, Other
Stress:Oxidative stress;RONS
Tissue;cell: Blood cells Preparation: Intact cells
HRR: Oxygraph-2k
Labels, 2016-08
