Difference between revisions of "Hildebrandt 2008 FEBS J"
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{{Publication | {{Publication | ||
|title=Hildebrandt TM, Grieshaber MK (2008) Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria. FEBS J 275: 3352- | |title=Hildebrandt TM, Grieshaber MK (2008) Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria. FEBS J 275:3352-6. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/18494801 PMID: 18494801] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/18494801 PMID: 18494801] | ||
|authors=Hildebrandt TM, Grieshaber MK | |authors=Hildebrandt TM, Grieshaber MK | ||
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|taxonomic group=Annelids | |taxonomic group=Annelids | ||
|tissues=Liver | |tissues=Liver | ||
|preparations=Isolated | |preparations=Isolated mitochondria | ||
|injuries=Hypoxia | |injuries=Hypoxia | ||
|topics=Inhibitor, Substrate | |topics=Inhibitor, Substrate | ||
Revision as of 12:44, 24 February 2015
| Hildebrandt TM, Grieshaber MK (2008) Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria. FEBS J 275:3352-6. |
Hildebrandt TM, Grieshaber MK (2008) FEBS J
Abstract: Hydrogen sulfide is a potent toxin of aerobic respiration, but also has physiological functions as a signalling molecule and as a substrate for ATP production. A mitochondrial pathway catalyzing sulfide oxidation to thiosulfate in three consecutive reactions has been identified in rat liver as well as in the body-wall tissue of the lugworm, Arenicola marina. A membrane-bound sulfide : quinone oxidoreductase converts sulfide to persulfides and transfers the electrons to the ubiquinone pool. Subsequently, a putative sulfur dioxygenase in the mitochondrial matrix oxidizes one persulfide molecule to sulfite, consuming molecular oxygen. The final reaction is catalyzed by a sulfur transferase, which adds a second persulfide from the sulfide : quinone oxidoreductase to sulfite, resulting in the final product thiosulfate. This role in sulfide oxidation is an additional physiological function of the mitochondrial sulfur transferase, rhodanese. • Keywords: Mitochondria, Sulfide oxidation, Sulfide : quinone oxidoreductase, Sulfur dioxygenase, Sulfur transferase
• O2k-Network Lab: DE Duesseldorf Grieshaber MK
Labels: MiParea: Respiration, Comparative MiP;environmental MiP
Stress:Hypoxia Organism: Rat Tissue;cell: Liver Preparation: Isolated mitochondria
Regulation: Inhibitor, Substrate Coupling state: OXPHOS
HRR: Oxygraph-2k
Sulfide
