Difference between revisions of "Hildebrandt 2008 FEBS J"
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| | |organism=Rat | ||
| | |taxonomic group=Annelids | ||
|tissues=Liver | |||
|couplingstates=OXPHOS | |couplingstates=OXPHOS | ||
|kinetics=Inhibitor; Uncoupler | |kinetics=Inhibitor; Uncoupler | ||
|instruments=Oxygraph-2k | |||
|additional=Sulfide | |||
|discipline=Mitochondrial Physiology, Pharmacology; Biotechnology | |discipline=Mitochondrial Physiology, Pharmacology; Biotechnology | ||
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Revision as of 18:02, 8 August 2013
Hildebrandt TM, Grieshaber MK (2008) Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria. FEBS J 275: 3352-3356. |
Hildebrandt TM, Grieshaber MK (2008) FEBS J
Abstract: Hydrogen sulfide is a potent toxin of aerobic respiration, but also has physiological functions as a signalling molecule and as a substrate for ATP production. A mitochondrial pathway catalyzing sulfide oxidation to thiosulfate in three consecutive reactions has been identified in rat liver as well as in the body-wall tissue of the lugworm, Arenicola marina. A membrane-bound sulfide : quinone oxidoreductase converts sulfide to persulfides and transfers the electrons to the ubiquinone pool. Subsequently, a putative sulfur dioxygenase in the mitochondrial matrix oxidizes one persulfide molecule to sulfite, consuming molecular oxygen. The final reaction is catalyzed by a sulfur transferase, which adds a second persulfide from the sulfide : quinone oxidoreductase to sulfite, resulting in the final product thiosulfate. This role in sulfide oxidation is an additional physiological function of the mitochondrial sulfur transferase, rhodanese. β’ Keywords: Mitochondria, Sulfide oxidation, Sulfide : quinone oxidoreductase, Sulfur dioxygenase, Sulfur transferase
Labels:
Organism: Rat
Tissue;cell: Liver
Coupling state: OXPHOS
HRR: Oxygraph-2k
Sulfide