Difference between revisions of "Gnaiger 2018 MiPschool Tromso A2"
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== Affiliations and support == | == Affiliations and support == | ||
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::::::## Express -460 kJ/mol in units of volt [V]. | ::::::## Express -460 kJ/mol in units of volt [V]. | ||
::::::## Why should we do that? | ::::::## Why should we do that? | ||
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|area=Respiration | |||
|topics=mt-Membrane potential | |||
|instruments=Theory | |||
|event=A4, Oral | |||
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Revision as of 12:09, 14 October 2018
The protonmotive force and respiratory control. 1. Coupling of electron transfer reactions to vectorial translocation of protons. |
Link: MitoEAGLE
Gnaiger E (2018)
Event: MiPschool Tromso-Bergen 2018
Peter Mitchell's protonmotive force is one of the most fundamental concepts in biology [1]. The catabolic reactions of mitochondrial electron transfer (ET) are coupled to vectorial translocation of protons at three coupling sites, which are the proton pumps of the ET system, the respiratory Complexes CI, CIII, and CIV. The driving force of the ET system in the catabolic (k) reaction expressed as OO2 consumption is the Gibbs force of reaction, ฮkFO2, which is typically in the range of -460 to -480 kJ/mol. This is an isomorphic force, also known as a generalized force (the negative affinity of chemical reactions) in nonequilibrium thermodynamics. Confusion is caused by the failure of terminological distinction between Gibbs energy change of reaction, ฮrG [J], and Gibbs force equal to the partial Gibbs energy change per advancement of reaction [2]. For the protonmotive force the proton is the motive entity, which can be expressed in a variety of formats with different motive units, MU.
Work in progress
โข Keywords: Force, Protonmotive force โข Bioblast editor: Gnaiger E
Affiliations and support
- D. Swarovski Research Lab, Dept. Visceral, Transplant Thoracic Surgery, Medical Univ Innsbruck
- Oroboros Instruments, Innsbruck, Austria
- Contribution to COST Action CA15203 MitoEAGLE, supported by COST (European Cooperation in Science and Technology), and K-Regio project MitoFit.
References
- MitoEAGLE preprint 2018-09-04(41) Mitochondrial respiratory states and rates: Building blocks of mitochondrial physiology Part 1. - www.mitoeagle.org/index.php/MitoEAGLE_preprint_2018-02-08
- Gnaiger E (2018) Gibbs energy or Gibbs force? Mitochondr Physiol Network 2018-08-07. - ยปBioblast linkยซ
Figures
Questions
- Convert the molar format of the Gibbs force of reaction, ฮkFnO2 [kJ/mol], into the electrical format, ฮkFeO2 [V].
- Which physicochemical constant is required?
- What is the meaning of the symbol zO2?
- How are the units of electric energy [J] and electric force [V] related?
- Express -460 kJ/mol in units of volt [V].
- Why should we do that?
Labels: MiParea: Respiration
Regulation: mt-Membrane potential
HRR: Theory
Event: A4, Oral