Gellerich 2009 PLoS One: Difference between revisions
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{{Publication | {{Publication | ||
|title=Gellerich FN, Gizatullina Z, Arandarcikaite O, Jerzembek D, Vielhaber S, Seppet E, Striggow F (2009) Extramitochondrial Ca2+ in the nanomolar range regulates glutamate-dependent oxidative phosphorylation on demand. PloS One 4: e8181. | |title=Gellerich FN, Gizatullina Z, Arandarcikaite O, Jerzembek D, Vielhaber S, Seppet E, Striggow F (2009) Extramitochondrial Ca2+ in the nanomolar range regulates glutamate-dependent oxidative phosphorylation on demand. PloS One 4:e8181. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/20011041 PMID: 20011041 Open Access] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/20011041 PMID: 20011041 Open Access] | ||
|authors=Gellerich FN, Gizatullina Z, Arandarcikaite O, Jerzembek D, Vielhaber S, Seppet E, Striggow F | |authors=Gellerich FN, Gizatullina Z, Arandarcikaite O, Jerzembek D, Vielhaber S, Seppet E, Striggow F | ||
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|area=Respiration | |area=Respiration | ||
|tissues=Nervous system | |tissues=Nervous system | ||
|enzymes=Inner | |enzymes=Inner mt-membrane transporter | ||
|topics=Calcium, Inhibitor | |topics=Calcium, Inhibitor | ||
|couplingstates=OXPHOS | |couplingstates=OXPHOS |
Revision as of 16:38, 17 February 2015
Gellerich FN, Gizatullina Z, Arandarcikaite O, Jerzembek D, Vielhaber S, Seppet E, Striggow F (2009) Extramitochondrial Ca2+ in the nanomolar range regulates glutamate-dependent oxidative phosphorylation on demand. PloS One 4:e8181. |
Gellerich FN, Gizatullina Z, Arandarcikaite O, Jerzembek D, Vielhaber S, Seppet E, Striggow F (2009) PLoS One
Abstract: We present unexpected and novel results revealing that glutamate-dependent oxidative phosphorylation (OXPHOS) of brain mitochondria is exclusively and efficiently activated by extramitochondrial Ca2+ in physiological concentration ranges (S0.5= 360 nM Ca2+). This regulation was not affected by RR, an inhibitor of the mitochondrial Ca2+ uniporter. Active respiration is regulated by glutamate supply to mitochondria via aralar, a mitochondrial glutamate/aspartate carrier with regulatory Ca2+-binding sites in the mitochondrial intermembrane space providing full access to cytosolic Ca2+. At micromolar concentrations, Ca2+ can also enter the intramitochondrial matrix and activate specific dehydrogenases. However, the latter mechanism is less efficient than extramitochondrial Ca2+ regulation of respiration/OXPHOS via aralar. These results imply a new mode of glutamate-dependent OXPHOS regulation as a demand-driven regulation of mitochondrial function. This regulation involves the mitochondrial glutamate/aspartate carrier aralar which controls mitochondrial substrate supply according to the level of extramitochondrial Ca2+. โข Keywords: Glutamate/aspartate carrier aralar, Extramitochondrial Ca (2+), Brain mitochondria
โข O2k-Network Lab: EE_Tartu_Seppet EK, DE_Magdeburg_Gellerich FN
Labels: MiParea: Respiration
Tissue;cell: Nervous system
Enzyme: Inner mt-membrane transporter Regulation: Calcium, Inhibitor Coupling state: OXPHOS
HRR: Oxygraph-2k