Difference between revisions of "E-R control efficiency"

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E-R control efficiency

Description

The apparent excess E-R capacity factor (E-R coupling control factor), j_ExR = (E-R)/E = 1-R/E, is an expression of the relative scope of increasing ROUTINE respiration in intact cells by uncoupling. j_ExR = 0.0 for zero excess capacity when R=E; j_ExR = 1.0 for the maximum limit when R=0. The ROUTINE state of intact cells is stimulated to ETS by uncoupler titration, which yields the excess E-R capacity, ExR=E-R. Since ETS capacity is significantly higher than OXPHOS capacity in various cell types (as shown by cell ergometry), ExR or j_ExR is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent excess E-P capacity, ExP=E-P, is not a respiratory reserve in the sense of oxidative phosphorylation.

Abbreviation: j_ExR

Reference: Flux control factor

MitoPedia methods: Respirometry

MitoPedia topics: "Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory control ratio"Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.

Compare

» ROUTINE control ratio, R/E

» Excess E-P capacity factor, j_ExP = (E-P)/E = 1-P/E

» ETS coupling efficiency, j_≈E = 1-L/E

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 {{MitoPedia
 |abbr=''j<sub>ExR</sub>''
-|description=[[Image:jExR.jpg|50 px|link=Excess E-R capacity factor |Excess ''E-R'' capacity factor]]
+|description=[[Image:jExR.jpg|50 px|Excess ''E-R'' capacity factor]] The apparent '''excess ''E-R'' capacity factor''' (''E-R'' coupling control factor), ''j<sub>ExR</sub>'' = (''E-R'')/''E'' = 1-''R/E'', is an expression of the relative scope of increasing [[ROUTINE respiration]] in intact cells by uncoupling. ''j<sub>ExR</sub>'' = 0.0 for zero excess capacity when ''R''=''E''; ''j<sub>ExR</sub>'' = 1.0 for the maximum limit when ''R''=0. The [[ROUTINE]] state of intact cells is stimulated to [[ETS]] by [[uncoupler]] titration, which yields the [[Excess E-R capacity |excess ''E-R'' capacity]], ''ExR''=''E-R''. Since ETS capacity is significantly higher than OXPHOS capacity in various cell types (as shown by '''[[cell ergometry]]'''), ''ExR'' or ''j<sub>ExR</sub>'' is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent [[Excess E-P capacity |excess ''E-P'' capacity]], ''ExP''=''E-P'', is not a respiratory reserve in the sense of oxidative phosphorylation.
-The apparent '''excess ''E-R'' capacity factor''' (''E-R'' coupling control factor), ''j<sub>ExR</sub>'' = (''E-R'')/''E'' = 1-''R/E'', is an expression of the relative scope of increasing [[ROUTINE respiration]] in intact cells by uncoupling. ''j<sub>ExR</sub>'' = 0.0 for zero excess capacity when ''R''=''E''; ''j<sub>ExR</sub>'' = 1.0 for the maximum limit when ''R''=0. The [[ROUTINE]] state of intact cells is stimulated to [[ETS]] by [[uncoupler]] titration, which yields the [[Excess E-R capacity |excess ''E-R'' capacity]], ''ExR''=''E-R''. Since ETS capacity is significantly higher than OXPHOS capacity in various cell types (as shown by '''[[cell ergometry]]'''), ''ExR'' or ''j<sub>ExR</sub>'' is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent [[Excess E-P capacity |excess ''E-P'' capacity]], ''ExP''=''E-P'', is not a respiratory reserve in the sense of oxidative phosphorylation.
 |info=[[Flux control factor]]
 }}