Difference between revisions of "E-R control efficiency"

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E-R control efficiency

Description

The apparent ET-reserve control efficiency (E-R control efficiency), j_E-R = (E-R)/E = 1-R/E, is an expression of the relative scope of increasing ROUTINE respiration in living cells by uncoupling. j_E-R = 0.0 for zero excess capacity when R=E; j_E-R = 1.0 for the maximum limit when R=0. The ROUTINE state of living cells is stimulated to electron transfer pathway by uncoupler titration, which yields the ET-reserve capacity E-R. Since ET-capacity is significantly higher than OXPHOS capacity in various cell types (as shown by cell ergometry), j_E-R is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve) for uncoupling respiration. Similarly, the apparent ET-excess capacity E-P is not a respiratory reserve in the sense of oxidative phosphorylation.

Abbreviation: j_E-R

Reference: Flux control efficiency

Compare

» ROUTINE-control ratio R/E

» ET-excess coupling efficiency E-P j_E-P = (E-P)/E = 1-P/E

» ET-coupling efficiency E-L j_E-L = 1-L/E

MitoPedia concepts: Respiratory control ratio

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 {{MitoPedia
-|abbr=''j<sub>ExR</sub>''
+|abbr=''j<sub>E-R</sub>''
-|description=[[Image:jExR.jpg|50 px|ET-reserve coupling efficiency]] The apparent '''ET-reserve coupling efficiency''' (''E-R'' coupling control efficiency), ''j<sub>E-R</sub>'' = (''E-R'')/''E'' = 1-''R/E'', is an expression of the relative scope of increasing [[ROUTINE respiration]] in living cells by uncoupling. ''j<sub>E-R</sub>'' = 0.0 for zero excess capacity when ''R''=''E''; ''j<sub>E-R</sub>'' = 1.0 for the maximum limit when ''R''=0. The [[ROUTINE]] state of living cells is stimulated to [[Electron transfer pathway]] by [[uncoupler]] titration, which yields the [[Excess E-R capacity |excess ''E-R'' capacity]], ''E-R''. Since ET-capacity is significantly higher than OXPHOS capacity in various cell types (as shown by '''[[cell ergometry]]'''), ''ExR'' or ''j<sub>ExR</sub>'' is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve?) for uncoupling respiration. Similarly, the apparent [[Excess E-P capacity |excess ''E-P'' capacity]], ''E-P'', is not a respiratory reserve in the sense of oxidative phosphorylation.
+|description=[[Image:jExR.jpg|50 px|ET-reserve control efficiency]] The apparent '''ET-reserve control efficiency''' (''E-R'' control efficiency), ''j<sub>E-R</sub>'' = (''E-R'')/''E'' = 1-''R/E'', is an expression of the relative scope of increasing [[ROUTINE respiration]] in living cells by uncoupling. ''j<sub>E-R</sub>'' = 0.0 for zero excess capacity when ''R''=''E''; ''j<sub>E-R</sub>'' = 1.0 for the maximum limit when ''R''=0. The [[ROUTINE]] state of living cells is stimulated to [[electron transfer pathway]] by [[uncoupler]] titration, which yields the [[ET-reserve capacity]] ''E-R''. Since ET-capacity is significantly higher than OXPHOS capacity in various cell types (as shown by '''[[cell ergometry]]'''), ''j<sub>E-R</sub>'' is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve) for uncoupling respiration. Similarly, the apparent [[ET-excess capacity]] ''E-P'' is not a respiratory reserve in the sense of oxidative phosphorylation.
 |info=[[Flux control efficiency]]
 }}
 == Compare ==
-:::» [[ROUTINE-control ratio]], ''R/E''
+:::» [[ROUTINE-control ratio]] ''R/E''
-:::» [[ET-excess coupling efficiency]], ''j<sub>E-P</sub>'' = (''E-P'')/''E'' = 1-''P/E''
+:::» [[ET-excess coupling efficiency E-P]] ''j<sub>E-P</sub>'' = (''E-P'')/''E'' = 1-''P/E''
-:::» [[ET-coupling efficiency]], ''j<sub>E-L</sub>'' = 1-''L/E''
+:::» [[ET-coupling efficiency E-L]] ''j<sub>E-L</sub>'' = 1-''L/E''