Chinopoulos 2013 J Neurosci Res: Difference between revisions
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{{Publication | {{Publication | ||
|title=Chinopoulos C (2013) Which way does the citric acid cycle turn during hypoxia? The critical role of ฮฑ-ketoglutarate dehydrogenase complex | |title=Chinopoulos C (2013) Which way does the citric acid cycle turn during hypoxia? The critical role of ฮฑ-ketoglutarate dehydrogenase complex. Journal of Neuroscience Research 91(8): 1030-43. | ||
|info=https://pubmed.ncbi.nlm.nih.gov/23378250/ | |info=https://pubmed.ncbi.nlm.nih.gov/23378250/ | ||
|authors=Chinopoulos C | |authors=Chinopoulos C |
Revision as of 10:31, 14 March 2022
Chinopoulos C (2013) Which way does the citric acid cycle turn during hypoxia? The critical role of ฮฑ-ketoglutarate dehydrogenase complex. Journal of Neuroscience Research 91(8): 1030-43. |
ยป https://pubmed.ncbi.nlm.nih.gov/23378250/
Chinopoulos C (2013) J Neurosci Res
Abstract: The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway remain operational but exhibit opposing directionalities. This serves the purpose of harnessing high-energy phosphates through matrix substrate-level phosphorylation in the absence of oxidative phosphorylation. In this Mini-Review, these segments are appraised, pointing to the critical importance of the ฮฑ-ketoglutarate dehydrogenase complex dictating their directionalities. โข Keywords: TCA cycle โข Bioblast editor: Cardoso LHD โข O2k-Network Lab: HU Budapest Chinopoulos C
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Stress:Hypoxia
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