Difference between revisions of "Alternative oxidase"

Latest revision as of 15:42, 26 May 2020

high-resolution terminology - matching measurements at high-resolution

Alternative oxidase

Description

Alternative quinol oxidases AOX are membrane-bound enzymes capable of supporting cyanide- and antimycin A-resistant mitochondrial respiration. AOX catalyzes the oxidation of ubiquinol and the reduction of oxygen to water in a four-electron process. As this bypasses several proton-translocating steps, induction of this alternative pathway is associated with a reduction of ATP production per oxygen consumed. AOX is found in most plants (including microalgae), many fungi and protists, but is not expressed in animals. AOX is inhibited by salicylhydroxamic acid (SHAM). Expression and activity of the enzyme are modified by environmental conditions such as temperature, oxidative stress, nutrient availability, and pathogens such as viruses.

Abbreviation: AOX

Reference: Young 2013 Biochem Soc Trans

SUITbrowser question: AOX activity

AOX activity can be measured with SUIT protocols: use the SUITbrowser to find your protocol.

References

Bioblast link	Reference	Year
BEC 2020.1 doi10.26124bec2020-0001.v1	Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1	2020

MitoPedia topics: Enzyme

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 {{MitoPedia
 |abbr=AOX
-|description=The alternative oxidase is a membrane-bound enzyme capable of supporting [[cyanide| cyanide]]-and [[Antimycin_A| antimycin A]]-resistant mitochondrial respiration. It catalyzes the oxidation of ubiquinol and the reduction of oxygen to water in a four electron process. As this bypasses several proton-translocating steps, inducton of this alternative pathway is associated with a dramatic reduction of ATP production. Expression and activity of the enzyme is modified by environmental conditions such as temperature, oxidative stress, nutrient availability, as well as by pathogens such as viruses. AOX can be found in most plants (including microalgae), many fungi and protists, but is not expressed in animals.
+|description='''Alternative quinol oxidases''' AOX are membrane-bound enzymes capable of supporting [[cyanide]]- and [[antimycin A]]-resistant mitochondrial respiration. AOX catalyzes the oxidation of ubiquinol and the reduction of oxygen to water in a four-electron process. As this bypasses several proton-translocating steps, induction of this alternative pathway is associated with a reduction of ATP production per oxygen consumed. AOX is found in most plants (including microalgae), many fungi and protists, but is not expressed in animals. AOX is inhibited by [[salicylhydroxamic acid]] (SHAM). Expression and activity of the enzyme are modified by environmental conditions such as temperature, oxidative stress, nutrient availability, and pathogens such as viruses.
 |info=[http://www.ncbi.nlm.nih.gov/pubmed/24059524 Young 2013 Biochem Soc Trans]
 }}
-{{MitoPedia methods}}
+__TOC__
+== [[SUITbrowser]] question: AOX activity ==
+:::: AOX activity can be measured with SUIT protocols: use the [https://suitbrowser.oroboros.at/ SUITbrowser] to find your protocol.
+== References ==
+{{#ask:[[Additional label::Alternative oxidase]]
+| mainlabel=Bioblast link
+|?Has title=Reference
+|?Was published in year=Year
+|format=broadtable
+|limit=5000
+|offset=0
+|sort=Has title
+|order=ascending
+}}
 {{MitoPedia topics
 |mitopedia topic=Enzyme
 }}
-__TOC__
-== SUITbrowser question: AOX activity ==
- Work in progress